tolbutamide has been researched along with Pregnancy in 130 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with oral diazoxide for periods of 4 to 10 weeks in hospital allowed adequate control of hypertension with continuation of fetal growth in four patients with severe toxaemia." | 7.65 | Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy. ( Davis, D; Morgan, MY; Pohl, JE; Thurston, H, 1972) |
| " Oral glucose tolerance tests (OGTTs) and frequently sampled intravenous glucose tolerance tests (FSIGTs) were conducted on Latino women with impaired glucose tolerance and a history of gestational diabetes before and after 12 weeks of treatment with 400 mg/day troglitazone (n = 13) or placebo (n = 12)." | 5.09 | Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes. ( Azen, SP; Berkowitz, K; Buchanan, TA; Goico, J; Kjos, SL; Marroquin, A; Ochoa, C; Peters, RK; Xiang, AH, 2000) |
| "We conducted a randomized placebo-controlled study to determine the effects of the thiazolidinedione compound troglitazone on whole-body insulin sensitivity (SI), pancreatic beta-cell function, and glucose tolerance in 42 Latino women with impaired glucose tolerance (IGT) and a history of gestational diabetes mellitus (GDM), characteristics that carry an 80% risk of developing NIDDM within 5 years." | 5.08 | Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM. ( Azen, S; Berkowitz, K; Buchanan, TA; Dunn, ME; Goico, J; Kjos, SL; Marroquin, A; Peters, R; Xiang, A, 1996) |
| "The prevalence of pre-eclampsia was significantly increased in the group of women treated with metformin compared to women treated with sulphonylurea or insulin (32 vs." | 3.70 | Oral hypoglycaemic agents in 118 diabetic pregnancies. ( Damm, P; Hellmuth, E; Mølsted-Pedersen, L, 2000) |
| "An intravenous and oral glucose tolerance test and an intravenous tolbutamide test have been performed in 11 MZ twin pairs, discordant for diabetes mellitus." | 3.65 | Metabolic research in monozygotic twins with diabetes mellitus: progress report. ( Goecke, T; Grote, W; Grueneklee, D, 1976) |
| "Treatment with oral diazoxide for periods of 4 to 10 weeks in hospital allowed adequate control of hypertension with continuation of fetal growth in four patients with severe toxaemia." | 3.65 | Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy. ( Davis, D; Morgan, MY; Pohl, JE; Thurston, H, 1972) |
| "So far, gestational diabetes treated with tolbutamide has never been associated with severe hypoglycaemia in the newborn when the mother's diabetes was well controlled." | 1.30 | Prolonged elimination of tolbutamide in a premature newborn with hyperinsulinaemic hypoglycaemia. ( Christesen, HB; Melander, A, 1998) |
| "Cromakalim is a K(+) channel opener that causes smooth muscle relaxation by activating ATP-sensitive K(+) (K(ATP)) channels and producing membrane hyperpolarization." | 1.30 | Cromakalim: embryonic effects and reduction of tolbutamide-induced dysmorphogenesis in vitro. ( Smoak, IW, 1999) |
| "Tolbutamide was without any effect on these parameters." | 1.28 | Pharmacological studies with the alpha 2-adrenoceptor antagonist midaglizole. Part III: Smooth muscle, gastrointestinal and miscellaneous systems. ( Hirohashi, M; Kasai, Y; Kojima, H; Takasuna, K; Usui, C, 1991) |
| "Tolbutamide was administered intravenously to 42 nondiabetic subjects, eight of their relatives, and to five sets of twins." | 1.26 | Pharmacogenetics of tolbutamide metabolism in humans. ( Poffenbarger, PL; Scott, J, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 116 (89.23) | 18.7374 |
| 1990's | 7 (5.38) | 18.2507 |
| 2000's | 3 (2.31) | 29.6817 |
| 2010's | 3 (2.31) | 24.3611 |
| 2020's | 1 (0.77) | 2.80 |
| Authors | Studies |
|---|---|
| Giampietro, PF | 1 |
| Bastos, FC | 1 |
| Corceiro, VN | 1 |
| Lopes, SA | 1 |
| de Almeida, JG | 1 |
| Matias, CM | 1 |
| Dionisio, JC | 1 |
| Mendes, PJ | 1 |
| Sampaio Dos Aidos, FDS | 1 |
| Quinta-Ferreira, RM | 1 |
| Quinta-Ferreira, ME | 1 |
| Brown, J | 1 |
| Martis, R | 1 |
