tolbutamide has been researched along with Sensitivity and Specificity in 15 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The method is simple, rapid and rugged, and has been applied successfully to sample analysis in support of a drug-drug interaction study." | 1.36 | Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions. ( Bertelsen, K; Guo, P; Han, F; Huang, MQ; Lin, ZJ; Weng, N; Zhang, W; Zhao, H, 2010) |
| "Normal-weight and underweight cancer patients had a 32% to 44% reduction in insulin sensitivity (P < ." | 1.30 | Insulin secretion, glucose production, and insulin sensitivity in underweight and normal-weight volunteers, and in underweight and normal-weight cancer patients: a Clinical Research Center study. ( Abemayor, E; Manglik, S; Tayek, JA, 1997) |
| "Tolbutamide hydroxylation was apparently inhibited by cotinine and relatively less inhibited by nicotine." | 1.30 | Inhibitory effect of nicotine and its metabolites on tolbutamide hydroxylation in rat liver microsomes. ( Ho, JW; Leung, YK, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Li, H | 1 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 1 |
| Yan, Z | 1 |
| Liu, X | 1 |
| Sun, Y | 1 |
| He, Z | 1 |
| Zhang, S | 1 |
| Song, N | 1 |
| Li, Q | 1 |
| Fan, H | 1 |
| Liu, C | 1 |
| Desjardins, C | 1 |
| Saxton, P | 1 |
| Lu, SX | 1 |
| Li, X | 2 |
| Rowbottom, C | 1 |
| Wong, YN | 1 |
| Feng, CH | 1 |
| Yang, CM | 1 |
| Lu, CY | 1 |
| Zhang, W | 1 |
| Han, F | 1 |
| Guo, P | 1 |
| Zhao, H | 1 |
| Lin, ZJ | 1 |
| Huang, MQ | 1 |
| Bertelsen, K | 1 |
| Weng, N | 1 |
| Liu, Y | 1 |
| Yang, C | 1 |
| Tai, S | 1 |
| Zhang, X | 1 |
| Liu, G | 1 |
| Griesemer, D | 1 |
| Zawar, C | 1 |
| Neumcke, B | 1 |
| Gordillo-Moscoso, A | 1 |
| Valadéz-Castillo, JF | 1 |
| Mandeville, PB | 1 |
| Hernández-Sierra, JF | 1 |
| Findlay, I | 1 |
| Tayek, JA | 1 |
| Manglik, S | 1 |
| Abemayor, E | 1 |
| Zünkler, BJ | 1 |
| Henning, B | 1 |
| Ott, T | 1 |
| Hildebrandt, AG | 1 |
| Fleck, E | 1 |
| Leung, YK | 1 |
| Ho, JW | 1 |
| Hansen, LL | 1 |
| Brøsen, K | 1 |
| Judd, RL | 1 |
| Kunjathoor, VV | 1 |
| Pillai, UA | 1 |
| Ferguson, PW | 1 |
| Medon, PJ | 1 |
1 review available for tolbutamide and Sensitivity and Specificity
| Article | Year |
|---|---|
Comparison of equivalence and determination of diagnostic utility of min-mod and clamp methods for insulin resistance in diabetes free subjects: a meta-analysis.
Topics: Blood Glucose; Diabetes Mellitus; Glucose; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insu | 2004 |
14 other studies available for tolbutamide and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats.
Topics: Animals; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 | 2008 |
A high-performance liquid chromatography-tandem mass spectrometry method for the clinical combination study of carboplatin and anti-tumor agent eribulin mesylate (E7389) in human plasma.
Topics: Antineoplastic Agents; Carboplatin; Chromatography, High Pressure Liquid; Drug Stability; Furans; Hu | 2008 |
Trace analysis of glyclazide in human plasma at microscale level by mass spectrometry.
Topics: Chromatography, Liquid; Gliclazide; Green Chemistry Technology; Humans; Hypoglycemic Agents; Molecul | 2009 |
Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions.
Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Discovery; Drug Inter | 2010 |
UPLC-MS-MS method for simultaneous determination of caffeine, tolbutamide, metoprolol, and dapsone in rat plasma and its application to cytochrome P450 activity study in rats.
Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dapsone; Dr | 2013 |
Cell-type specific depression of neuronal excitability in rat hippocampus by activation of ATP-sensitive potassium channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Diazoxide; Hippocampus; In Vitro Techniques; Int | 2002 |
Sulphonylurea drugs no longer inhibit ATP-sensitive K+ channels during metabolic stress in cardiac muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Ce | 1993 |
Insulin secretion, glucose production, and insulin sensitivity in underweight and normal-weight volunteers, and in underweight and normal-weight cancer patients: a Clinical Research Center study.
Topics: Anthropometry; Blood Glucose; Body Weight; Glucose Tolerance Test; Head and Neck Neoplasms; Humans; | 1997 |
Effects of tolbutamide on ATP-sensitive K+ channels from human right atrial cardiac myocytes.
Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Atrial Function, Right; Benzopyrans; Child; Cromaka | 1997 |
Inhibitory effect of nicotine and its metabolites on tolbutamide hydroxylation in rat liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Cotinine; Fluorescence; Hydroxylation; Hypoglycemic A | 1998 |
Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection.
Topics: Chromatography, High Pressure Liquid; Humans; Hypoglycemic Agents; Reproducibility of Results; Sensi | 1999 |
Effect of tolbutamide and glyburide on pyruvate kinase flux in isolated rat hepatocytes.
Topics: Animals; Bicarbonates; Carbon Radioisotopes; Glucose; Glyburide; Lactates; Liver; Male; Pyruvate Kin | 1992 |