tolbutamide has been researched along with Hyperinsulinism in 113 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Hyperinsulinism: A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The data indicate: 1) insulin-secreting islet cell tumors have decreased storage capacity for insulin, 2) elevated concentration of proinsulin in tumors may be due to decreased capacity to store insulin and in some to decreased conversion of proinsulin to insulin as well, 3) tolbutamide stimulates the exaggerated release of a relatively constant fraction of insulin stored in adenomas." | 5.26 | Insulin, proinsulin, glucagon and gastrin in pancreatic tumors and in plasma of patients with organic hyperinsulinism. ( Fajans, SS; Floyd, JC; Hayashi, M; Pek, S, 1977) |
| " Plasma glucose and serum insulin, C-peptide, and proinsulin levels were measured before as well as 1 and 2 h after breakfast in 23 patients with non-insulin-dependent diabetes mellitus and 17 patients with impaired glucose tolerance." | 5.08 | Acarbose controls postprandial hyperproinsulinemia in non-insulin dependent diabetes mellitus. ( Awata, T; Inoue, I; Katayama, S; Negishi, K; Noji, S; Takahashi, K, 1997) |
| "We define a syndrome of prolonged neonatal hyperinsulinism that is responsive to diazoxide, persists for several months, and resolves spontaneously." | 3.73 | Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism. ( Hoe, FM; Simmons, RA; Stanley, CA; Steinkrauss, L; Thornton, PS; Wanner, LA, 2006) |
| "In order to elucidate the mechanism of hyperinsulinism following a treatment with glucocorticoid, insulin secretion induced with glucose or tolbutamide was investigated by a perifusion experiment on isolated islets of rats." | 3.66 | [Hyperinsulinism induced with glucocorticoid--a study on using a perifusion system of isolated islets in rats (author's transl)]. ( Ueki, A, 1980) |
| "In four patients with organic hyperinsulinism (two with surgically proven beta-cell adenomas of the body of the pancreas) a standard tolbutamide test during continuous somatostatin infusion (5 microgram/min) was carried out." | 3.66 | Failure of somatostatin to diagnose organic hyperinsulinism. ( Adami, S; Bianchi, I; Cascio, VL; Cinti, S; Cominacini, L; Galvanini, G; Scuro, LA, 1978) |
| "The inhibitory effect of epinephrine on basal and tolbutamide-stimulated insulin release was studied in 5 patients with hyperinsulinemic hypoglycemia." | 3.65 | Hyperinsulinemic hypoglycemia: effect of epinephrine suppression. ( Bandisode, MS; Boshell, BR; Buse, J; Buse, MG; Kansal, PC; Roddam, RF, 1977) |
| " Insulin responses to tolbutamide, glucagon, arginine and leucine were determined and insulin resistance was measured with exogenous iv insulin." | 3.65 | Carbohydrate metabolism and insulin resistance in myotonia dystrophica. ( Hudson, AJ; Tevaarwerk, GJ, 1977) |
| "So far, gestational diabetes treated with tolbutamide has never been associated with severe hypoglycaemia in the newborn when the mother's diabetes was well controlled." | 1.30 | Prolonged elimination of tolbutamide in a premature newborn with hyperinsulinaemic hypoglycaemia. ( Christesen, HB; Melander, A, 1998) |
| "Tolbutamide was shown to have no independent effect on VLDL TG or VLDL apo B production in four insulin-deficient diabetic subjects." | 1.29 | VLDL production is decreased to a similar extent by acute portal vs. peripheral venous insulin. ( Lewis, GF; Steiner, G; Szeto, L; Uffelman, KD; Weller, B; Zinman, B, 1994) |
| "Glucose-induced hyperinsulinemia also results in a 5-fold increase in the insulin content of Golgi fractions at 15 min." | 1.27 | Changes in the subcellular distribution of insulin receptors in rat liver induced by acute endogenous hyperinsulinemia. ( Desbuquois, B; Lopez, S, 1983) |
