Page last updated: 2024-11-05

tolbutamide and Insulinoma

tolbutamide has been researched along with Insulinoma in 43 studies

Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.

Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.

Research Excerpts

ExcerptRelevanceReference
" This study investigated the interactions of calcium and somatostatin analogues on peptide release in two patients, one with a glucagonoma (patient A) and one with an insulinoma (patient B)."9.08Calcium reverses octreotide inhibition of insulin and glucagon levels in patients with insulinoma and glucagonoma. ( O'Dorisio, TM; Thompson, CS; Woltering, EA, 1996)
"The phytostilbene resveratrol (RV) improves the metabolic state in animal models by increasing the insulin responsiveness of tissues and there is evidence that RV affects insulin secretion from native beta-cells and insulinoma cells."7.74Resveratrol inhibits electrical activity and insulin release from insulinoma cells by block of voltage-gated Ca+ channels and swelling-dependent Cl- currents. ( Bacová, Z; Geibel, J; Iglseder, E; Jakab, M; Lach, S; Langelüddecke, C; Paulmichl, M; Ritter, M; Schmidt, S; Strbák, V, 2008)
"The plasma glucose and insulin responses to intravenous administration of tolbutamide in patients with insulinoma and healthy control subjects were compared to determine the sensitivity and specificity of the intravenous tolbutamide test for the diagnosis of insulinoma."7.67Diagnostic interpretation of the intravenous tolbutamide test for insulinoma. ( McMahon, MM; O'Brien, PC; Service, FJ, 1989)
"Thus, alpha-TC glucagonoma cells contain ATP-sensitive K+ channels that regulate glucagon release, yet allow inhibition of hormone release by glucose."5.29Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells. ( Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P, 1993)
" This study investigated the interactions of calcium and somatostatin analogues on peptide release in two patients, one with a glucagonoma (patient A) and one with an insulinoma (patient B)."5.08Calcium reverses octreotide inhibition of insulin and glucagon levels in patients with insulinoma and glucagonoma. ( O'Dorisio, TM; Thompson, CS; Woltering, EA, 1996)
"The phytostilbene resveratrol (RV) improves the metabolic state in animal models by increasing the insulin responsiveness of tissues and there is evidence that RV affects insulin secretion from native beta-cells and insulinoma cells."3.74Resveratrol inhibits electrical activity and insulin release from insulinoma cells by block of voltage-gated Ca+ channels and swelling-dependent Cl- currents. ( Bacová, Z; Geibel, J; Iglseder, E; Jakab, M; Lach, S; Langelüddecke, C; Paulmichl, M; Ritter, M; Schmidt, S; Strbák, V, 2008)
"The response of insulinoma tissue to glucose, alpha-ketoisocaproate, and the modifiers of insulin release, tolbutamide, isoproterenol, and acetylcholine, was studied."3.67Pharmacological modifications of insulin release in vitro from fuel-responsive transplantable insulinomas. ( Ferguson, DC; Hoenig, M; Matschinsky, FM, 1984)
"The plasma glucose and insulin responses to intravenous administration of tolbutamide in patients with insulinoma and healthy control subjects were compared to determine the sensitivity and specificity of the intravenous tolbutamide test for the diagnosis of insulinoma."3.67Diagnostic interpretation of the intravenous tolbutamide test for insulinoma. ( McMahon, MM; O'Brien, PC; Service, FJ, 1989)
"In order to clarify the mechanism of insulin secretion, responses of insulin (IRI) and C-peptide (CPR) in plasma to various stimuli were investigated in normal subjects and patients with diabetes mellitus, liver cirrhosis, chronic nephritis or insulinoma."3.66Analysis of insulin secretion based on changes in plasma insulin and C-peptide in man. ( Kobayashi, T; Nihei, J; Ohneda, A; Sakai, T, 1982)
"Insulinomas are β-cell tumors that cause hypoglycemia through inappropriate secretion of insulin."1.42Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro. ( Guiot, Y; Henquin, JC; Nenquin, M; Rahier, J; Sempoux, C, 2015)
" Moreover, the effectiveness of tolbutamide on [Ca(2+)](i) increase was reduced and the dose-response relations for insulin secretion induced by the agent was shifted toward the right in the UCP1-expressing cells."1.31Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells. ( Aso, K; Fukudome, M; Hashiguchi, H; Ishihara, H; Kakei, M; Koriyama, N; Nakazaki, M; Oka, Y; Tei, C; Yada, T, 2002)
" By applying the patch-clamp technique, dose-response curves for ATP and the sulfonylurea tolbutamide were obtained in inside-out patches."1.30RIN14B: a pancreatic delta-cell line that maintains functional ATP-dependent K+ channels and capability to secrete insulin under conditions where it no longer secretes somatostatin. ( Berggren, PO; Bränström, R; Höög, A; Larsson, O; Wahl, MA, 1997)
"Thus, alpha-TC glucagonoma cells contain ATP-sensitive K+ channels that regulate glucagon release, yet allow inhibition of hormone release by glucose."1.29Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells. ( Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P, 1993)
"Therefore, the hyperproinsulinemia of type 2 diabetes and in insulinoma patients may be caused by additional defects in the proinsulin to insulin conversion process."1.28Prolonged maximal stimulation of insulin secretion in healthy subjects does not provoke preferential release of proinsulin. ( Creutzfeldt, W; Nauck, MA; Siegel, EG, 1991)
"If a diagnosis of insulinoma is in doubt after several overnight fasts, C-peptide suppression test should be carried out since the test is safe and convenient."1.27[Studies on the diagnosis of insulinoma]. ( Kurihara, Y, 1987)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199017 (39.53)18.7374
1990's12 (27.91)18.2507
2000's12 (27.91)29.6817
2010's1 (2.33)24.3611
2020's1 (2.33)2.80

