tolbutamide has been researched along with Muscle Contraction in 11 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The rate and amplitude of smooth muscle relaxation at low PO2 were significantly decreased by tolbutamide (5 mmol l-1), which is known to inhibit cyclic AMP-dependent protein kinases." | 3.68 | Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats. ( Basilyuk, OV; Soloviev, AI, 1993) |
| " It also produced little or no changes in electroencephalogram (cat) and spinal reflex (cat) after intravenous dosing of 10 mg/kg." | 1.28 | Pharmacological studies with the alpha 2-adrenoceptor antagonist midaglizole. Part II: Central and peripheral nervous systems. ( Hirohashi, M; Kasai, Y; Kojima, H; Takasuna, K; Usui, C, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 7 (63.64) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Comtois, A | 2 |
| Light, P | 2 |
| Renaud, JM | 2 |
| Kong, M | 1 |
| Soloviev, AI | 1 |
| Basilyuk, OV | 1 |
| Gasser, R | 1 |
| Klein, W | 1 |
| Kickenweiz, E | 1 |
| Herr, C | 1 |
| Smyth, N | 1 |
| Ullrich, S | 1 |
| Yun, F | 1 |
| Sasse, P | 1 |
| Hescheler, J | 1 |
| Fleischmann, B | 1 |
| Lasek, K | 1 |
| Brixius, K | 1 |
| Schwinger, RH | 1 |
| Fässler, R | 1 |
| Schröder, R | 1 |
| Noegel, AA | 1 |
| Jorgensen, KD | 1 |
| Hirohashi, M | 1 |
| Takasuna, K | 1 |
| Kasai, Y | 1 |
| Usui, C | 1 |
| Kojima, H | 1 |
| Lebrun, P | 1 |
| Fang, ZY | 1 |
| Antoine, MH | 1 |
| Herchuelz, A | 1 |
| Hermann, M | 1 |
| Berkenboom, G | 1 |
| Fontaine, J | 1 |
| Cocks, TM | 1 |
| King, SJ | 1 |
| Angus, JA | 1 |
| Levey, GS | 1 |
| Palmer, RF | 1 |
| Lasseter, KC | 1 |
| McCarthy, J | 1 |
| Parr, F | 1 |
11 other studies available for tolbutamide and Muscle Contraction
| Article | Year |
|---|---|
Effect of tolbutamide on the rate of fatigue and recovery in frog sartorius muscle.
Topics: Action Potentials; Animals; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Potassium Channel | 1995 |
Tolbutamide, but not glyburide, affects the excitability and contractility of unfatigued frog sartorius muscle.
Topics: Action Potentials; Animals; Electric Stimulation; Glyburide; Hydrogen-Ion Concentration; Muscle Cont | 1993 |
Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats.
Topics: Actin Cytoskeleton; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Calcium; Chlorides; Cy | 1993 |
Vasodilative response to hypoxia and simulated ischemia is mediated by ATP-sensitive K+ channels in guinea pig thoracic aorta.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Deoxyglucose; Guinea Pigs; In Vitro Techniques; Is | 1993 |
Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes.
Topics: Animals; Annexin A7; Caffeine; Calcium; Cardiotonic Agents; Central Nervous System Stimulants; Colfo | 2001 |
The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo(b)furan-7-carboxamid o)-ethyl)-benzenesulphonyl]-N'-cyclohexlurea (NOVO CS 476). III. General pharmacological studies.
Topics: Animals; Blood Pressure; Cats; Chlorpropamide; Diuresis; Dogs; Female; Glyburide; Guinea Pigs; Heart | 1977 |
Pharmacological studies with the alpha 2-adrenoceptor antagonist midaglizole. Part II: Central and peripheral nervous systems.
Topics: Adrenergic alpha-Antagonists; Animals; Autonomic Nervous System; Avoidance Learning; Body Temperatur | 1991 |
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vi | 1990 |
Glibenclamide is a competitive antagonist of the thromboxane A2 receptor in dog coronary artery in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Coronary Vessels; Dogs; | 1990 |
Effect of tolbutamide on adenyl cyclase in rabbit and human heart and contractility of isolated rabbit atria.
Topics: Adenine Nucleotides; Adenylyl Cyclases; Animals; Cyclic AMP; Enzyme Activation; Enzymes; Heart; Hear | 1971 |
[Astonin-H effect on blood circulation and metabolism].
Topics: Blood Circulation; Blood Pressure; Blood Vessels; Carbohydrate Metabolism; Coronary Disease; Fludroc | 1971 |