Compounds > tolbutamide
Page last updated: 2024-11-05

tolbutamide and Hypertension

tolbutamide has been researched along with Hypertension in 38 studies

Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
"Treatment with oral diazoxide for periods of 4 to 10 weeks in hospital allowed adequate control of hypertension with continuation of fetal growth in four patients with severe toxaemia."7.65Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy. ( Davis, D; Morgan, MY; Pohl, JE; Thurston, H, 1972)
"Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment."7.65Use of diazoxide in hypertension with renal failure. ( Pohl, JE; Thurston, H, 1971)
"Treatment with oral diazoxide for periods of 4 to 10 weeks in hospital allowed adequate control of hypertension with continuation of fetal growth in four patients with severe toxaemia."3.65Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy. ( Davis, D; Morgan, MY; Pohl, JE; Thurston, H, 1972)
"Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment."3.65Use of diazoxide in hypertension with renal failure. ( Pohl, JE; Thurston, H, 1971)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199034 (89.47)18.7374
1990's4 (10.53)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
GELFAND, M1
FORBES, JI1
SCHWARTZ, W1
WOLFF, FW1
LANGDON, RG1
FABRYKANT, M1
GELFAND, ML1
ROSENBERG, AS1
Dieterle, P2
Fehm, H2
Ströder, W2
Henner, J2
Bottermann, P2
Schwarz, K2
Ziegelasch, HJ1
Ziegelasch, H1
Mauve, L1
Tötterman, KJ1
Groop, LC1
Deng, LY1
Li, JS1
Schiffrin, EL1
Kau, ST1
Zografos, P1
Do, ML1
Halterman, TJ1
McConville, MW1
Yochim, CL1
Trivedi, S1
Howe, BB1
Li, JH1
Ferrara, A1
Wijdeveld, P1
Koene, R1
Buchanan, TA1
Youn, JH1
Campese, VM1
Sipos, GF1
Dzúrik, R1
Dzúriková, K1
Spustová, V1
Koev, D1
Borisova, AM1
Zlatareva, N1
Kirilov, G1
Ryan, JR1
Podolsky, S1
Pattavina, CG1
Catellier, C1
Ringuet, J1
Rivière, L1
Plamondon, C1
Finnerty, FA1
Tanaka, N1
Takenouchi, A1
Trautwein, H3
Julitz, R3
Prout, TE1
Pohl, JE2
Thurston, H2
Davis, D1
Morgan, MY1
Constam, GR1
Keen, H1
Juhl, F1
Persson, I2
Schwarzbach, W1
Möller, E1
Klein, B1
Andersen, OO1
Krecke, HJ1
Timmler, R1
Betzien, G1
Hanusch, AW1
Kaiser, G1
Lenti, G1
Pellegrini, A1
Pagano, G1
Porrazzo, G1
Brotzu, M1
Srivastava, SC1
Singh, A1
Arora, BS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective, Parallel Goups Study, Aimed to Evaluating Possible Benefits of the Treatment of New Generation Hypoglycaemic Drugs Compared to Sulphonylureas for the Tratment of Type 2 Diabetes Mellitus[NCT04272359]138 participants (Anticipated)Observational [Patient Registry]2019-05-06Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

4 trials available for tolbutamide and Hypertension

ArticleYear
No effect of propranolol and metoprolol on tolbutamide-stimulated insulin-secretion in hypertensive diabetic and non-diabetic patients.
    Annals of clinical research, 1982, Volume: 14, Issue:4

    Topics: Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Double-Blind Method; Female; Hu

1982
The University Group Diabetes Program. A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. V. Evaluation of pheniformin therapy.
    Diabetes, 1975, Volume: 24 Suppl 1

    Topics: Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Clinical Tri

1975
A prospective view of the treatment of adult-onset diabetes with special reference to the University Group Diabetes Program and oral hypoglycemic agents.
    The Medical clinics of North America, 1971, Volume: 55, Issue:4

    Topics: Angina Pectoris; Blood Glucose; Clinical Trials as Topic; Creatinine; Diabetes Complications; Diabet

1971
Carbohydrate metabolism during treatment with chlorthalidone and ethacrynic acid.
    British medical journal, 1968, Jun-29, Volume: 2, Issue:5608

    Topics: Aged; Blood Glucose; Carbohydrate Metabolism; Chlorthalidone; Cortisone; Diabetes Mellitus; Ethacryn

1968

Other Studies

34 other studies available for tolbutamide and Hypertension

ArticleYear
DIABETES MELLITUS IN THE RHODESIAN AFRICAN.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1963, Nov-30, Volume: 37

    Topics: Adolescent; Child; Chlorpropamide; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Coma; Diabetic

1963
MEBUTAMATE AND HYDROCHLOROTHIAZIDE IN HYPERTENSION.
    Journal of the American Geriatrics Society, 1964, Volume: 12