Authors

AuthorsStudies
Bahekar, RH1
Jain, MR1
Goel, A1
Patel, DN1
Prajapati, VM1
Gupta, AA1
Jadav, PA1
Patel, PR1
Zhao, L1
Carmean, CM1
Landeche, M1
Chellan, B1
Sargis, RM1
Henquin, JC1
Nenquin, M1
Guiot, Y1
Rahier, J2
Sempoux, C1
Mayer, SI1
Thiel, G1
Jakab, M2
Lach, S1
Bacová, Z1
Langelüddecke, C1
Strbák, V2
Schmidt, S2
Iglseder, E1
Paulmichl, M2
Geibel, J1
Ritter, M2
Cosgrove, KE2
Antoine, MH1
Lee, AT1
Barnes, PD1
de Tullio, P1
Clayton, P1
McCloy, R1
De Lonlay, P1
Nihoul-Fékété, C1
Robert, JJ1
Saudubray, JM1
Lindley, KJ1
Hussain, K1
Aynsley-Green, A1
Pirotte, B1
Lebrun, P1
Dunne, MJ3
CREUTZFELDT, W2
WILLE, K1
KAUP, H1
REESE, JL1
KISER, WJ1
MATASSARIN, BM1
BLACK, KO1
BIRNSTINGL, MA1
MARRACK, D1
ROSE, FC1
MARKS, V2
Merglen, A1
Theander, S1
Rubi, B1
Chaffard, G1
Wollheim, CB1
Maechler, P1
Al-Majed, HT1
Squires, PE1
Persaud, SJ1
Huang, GC1
Amiel, S1
Whitehouse, BJ1
Jones, PM1
Grundbichler, M1
Benicky, J1
Ravasio, A1
Chwatal, S1
Fürst, J1
Uebersax, R1
Cananau, S1
Beuret, P1
Zahnd, G1
Jara Albarrán, A1
Caballero Asensi, A1
García Peris, P1
Coste, A1
Toledano, E1
Gorospe, C1
Caviola, E1
Palacios Mateos, JM1
Hoenig, M1
Ferguson, DC1
Matschinsky, FM2
Ohneda, A2
Kobayashi, T2
Nihei, J2
Kazeĭ, NS1
Khar'kovaia, VV1
Petrukhin, VI1
Tsaguriia, EG1
Sakai, T1
Matsumoto, K1
Fukunaga, K1
Miyazaki, J2
Shichiri, M1
Miyamoto, E1
Khan, RN1
Hales, CN1
Ozanne, SE1
Adogu, AA1
Ashford, ML1
Sekine, N1
Yamashita, N1
Kojima, I1
Ogata, E1
Ronner, P1
Hang, TL1
Epstein, AJ1
Buettger, C1
Sjöholm, A1
Arkhammar, P1
Welsh, N1
Bokvist, K1
Rorsman, P1
Hallberg, A1
Nilsson, T1
Welsh, M1
Berggren, PO2
Thompson, CS1
O'Dorisio, TM1
Woltering, EA1
Khoo, S1
Cobb, MH1
Bränström, R1
Höög, A1
Wahl, MA1
Larsson, O1
Tian, YA1
Johnson, G1
Ashcroft, SJ1
Chapman, JC1
McClenaghan, NH1
Hashmi, MN1
Shepherd, RM1
Giesberts, AN1
White, SJ1
Ammälä, C1
Flatt, PR1
Kulkarni, RN1
Wang, ZL1
Wang, RM1
Smith, DM1
Ghatei, MA1
Bloom, SR1
Su, J1
Yu, H1
Lenka, N1
Hescheler, J1
Ullrich, S1
Park, KH1
Kim, SW1
Bae, YH1
Sheader, EA1
Brown, PD1
Best, L1
Nakazaki, M1
Kakei, M1
Ishihara, H1
Koriyama, N1
Hashiguchi, H1
Aso, K1
Fukudome, M1
Oka, Y1
Yada, T1
Tei, C1
Nauck, MA1
Siegel, EG1
Yule, DI1
Gallacher, DV1
Petersen, OH1
Thivolet, CH1
Demidem, A1
Haftek, M1
Durand, A1
Bertrand, J1
McMahon, MM1
O'Brien, PC1
Service, FJ1
Grimaldi, KA1
Siddle, K1
Hutton, JC1
Gorini, M1
Ghizzi, A1
Carlo Stella, C1
De Caro, L1
Kurihara, Y1
Sinagra, D1
Randazzo, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563]Phase 270 participants (Anticipated)Interventional2023-03-14Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for tolbutamide and Insulinoma

