tolbutamide has been researched along with Progeria in 2 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Progeria: An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature graying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dihydrotachysterol (DHT)-induced progeria, a syndrome with symptoms similar to those seen in normal aging, was evaluated as an old age model." | 7.66 | Examination of dihydrotachysterol-induced progeria as a model for aging changes in carbohydrate metabolism. ( Schriefer, JA; Spratto, GR, 1980) |
| " Dihydrotachysterol (DHT)-induced progeria, a syndrome with symptoms similar to those seen in normal aging, was evaluated as an old age model." | 3.66 | Examination of dihydrotachysterol-induced progeria as a model for aging changes in carbohydrate metabolism. ( Schriefer, JA; Spratto, GR, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schriefer, JA | 1 |
| Spratto, GR | 1 |
| Villee, DB | 1 |
| Nichols, G | 1 |
| Talbot, NB | 1 |
2 other studies available for tolbutamide and Progeria
| Article | Year |
|---|---|
Examination of dihydrotachysterol-induced progeria as a model for aging changes in carbohydrate metabolism.
Topics: Aging; Animals; Body Weight; Carbohydrate Metabolism; Dihydrotachysterol; Eating; Glucose; Insulin; | 1980 |
Metabolic studies in two boys with classical progeria.
Topics: Adult; Amino Acids; Basal Metabolism; Bone and Bones; Child; Collagen; Connective Tissue; Endocrine | 1969 |