    Topics: Antihypertensive Agents; Arthritis; Arthritis, Rheumatoid; Blood Pressure Determination; Carbamates;

1964
CONJOINT CLINIC ON DRUGS AND DIABETES.
    Journal of chronic diseases, 1964, Volume: 17

    Topics: Adrenalectomy; Antihypertensive Agents; Benzothiadiazines; Biomedical Research; Blood; Blood Glucose

1964
FURTHER EXPERIENCE WITH ANABOLIC STEROIDS IN DIABETIC RETINOPATHY: FACTORS PRECIPITATING RETINAL HEMORRHAGES.
    The American journal of the medical sciences, 1964, Volume: 248

    Topics: Diabetic Nephropathies; Diabetic Retinopathy; Diet, Diabetic; Drug Therapy; Estrogens; Geriatrics; H

1964
[Asymptomatic diabetes mellitus in normal weight subjects with hypertension. Studies on glucose tolerance, serum insulin and nonesterified fatty acids in essential hypertension].
    Deutsche medizinische Wochenschrift (1946), 1967, Dec-29, Volume: 92, Issue:52

    Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucose Tolerance Test; H

1967
[Incidence of pathological ECG findings, hypertension and obesity in diabetic patients depending on their mode of therapy].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1981, Feb-15, Volume: 36, Issue:4

    Topics: Cardiomegaly; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Electrocardiograph

1981
Endothelium-dependent relaxation of small arteries from essential hypertensive patients: mechanisms and comparison with normotensive subjects and with responses of vessels from spontaneously hypertensive rats.
    Clinical science (London, England : 1979), 1995, Volume: 88, Issue:6

    Topics: Acetylcholine; Adult; Animals; Apamin; Arginine; Arterioles; Charybdotoxin; Endothelium, Vascular; H

1995
Characterization of ATP-sensitive potassium channel-blocking activity of ZENECA ZM181,037, a eukalemic diuretic.
    Pharmacology, 1994, Volume: 49, Issue:4

    Topics: Acetamides; Adenosine Triphosphate; Administration, Oral; Animals; Benzopyrans; Blood Glucose; Blood

1994
[Effect of prolonged nicotinic acid load on the tolbutamide test].
    Minerva medica, 1979, Nov-10, Volume: 70, Issue:49

    Topics: Aged; Blood Glucose; Diabetes Mellitus; Endarteritis; Female; Humans; Hyperglycemia; Hypertension; H

1979
A study of the effects of hypoglycemia agents on vascular complications in patients with adult-onset diabetes. VI. Supplementary report on nonfatal events in patients treated with tolbutamide.
    Diabetes, 1976, Volume: 25, Issue:12

    Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic

1976
[Diazoxide: new way in treatment of hypertension].
    Nederlands tijdschrift voor geneeskunde, 1975, Mar-15, Volume: 119, Issue:11

    Topics: Adult; Chlorthalidone; Diazoxide; Diet, Sodium-Restricted; Female; Humans; Hydralazine; Hypertension

1975
Enhanced glucose tolerance in spontaneously hypertensive rats. Pancreatic beta-cell hyperfunction with normal insulin sensitivity.
    Diabetes, 1992, Volume: 41, Issue:7

    Topics: 3-O-Methylglucose; Animals; Blood Glucose; Glucose Tolerance Test; Hypertension; Insulin; Insulin Se

1992
[Improvement in glucose tolerance and insulin sensitivity after a single administration of tolbutamide in hypertensive patients].
    Vnitrni lekarstvi, 1991, Volume: 37, Issue:3

    Topics: Blood Glucose; Female; Glucose Tolerance Test; Humans; Hypertension; Insulin; Insulin Resistance; Ma

1991
[Effect of antihypertensive drugs on insulin secretion and efficacy].
    Vutreshni bolesti, 1989, Volume: 28, Issue:2

    Topics: Adult; Aged; Antihypertensive Agents; C-Peptide; Diabetes Mellitus, Type 2; Drug Evaluation; Drug In

1989
Clinical pharmacology of acebutolol.
    American heart journal, 1985, Volume: 109, Issue:5 Pt 2

    Topics: Acebutolol; Adrenergic beta-Antagonists; Adult; Aged; Digoxin; Drug Interactions; Female; Humans; Hy

1985
Hyperosmolar nonketotic diabetic coma: a complication of propranolol therapy.
    Metabolism: clinical and experimental, 1973, Volume: 22, Issue:5

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Diabetes Complications; Diabetes Mellitus; Diabet

1973
[Insulinoma in aged patients].
    Laval medical, 1968, Volume: 39, Issue:3

    Topics: Adenoma, Islet Cell; Age Factors; Aged; Female; Glucagon; Glucose Tolerance Test; Humans; Hyperglyce

1968
Hypertensive crisis.
    JAMA, 1974, Sep-09, Volume: 229, Issue:11

    Topics: Acute Disease; Cerebrovascular Circulation; Cerebrovascular Disorders; Diagnosis, Differential; Diaz