| "The data indicate: 1) insulin-secreting islet cell tumors have decreased storage capacity for insulin, 2) elevated concentration of proinsulin in tumors may be due to decreased capacity to store insulin and in some to decreased conversion of proinsulin to insulin as well, 3) tolbutamide stimulates the exaggerated release of a relatively constant fraction of insulin stored in adenomas." | 1.26 | Insulin, proinsulin, glucagon and gastrin in pancreatic tumors and in plasma of patients with organic hyperinsulinism. ( Fajans, SS; Floyd, JC; Hayashi, M; Pek, S, 1977) |
| "Extreme hyperinsulinism was observed in endotoxin-shock dogs made hyperglycemic by glucose infusion." | 1.26 | Hyperinsulinism in endotoxin shock dogs. ( Anderson, JH; Blackard, WG; Spitzer, JJ, 1976) |
| "Endogenous hyperinsulinism was considered after the systematic exclusion of other causes of hypoglycemia, and this possibility was confirmed by measurement of serum C-peptide reactivity (CPR), an indicator of beta cell secretory function." | 1.25 | Hypoglycemia and endogenous hyperinsulinism complicating diabetes mellitus. Application of the C-peptide assay to diagnosis and therapy. ( Horwitz, DL; Kuzuya, H; Rubenstein, AH; Sandler, R, 1975) |
| "Insular hyperplasia was the only abnormal factor determined to be present." | 1.25 | Hypoglycemia and insular hyperplasia: review of 148 cases. ( Basoli, A; Carboni, M; Patrassi, N; Stefanini, P, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 97 (85.84) | 18.7374 |
| 1990's | 7 (6.19) | 18.2507 |
| 2000's | 8 (7.08) | 29.6817 |
| 2010's | 1 (0.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Henquin, JC | 1 |
| Sempoux, C | 2 |
| Marchandise, J | 1 |
| Godecharles, S | 1 |
| Guiot, Y | 1 |
| Nenquin, M | 1 |
| Rahier, J | 4 |
| Huopio, H | 3 |
| Jääskeläinen, J | 1 |
| Komulainen, J | 3 |
| Miettinen, R | 1 |
| Kärkkäinen, P | 1 |
| Laakso, M | 3 |
| Tapanainen, P | 1 |
| Voutilainen, R | 1 |
| Otonkoski, T | 3 |
| Cosgrove, KE | 2 |
| Antoine, MH | 1 |
| Lee, AT | 1 |
| Barnes, PD | 2 |
| de Tullio, P | 1 |
| Clayton, P | 1 |
| McCloy, R | 1 |
| De Lonlay, P | 2 |
| Nihoul-Fékété, C | 2 |
| Robert, JJ | 2 |
| Saudubray, JM | 2 |
| Lindley, KJ | 2 |
| Hussain, K | 1 |
| Aynsley-Green, A | 2 |
| Pirotte, B | 1 |
| Lebrun, P | 1 |
| Dunne, MJ | 3 |
| UNDERWOOD, LE | 1 |
| JACOBS, NM | 1 |
| STAFFIERI, JJ | 1 |
| LENCIONI, LJ | 1 |
| EBERHARDT, DR | 1 |
| GORNI, DL | 1 |
| BOUMAN, PR | 1 |
| POLI, E | 1 |
| CARNEVALI, R | 1 |
| RAINERI, P | 1 |
| MAHLER, RJ | 1 |
| GRANN, V | 1 |
| PURDY, R | 1 |
| HRNCIAROVA, M | 1 |
| BIELIK, E | 1 |
| HRNCIAR, J | 1 |
| GALIK, L | 1 |
| ROBERTS, HJ | 2 |
| FLOYD, JC | 3 |
| FAJANS, SS | 3 |
| KNOPF, RF | 2 |
| CONN, JW | 2 |
| HECKER, E | 1 |
| FROMM, GA | 1 |
| NAJENSON, H | 1 |
| FARAONI, H | 1 |
| BOTTERMANN, P | 3 |
| SCHWARZ, K | 3 |
| KOPETZ, K | 3 |
| FORD, HC | 1 |
| BAILEY, RE | 1 |
| Giurgea, I | 1 |
| Laborde, K | 1 |
| Touati, G | 1 |
| Bellanné-Chantelot, C | 1 |
| Nassogne, MC | 1 |
| Jaubert, F | 1 |
| Khoa, N | 1 |
| Chigot, V | 1 |
| Brunelle, F | 1 |
| Stanley, C | 1 |
| Hoe, FM | 1 |
| Thornton, PS | 2 |
| Wanner, LA | 1 |
| Steinkrauss, L | 1 |
| Simmons, RA | 1 |
| Stanley, CA | 2 |
| Knick, B | 2 |
| Lopez, S | 1 |
| Desbuquois, B | 1 |
| Cotrozzi, G | 2 |
| Matteini, M | 2 |
| Relli, P | 2 |
| Lazzari, T | 2 |
| Bufalini, GN | 1 |
| Ueki, A | 1 |
| Torella, R | 1 |
| Improta, L | 1 |
| Scognamiglio, G | 1 |
| Siniscalchi, N | 1 |
| Jori, GP | 1 |
| Lewis, GF | 3 |
| Zinman, B | 1 |
| Uffelman, KD | 1 |
| Szeto, L | 1 |
| Weller, B | 1 |
| Steiner, G | 1 |
| Chen, C | 1 |
| Bumbalo, L | 1 |
| Leahy, JL | 1 |
| Vranic, M | 2 |
| Harley, P | 1 |
| Giacca, A | 2 |
| Inoue, I | 1 |
| Takahashi, K | 1 |
| Noji, S | 1 |
| Awata, T | 1 |
| Negishi, K | 1 |
| Katayama, S | 1 |
| Christesen, HB | 1 |
| Melander, A | 1 |
| Carpentier, A | 1 |
| Bilinski, D | 1 |
| MacFarlane, WM | 1 |
| Chapman, JC | 1 |
| Shepherd, RM | 1 |
| Hashmi, MN | 1 |
| Kamimura, N | 1 |
| O'Brien, RE | 1 |
| Hart, AW | 1 |
| Docherty, HM | 1 |
| James, RF | 1 |
| Docherty, K | 1 |
| Reimann, F | 1 |
| Ashfield, R | 1 |