ArticleYear
[Diagnostic and therapeutic use of the artificial endocrine pancreas in hypoglycemia].
    Giornale di clinica medica, 1988, Volume: 69, Issue:2

    Topics: Humans; Hypoglycemia; Insulin Infusion Systems; Insulinoma; Monitoring, Physiologic; Pancreatic Neop

1988

Trials

1 trial available for tolbutamide and Insulinoma

ArticleYear
Calcium reverses octreotide inhibition of insulin and glucagon levels in patients with insulinoma and glucagonoma.
    Digestion, 1996, Volume: 57 Suppl 1

    Topics: Antineoplastic Agents, Hormonal; Calcium; Glucagon; Glucagonoma; Humans; Hypoglycemic Agents; Infusi

1996

Other Studies

41 other studies available for tolbutamide and Insulinoma

ArticleYear
Design, synthesis, and biological evaluation of substituted-N-(thieno[2,3-b]pyridin-3-yl)-guanidines, N-(1H-pyrrolo[2,3-b]pyridin-3-yl)-guanidines, and N-(1H-indol-3-yl)-guanidines.
    Bioorganic & medicinal chemistry, 2007, May-01, Volume: 15, Issue:9

    Topics: Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinic

2007
Selenomethionine modulates insulin secretion in the MIN6-K8 mouse insulinoma cell line.
    FEBS letters, 2021, Volume: 595, Issue:24

    Topics: Animals; Calcium; Cell Death; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplasti

2021
Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro.
    Diabetes, 2015, Volume: 64, Issue:10

    Topics: Adult; Aged, 80 and over; Calcium Chloride; Diazoxide; Female; Gene Expression Regulation; Glucose;

2015
Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB.
    European journal of cell biology, 2009, Volume: 88, Issue:1

    Topics: Animals; Calcium; Cell Line, Tumor; Cyclic AMP Response Element-Binding Protein; Dual Specificity Ph

2009
Resveratrol inhibits electrical activity and insulin release from insulinoma cells by block of voltage-gated Ca+ channels and swelling-dependent Cl- currents.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2008, Volume: 22, Issue:5-6

    Topics: Animals; Calcium Channels; Chloride Channels; Glucose; Insulin; Insulin Secretion; Insulinoma; Ion C

2008
BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:11

    Topics: Adenosine Triphosphate; Adolescent; Adrenergic alpha-Antagonists; Animals; Benzofurans; Benzothiadia

2002
[Intravenous injections of glucose, insulin and tolbutamide in healthy persons, diabetics, cirrhotics, and patients with insuloma (together with a contribution on the diagnostic value of the tolbutamide tests)].
    Deutsche medizinische Wochenschrift (1946), 1962, Oct-26, Volume: 87

    Topics: Adenoma, Islet Cell; Blood Glucose; Diabetes Mellitus; Glucose; Glucose Tolerance Test; Humans; Inje