1974
[A case of acute erythremia occurring during treatment of diabetes and hypertension].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1972, Volume: 13, Issue:6

    Topics: Chlorothiazide; Diabetes Complications; Diabetes Mellitus; Humans; Hydroflumethiazide; Hypertension;

1972
[Diabetic metabolism and arteriosclerosis].
    Medizinische Klinik, 1973, Apr-13, Volume: 68, Issue:15

    Topics: Adult; Aged; Arteries; Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopa

1973
Successful use of oral diazoxide in the treatment of severe toxaemia of pregnancy.
    British medical journal, 1972, Jun-03, Volume: 2, Issue:5813

    Topics: Acute Disease; Administration, Oral; Adult; Albuminuria; Blood Glucose; Diazoxide; Female; Furosemid

1972
Is the use of sulphonylurea derivatives in the treatment of diabetes mellitus dangerous?
    Diabetologia, 1971, Volume: 7, Issue:4

    Topics: Adult; Aged; Autopsy; Diabetes Complications; Diabetes Mellitus; Diet Therapy; Drug Synergism; Femal

1971
Use of diazoxide in hypertension with renal failure.
    British medical journal, 1971, Oct-16, Volume: 4, Issue:5780

    Topics: Adolescent; Adult; Blood Glucose; Creatine; Diazoxide; Dietary Proteins; Female; Humans; Hyperglycem

1971
Factors influencing the progress of atherosclerosis in the diabetic.
    Acta diabetologica latina, 1971, Volume: 8 Suppl 1

    Topics: Adolescent; Adult; Aged; Arteriosclerosis; Child; Diabetes Mellitus; Diabetic Angiopathies; Female;

1971
[Carbohydrate metabolism during treatment with chlorthalidone and cyclothiazide].
    Ugeskrift for laeger, 1970, Jan-29, Volume: 132, Issue:5

    Topics: Aged; Antihypertensive Agents; Benzothiadiazines; Carbohydrate Metabolism; Chlorthalidone; Cortisone

1970
[Extracellular potassium concentration and fasting blood sugar in diabetes mellitus].
    Medizinische Klinik, 1970, Jun-12, Volume: 65, Issue:24

    Topics: Biological Transport; Blood Glucose; Cell Membrane Permeability; Diabetes Mellitus; Diuretics; Extra

1970
[Heart infarct and subclinical diabetes].
    Die Medizinische Welt, 1970, Jun-27, Volume: 26

    Topics: Adult; Aged; Blood Glucose; Carbohydrate Metabolism; Diabetes Complications; Female; Humans; Hyperte

1970
[Myocardial infarct, diabetic metabolism and lipid value].
    Medizinische Klinik, 1967, Mar-10, Volume: 62, Issue:10

    Topics: Adult; Aged; Blood Glucose; Cholesterol; Diabetes Complications; Diabetes Mellitus; Diagnosis, Diffe

1967
[Clinical experience with a new spironolactone-thiabuzide combination].
    Medizinische Klinik, 1968, Jun-07, Volume: 63, Issue:23

    Topics: Aged; Body Weight; Digoxin; Diuretics; Drug Synergism; Edema; Female; Furosemide; Glycosuria; Humans

1968
Asymptomatic diabetes mellitus in hypertensive patients of normal weight. Glucose tolerance and serum levels of insulin and nonesterified fatty acids in essential hypertension.
    German medical monthly, 1968, Volume: 13, Issue:10

    Topics: Adult; Blood Glucose; Body Weight; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucose Tolerance

1968
[Studies of latent diabetes mellitus].
    Zeitschrift fur arztliche Fortbildung, 1969, Volume: 63, Issue:1

    Topics: Adult; Aged; Blood Glucose; Cortisone; Diabetes Mellitus; Diagnosis, Differential; Female; Glucose;

1969
[Early diagnosis of diabetes mellitus by means of the tolbutamide test, especially in adipose, hypertensive and cardiovascular patients].
    Die Medizinische Welt, 1966, Apr-16, Volume: 16

    Topics: Diabetes Mellitus; Humans; Hypertension; Myocardial Infarction; Obesity; Tolbutamide

1966
[Familial aspects of the relations between diabetes mellitus and cardiovascular diseases. Clinico-experimental research].
    Minerva medica, 1966, Nov-14, Volume: 57, Issue:91

    Topics: Adult; Coronary Disease; Cryoglobulins; Diabetes Complications; Diabetes Mellitus; Female; Glucose T

1966
Chemical and latent chemical diabetes in myocardial infarction, cerebral thrombosis and hypertension.
    Indian heart journal, 1966, Volume: 18, Issue:4

    Topics: Adult; Aged; Diabetes Complications; Diabetes Mellitus; Female; Glucose Tolerance Test; Humans; Hype

1966