| Hughes, B | 1 |
| Rowan, J | 1 |
| Crowther, CA | 1 |
| Vanzela, EC | 1 |
| Ribeiro, RA | 1 |
| de Oliveira, CA | 1 |
| Rodrigues, FB | 1 |
| Bonfleur, ML | 1 |
| Carneiro, EM | 1 |
| Souza, KL | 1 |
| Boschero, AC | 1 |
| CAPPETTI, CA | 1 |
| SIMONETTA, R | 1 |
| BURT, RL | 2 |
| CHESLEY, LC | 1 |
| KAUFMANN, P | 1 |
| PAUERSTEIN, C | 1 |
| LARSSON, Y | 1 |
| STERKY, G | 1 |
| ENDEAN, DH | 1 |
| SMIT, GJ | 1 |
| JACKSON, WP | 1 |
| CAMPBELL, GD | 1 |
| NOTELOVITZ, M | 5 |
| BLUMSOHN, D | 1 |
| BALDI, EM | 2 |
| MIR, P | 2 |
| FOX, D | 2 |
| NUSIMOVICH, B | 2 |
| DOLGER, H | 1 |
| BOOKMAN, JJ | 1 |
| NECHEMIAS, C | 1 |
| SMITHBERG, M | 1 |
| RUNNER, MN | 1 |
| COHLAN, SQ | 2 |
| POULSEN, JE | 1 |
| LOPEZFERNANDEZ, RJ | 1 |
| AHUJA, MM | 1 |
| BRUNET, J | 1 |
| NADEAU, G | 1 |
| MOISAN, A | 1 |
| SAUCIER, G | 1 |
| CAGLI, V | 1 |
| CORNBLATH, M | 1 |
| WYBREGT, SH | 1 |
| BAENS, GS | 1 |
| KLEIN, RI | 1 |
| MALINS, JM | 1 |
| COOKE, AM | 1 |
| PYKE, DA | 1 |
| FITZGERALD, MG | 1 |
| FOA, PP | 2 |
| SCOW, RO | 1 |
| CHERNICK, SS | 1 |
| BRINLEY, MS | 1 |
| OMORI, Y | 1 |
| ONOE, K | 1 |
| KOBASHI, K | 1 |
| FUJINAKA, S | 1 |
| MOSS, JM | 1 |
| DELAWTER, DE | 1 |
| GALLAGHER, EJ | 1 |
| JANATA, J | 1 |
| NELMANS, FA | 1 |
| KEEN, H | 1 |
| LEAKE, NH | 1 |
| KALKHOFF, R | 1 |
| SCHALCH, DS | 1 |
| WALKER, JL | 1 |
| BECK, P | 1 |
| KIPNIS, DM | 1 |
| DAUGHADAY, WH | 1 |
| MCCOLL, JD | 1 |
| GLOBUS, M | 1 |
| ROBINSON, S | 1 |
| DITTMAR, F | 1 |
| MEHNERT, H | 1 |
| NAVARRETE, VN | 3 |
| TORRES, IH | 2 |
| Bruns, CM | 1 |
| Baum, ST | 1 |
| Colman, RJ | 1 |
| Eisner, JR | 1 |
| Kemnitz, JW | 1 |
| Weindruch, R | 1 |
| Abbott, DH | 1 |
| Moiel, RH | 1 |
| Ryan, JR | 1 |
| Cerasi, E | 2 |
| Luft, R | 2 |
| Mouratoff, GJ | 1 |
| Carroll, NV | 1 |
| Scott, EM | 1 |
| Weir, GC | 1 |
| Clore, ET | 1 |
| Zmachinski, CJ | 1 |
| Bonner-Weir, S | 1 |
| Rokicki, W | 1 |
| Bergler, B | 1 |
| Gocyla, I | 1 |
| Philipps, AF | 3 |
| Dubin, JW | 3 |
| Raye, JR | 3 |
| Elliott, BD | 1 |
| Schenker, S | 1 |
| Langer, O | 1 |
| Johnson, R | 1 |
| Prihoda, T | 1 |
| Berkowitz, K | 2 |
| Peters, R | 1 |
| Kjos, SL | 2 |
| Goico, J | 2 |
| Marroquin, A | 2 |
| Dunn, ME | 1 |
| Xiang, A | 1 |
| Azen, S | 1 |
| Buchanan, TA | 2 |
| Fanelli, CG | 1 |
| Bolli, GB | 1 |
| Christesen, HB | 1 |
| Melander, A | 1 |
| Smoak, IW | 1 |
| Xiang, AH | 1 |
| Peters, RK | 1 |
| Ochoa, C | 1 |
| Azen, SP | 1 |
| Hellmuth, E | 1 |
| Damm, P | 1 |
| Mølsted-Pedersen, L | 1 |
| Ganda, OP | 1 |
| Soeldner, JS | 1 |
| Gleason, RE | 1 |
| Smith, TM | 1 |
| Kilo, C | 1 |
| Williamson, JR | 1 |
| Scott, J | 1 |
| Poffenbarger, PL | 1 |
| Milad, M | 1 |
| Wassif, N | 1 |
| Sabet, S | 1 |
| Gabr, Y | 1 |
| Amin, N | 1 |
| Ghanem, M | 1 |
| El Abd, M | 1 |
| El Dardiry, N | 1 |
| Feige, A | 1 |
| Feige-Bruhns, R | 1 |
| Domula, M | 1 |
| Weissbach, G | 1 |
| Lenk, H | 1 |
| Keller, J | 1 |
| James, S | 1 |
| Sodoyez-Goffaux, F | 2 |
| Sodoyez, JC | 3 |
| Belisle, RJ | 1 |
| Long, SY | 1 |
| Ennis, G | 1 |
| Goecke, T | 1 |
| Grote, W | 1 |
| Grueneklee, D | 1 |
| Villanueva Gasca, A | 1 |
| María García, L | 1 |
| López Villegas, J | 1 |
| Núñez, E | 1 |
| Brearley, BF | 1 |
| Förster, VH | 1 |
| Hirohashi, M | 1 |
| Takasuna, K | 1 |
| Kasai, Y | 1 |
| Usui, C | 1 |
| Kojima, H | 1 |
| Saili, A | 1 |
| Sarna, MS | 1 |
| Villar, A | 1 |
| Ivorra, MD | 1 |
| D'Ocon, MP | 1 |
| Anselmi, E | 1 |
| Gropp, C | 1 |
| Göres, E | 1 |
| Kiesewetter, R | 1 |
| Ito, S | 1 |
| Keberle, H | 1 |
| Schmid, K | 1 |
| Faigle, JW | 1 |
| Fritz, H | 1 |
| Loustalot, P | 1 |
| Kogut, MD | 1 |
| Blaskovics, M | 1 |
| Donnell, GN | 1 |
| Ewer, RW | 1 |
| Deiss, WP | 1 |
| Rubay, J | 1 |
| Parmentier, J | 1 |
| Milner, RD | 1 |
| Ashworth, MA | 1 |
| Allner, R | 1 |
| Awini, A | 1 |
| Göltner, E | 1 |
| Ratzmann, KP | 1 |
| Underwood, LE | 1 |
| Van den Brande, JL | 1 |
| Antony, GJ | 1 |
| Voina, SJ | 1 |
| Van Wyk, JJ | 1 |
| Sodoyez-Goffaux, FR | 1 |
| Turtle, JR | 1 |
| Sensi, S | 1 |
| Moneta, E | 1 |
| Capani, F | 1 |