| Lenko, HL | 1 |
| Vauhkonen, I | 2 |
| Kere, J | 1 |
| Ashcroft, F | 1 |
| Yaspelkis, BB | 1 |
| Davis, JR | 1 |
| Saberi, M | 1 |
| Smith, TL | 1 |
| Jazayeri, R | 1 |
| Singh, M | 1 |
| Fernandez, V | 1 |
| Trevino, B | 1 |
| Chinookoswong, N | 1 |
| Wang, J | 1 |
| Shi, ZQ | 1 |
| Levin, N | 1 |
| Grimberg, A | 1 |
| Ferry, RJ | 1 |
| Kelly, A | 1 |
| Koo-McCoy, S | 1 |
| Polonsky, K | 1 |
| Glaser, B | 1 |
| Permutt, MA | 2 |
| Aguilar-Bryan, L | 1 |
| Stafford, D | 1 |
| Baker, L | 1 |
| Niskanen, L | 1 |
| Hayashi, M | 1 |
| Pek, S | 1 |
| Sailer, R | 1 |
| Katoh, E | 1 |
| Drüneklee, D | 1 |
| Kovaciecek, S | 1 |
| Berger, M | 1 |
| Del Arbol, JL | 2 |
| Jimenez Alonso, J | 1 |
| Yañez, AP | 1 |
| Escobar-Jimenez, F | 1 |
| DeLa Higuare, J | 1 |
| Zubeldia, R | 1 |
| Diaz-Flores, L | 1 |
| Arcelus, I | 1 |
| Berger, H | 1 |
| Costamaillere, L | 1 |
| Riesco, J | 1 |
| Pumarino, H | 1 |
| Michelsen, H | 1 |
| Zlatar, N | 1 |
| Kansal, PC | 1 |
| Boshell, BR | 2 |
| Buse, J | 1 |
| Bandisode, MS | 1 |
| Roddam, RF | 2 |
| Buse, MG | 1 |
| Tevaarwerk, GJ | 1 |
| Hudson, AJ | 1 |
| Jiménez-Alonso, J | 1 |
| García Romero, E | 1 |
| Osorio, J | 1 |
| Peña Yañez, A | 1 |
| Cascio, VL | 1 |
| Galvanini, G | 1 |
| Adami, S | 1 |
| Cinti, S | 1 |
| Bianchi, I | 1 |
| Cominacini, L | 1 |
| Scuro, LA | 1 |
| Schlienger, JL | 1 |
| Blickle, F | 1 |
| Demangeat, C | 1 |
| Hasselmann, M | 1 |
| Imler, M | 1 |
| Blackard, WG | 1 |
| Anderson, JH | 1 |
| Spitzer, JJ | 1 |
| Couropmitree, C | 1 |
| Freinkel, N | 1 |
| Nagel, TC | 1 |
| Horwitz, DL | 2 |
| Rubenstein, AH | 3 |
| Metzger, B | 1 |
| Hahnel, R | 1 |
| Krämer, K | 1 |
| Sailer, FX | 1 |
| Sandler, R | 1 |
| Kuzuya, H | 1 |
| Hed, R | 1 |
| Nygren, A | 1 |
| Sundblad, L | 1 |
| Randall, RV | 1 |
| Miles, LE | 1 |
| Lacroix, L | 1 |
| Bruni, B | 1 |
| Lundbaek, K | 1 |
| Lyngsoe, J | 1 |
| Madsen, B | 1 |
| Yde, H | 1 |
| Orskov, H | 1 |
| Frawley, TF | 1 |
| Pensuwan, S | 1 |
| Kollmannsberger, A | 2 |
| Knoke, M | 1 |
| Reding, R | 1 |
| Markert, J | 1 |
| Glöckner, E | 1 |
| Thiffault, CA | 1 |
| Harrison, TS | 1 |
| Marks, V | 1 |
| Samols, E | 1 |
| Power, L | 1 |
| Laurent, J | 2 |
| Debry, G | 2 |
| Lawrence, AM | 1 |
| Kirsteins, L | 1 |
| Sodoyez, JC | 1 |
| Sodoyez-Goffaux, F | 1 |
| Lefebvre, PJ | 1 |
| Foà, PP | 1 |
| van de Weyer, KH | 1 |
| Overzier, C | 1 |
| Kümmerle, F | 1 |
| Remigio, PA | 1 |
| Grinvalsky, HT | 1 |
| AvRuskin, TW | 1 |
| Coran, AG | 1 |
| Crigler, JF | 1 |
| Nardi, GL | 1 |
| Wolfe, WG | 1 |
| Mullen, DC | 1 |
| Silver, D | 1 |
| Perreau, P | 1 |
| Joubaud, F | 1 |
| Cheguillaume, J | 1 |
| Boyer, J | 1 |
| Vernin, H | 1 |
| Kavlie, H | 1 |
| White, TT | 1 |
| Felber, JP | 1 |
| Kuroda, A | 1 |
| Wada, Y | 1 |
| Ishihara, Y | 1 |
| Sato, N | 1 |
| Tajima, Y | 1 |
| Stefanini, P | 1 |
| Carboni, M | 1 |
| Patrassi, N | 1 |
| Basoli, A | 1 |
| Gorden, P | 1 |
| Roth, J | 1 |
| Hendricks, CM | 1 |
| Kahn, CR | 1 |
| Vance, JE | 1 |
| Kitabchi, AE | 1 |
| Buchanan, KD | 1 |
| Stoli, RW | 1 |
| Hollander, D | 1 |
| Wood, FC | 1 |
| Romsos, DR | 1 |
| Leveille, GA | 1 |
| Allee, GL | 1 |
| Rosenbloom, AL | 1 |
| Bianchi, R | 1 |
| Chin, FT | 1 |
| Páv, J | 1 |
| Srámková, J | 1 |
| Genuth, SM | 1 |
| Ratzmann, KP | 1 |
| Pfeifer, EF | 1 |
| Schiff, D | 1 |
| Colle, E | 1 |
| Wells, D | 1 |
| Stern, L | 1 |
| Kelly, J | 1 |
| Berstein, R | 1 |
| Alpers, DH | 1 |
| Siegel, BA | 1 |
| Kipnis, DM | 2 |
| Serrano-Rios, M | 2 |
| Ramos, F | 2 |
| Vivanco, F | 2 |
| Rodriguez-Minon, JL | 1 |
| Lubetzki, J | 2 |
| Duprey, J | 2 |
| Barbosa, J | 1 |
| Nuttall, FQ | 1 |
| Kennedy, W | 1 |
| Goetz, F | 1 |
| Loubatières, AL | 1 |
| Berkowitz, D | 1 |
| Capen, CC | 1 |
| Martin, SL | 1 |
| Crepaldi, G | 2 |
| Tiengo, A | 3 |
| Muggeo, M | 3 |
| Trisotto, A | 3 |
| Federspil, G | 3 |
| Scandellari, C | 1 |
| Melani, F | 1 |
| Wüstenberg, PW | 1 |
| Wolff, G | 1 |
| Devrim, S | 1 |
| Koniçe, M | 1 |
| Sencer, E | 1 |
