tolbutamide has been researched along with Hypoxia in 23 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "kg-1 iv 10 min before ischemia or ouabain infusion prevented ventricular fibrillation induced by ischemia in rat and arrhythmias induced by ouabain in guinea pig." | 7.68 | Effects of glibenclamide and tolbutamide on ischemia- and ouabain-induced arrhythmias and membrane potentials of ventricular myocardium from rat and guinea pig. ( Fu, SX; Li, YS; Yang, XP; Zhang, HL, 1991) |
| "The K(ATP) channel activator, diazoxide (100 microM, n=6) or hypoxia (0% O2/5% CO2, n=6) significantly attenuated the HR response to 3 Hz SNS by -10+/-4% and -27+/-6% respectively; an effect that was reversed by the K(ATP) channel inhibitor, glibenclamide (30 microM)." | 3.70 | Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation. ( Mohan, RM; Paterson, DJ, 2000) |
| "Perfused hearts (n = 127) were exposed to acute hypoxia (10% O2 for 12 or 20 min) or left atrial stretch (increase in atrial pressure) in the presence or absence of 100 mumol/l ATP-sensitive potassium channel blocker (tolbutamide) or openers (pinacidil and diazoxide)." | 3.69 | ATP-sensitive potassium channels regulate stimulated ANF secretion in isolated rat heart. ( Baertschi, AJ; Jiao, JH; Pence, RA; Xu, T, 1996) |
| " The rate and amplitude of smooth muscle relaxation at low PO2 were significantly decreased by tolbutamide (5 mmol l-1), which is known to inhibit cyclic AMP-dependent protein kinases." | 3.68 | Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats. ( Basilyuk, OV; Soloviev, AI, 1993) |
| "kg-1 iv 10 min before ischemia or ouabain infusion prevented ventricular fibrillation induced by ischemia in rat and arrhythmias induced by ouabain in guinea pig." | 3.68 | Effects of glibenclamide and tolbutamide on ischemia- and ouabain-induced arrhythmias and membrane potentials of ventricular myocardium from rat and guinea pig. ( Fu, SX; Li, YS; Yang, XP; Zhang, HL, 1991) |
| " In order to determine whether activation of adenosine triphosphate (ATP)-sensitive K+ channels exclusively explains the hypoxia- and ischaemia-induced action potential shortening, effects of tolbutamide and glibenclamide on changes in action potential duration (APD) during hypoxia, metabolic blockade or experimental ischaemia were examined in guinea-pig and canine isolated myocardium by standard microelectrode techniques." | 3.68 | Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium. ( Kanno, M; Nakaya, H; Takeda, Y; Tohse, N, 1991) |
| "Diazoxide was without effect on tau(open) and tau(closed,fast) but decreased significantly tau(closed,slow) (24." | 1.31 | Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells. ( Carlen, PL; Pahapill, PA; Pelletier, MR; Pennefather, PS, 2000) |
| "3." | 1.28 | Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction. ( Kozlowski, RZ; Nye, PC; Robertson, BE, 1992) |
| "Reversible effects of brief periods of anoxia (replacing 95% O2-5% CO2 with 95% N2-5% CO2 for 2-4 min) were studied in CA1 neurons in hippocampal slices (from Sprague-Dawley rats), kept in an interface-type chamber at 33." | 1.28 | Hypoxic changes in hippocampal neurons. ( Krnjevic, K; Leblond, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 10 (43.48) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Specterman, MJ | 1 |
| Aziz, Q | 1 |
| Li, Y | 1 |
| Anderson, NA | 1 |
| Ojake, L | 1 |
| Ng, KE | 1 |
| Thomas, AM | 1 |
| Finlay, MC | 1 |
| Schilling, RJ | 1 |
| Lambiase, PD | 1 |
| Tinker, A | 1 |
| Zhang, W | 1 |
| Carreño, FR | 1 |
| Cunningham, JT | 1 |
| Mifflin, SW | 1 |
| CALDERON, R | 1 |
| LLERENA, LA | 1 |
| Hepp, S | 1 |
| Gerich, FJ | 1 |
| Müller, M | 1 |
| Albrecht, J | 1 |
| Hanganu, IL | 1 |
| Heck, N | 1 |
| Luhmann, HJ | 1 |
| Reid, JM | 1 |
| Paterson, DJ | 3 |
| Ashcroft, FM | 1 |
| Bergel, DH | 1 |
| Soloviev, AI | 1 |
| Basilyuk, OV | 1 |
| Pierrefiche, O | 1 |
| Bischoff, AM | 1 |
| Richter, DW | 2 |
| Xu, T | 1 |
| Jiao, JH | 1 |
| Pence, RA | 1 |
| Baertschi, AJ | 1 |
| Mironov, SL | 1 |
| Langohr, K | 1 |
| Haller, M | 1 |
| Golanov, EV | 1 |
| Reis, DJ | 1 |
| Mohan, RM | 1 |
| Pelletier, MR | 1 |
| Pahapill, PA | 1 |
| Pennefather, PS | 1 |
| Carlen, PL | 1 |
| Robertson, BE | 2 |
| Kozlowski, RZ | 1 |
| Nye, PC | 2 |
| Zhang, HL | 1 |
| Li, YS | 1 |
| Fu, SX | 1 |
| Yang, XP | 1 |
| Nakaya, H | 1 |
| Takeda, Y | 1 |
| Tohse, N | 1 |
| Kanno, M | 1 |
| Krnjević, K | 2 |
| Leblond, J | 1 |
| Peers, C | 1 |
| Etheridge, JE | 1 |
| Krzanowski, JJ | 1 |
| Fertel, R | 1 |
| Matschinsky, FM | 1 |
| Coore, HG | 1 |
| Randle, PJ | 1 |
| Milner, RD | 1 |
| Hales, CN | 1 |
1 review available for tolbutamide and Hypoxia
| Article | Year |
|---|---|
Hypoglycemia and the central nervous system.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Diazoxide; Diet Therapy; Epin | 1967 |
22 other studies available for tolbutamide and Hypoxia
| Article | Year |
|---|---|
Hypoxia Promotes Atrial Tachyarrhythmias via Opening of ATP-Sensitive Potassium Channels.