| Caradonna, P | 1 |
| Garcea, N | 1 |
| Carotenuto, M | 1 |
| Heisig, N | 3 |
| Kewitz, H | 1 |
| Coscelli, C | 1 |
| Alpi, O | 1 |
| Bobbioni, E | 1 |
| Campari, M | 1 |
| Lugari, R | 1 |
| Zavaroni, I | 1 |
| Butturini, U | 1 |
| Tuchmann-Duplessis, H | 1 |
| Kanazawa, Y | 1 |
| Orci, L | 1 |
| Lambert, AE | 2 |
| Tanimura, T | 1 |
| Takino, T | 1 |
| Nishimura, H | 1 |
| Roth, J | 1 |
| Glick, SM | 1 |
| Cuatrecasas, P | 1 |
| Hollander, CS | 1 |
| Mintz, DH | 1 |
| Chez, RA | 1 |
| Horger, EO | 1 |
| Kulkarni, HJ | 1 |
| Gaitonde, BB | 1 |
| Pohl, JE | 1 |
| Thurston, H | 1 |
| Davis, D | 1 |
| Morgan, MY | 1 |
| Holtorff, J | 2 |
| Haller, H | 2 |
| Strauzenberg, E | 1 |
| Krafft, W | 1 |
| Schmechel, H | 1 |
| Birkholz, U | 1 |
| Marzotko, F | 1 |
| Harris, EL | 1 |
| Kahl, GF | 1 |
| Shah, CP | 1 |
| Venugopal, K | 1 |
| Gulati, OD | 1 |
| Castelazo Ayala, L | 1 |
| Alger, CR | 2 |
| Flores, HV | 1 |
| Janisch, H | 1 |
| Eiselmayr, G | 1 |
| Töndury, G | 1 |
| Müntener, M | 1 |
| Sani, G | 1 |
| Floris, F | 1 |
| Paniagua, HE | 1 |
| Manzo, PB | 1 |
| Schiff, D | 1 |
| Aranda, JV | 1 |
| Stern, L | 1 |
| Kuntz, E | 1 |
| Teuscher, A | 1 |
| Richterich, R | 1 |
| Strauzenberg, SE | 1 |
| Horner, R | 1 |
| Thomson, AJ | 1 |
| McDonald, R | 1 |
| Herre, HD | 1 |
| Falkenthal, S | 1 |
| Lenz, P | 1 |
| Serantes, NA | 1 |
| Kleiner, B | 1 |
| Löffler, F | 1 |
| Beissert, M | 1 |
| de L'Hortet, GC | 1 |
| Bercovici, JP | 1 |
| Robertson, DW | 1 |
| Johansen, K | 1 |
| Orskov, H | 1 |
| Velasco, MS | 1 |
| Paulsen, EP | 1 |
| Jeanrenaud, B | 1 |
| Junod, A | 1 |
| Renold, AE | 1 |
| Spellacy, WN | 1 |
| Goetz, FC | 1 |
| Greenberg, BZ | 1 |
| Schoeller, KL | 1 |
| Lange, HJ | 1 |
| Knick, B | 1 |
| Stark, G | 1 |
| Kahlert, F | 1 |
| Horký, Z | 1 |
| Bank, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Gain on Closed-Loop Insulin[NCT02065895] | 8 participants (Actual) | Interventional | 2013-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Glucose Area Under the Curve (AUC) Breakfast defines the total exposure to glucose during breakfast. Breakfast is typically considered the most difficult meal to control; low AUC is desirable.This outcome measure was analyzed for each of the three calibration error values (high error, no error and low error). (NCT02065895)
Timeframe: On day #1, day #2 and day #3 (each day could be 24 hours to 7 days apart from prior one, and completed within 6 week period) 8:00 AM to 2:00 PM on day following admission, with samples obtained every 10-15 minutes, for each sequence of calibration errors
| Intervention | mmol/l/min (Mean) |
|---|---|
| HIGH Error | 66.8 |
| NO Error | 48.8 |
| LOW Error | 37.4 |
Night-time in target range 5.0-8.33, following the 3 hour controller initialization period blood glucose remained at or near target. (NCT02065895)
Timeframe: On day #1, day #2 and day #3 (each day could be 24 hours to 7 days apart from prior one, and completed within 6 week period) 12:00 AM to 6:00 AM on day following admission, with samples obtained every 10-15 minutes, for each sequence of calibration errors
| Intervention | percentage of time in target range (Median) |
|---|---|
| HIGH Error | 88 |
| NO Errror | 100 |
| LOW Error | 80 |
Highest and lowest glucose concentrations obtained during breakfast meal. (NCT02065895)
Timeframe: On day #1, day #2 and day #3 (each day could be 24 hours to 7 days apart from prior one, and completed within 6 week period) 8:00 AM to 12:00 PM on day following admission, with samples obtained every 10-15 minutes, for each sequence of calibration errors
| Intervention | mmol/l (Mean) | |
|---|---|---|
| Peak glucose concentration | Nadir glucose concentration | |
| Gain Decreased and Target Increased | 11.3 | 6.6 |
| Gain Increased and Target Decreased | 13.3 | 4.5 |
| Nadir Mean | 11.8 | 4.8 |
9 reviews available for tolbutamide and Pregnancy
| Article | Year |
|---|---|
Oral anti-diabetic pharmacological therapies for the treatment of women with gestational diabetes.