| Molvalìlar, S | 1 |
| Alp, H | 1 |
| Bompiani, GD | 1 |
| Laudicina, E | 1 |
| Rodriguez Miñón, JL | 1 |
| McAdams, GL | 1 |
| Creutzfeldt, W | 2 |
| Frerichs, H | 2 |
| Heully, F | 1 |
| Giry, D | 1 |
| Lopez, N | 1 |
| Basabe, J | 1 |
| Grant, A | 1 |
| Krees, S | 1 |
| Terry, M | 1 |
| Viktora, J | 1 |
| Wolff, F | 1 |
| Frezzato, S | 1 |
| Macrì, C | 1 |
| Vianello, A | 1 |
| Avogaro, P | 1 |
| Enzi, G | 1 |
| Hornbostel, H | 1 |
| Lange, HJ | 1 |
| Kössling, FK | 1 |
| Kremer, GJ | 1 |
| Beringer, A | 1 |
| Irsigler, K | 1 |
| Thaler, H | 1 |
| Yoshikawa, K | 1 |
| Helge, H | 1 |
| Weber, B | 1 |
| Quabbe, HJ | 1 |
| Werner, E | 1 |
| de L'Hortet, GC | 1 |
| Bercovici, JP | 1 |
| Chiumello, G | 1 |
| Carnelutti, M | 1 |
| Del Guercio, MJ | 1 |
| Bidone, G | 1 |
| Cantone, A | 1 |
| Beck, P | 1 |
| Schalch, DS | 1 |
| Parker, ML | 1 |
| Daughaday, WH | 1 |
13 reviews available for tolbutamide and Hyperinsulinism
| Article | Year |
|---|---|
[POSSIBILITIES AND LIMITATIONS IN THE DETERMINATION OF INSULIN IN BLOOD IN THE DIAGNOSIS OF HYPERINSULINISM].
Topics: Adenoma, Islet Cell; Blood; Diagnosis; Humans; Hyperglycemia; Hyperinsulinism; Insulin; Leucine; Pan | 1963 |
[HYPERINSULINISM. DIAGNOSTIC AND THERAPEUTIC ASPECTS].
Topics: Diagnosis, Differential; Electrodiagnosis; Electroencephalography; Glucose Tolerance Test; Humans; H | 1964 |
Hypoglycemia: tolbutamide and leucine tests in insulinoma.
Topics: Adenoma, Islet Cell; Blood Glucose; Fasting; Female; Glucagon; Glucose Tolerance Test; Humans; Hyper | 1968 |
Insulinomas.
Topics: Adenoma, Islet Cell; Blood Glucose; Brain Damage, Chronic; Child; Fasting; Female; Humans; Hyperinsu | 1971 |
[Insulinoma].
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Angiography; Child; Diagnosis, Differential; Diagnosti | 1973 |
Plasma proinsulin-like components.
Topics: Adenoma, Islet Cell; Animals; Antigen-Antibody Reactions; Antigens; Blood Glucose; Chromatography, G | 1974 |
[Pathogenesis of hepatogenic diabetes mellitus].
Topics: Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Glucose Tolerance Test; Humans; Hyperg | 1972 |
Obesity, islet function and diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diet, Reducing; Dietary Carbohydr | 1974 |
[Hypoglycemic sulfonamides].
Topics: Acetohexamide; Animals; Blood Glucose; Carbutamide; Chlorpropamide; Dogs; Humans; Hyperinsulinism; H | 1968 |
[Critical considerations regarding the obesity-hyperinsulinism concept].
Topics: Animals; Blood Glucose; Glucagon; Glucocorticoids; Glucose; Glucose Tolerance Test; Growth Hormone; | 1968 |
[Blood insulin and diabetes. I. Method of study--normal subjects--diabetic disease].
Topics: Cortisone; Diabetes Mellitus; Dietary Proteins; Gastrointestinal Hormones; Glucagon; Glucose Toleran | 1971 |
[The hypoglycemia syndrome].
Topics: Alloxan; Angiography; Antibiotics, Antineoplastic; Blood Glucose; Diagnosis, Differential; Diazoxide | 1970 |
[Hypoglycemia. II].
Topics: Adolescent; Adult; Age Factors; Animals; Blood Glucose; Cricetinae; Diagnosis, Differential; Female; | 1970 |
3 trials available for tolbutamide and Hyperinsulinism
| Article | Year |
|---|---|
Acarbose controls postprandial hyperproinsulinemia in non-insulin dependent diabetes mellitus.
Topics: Acarbose; Aged; Blood Glucose; C-Peptide; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; | 1997 |
Chemical diabetes mellitus in siblings of children with overt diabetes.
Topics: Child; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Glucose Tolerance Test; Humans; Hyperins | 1972 |
Glucose tolerance, free fatty acid, and serum insulin responses in patients with cirrhosis.
Topics: Adult; Alcoholism; Blood Glucose; Clinical Trials as Topic; Fatty Acids, Nonesterified; Female; Gluc | 1969 |
97 other studies available for tolbutamide and Hyperinsulinism
| Article | Year |
|---|---|
Congenital hyperinsulinism caused by hexokinase I expression or glucokinase-activating mutation in a subset of β-cells.