1962
ISLET CELL ADENOMA. INSULINOMAS AND THE INTRAVENOUS SODIUM TOLBUTAMIDE TEST: A CASE REPORT.
    The Journal of the Kansas Medical Society, 1964, Volume: 65

    Topics: Adenoma, Islet Cell; Blood Chemical Analysis; Glucose Tolerance Test; Humans; Insulinoma; Pancreatic

1964
INSULINOMA WITH SYMPTOMS FOR THIRTY YEARS.
    Proceedings of the Royal Society of Medicine, 1964, Volume: 57

    Topics: Adenoma, Islet Cell; Blood Glucose; Fasting; Geriatrics; Glucose Tolerance Test; Humans; Hypoglycemi

1964
Glucagon and tolbutamide tests in the recognition of insulinomas.
    Proceedings of the Royal Society of Medicine, 1961, Volume: 54

    Topics: Adenoma, Islet Cell; Blood Glucose; Glucagon; Humans; Insulinoma; Pancreatic Neoplasms; Tolbutamide

1961
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.
    Endocrinology, 2004, Volume: 145, Issue:2

    Topics: Adenosine Triphosphate; Animals; Calcium; Cell Differentiation; Cell Division; Cytosol; Diazoxide; E

2004
Effect of 17beta-estradiol on insulin secretion and cytosolic calcium in Min6 mouse insulinoma cells and human islets of Langerhans.
    Pancreas, 2005, Volume: 30, Issue:4

    Topics: Animals; Calcium; Cell Line, Tumor; Cytosol; Estradiol; Glucose; Humans; Hypoglycemic Agents; Insuli

2005
Glucose induces anion conductance and cytosol-to-membrane transposition of ICln in INS-1E rat insulinoma cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2006, Volume: 18, Issue:1-3

    Topics: 3-O-Methylglucose; Animals; Anions; Cell Line, Tumor; Cell Membrane; Cytosol; Fluorescence Resonance

2006
[Insulinoma: what symptomatology?].
    Revue medicale de la Suisse romande, 1984, Volume: 104, Issue:9

    Topics: Adenoma, Islet Cell; Humans; Hypoglycemia; Insulin Coma; Insulinoma; Male; Middle Aged; Pancreatic N

1984
[Tolbutamide plus somatostatin test in the diagnosis of insulinomas].
    Revista clinica espanola, 1982, Jan-31, Volume: 164, Issue:2

    Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Female; Humans; Hypoglycemia; Insulin; Insulinoma; Middle

1982
Pharmacological modifications of insulin release in vitro from fuel-responsive transplantable insulinomas.
    Endocrinology, 1984, Volume: 115, Issue:4

    Topics: Acetylcholine; Adenoma, Islet Cell; Animals; Blood Glucose; Glucagon; Glucose; Insulin; Insulinoma;

1984
Plasma insulin response to various secretagogues in insulinoma.
    The Tohoku journal of experimental medicine, 1982, Volume: 136, Issue:4

    Topics: Adenoma, Islet Cell; Adult; Aged; Arginine; Blood Glucose; Child; Fasting; Female; Glucagon; Glucose

1982
[Insulin-producing tumor of the pancreas].
    Meditsinskaia sestra, 1982, Volume: 41, Issue:10

    Topics: Adenoma, Islet Cell; Adult; Diagnosis, Differential; Fasting; Humans; Hypoglycemia; Insulinoma; Male

1982
Analysis of insulin secretion based on changes in plasma insulin and C-peptide in man.
    The Tohoku journal of experimental medicine, 1982, Volume: 138, Issue:4

    Topics: Adult; Aged; Arginine; C-Peptide; Diabetes Mellitus; Female; Glucagon; Glucose Tolerance Test; Human

1982
Ca2+/calmodulin-dependent protein kinase II and synapsin I-like protein in mouse insulinoma MIN6 cells.
    Endocrinology, 1995, Volume: 136, Issue:9

    Topics: Animals; Autoradiography; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Electrophoresis, Po

1995
Dissociation of KATP channel and sulphonylurea receptor in the rat clonal insulin-secreting cell line, CRI-D11.
    Proceedings. Biological sciences, 1993, Sep-22, Volume: 253, Issue:1338

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cel

1993
Bimodal effect of transforming growth factor-beta on insulin secretion in MIN6 cells.
    Diabetes research and clinical practice, 1994, Volume: 26, Issue:1

    Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Glucose; Humans; Insulin; Insulin Secretion; I

1994
Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells.
    Diabetes, 1993, Volume: 42, Issue:12

    Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Diazoxide; Glucagon; Glucagono