Topics: Acarbose; Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypo | 2017 |
TERATOGENIC AGENTS AND CONGENITAL MALFORMATIONS.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminopterin; Congenital Abnormalities; Female; | 1963 |
FETAL AND NEONATAL HAZARDS FROM DRUGS ADMINISTERED DURING PREGNANCY.
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Anticoagulants; Antimetabolites; Antineoplastic | 1964 |
EXPERIMENTAL DIABETES AND THE MODE OF ACTION OF THE SULFONYLUREAS. WITH SOME SPECULATIONS ON THE PREVENTION OF DIABETES.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Cortisone; Diabetes Mellitus; Diabete | 1964 |
[PREDIABETES AND PREGNANCY].
Topics: Abortion, Induced; Abortion, Spontaneous; Congenital Abnormalities; Diabetes Mellitus; Diabetic Reti | 1964 |
[INSULIN ANTIBODIES].
Topics: Adrenocorticotropic Hormone; Animals; Autoimmune Diseases; Diabetes Mellitus; Diabetic Angiopathies; | 1964 |
[THE PANCREAS AND PREGNANCY. I].
Topics: Carbohydrate Metabolism; Diabetes Mellitus; Female; Glucose Tolerance Test; Glycosuria; Humans; Insu | 1964 |
Recent developments in the management of diabetes mellitus.
Topics: Animals; Australia; Coronary Disease; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathie | 1974 |
Alcohol: another intoxicating instalment.
Topics: Alcohol Oxidoreductases; Animals; Barbiturates; Caffeine; Drug Incompatibility; Ethanol; Fatty Liver | 1970 |
5 trials available for tolbutamide and Pregnancy
| Article | Year |
|---|---|
Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM.
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; California; Cholesterol, HDL; Cholesterol, LD | 1996 |
Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes.
Topics: Adult; Chromans; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucose; Glucose Intolera | 2000 |
Bood glucose level in pregnancy.
Topics: Alkaline Phosphatase; Blood Glucose; Clinical Trials as Topic; Female; Humans; Insulin; Phosphorus; | 1975 |
Sulphonylurea therapy in the treatment of the pregnant diabetic.
Topics: Abnormalities, Drug-Induced; Adult; Apgar Score; Blood Glucose; Chlorpropamide; Diet Therapy; Female | 1971 |
Insulin response to glucose infusion in diabetic and non-diabetic monozygotic twin pairs. Genetic control of insulin response?
Topics: Adult; Aged; Blood Glucose; Clinical Trials as Topic; Computers, Analog; Diabetes Mellitus; Diseases | 1967 |
116 other studies available for tolbutamide and Pregnancy
| Article | Year |
|---|---|
50 Years Ago in The Journal of Pediatrics: Tolubtamide-Mediated Dysregulation of Apoptosis.
Topics: Adult; Apoptosis; Female; Humans; Hypoglycemic Agents; Infant, Newborn; Male; Pregnancy; Prenatal Ex | 2020 |
Effect of tolbutamide on tetraethylammonium-induced postsynaptic zinc signals at hippocampal mossy fiber-CA3 synapses.
Topics: Animals; CA3 Region, Hippocampal; Female; KATP Channels; Long-Term Potentiation; Mossy Fibers, Hippo | 2017 |
Pregnancy restores insulin secretion from pancreatic islets in cafeteria diet-induced obese rats.
Topics: Animals; Blood Glucose; Body Weight; Calcium; Calcium Channels; Diet; DNA; Female; Gene Expression; | 2010 |
[A case of diabetes in pregnancy treated with tolbutamide].
Topics: Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Pregnancy; Tolbutamide | 1958 |
Reactivity to tolbutamide in normal pregnancy.
Topics: Female; Humans; Hypoglycemic Agents; Pregnancy; Tolbutamide | 1958 |
Progressive resistance to intravenous tolbutamide in pregnancy.
Topics: Female; Humans; Pregnancy; Tolbutamide | 1961 |
Possible teratogenic effect of tolbutamide in pregnant prediabeti.
Topics: Congenital Abnormalities; Female; Humans; Pregnancy; Tolbutamide | 1960 |
Use of tolbutamide in pregnant diabetics.
Topics: Diabetes Mellitus; Female; Pregnancy; Pregnancy Complications; Tolbutamide | 1961 |
Tolbutamide and chlorpropamide during pregnancy in human diabetics.
Topics: Carbutamide; Chlorpropamide; Diabetes Mellitus; Female; Pregnancy; Pregnancy Complications; Tolbutam | 1962 |
[Unger's test in pregnant women. Intravenous tolbutamide tolerance test].
Topics: Diabetes Mellitus; Female; Humans; Pancreatic Function Tests; Pregnancy; Pregnancy in Diabetics; Tol | 1963 |
The diagnostic and therapeutic value of tolbutamide in pregnant diabetics.
Topics: Diabetes Mellitus; Female; Humans; Pregnancy; Pregnancy Complications; Tolbutamide | 1962 |
[UNGER'S TEST IN PREGNANT WOMEN].
Topics: Blood Glucose; Diabetes Mellitus; Diagnosis; Female; Humans; Pregnancy; Pregnancy in Diabetics; Tolb | 1963 |
TERATOGENIC EFFECTS OF HYPOGLYCEMIC TREATMENTS IN INBRED STRAINS OF MICE.
Topics: Abnormalities, Drug-Induced; Animals; Hypoglycemic Agents; Insulin; Mice; Mice, Inbred Strains; Niac | 1963 |
[ORAL DIABETIC DRUGS].