Topics: Amino Acid Substitution; Diazoxide; Glucokinase; Hexokinase; Humans; Hyperinsulinism; Hypoglycemic A | 2013 |
Acute insulin response tests for the differential diagnosis of congenital hyperinsulinism.
Topics: Adolescent; Adult; C-Peptide; Calcium; Child; Child, Preschool; Diagnosis, Differential; DNA Mutatio | 2002 |
BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism.
Topics: Adenosine Triphosphate; Adolescent; Adrenergic alpha-Antagonists; Animals; Benzofurans; Benzothiadia | 2002 |
FAMILIAL ENDOCRINE ADENOMATOSIS. A FAMILY WITH HYPERINSULINISM AS THE PREDOMINANT MANIFESTATION.
Topics: Adenoma; Adenoma, Islet Cell; Adolescent; Carcinoma, Bronchogenic; Child; Clinical Laboratory Techni | 1963 |
[HYPOGLYCEMIC SYNDROME DUE TO HYPERFUNCTIONING ISLET CELL ADENOMA].
Topics: Adenoma, Islet Cell; Clinical Laboratory Techniques; Glucose Tolerance Test; Humans; Hyperinsulinism | 1963 |
[HYPOGLYCEMIC REACTION TO LEUCINE, VALINE AND PHENYLALANINE IN A CASE OF DIFFUSE HYPERPLASIA OF THE BETA CELLS].
Topics: Glucose Tolerance Test; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; Hypoglycemic Agents; Ins | 1963 |
FUNCTIONING ISLET CELL ADENOMA.
Topics: Adenoma, Islet Cell; Cerebrovascular Disorders; Diagnosis, Differential; Geriatrics; Humans; Hyperin | 1964 |
AFTERNOON GLUCOSE TOLERANCE TESTING: A KEY TO THE PATHOGENESIS, EARLY DIAGNOSIS AND PROGNOSIS OF DIABETOGENIC HYPERINSULINISM.
Topics: Adolescent; Alcoholism; Black People; Cortisone; Diabetes Mellitus; Diet; Diet Therapy; Early Diagno | 1964 |
PLASMA INSULIN IN ORGANIC HYPERINSULINISM: COMPARATIVE EFFECTS OF TOLBUTAMIDE, LEUCINE AND GLUCOSE.
Topics: Adenoma, Islet Cell; Blood; Blood Chemical Analysis; Blood Glucose; Glucagon; Glucose; Humans; Hyper | 1964 |
[DIAGNOSTIC VALUE OF TOLBUTAMIDE AND 1-LYSINE IN INSULAR ADENOMA OF THE PANCREAS].
Topics: Adenoma, Islet Cell; Humans; Hyperinsulinism; Hypoglycemia; Lysine; Neoplasms; Pancreatic Neoplasms; | 1964 |
[ON THE BEHAVIOR OF THE INSULIN-LIKE ACTIVITY OF THE BLOOD SERUM IN ADIPOSITY].
Topics: Adiposity; Cushing Syndrome; Diabetes Mellitus; Glucose Tolerance Test; Humans; Hyperinsulinism; Ins | 1965 |
TOLBUTAMIDE TEST: A MISLEADING RESPONSE.
Topics: Adenoma, Islet Cell; Diagnosis, Differential; Glucose; Glucose Tolerance Test; Humans; Hyperinsulini | 1965 |
Acute insulin responses to calcium and tolbutamide do not differentiate focal from diffuse congenital hyperinsulinism.
Topics: Calcium Gluconate; Child, Preschool; Diagnosis, Differential; Female; Glucose Tolerance Test; Humans | 2004 |
Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism.
Topics: Antihypertensive Agents; Calcium; Case-Control Studies; Diazoxide; Enteral Nutrition; Fasting; Femal | 2006 |
Diabetogenic hyperinsulinism: pathogenesis and implications of sulfonylurea-induced hypothyroidism.
Topics: Adult; Cholesterol; Diabetes Complications; Diet Therapy; Female; Glucose Tolerance Test; Goiter; Go | 1967 |
[Therapeutic tests on endocrine and exocrine function of pancreas in patients with stomach resection].
Topics: Adult; Amylases; Body Weight; Carboxypeptidases; Diet Therapy; Dumping Syndrome; Female; Gastrectomy | 1967 |
Changes in the subcellular distribution of insulin receptors in rat liver induced by acute endogenous hyperinsulinemia.
Topics: Acute Disease; Animals; Glucagon; Glucose; Golgi Apparatus; Hyperinsulinism; Insulin; Kinetics; Live | 1983 |
[Hyperinsulinism and insulin resistance diagnosed by oral and intravenous glucose loading and by the tolbutamide test in polycystic ovary syndrome].
Topics: Adolescent; Adult; Female; Glucose Tolerance Test; Humans; Hyperinsulinism; Insulin Resistance; Obes | 1983 |
[Hyperinsulinism and insulin resistance in the polycystic ovary syndrome as tested with tolbutamide].
Topics: Adolescent; Adult; Blood Glucose; Female; Humans; Hyperinsulinism; Insulin; Insulin Resistance; Poly | 1982 |
[Hyperinsulinism induced with glucocorticoid--a study on using a perifusion system of isolated islets in rats (author's transl)].
Topics: Animals; Blood Glucose; Cortisone; Glucocorticoids; Glucose; Hyperinsulinism; Insulin; Insulin Secre | 1980 |
[Effect of circulating insulin on liver damage by CCl4 in the rat. II. Histological aspects].
