tolbutamide has been researched along with Muscle Relaxation in 6 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The rate and amplitude of smooth muscle relaxation at low PO2 were significantly decreased by tolbutamide (5 mmol l-1), which is known to inhibit cyclic AMP-dependent protein kinases." | 3.68 | Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats. ( Basilyuk, OV; Soloviev, AI, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kau, ST | 1 |
| Zografos, P | 1 |
| Do, ML | 1 |
| Halterman, TJ | 1 |
| McConville, MW | 1 |
| Yochim, CL | 1 |
| Trivedi, S | 1 |
| Howe, BB | 1 |
| Li, JH | 1 |
| Soloviev, AI | 1 |
| Basilyuk, OV | 1 |
| Cowan, CL | 1 |
| Palacino, JJ | 1 |
| Najibi, S | 1 |
| Cohen, RA | 1 |
| Sheridan, BC | 1 |
| McIntyre, RC | 1 |
| Meldrum, DR | 1 |
| Fullerton, DA | 1 |
| Lebrun, P | 1 |
| Fang, ZY | 1 |
| Antoine, MH | 1 |
| Herchuelz, A | 1 |
| Hermann, M | 1 |
| Berkenboom, G | 1 |
| Fontaine, J | 1 |
| Villar, A | 1 |
| Ivorra, MD | 1 |
| D'Ocon, MP | 1 |
| Anselmi, E | 1 |
6 other studies available for tolbutamide and Muscle Relaxation
| Article | Year |
|---|---|
Characterization of ATP-sensitive potassium channel-blocking activity of ZENECA ZM181,037, a eukalemic diuretic.
Topics: Acetamides; Adenosine Triphosphate; Administration, Oral; Animals; Benzopyrans; Blood Glucose; Blood | 1994 |
Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats.
Topics: Actin Cytoskeleton; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Calcium; Chlorides; Cy | 1993 |
Potassium channel-mediated relaxation to acetylcholine in rabbit arteries.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Aorta, Thoracic; Arginine; Cyclic GMP; Endothelium, Vascul | 1993 |
KATP channels contribute to beta- and adenosine receptor-mediated pulmonary vasorelaxation.
Topics: Acetylcholine; Adenosine; Adenylyl Cyclases; Animals; ATP-Binding Cassette Transporters; Colforsin; | 1997 |
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vi | 1990 |
[Importance of calcium in the interaction between prostaglandins E and sulfonylureas in utero].
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Female; Glyburide; Muscle Rel | 1986 |