Topics: Carbutamide; Chlorpropamide; Diabetes Mellitus; Female; Humans; Metformin; Phenformin; Pregnancy; Pr | 1964 |
[VARIANTS OF THE PRE-DIABETIC STATE IN PREGNANCY].
Topics: Chlorpropamide; Diabetes Mellitus; Female; Prediabetic State; Pregnancy; Pregnancy in Diabetics; Pro | 1963 |
RENAL GLYCOSURIA. FAILURE TO ESTABLISH EVIDENCE OF 'POTENTIAL' DIABETES BY THE PREDNISOLONE TOLBUTAMIDE TEST.
Topics: Diabetes Mellitus; Diagnosis, Differential; Glucose Tolerance Test; Glycosuria; Glycosuria, Renal; H | 1964 |
[EXPERIMENTAL STUDY OF THE INDUCED HYPERGLYCEMIA TEST INDUCED BY VENOUS ROUTE].
Topics: Acromegaly; Androgens; Cortisone; Diabetes Mellitus; Female; Glucose Tolerance Test; Glycosuria; Hyp | 1964 |
[THE THERAPY OF DIABETES MELLITUS].
Topics: Carbutamide; Chlorpropamide; Diabetes Mellitus; Diabetic Coma; Diet, Diabetic; Female; Globins; Hypo | 1964 |
SYMPTOMATIC NEONATAL HYPOGLYCEMIA. STUDIES OF CARBOHYDRATE METABOLISM IN THE NEWBORN INFANT. VIII.
Topics: Adolescent; Black People; Blood Chemical Analysis; Carbohydrate Metabolism; Central Nervous System D | 1964 |
SULPHONYLUREA DRUGS IN PREGNANCY.
Topics: Abnormalities, Drug-Induced; Chlorpropamide; Diabetes Mellitus; Female; Fetal Death; Humans; Pregnan | 1964 |
HYPERLIPEMIA AND KETOSIS IN THE PREGNANT RAT.
Topics: Acidosis; Adipose Tissue; Animals; Blood Glucose; Body Weight; Cholesterol; Fasting; Fatty Acids; Fa | 1964 |
ORAL HYPOGLYCEMIC DRUGS: COMPARATIVE EVALUATION OF TOLBUTAMIDE, CHLORPROPAMIDE AND PHENFORMIN.
Topics: Alkaline Phosphatase; Biomedical Research; Blood Glucose; Chlorpropamide; Diabetes Mellitus; Diabete | 1964 |
[DRUGS WHICH SHOULD NOT BE GIVEN TO A PREGNANT WOMAN].
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Antineoplastic Agents; Dihydrostreptomycin Sul | 1964 |
THE FAMILY DOCTOR AND THE DIABETIC.
Topics: Acidosis; Adolescent; Child; Chlorpropamide; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetic | 1965 |
SERUM INSULIN-LIKE ACTIVITY AFTER TOLBUTAMIDE DURING PREGNANCY AND EARLY PUERPERIUM.
Topics: Adipose Tissue; Biomedical Research; Blood; Female; Humans; Injections; Injections, Intravenous; Ins | 1965 |
DIABETOGENIC FACTORS ASSOCIATED WITH PREGNANCY.
Topics: Diabetes Mellitus; Fatty Acids; Female; Glucose Tolerance Test; Growth Hormone; Hormones; Humans; In | 1964 |
EFFECT OF SOME THERAPEUTIC AGENTS ON THE DEVELOPING RAT FETUS.
Topics: Abnormalities, Drug-Induced; Animals; Antipyrine; Aspirin; Chloral Hydrate; Dimenhydrinate; Female; | 1965 |
[ON THE RECOGNITION OF LATENT DIABETIC CONDITIONS N THE PUERPERA WITH THE HELP OF THE TOLBUTAMIDE TEST].
Topics: Diabetes Mellitus; Diagnosis; Female; Humans; Pharmacology; Pregnancy; Puerperal Disorders; Tolbutam | 1964 |
A TRIAMCINOLONE-GLUCOSE TOLERANCE TEST IN THE EARLY DIAGNOSIS OF DIABETES.
Topics: Cortisone; Diabetes Mellitus; Early Diagnosis; Female; Genetics, Medical; Glucose Tolerance Test; Hu | 1965 |
Insulin resistance and impaired insulin secretion in prenatally androgenized male rhesus monkeys.
Topics: Animals; Area Under Curve; Female; Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; In | 2004 |
Tolbutamide orinase in human breast milk.
Topics: Blood Glucose; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Milk, Human; Pregnancy; Pre | 1967 |
"What is inherited--what is added" hypothesis for the pathogenesis of diabetes mellitus.
Topics: Acromegaly; Adult; Carbon Isotopes; Computers, Analog; Diabetes Mellitus; Female; Glucose; Glucose T | 1967 |
Diabetes mellitus in Eskimos.
Topics: Adult; Aged; Alaska; Arthritis, Rheumatoid; Blood Glucose; Body Weight; Diabetes Mellitus; Female; F | 1967 |
Islet secretion in a new experimental model for non-insulin-dependent diabetes.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucagon; Glucos | 1981 |
[Tolbutamide (diabetol) and pregnancy. Effect of tolbutamide on the condition of the fetus and newborn infant].
Topics: Adult; Apgar Score; Birth Weight; Female; Fetal Death; Humans; Infant, Newborn; Maternal-Fetal Excha | 1983 |
Effect of endogenous insulin release on fetal alanine concentration and uptake.
Topics: Alanine; Amino Acids; Animals; Blood Glucose; Female; Fetus; Insulin; Pregnancy; Sheep; Tolbutamide | 1981 |
Fetal metabolic response to endogenous insulin release.