Topics: Animals; Carbon Tetrachloride Poisoning; Diabetes Mellitus, Experimental; Hyperinsulinism; Liver; Ra | 1980 |
VLDL production is decreased to a similar extent by acute portal vs. peripheral venous insulin.
Topics: Adult; Apolipoproteins B; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Humans; Hyperinsuli | 1994 |
Increased catalytic activity of glucokinase in isolated islets from hyperinsulinemic rats.
Topics: Animals; Blood Glucose; Catalysis; DNA; Glucokinase; Glucose; Hexokinase; Hyperinsulinism; Immunoblo | 1994 |
Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans.
Topics: Adult; C-Peptide; Cohort Studies; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Glucagon; | 1997 |
Prolonged elimination of tolbutamide in a premature newborn with hyperinsulinaemic hypoglycaemia.
Topics: Adult; Diabetes, Gestational; Female; Half-Life; Humans; Hyperinsulinism; Hypoglycemia; Hypoglycemic | 1998 |
Counterregulatory response to hypoglycemia differs according to the insulin delivery route, but does not affect glucose production in normal humans.
Topics: Adult; Blood Glucose; C-Peptide; Fatty Acids, Nonesterified; Glucose; Hormones; Humans; Hyperinsulin | 1999 |
Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Calcium; | 1999 |
Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; ATP-Binding Cassette Transporters; | 2000 |
Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats.
Topics: 3-O-Methylglucose; Animals; Blood Glucose; Body Mass Index; Diet; Dietary Fats; Energy Intake; Gluco | 2001 |
Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations.
Topics: Adolescent; Adult; ATP-Binding Cassette Transporters; Child; Child, Preschool; Female; Glucose; Hete | 2001 |
Carriers of an inactivating beta-cell ATP-sensitive K(+) channel mutation have normal glucose tolerance and insulin sensitivity and appropriate insulin secretion.
Topics: Adult; Amino Acid Substitution; ATP-Binding Cassette Transporters; C-Peptide; Female; Genetic Carrie | 2002 |
Insulin, proinsulin, glucagon and gastrin in pancreatic tumors and in plasma of patients with organic hyperinsulinism.
Topics: Adenoma; Adenoma, Islet Cell; Adolescent; Adult; Aged; Antigen-Antibody Reactions; Carcinoma; Female | 1977 |
[Experience in the treatment of islet adenomas (author's transl)].
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Blood Glucose; Brain Damage, Chronic; Child; Female; F | 1976 |
Somatostatin-tolbutamide test in hyperinsulinism due to beta-cell hyperplasia.
Topics: Adenoma, Islet Cell; Humans; Hyperinsulinism; Hyperplasia; Insulin; Islets of Langerhans; Pancreatic | 1978 |
Somatostatin-tolbutamide test: A reliable test for hyperinsulinism?
Topics: Adenoma; Diagnosis, Differential; Drug Evaluation; Humans; Hyperinsulinism; Pancreatic Neoplasms; So | 1978 |
Hypoglycemia: a perspective.
Topics: Adenoma, Islet Cell; Citric Acid Cycle; Diabetes Complications; Diazoxide; Female; Glucose; Glucose | 1975 |
[A clinical experience with hyperinsulinism (author's transl)].
Topics: Adenoma, Islet Cell; Adolescent; Adult; Blood Glucose; Celiac Artery; Child; Child, Preschool; Femal | 1976 |
Hyperinsulinemic hypoglycemia: effect of epinephrine suppression.
Topics: Adenoma; Adenoma, Islet Cell; Adult; Carcinoma; Epinephrine; Female; Humans; Hyperinsulinism; Hyperp | 1977 |
Carbohydrate metabolism and insulin resistance in myotonia dystrophica.
Topics: Adult; Aged; Arginine; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus; Female; Fructose; | 1977 |
[Hyperinsulinism due to hyperplasia of pancreatic beta cells. Value of proinsulin determination and of the somatostatin-tolbutamide test].
Topics: Adult; Diagnosis, Differential; Female; Humans; Hyperinsulinism; Hyperplasia; Pancreas; Pancreatic D | 1979 |
Failure of somatostatin to diagnose organic hyperinsulinism.
Topics: Adult; Female; Humans; Hyperinsulinism; Insulin; Insulin Secretion; Middle Aged; Secretory Rate; Som | 1978 |
[Insulin secretion in alcoholic hepatopathy: analysis by measurement of C-peptide (author's transl)].
Topics: Adolescent; Adult; C-Peptide; Fatty Liver, Alcoholic; Female; Glucose Tolerance Test; Humans; Hyperi | 1978 |
Hyperinsulinism in endotoxin shock dogs.
Topics: Alloxan; Animals; Blood Glucose; Dogs; Escherichia coli; Glucose; Hyperinsulinism; Islets of Langerh | 1976 |
Plasma C-peptide and diagnosis of factitious hyperinsulinism. Study of an insulin-dependent diabetic patient with "spontaneous" hypoglycemia.
Topics: Diabetes Mellitus; Diagnosis, Differential; Glucagon; Glucose; Humans; Hyperinsulinism; Hypoglycemia | 1975 |
[Diagnosis of organic hyperinsulinism].
Topics: Diagnosis, Differential; Diazoxide; Fasting; Glucagon; Glucose Tolerance Test; Humans; Hyperinsulini | 1975 |
Hypoglycemia and endogenous hyperinsulinism complicating diabetes mellitus. Application of the C-peptide assay to diagnosis and therapy.
Topics: Blood Glucose; Diabetes Complications; Diabetes Mellitus; Growth Hormone; Humans; Hyperinsulinism; H | 1975 |
Insulin response in chronic alcoholism.
