tolfenamic-acid and Uterine-Hemorrhage

The efficacy of an anti-prostaglandin, tolfenamic acid (T.A.), in the prevention of side-effects after insertion of a copper-T200 intrauterine contraceptive device (I.U.D.) was evaluated in a double-blind trial in 160 women. T.A. relieved pain and reduced bleeding after insertion and during three subsequent menstruations without serious side-effects. A scoring system for the assessment of I.U.D. side-effects showed that the acceptability of I.U.D. was significantly better in women treated with T.A. than in those given placebo.

Topics: Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Humans; Intrauterine Devices, Copper; Menstruation Disturbances; ortho-Aminobenzoates; Pain; Placebos; Prostaglandin Antagonists; Uterine Hemorrhage