Topics: Animals; Blood Glucose; Female; Fetal Blood; Fetus; Insulin; Insulin Secretion; Oxygen; Pregnancy; S | 1981 |
Comparative placental transport of oral hypoglycemic agents in humans: a model of human placental drug transfer.
Topics: Administration, Oral; Analysis of Variance; Antipyrine; Biological Transport; Chlorpropamide; Chroma | 1994 |
Sulphonylureas and pregnancy.
Topics: Diabetes, Gestational; Female; Half-Life; Humans; Hypoglycemic Agents; Maternal-Fetal Exchange; Preg | 1998 |
Prolonged elimination of tolbutamide in a premature newborn with hyperinsulinaemic hypoglycaemia.
Topics: Adult; Diabetes, Gestational; Female; Half-Life; Humans; Hyperinsulinism; Hypoglycemia; Hypoglycemic | 1998 |
Cromakalim: embryonic effects and reduction of tolbutamide-induced dysmorphogenesis in vitro.
Topics: Abnormalities, Multiple; Animals; Cromakalim; Embryonic and Fetal Development; Female; Hypoglycemic | 1999 |
Oral hypoglycaemic agents in 118 diabetic pregnancies.
Topics: Abruptio Placentae; Adult; Birth Weight; Cesarean Section; Cohort Studies; Diabetes Mellitus, Type 2 | 2000 |
Monozygotic triplets with discordance for diabetes mellitus and diabetic microangiopathy.
Topics: Adolescent; Adult; Antigens; Basement Membrane; Blood Glucose; Capillaries; Cortisone; Diabetes Mell | 1977 |
Response of the fetal and newborn lamb to glucose and tolbutamide infusions.
Topics: Animals; Animals, Newborn; Blood Glucose; Dose-Response Relationship, Drug; Female; Fetal Blood; Fet | 1979 |
Pharmacogenetics of tolbutamide metabolism in humans.
Topics: Adolescent; Adult; Aged; Female; Gene Frequency; Humans; Liver; Male; Middle Aged; Pedigree; Pharmac | 1979 |
The pathogenesis of the teratogenic effect of the antidiabetic drug "tolbutamide": an experimental study.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Mice; Mice, Inbred Strains; Muscles; Pregnancy; | 1977 |
[Diabetes detection diagnosis in pregnancy].
Topics: Female; Glucose Tolerance Test; Glycosuria; Humans; Pregnancy; Pregnancy in Diabetics; Tolbutamide | 1977 |
[Effect of drug therapy during pregnancy on the clotting potential of the newborn].
Topics: Aspirin; Blood Coagulation Disorders; Drug-Related Side Effects and Adverse Reactions; Female; Hemos | 1977 |
Tolbutamide-induced insulin release in pregnant diabetics.
Topics: Adult; Blood Glucose; Body Height; Body Weight; Female; Glucose; Humans; Insulin; Pregnancy; Pregnan | 1977 |
Transient diabetes mellitus in a neonate. Evaluation of insulin, glucagon, and growth hormone secretion and management with a continuous low-dose insulin infusion.
Topics: Adolescent; Antigens; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glucagon; Glucose Tolerance | 1977 |
Tolbutamide treatment of pregnant mice: repeated administration reduces fetal lethality.
Topics: Abnormalities, Drug-Induced; Animals; Enzyme Induction; Female; Fetal Death; Fetal Resorption; Fetus | 1976 |
Oral hypoglycaemic agents--dangers and contraindications.
Topics: Aged; Biguanides; Cardiovascular Diseases; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; L | 1976 |
Metabolic research in monozygotic twins with diabetes mellitus: progress report.
Topics: Adolescent; Adult; Aged; Body Weight; Diabetes Mellitus; Diseases in Twins; Fatty Acids; Female; Glu | 1976 |
Editorial: The tolbutamide controversy: doctor's dilemma and patient's plight.
Topics: Adolescent; Adult; Diabetes Mellitus; Diet Therapy; Drug Evaluation; Female; Humans; Pregnancy; Tolb | 1975 |
[Use of tolbutamide in diabetes and pregnancy].
Topics: Adult; Diabetes Mellitus; Drug Evaluation; Female; Humans; Infant, Newborn; Insulin; Middle Aged; Pr | 1975 |
The management of pregnancy in diabetes mellitus.
Topics: Birth Weight; Blood Glucose; Chlorpropamide; Delivery, Obstetric; Diet, Diabetic; Female; Fetal Deat | 1975 |
[Hypoglycemia. Series 2: symptoms, diagnosis].
Topics: Adult; Blood Glucose; Catecholamines; Fatigue; Female; Glucagon; Glucose Tolerance Test; Headache; H | 1976 |
Pharmacological studies with the alpha 2-adrenoceptor antagonist midaglizole. Part III: Smooth muscle, gastrointestinal and miscellaneous systems.
Topics: Adrenergic alpha-Antagonists; Animals; Digestive System; Dogs; Electrolytes; Female; Gastric Acid; G | 1991 |
Tolbutamide: teratogenic effects.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Arm; Female; Humans; Infant, Newborn; Leg; Mal | 1991 |
[Importance of calcium in the interaction between prostaglandins E and sulfonylureas in utero].
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Female; Glyburide; Muscle Rel | 1986 |
[Staining and immunohistological differentiation of acidophilic cells of the pituitary gland anterior lobe].
Topics: Acromegaly; Adult; Animals; Cats; Cattle; Dogs; Female; Fetus; Fluorescent Antibody Technique; Human | 1971 |
[Dangers in drug combinations].
Topics: Dicumarol; Dosage Forms; Drug Antagonism; Drug Interactions; Drug Synergism; Erythroblastosis, Fetal | 1972 |
Letter: Oral hypoglycaemic therapy in diabetic pregnancies.