Topics: Adenosine Triphosphate; Animals; Atrial Fibrillation; Heart Atria; Humans; Hypoxia; KATP Channels; M | 2023 |
Chronic sustained and intermittent hypoxia reduce function of ATP-sensitive potassium channels in nucleus of the solitary tract.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Carotid Body; Chronic Disease; Diazoxide; Elect | 2008 |
CARBOHYDRATE METABOLISM IN PEOPLE LIVING IN CHRONIC HYPOXIA.
Topics: Altitude; Biomedical Research; Blood Glucose; Carbohydrate Metabolism; Glucagon; Glucose; Glucose To | 1965 |
Sulfhydryl oxidation reduces hippocampal susceptibility to hypoxia-induced spreading depression by activating BK channels.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aniline Compounds; Animals; Calcium; Charybdotoxin; Cortical S | 2005 |
Oxygen and glucose deprivation induces major dysfunction in the somatosensory cortex of the newborn rat.
Topics: Animals; Animals, Newborn; Caspase 3; Caspases; Dizocilpine Maleate; Dose-Response Relationship, Rad | 2005 |
The effect of tolbutamide on cerebral blood flow during hypoxia and hypercapnia in the anaesthetized rat.
Topics: Anesthesia; Animals; Blood Gas Analysis; Cerebrovascular Circulation; Hypercapnia; Hypoxia; Potassiu | 1993 |
Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats.
Topics: Actin Cytoskeleton; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Calcium; Chlorides; Cy | 1993 |
ATP-sensitive K+ channels are functional in expiratory neurones of normoxic cats.
Topics: Adenosine Triphosphate; Animals; Bicuculline; Blood-Brain Barrier; Brain Stem; Cats; Female; Glyburi | 1996 |
ATP-sensitive potassium channels regulate stimulated ANF secretion in isolated rat heart.
Topics: Adenosine Triphosphate; Animals; Atrial Function, Left; Atrial Natriuretic Factor; Dose-Response Rel | 1996 |
Hypoxia activates ATP-dependent potassium channels in inspiratory neurones of neonatal mice.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Diazoxide; Electric Stimulation; Glyburi | 1998 |
A role for KATP+-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Brain Chemistry; Cerebrovascular Circulation; Glybu | 1999 |
Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation.
Topics: Analysis of Variance; Animals; Cyclic GMP; Diazoxide; Electric Stimulation; Enzyme Inhibitors; Glybu | 2000 |
Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells.
Topics: Animals; Antihypertensive Agents; Dentate Gyrus; Diazoxide; Glyburide; Hypoglycemia; Hypoglycemic Ag | 2000 |
Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Po | 1992 |
Effects of glibenclamide and tolbutamide on ischemia- and ouabain-induced arrhythmias and membrane potentials of ventricular myocardium from rat and guinea pig.
Topics: Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; Hyp | 1991 |
Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Fe | 1991 |
Adenosine triphosphate-sensitive potassium channels in anoxia.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Electrophysiology; Glyburide; Hippocampus; Hypoxia; Neur | 1990 |
Hypoxic changes in hippocampal neurons.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Apamin; Caffeine; Calcium; Egtazic | 1989 |
Tolbutamide reverses hypoxic pulmonary vasoconstriction in isolated rat lungs.
Topics: Adenosine Triphosphate; Animals; Hypoxia; Lung; Male; Potassium Channels; Rats; Rats, Inbred Strains | 1989 |
Energy metabolism in pancreatic islets of rats. Studies with tolbutamide and hypoxia.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Glucose; Glycogen; Hypoxia; Insulin; Insulin Secreti | 1971 |
Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro.
Topics: Acetylcholine; Aniline Compounds; Animals; Dinitrophenols; Fumarates; Glucose; Glutamates; Hormones; | 1964 |
The interaction of various inhibitors and stimuli of insulin release studied with rabbit pancreas in vitro.
Topics: Animals; Barium; Diazoxide; Dibucaine; Dinitrophenols; Epinephrine; Glucose; Heptoses; Hypoxia; In V | 1969 |