tolfenamic-acid and Malabsorption-Syndromes

tolfenamic-acid has been researched along with Malabsorption-Syndromes* in 1 studies

Other Studies

1 other study(ies) available for tolfenamic-acid and Malabsorption-Syndromes

ArticleYear
Intestinal absorption of tolfenamic acid at experimental malabsorption states in rats.
    Arzneimittel-Forschung, 1981, Volume: 31, Issue:12

    Absorption kinetics of 14C-labelled N-(3-chloro-o-tolyl)-anthranilic acid (tolfenamic acid, 14C-TA, Clotam) from the small intestine was studied in intact rats and in rats with malabsorption states provoked by methotrexate, starvation, and triparanol. 14C-TA was administered intravenously and intraduodenally, and the drug concentrations in the blood were followed up radiometrically. A multi-compartmental model was applied for mathematical analysis. Theoretical model parameters were computed, and absorption parameters were then derived from the theoretical ones. The absorption half-life of 14C-TA was 5.3 min in the controls, 10.8 min in the methotrexate-intoxicated, 7.5 min in the fasted, and 5.3 min in the triparanol-intoxicated rats. The absorbed fraction of the intraduodenal 14C-TA dose was 100% in each experimental group as well as in the controls. It is suggested that the slower transfer of 14C-TA through the intestinal barrier in the methotrexate-intoxicated and fasted rats may be caused by the reduction of the absorptive surface.

    Topics: Animals; Female; Intestinal Absorption; Intestine, Small; Malabsorption Syndromes; Methotrexate; ortho-Aminobenzoates; Rats; Rats, Inbred Strains

1981