Topics: Administration, Oral; Antigens; Biguanides; Blood Glucose; Chlorpropamide; Female; Humans; Insulin; | 1974 |
[Thyroid hormones].
Topics: Androgens; Chloroquine; Diethylstilbestrol; Estrogens; Female; Humans; Hydrocortisone; Hydroflumethi | 1967 |
[On the penetration of foreign body materials into the young vertebrate embryo].
Topics: Animals; Deferoxamine; Embryo Implantation; Embryo, Mammalian; Female; Glycosaminoglycans; Lipids; P | 1966 |
Idiopathic hypoglycemia: a study of twenty-six children.
Topics: Adrenocorticotropic Hormone; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Diabetes | 1969 |
Clinical experience with human growth hormone immunoassay by a two-antibody method.
Topics: Acromegaly; Adenoma, Chromophobe; Adenoma, Islet Cell; Amenorrhea; Anorexia Nervosa; Arginine; Dwarf | 1969 |
[2 cases of Langerhans adenoma].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adult; Aged; Angiography; Celiac Ar | 1969 |
Insulin release from human fetal pancreas in vitro.
Topics: Arginine; Barium; Body Weight; Cyclic AMP; Female; Fetus; Gestational Age; Glucagon; Glucose; Humans | 1971 |
[Significance of the tolbutamide test in the puerperium].
Topics: Diabetes Mellitus; Female; Humans; Methods; Postpartum Period; Pregnancy; Tolbutamide | 1974 |
[Value and interpretation of the intravenous Tolbutamide Test (i.v.TT)].
Topics: Blood Glucose; Diabetes Mellitus; Fasting; Female; Humans; Hypoglycemic Agents; Injections, Intraven | 1974 |
Islet cell function and glucose homeostasis in hypopituitary dwarfism: synergism between growth hormone and cortisone.
Topics: Blood Glucose; Child; Cortisone; Drug Synergism; Dwarfism, Pituitary; Female; Glucose; Glucose Toler | 1973 |
Effect of the daily injection of tolbutamide into pregnant rats on the pancreatic insulin content of their offspring.
Topics: Animals; Blood Glucose; Female; Insulin; Insulin Secretion; Islets of Langerhans; Male; Maternal-Fet | 1973 |
Studies of glucose metabolism in mothers of large babies.
Topics: Adult; Birth Weight; Blood Glucose; Female; Glucose; Glucose Tolerance Test; Growth Hormone; Humans; | 1972 |
[Diagnosis of diabetic states in pregnancy].
Topics: Blood Glucose; Diabetes Mellitus; Diagnostic Errors; False Positive Reactions; Female; Glucose Toler | 1973 |
[Drugs as causes of diseases].
Topics: Adult; Aged; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Female; Humans; | 1973 |
[Value of mass screening for the early diagnosis of diabetes mellitus. Experience in the Province of Parma].
Topics: Adolescent; Adult; Age Factors; Aged; Body Weight; Child; Child, Preschool; Cholesterol; Diabetes Me | 1973 |
[The teratogenic risk].
Topics: Abnormalities, Drug-Induced; Animals; Azathioprine; Busulfan; Carbutamide; Congenital Abnormalities; | 1968 |
Organ culture of fetal rat pancreas. IV. Effects of metabolic inhibitors on insulin release.
Topics: Animals; Binding Sites; Biological Transport, Active; Caffeine; Citrates; Female; Glucose; Heptoses; | 1971 |
Effects of gestational age, birth and feeding on the insulinogenic response to glucose and tolbutamide by fetal and newborn rat pancreas.
Topics: Animals; Animals, Newborn; Feeding Behavior; Female; Gestational Age; Glucose; Insulin; Islets of La | 1971 |
Modification of the teratogenic effect of thio-TEPA on the mouse offspring by successive maternal treatment with tolbutamide.
Topics: Abnormalities, Drug-Induced; Animals; Female; Mice; Pregnancy; Thiotepa; Tolbutamide | 1966 |
Acromegaly and other disorders of growth hormone secretion. Combined clinical staff conference at the National Institutes of Health.
Topics: Acromegaly; Adolescent; Adult; Aged; Blood Glucose; Child; Diabetes Mellitus; Diagnosis, Differentia | 1967 |
Fetal insulin and growth hormone metabolism in the subhuman primate.
Topics: Animals; Arginine; Blood Glucose; Female; Glucose; Growth Hormone; Haplorhini; Immune Sera; Insulin; | 1969 |
Oral contraceptive steroids and carbohydrate metabolism.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Contraceptives, Oral; Diabetes Mellitus; Estrogens; | 1972 |
Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy.
Topics: Acute Disease; Administration, Oral; Adult; Albuminuria; Blood Glucose; Diazoxide; Female; Furosemid | 1972 |
[Significance of abnormal fetal developments for the detection of prediabetic state].
Topics: Birth Weight; Congenital Abnormalities; Diabetes Mellitus; Embryonic and Fetal Development; Female; | 1972 |
[Diagnosis of subclinical diabetes mellitus in the puerperium by means of the intravenous tolbutamide test].
Topics: Adolescent; Adult; Diabetes Mellitus; Female; Humans; Pregnancy; Puerperal Disorders; Tolbutamide | 1972 |
Adverse reactions to oral antidiabetic agents.
Topics: Acetohexamide; Acidosis; Administration, Oral; Anemia; Chlorpropamide; Drug Antagonism; Drug Synergi | 1971 |
[Changes in the velocity of drug catabolism and their importance in drug therapy].
Topics: Administration, Oral; Age Factors; Alcohols; Anticoagulants; Anticonvulsants; Carcinogens; Contracep | 1971 |
Seminars on diabetes. II. Principles of management.
