tolbutamide has been researched along with Inflammation in 4 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to determine the effect of inflammation on the kinetics and dynamics of tolbutamide, two groups of seven and nine New Zealand rabbits received 50 mg/kg tolbutamide before and 48 hr after the production of an inflammatory reaction generated by the s." | 7.68 | Effect of inflammation on the rabbit hepatic cytochrome P-450 isoenzymes: alterations in the kinetics and dynamics of tolbutamide. ( Bélanger, PM; du Souich, P; Jutras, L; Parent, C, 1992) |
| "In order to determine the effect of inflammation on the kinetics and dynamics of tolbutamide, two groups of seven and nine New Zealand rabbits received 50 mg/kg tolbutamide before and 48 hr after the production of an inflammatory reaction generated by the s." | 3.68 | Effect of inflammation on the rabbit hepatic cytochrome P-450 isoenzymes: alterations in the kinetics and dynamics of tolbutamide. ( Bélanger, PM; du Souich, P; Jutras, L; Parent, C, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| ADAMKIEWICZ, VW | 1 |
| FITKO, RJ | 1 |
| FORTIER, AA | 1 |
| Pickkers, P | 1 |
| Dorresteijn, MJ | 1 |
| Bouw, MP | 1 |
| van der Hoeven, JG | 1 |
| Smits, P | 1 |
| Parent, C | 1 |
| Bélanger, PM | 1 |
| Jutras, L | 1 |
| du Souich, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Blockade of Vascular Potassium Channels During Human Endotoxemia[NCT00185003] | Phase 1 | 36 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for tolbutamide and Inflammation
| Article | Year |
|---|---|
In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia.
Topics: Adult; Dose-Response Relationship, Drug; Endotoxemia; Endotoxins; Enzyme Inhibitors; Escherichia col | 2006 |
3 other studies available for tolbutamide and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Hypoglycemic drugs and the dextran 'anaphylactoid' inflammation.
Topics: Animals; Dextrans; Diabetes Mellitus, Experimental; Hypersensitivity; Hypoglycemic Agents; Immune Sy | 1960 |
Effect of inflammation on the rabbit hepatic cytochrome P-450 isoenzymes: alterations in the kinetics and dynamics of tolbutamide.
Topics: Animals; Cytochrome P-450 Enzyme System; Hypoglycemia; Inflammation; Injections, Intravenous; Isoenz | 1992 |