tolbutamide has been researched along with Myocardial Ischemia in 6 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim was to study the effects of nicorandil (an ATP-sensitive K+ channel opener) and tolbutamide (an ATP-sensitive K+ channel blocker) on reperfusion-induced arrhythmias in pentobarbitone and ketamine anesthetized rabbits." | 7.71 | Effects of nicorandil administration on survival rate and arrhythmias during reperfusion in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2001) |
| "The aim was to study the effects of nicorandil (an ATP-sensitive K+ channel opener) and tolbutamide (an ATP-sensitive K+ channel blocker) on reperfusion-induced arrhythmias in pentobarbitone and ketamine anesthetized rabbits." | 3.71 | Effects of nicorandil administration on survival rate and arrhythmias during reperfusion in anesthetized rabbits. ( Das, B; Karanth, KS; Sarkar, C, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meier, JJ | 1 |
| Gallwitz, B | 1 |
| Schmidt, WE | 1 |
| Mügge, A | 1 |
| Nauck, MA | 1 |
| Nakaya, H | 1 |
| Zünkler, BJ | 1 |
| Henning, B | 1 |
| Ott, T | 1 |
| Hildebrandt, AG | 1 |
| Fleck, E | 1 |
| Knowler, WC | 1 |
| Sartor, G | 1 |
| Melander, A | 1 |
| Scherstén, B | 1 |
| Das, B | 1 |
| Sarkar, C | 1 |
| Karanth, KS | 1 |
| Vanheel, B | 1 |
| de Hemptinne, A | 1 |
2 reviews available for tolbutamide and Myocardial Ischemia
| Article | Year |
|---|---|
Is impairment of ischaemic preconditioning by sulfonylurea drugs clinically important?
Topics: Animals; Cardiovascular Agents; Catheterization; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Age | 2004 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1993 |
1 trial available for tolbutamide and Myocardial Ischemia
| Article | Year |
|---|---|
Glucose tolerance and mortality, including a substudy of tolbutamide treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Blood Glucose; Cause of Death; Confidence I | 1997 |
3 other studies available for tolbutamide and Myocardial Ischemia
| Article | Year |
|---|---|
Effects of tolbutamide on ATP-sensitive K+ channels from human right atrial cardiac myocytes.
Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Atrial Function, Right; Benzopyrans; Child; Cromaka | 1997 |
Effects of nicorandil administration on survival rate and arrhythmias during reperfusion in anesthetized rabbits.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; | 2001 |
Influence of KATP channel modulation on net potassium efflux from ischaemic mammalian cardiac tissue.
Topics: Action Potentials; Animals; Barium; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Hydrogen-Ion Co | 1992 |