Topics: Acetohexamide; Chlorpropamide; Diabetes Mellitus; Diet, Diabetic; Female; Health Education; Humans; | 1971 |
A study of some aspects of plasma free insulin-like activity.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Female; Glucose; Humans; Hypoglycemic Agents; Labor, Obst | 1971 |
Modification of response to the triamcinolone glucose tolerance test by treatment with oral hypoglycemic agents.
Topics: Abortion, Habitual; Adolescent; Adult; Blood Glucose; Congenital Abnormalities; Female; Fetal Death; | 1966 |
[Early recognition of latent diabetes].
Topics: Adult; Birth Weight; Blood Glucose; Female; Humans; Methods; Prediabetic State; Pregnancy; Pregnancy | 1969 |
[Abnormalities and diabetes].
Topics: Animals; Congenital Abnormalities; Female; Humans; Insulin; Mice; Pregnancy; Pregnancy in Diabetics; | 1969 |
[Behavior of blood sugar and blood nonesterified fatty acids in old primiparas and in pluriparas].
Topics: Age Factors; Blood Glucose; Fatty Acids, Nonesterified; Female; Humans; Maternal Age; Parity; Pregna | 1969 |
The significance of metabolic adjustment before a new pregnancy. Prophylaxis of congenital malformations.
Topics: Abortion, Spontaneous; Adult; Congenital Abnormalities; Diabetes Complications; Diabetes Mellitus; F | 1970 |
Neonatal thrombocytopenia and congenital malformations associated with administration of tolbutamide to the mother.
Topics: Abnormalities, Drug-Induced; Ear; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; | 1970 |
[Classification and clinical picture of diabetes mellitus].
Topics: Age Factors; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diabetic Neuropat | 1970 |
[Diagnostic procedures for diabetes in pregnancy].
Topics: Female; Glucose Tolerance Test; Glycosuria; Humans; Prednisone; Pregnancy; Pregnancy in Diabetics; T | 1971 |
[New Swiss guidelines for the diagnosis of diabetes mellitus].
Topics: Blood Glucose; Cortisone; Diabetes Mellitus; Female; Glucose Tolerance Test; Glycosuria; Growth Horm | 1971 |
[Oral antidiabetics in pregnancy].
Topics: Abnormalities, Drug-Induced; Biguanides; Carbutamide; Chlorpropamide; Female; Fetus; Humans; Hypogly | 1971 |
[The significance of prediabetes of the mother for the fate of the child].
Topics: Adult; Birth Weight; Congenital Abnormalities; Female; Fetal Death; Glucose Tolerance Test; Humans; | 1967 |
Neonatal transient diabetes mellitus.
Topics: Dehydration; Diabetes Mellitus; Female; Glucose Tolerance Test; Glycosuria; Humans; Hypoglycemia; In | 1968 |
[The tolbutamide effect in normal pregnancy].
Topics: Blood Glucose; Factor Analysis, Statistical; Female; Humans; Injections, Intravenous; Postpartum Per | 1968 |
[Obstetric syndrome in prediabetes and subclinical diabetes mellitus].
Topics: Adult; Argentina; Birth Weight; Diabetes Mellitus; Diet Therapy; Female; Fetal Death; Glucose Tolera | 1968 |
[The importance of the prednisone-glucose-test and the intravenous tolbutamide test in the detection of diabetes in the puerperium].
Topics: Adult; Birth Weight; Blood Glucose; Female; Glucose Tolerance Test; Humans; Prednisone; Pregnancy; P | 1968 |
[Diabetes mellitus. Present concepts and therapeutic implications].
Topics: Adolescent; Adult; Birth Weight; Child; Cortisone; Diabetes Mellitus; Diabetic Angiopathies; Fatty A | 1968 |
The effect of sodium tolbutamide on the uptake of sodium-35S-sulfate and 35S-methionine in inbred strains of mice.
Topics: Animals; Bone Development; Cartilage; Chondroitin; Embryo, Mammalian; Female; Methionine; Mice; Preg | 1968 |
Plasma insulin during remission in juvenile diabetes mellitus.
Topics: Adult; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus, Type 1; Female; Glucose Tolerance | 1969 |
The response of infants of diabetic women to tolbutamide and leucine at birth, and to glucose and tolbutamide at 2 years of age.
Topics: Blood Glucose; Child, Preschool; Diabetes Mellitus; Female; Glucose Tolerance Test; Humans; Infant, | 1969 |
Organ culture of fetal rat pancreas. II. Insulin release induced by amino and organic acids, by hormonal peptides, by cationic alterations of the medium and by other agents.
Topics: Acids; Adenylyl Cyclases; Amino Acids; Animals; Caffeine; Calcium; Culture Media; Culture Techniques | 1969 |
The adrenal cortex and the pregnant diabetic.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenal Glands; Adult; Chlorpropamide; Diabe | 1969 |
Tolbutamide response in normal pregnancy.
Topics: Blood; Blood Glucose; Female; Humans; Insulin; Insulin Resistance; Pregnancy; Tolbutamide | 1965 |
[Validity test of a new graphic evaluation procedure (T 3) of the intravenous tolbutamide test in diabetes-suspect groups (consanguineous family members of diabetics; big baby mothers; fatty liver patients)].
Topics: Blood Glucose; Congenital Abnormalities; Diabetes Mellitus; Fatty Liver; Female; Humans; Injections, | 1965 |
[Peroral antidiabetics during pregnancy].
Topics: Abnormalities, Drug-Induced; Carbutamide; Female; Fetal Death; Heart Defects, Congenital; Humans; Hy | 1965 |
The management of diabetes in the underprivileged, with special reference to pancreatic diabetes.
Topics: Africa, Southern; Alcoholism; Black or African American; Black People; Diabetes Mellitus; Diet, Diab | 1966 |