Topics: Alcoholism; Blood Glucose; Carbohydrate Metabolism; Glucose Tolerance Test; Humans; Hyperinsulinism; | 1968 |
Hypoglycemia.
Topics: Adenoma, Islet Cell; Blood Glucose; Diagnosis, Differential; Glucose Tolerance Test; Humans; Hyperin | 1966 |
Biochemical studies in a patient with hyperinsulinism.
Topics: Adenoma, Islet Cell; Adult; Female; Glucagon; Glucose Tolerance Test; Humans; Hydrocortisone; Hyperi | 1966 |
[On the problem of the differential diagnosis of hypoglycemias. Apropos of a case of pancreatic insuloma].
Topics: Adenoma, Islet Cell; Adult; Diagnosis, Differential; Female; Humans; Hyperinsulinism; Hyperplasia; H | 1966 |
The diagnosis of insuloma.
Topics: Adenoma, Islet Cell; Adult; Aged; Diagnosis, Differential; Fasting; Female; Glucagon; Glucose Tolera | 1967 |
[Contribution to the diagnosis of islet cell tumors].
Topics: Adenoma, Islet Cell; Diagnosis, Differential; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypog | 1967 |
[Current methods of study and morphologic findings in B-cell adenoma of the pancreas].
Topics: Adenoma, Islet Cell; Adolescent; Blood Glucose; Diagnosis, Differential; Female; Glucose Tolerance T | 1967 |
Further studies on diazoxide suppression of insulin release from abnormal and normal islet tissue in man.
Topics: Adenoma, Islet Cell; Arginine; Blood Glucose; Catecholamines; Depression, Chemical; Diazoxide; Femal | 1968 |
Glucagon test for insulinoma: a chemical study in 25 cases.
Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Diagnosis, Differential; Female; Glucagon; Humans; Hyperi | 1968 |
A glucose-responsive insulinoma.
Topics: Adenoma, Islet Cell; Blood Glucose; Dietary Carbohydrates; Fasting; Glucose; Glucose Tolerance Test; | 1969 |
[On the clinical diagnosis of islet cell adenoma. Clinical experiences and diagnostic procedure in organic hyperinsulism].
Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Diagnosis, Differential; Electroencephalography; Female; | 1969 |
[Hypoglycemic insular tumors in adults. Biological and radiologic diagnosis].
Topics: Adenoma, Islet Cell; Adult; Amino Acids; Angiography; Celiac Artery; Glucagon; Glucose Tolerance Tes | 1969 |
The effect of proinsulin on the immunoassay of insulin and its possible relation to states of hyperinsulinemia.
Topics: Adenoma, Islet Cell; Humans; Hyperinsulinism; Insulin; Iodine Isotopes; Peptides; Radioimmunoassay; | 1969 |
[A transplantable insuloma of the Syrian hamster Mesocricetus auratus auratus. Review of its properties and of its effects on the host].
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Body Weight; Carbon Isotopes; Cricetinae; Fasting; Gluc | 1968 |
[Clinical and radiological diagnosis of hyperinsulinism].
Topics: Adenoma, Islet Cell; Celiac Artery; Diagnosis, Differential; Fasting; Female; Humans; Hyperinsulinis | 1969 |
Islet cell tumor with hypoglycemia.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Female; Glucagon; Glucose Tolerance Test; Humans; Hyperinsul | 1971 |
Insulin and growth hormone regulation in organic hyperinsulinism.
Topics: Adenoma, Islet Cell; Adolescent; Glucagon; Glucose; Glucose Tolerance Test; Growth Hormone; Humans; | 1971 |
Surgical grand rounds from the University of Mississippi Medical Center. Management of hyperinsulinism.
Topics: Adenoma, Islet Cell; Diagnosis, Differential; Diazoxide; Dietary Carbohydrates; Female; Glucose Tole | 1971 |
Insulinoma of the pancreas. Use of the tolbutamide test, arteriography, and selenium scan in modern diagnosis.
Topics: Adenoma, Islet Cell; Adult; Aged; Angiography; Celiac Artery; Female; Glucose Tolerance Test; Humans | 1972 |
[Dynamic exploration of carbohydrate metabolism in liver cirrhosis. Determination of free fatty acids and insulin in the blood].
Topics: Blood Glucose; Carbohydrate Metabolism; Diabetes Complications; Fatty Acids, Nonesterified; Glucose | 1972 |
Pancreatic islet beta cell tumors and hyperplasia: experience in 14 Seattle hospitals.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Diazoxide; Female; Humans; Hyperinsulinism; Hyp | 1972 |
Clinical use of radioimmunological plasma insulin assessment.
Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Chlorpropamide; Diabetes Mellitus; Diet; Glucose Toleranc | 1973 |
Hypoglycemia and insular hyperplasia: review of 148 cases.
Topics: Adenoma, Islet Cell; Adult; Age Factors; Blood Glucose; Child; Diagnosis, Differential; Epilepsy; Fa | 1974 |
Hypersecretion of insulin, glucagon and gastrin in a kindred with multiple adenomatosis.
Topics: Adenoma, Islet Cell; Adrenal Gland Diseases; Gastrins; Glucagon; Glucose Tolerance Test; Humans; Hyp | 1968 |
Alloxan diabetes in the pig (Sus domesticus). Response to glucose, tolbutamide and insulin administration.
Topics: Acetoacetates; Ammonium Chloride; Animals; Antigens; Blood Glucose; Body Weight; Diabetes Mellitus, | 1971 |
New test of efficiency of pancreatic beta-cells and of carbohydrate metabolism.