1993
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:4

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne

1993
Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, May-27, Volume: 94, Issue:11

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Colforsin; Deoxyglucose; Enzyme Activation; E

1997
RIN14B: a pancreatic delta-cell line that maintains functional ATP-dependent K+ channels and capability to secrete insulin under conditions where it no longer secretes somatostatin.
    FEBS letters, 1997, Jul-14, Volume: 411, Issue:2-3

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diazoxide; Electrophysiology; Insulin; Insul

1997
Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C.
    Diabetes, 1998, Volume: 47, Issue:11

    Topics: Animals; Calcium; Enzyme Activation; Exocytosis; Glyburide; Guanosine 5'-O-(3-Thiotriphosphate); Hyp

1998
ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.
    Diabetes, 1999, Volume: 48, Issue:12

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Benzofurans; C

1999
Glibenclamide but not other sulphonylureas stimulates release of neuropeptide Y from perifused rat islets and hamster insulinoma cells.
    The Journal of endocrinology, 2000, Volume: 165, Issue:2

    Topics: Animals; Blotting, Northern; Cricetinae; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion;

2000
The expression and regulation of depolarization-activated K+ channels in the insulin-secreting cell line INS-1.
    Pflugers Archiv : European journal of physiology, 2001, Volume: 442, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Action Potenti

2001
Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion.
    Journal of biomedical materials research, 2001, Volume: 55, Issue:1

    Topics: Acrylic Resins; Animals; Biocompatible Materials; Culture Media, Conditioned; Diazoxide; Glucose; Gl

2001
Swelling-induced changes in cytosolic [Ca2++] in insulin-secreting cells: a role in regulatory volume decrease?
    Molecular and cellular endocrinology, 2001, Jul-05, Volume: 181, Issue:1-2

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Calcium Channel Blockers; Calciu

2001
Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells.
    The Journal of physiology, 2002, May-01, Volume: 540, Issue:Pt 3

    Topics: Adenosine Triphosphate; Animals; Calcium; Carrier Proteins; Cytosol; Gene Expression Regulation, Neo

2002
Prolonged maximal stimulation of insulin secretion in healthy subjects does not provoke preferential release of proinsulin.
    Pancreas, 1991, Volume: 6, Issue:6

    Topics: Adult; C-Peptide; Diabetes Mellitus, Type 2; Female; Glucagon; Humans; Hyperglycemia; Insulin; Insul

1991
Effects of alanine on insulin-secreting cells: patch-clamp and single cell intracellular Ca2+ measurements.
    Biochimica et biophysica acta, 1990, Nov-12, Volume: 1055, Issue:2

    Topics: Alanine; Animals; Calcium; Cell Membrane; Glucose; Insulin; Insulin Secretion; Insulinoma; Kinetics;

1990
Structure, function, and immunogenicity of human insulinoma cells.
    Diabetes, 1988, Volume: 37, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Adult; C-Peptide; Fluorescent Antibody Technique;

1988
Diagnostic interpretation of the intravenous tolbutamide test for insulinoma.
    Mayo Clinic proceedings, 1989, Volume: 64, Issue:12

    Topics: Adenoma, Islet Cell; Blood Glucose; Body Weight; Evaluation Studies as Topic; Female; Glucose Tolera

1989
Diagnosis and differential diagnosis of hypoglycemia.
    Mayo Clinic proceedings, 1989, Volume: 64, Issue:12

    Topics: Blood Glucose; Diagnosis, Differential; False Positive Reactions; Glucose Tolerance Test; Humans; Hy

1989
Biosynthesis of insulin secretory granule membrane proteins. Control by glucose.
    The Biochemical journal, 1987, Jul-15, Volume: 245, Issue:2

    Topics: Adenoma, Islet Cell; Animals; Calcium; Chemical Precipitation; Cytoplasmic Granules; Glucose; Immuno

1987
[Biochemical diagnosis of insulinoma: correlations between blood glucose, blood insulin and the titer of plasma non-esterified fatty acids during fasting and during various diagnostic tests].
    Minerva medica, 1985, Sep-29, Volume: 76, Issue:37

    Topics: Adenoma, Islet Cell; Adult; Aged; Blood Glucose; C-Peptide; Epinephrine; Fasting; Fatty Acids, Nones

1985
[Studies on the diagnosis of insulinoma].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1987, Volume: 62, Issue:1

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Blood Glucose; C-Peptide; Female; Glucagon; Humans; In

1987