Topics: Carbohydrate Metabolism; Diabetes Mellitus; Glucagon; Glucose; Humans; Hyperinsulinism; Islets of La | 1972 |
Metabolic clearance of insulin in man.
Topics: Adolescent; Adult; Aged; Animals; Body Surface Area; Body Weight; Cattle; Diabetes Mellitus; Fasting | 1972 |
Metabolic aspects of the Beckwith-Wiedemann syndrome.
Topics: Abnormalities, Multiple; Adrenal Gland Diseases; Blood Glucose; Child, Preschool; Diazoxide; Epineph | 1973 |
Alimentary hypoglycemia in the absence of gastrointestinal surgery.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Diagnosis, Differential; Eating; Fasting; Female; Gastroint | 1973 |
[Secretion of insulin during the first phases of diabetes. Summary of the experiments of the authors].
Topics: Acromegaly; Adolescent; Adult; Body Weight; Diabetes Mellitus; Female; Glucose Tolerance Test; Human | 1973 |
[Hypoglycemia].
Topics: Child; Dietary Carbohydrates; Epinephrine; Gastrointestinal Hormones; Glucagon; Gluconeogenesis; Glu | 1973 |
Plasma insulin in patients with myotonic dystrophy and their relatives.
Topics: Adolescent; Adult; Aged; Amino Acids; Antigens; Arginine; Child; Child, Preschool; Electromyography; | 1974 |
Hyperinsulinism in dogs with neoplasia of the pancreatic islets. A clinical, pathologic, and ultrastructural study.
Topics: Adenoma; Animals; Blood Glucose; Carcinoma; Dog Diseases; Dogs; Glucose Tolerance Test; Hyperinsulin | 1969 |
[Primary and secondary hyperinsulinism].
Topics: Acromegaly; Cushing Syndrome; Diabetes Complications; Glucagon; Glucose Tolerance Test; Humans; Hype | 1970 |
Serum immunoreactive insulin response to oral glucose and intravenous sodium tolbutamide administration in relation to obesity.
Topics: Blood Glucose; Diabetes Complications; Diabetes Mellitus; Glucose Tolerance Test; Humans; Hyperinsul | 1972 |
Obesity and diabetes.
Topics: Adolescent; Adult; Amino Acids; Diabetes Complications; Diabetes Mellitus; Glucose Tolerance Test; H | 1972 |
Glucose tolerance in acromegaly: a study of insulin secretion.
Topics: Acromegaly; Adult; Female; Glucose Tolerance Test; Growth Hormone; Humans; Hyperinsulinism; Insulin; | 1972 |
Effects of phenformin on insulin reserve and release.
Topics: Diabetes Mellitus; Drug Tolerance; Ethanol; Glucose Tolerance Test; Humans; Hyperinsulinism; Insulin | 1968 |
Factitious hypoglycaemia. Its importance in the differential diagnosis of hyperinsulinism.
Topics: Adolescent; Adult; Diagnosis, Differential; Female; Humans; Hyperinsulinism; Hypoglycemia; Insulin; | 1969 |
[Insulinemia and chronic pancreatitis].
Topics: Adult; Chronic Disease; Female; Humans; Hyperglycemia; Hyperinsulinism; Insulin; Male; Middle Aged; | 1970 |
AO44: an improved hyperglycemic agent.
Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Diazoxide; Diuresis; Dogs; Epinephrine | 1971 |
[Functional exploration of insulin secretion in sponteaneous hypoglycemia].
Topics: Adenoma; Arginine; Glucagon; Glucose; Humans; Hyperinsulinism; Hypoglycemia; Insulin; Insulin Secret | 1967 |
[The insulinemic response after oral administration of glucose and after intravenous administration of tolbutamide in patients with Cushin's syndrome].
Topics: Blood Glucose; Cushing Syndrome; Diabetes Mellitus; Fatty Acids; Glucose; Glucose Tolerance Test; Hu | 1967 |
[Etiological and diagnostic deliberations on hypoglycemia].
Topics: Blood Glucose; Fasting; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemia; Liver Disease | 1968 |
[Effect of tolbutamide on the fatty liver of diabetics].
Topics: Diabetes Mellitus; Diet Therapy; Fatty Liver; Humans; Hyperinsulinism; Liver Diseases; Tolbutamide; | 1968 |
Diagnostic value of sodium tolbutamide test in hypoglycemia.
Topics: Adrenal Insufficiency; Blood Glucose; Diabetes Complications; Diagnosis, Differential; Humans; Hyper | 1968 |
[Tolbutamide test in adipose children: Relation between insulin, TSH, glucose and free fatty acids].
Topics: Adolescent; Child; Fatty Acids; Female; Glucose; Humans; Hyperinsulinism; Male; Obesity; Prediabetic | 1968 |
[Diabetes mellitus. Present concepts and therapeutic implications].
Topics: Adolescent; Adult; Birth Weight; Child; Cortisone; Diabetes Mellitus; Diabetic Angiopathies; Fatty A | 1968 |
[Hypoglycemia factitia. A differential diagnostic significant form of hyperinsulinism].
Topics: Adolescent; Diabetes Mellitus, Type 1; Diabetic Coma; Diagnosis, Differential; Female; Humans; Hyper | 1969 |
[Studies on the function of pancreatic-beta in the essential obesity in children].
Topics: Child; Glucose Tolerance Test; Humans; Hyperinsulinism; Insulin; Obesity; Pancreas; Tolbutamide | 1969 |
Correlative studies of growth hormone and insulin plasma concentrations with metabolic abnormalities in acromegaly.
Topics: Acromegaly; Blood; Blood Glucose; Fatty Acids; Glucose Tolerance Test; Growth Hormone; Humans; Hyper | 1965 |