tolbutamide has been researched along with Glucose Intolerance in 13 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Glucose Intolerance: A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Oral glucose tolerance tests (OGTTs) and frequently sampled intravenous glucose tolerance tests (FSIGTs) were conducted on Latino women with impaired glucose tolerance and a history of gestational diabetes before and after 12 weeks of treatment with 400 mg/day troglitazone (n = 13) or placebo (n = 12)." | 5.09 | Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes. ( Azen, SP; Berkowitz, K; Buchanan, TA; Goico, J; Kjos, SL; Marroquin, A; Ochoa, C; Peters, RK; Xiang, AH, 2000) |
| "We conducted a randomized placebo-controlled study to determine the effects of the thiazolidinedione compound troglitazone on whole-body insulin sensitivity (SI), pancreatic beta-cell function, and glucose tolerance in 42 Latino women with impaired glucose tolerance (IGT) and a history of gestational diabetes mellitus (GDM), characteristics that carry an 80% risk of developing NIDDM within 5 years." | 5.08 | Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM. ( Azen, S; Berkowitz, K; Buchanan, TA; Dunn, ME; Goico, J; Kjos, SL; Marroquin, A; Peters, R; Xiang, A, 1996) |
| " Plasma glucose and serum insulin, C-peptide, and proinsulin levels were measured before as well as 1 and 2 h after breakfast in 23 patients with non-insulin-dependent diabetes mellitus and 17 patients with impaired glucose tolerance." | 5.08 | Acarbose controls postprandial hyperproinsulinemia in non-insulin dependent diabetes mellitus. ( Awata, T; Inoue, I; Katayama, S; Negishi, K; Noji, S; Takahashi, K, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DRURY, MI | 1 |
| TIMONEY, FJ | 1 |
| CHANMUGAM, D | 1 |
| FRUMIN, AM | 1 |
| Alarcon-Aguilar, FJ | 1 |
| Banderas-Dorantes, T | 1 |
| Gutierrez-Leon, A | 1 |
| Vazquez-Carrillo, L | 1 |
| Flores Saenz, JL | 1 |
| Roman-Ramos, R | 1 |
| Toye, AA | 1 |
| Lippiat, JD | 1 |
| Proks, P | 1 |
| Shimomura, K | 1 |
| Bentley, L | 1 |
| Hugill, A | 1 |
| Mijat, V | 1 |
| Goldsworthy, M | 1 |
| Moir, L | 1 |
| Haynes, A | 1 |
| Quarterman, J | 1 |
| Freeman, HC | 1 |
| Ashcroft, FM | 1 |
| Cox, RD | 1 |
| Liu, TP | 1 |
| Liu, IM | 1 |
| Cheng, JT | 1 |
| Hansen, T | 1 |
| Drivsholm, T | 1 |
| Urhammer, SA | 1 |
| Palacios, RT | 1 |
| Vølund, A | 1 |
| Borch-Johnsen, K | 1 |
| Pedersen, O | 1 |
| Dzúrik, R | 1 |
| Spustová, V | 1 |
| Melander, A | 2 |
| Berkowitz, K | 2 |
| Peters, R | 1 |
| Kjos, SL | 2 |
| Goico, J | 2 |
| Marroquin, A | 2 |
| Dunn, ME | 1 |
| Xiang, A | 1 |
| Azen, S | 1 |
| Buchanan, TA | 2 |
| Knowler, WC | 1 |
| Sartor, G | 1 |
| Scherstén, B | 1 |
| Inoue, I | 1 |
| Takahashi, K | 1 |
| Noji, S | 1 |
| Awata, T | 1 |
| Negishi, K | 1 |
| Katayama, S | 1 |
| Viviani, GL | 1 |
| Pacini, G | 1 |
| Xiang, AH | 1 |
| Peters, RK | 1 |
| Ochoa, C | 1 |
| Azen, SP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Gain on Closed-Loop Insulin[NCT02065895] | 8 participants (Actual) | Interventional | 2013-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Glucose Area Under the Curve (AUC) Breakfast defines the total exposure to glucose during breakfast. Breakfast is typically considered the most difficult meal to control; low AUC is desirable.This outcome measure was analyzed for each of the three calibration error values (high error, no error and low error). (NCT02065895)
Timeframe: On day #1, day #2 and day #3 (each day could be 24 hours to 7 days apart from prior one, and completed within 6 week period) 8:00 AM to 2:00 PM on day following admission, with samples obtained every 10-15 minutes, for each sequence of calibration errors
| Intervention | mmol/l/min (Mean) |
|---|---|
| HIGH Error | 66.8 |
| NO Error | 48.8 |
| LOW Error | 37.4 |
Night-time in target range 5.0-8.33, following the 3 hour controller initialization period blood glucose remained at or near target. (NCT02065895)
Timeframe: On day #1, day #2 and day #3 (each day could be 24 hours to 7 days apart from prior one, and completed within 6 week period) 12:00 AM to 6:00 AM on day following admission, with samples obtained every 10-15 minutes, for each sequence of calibration errors
| Intervention | percentage of time in target range (Median) |
|---|---|
| HIGH Error | 88 |
| NO Errror | 100 |
| LOW Error | 80 |
Highest and lowest glucose concentrations obtained during breakfast meal. (NCT02065895)
Timeframe: On day #1, day #2 and day #3 (each day could be 24 hours to 7 days apart from prior one, and completed within 6 week period) 8:00 AM to 12:00 PM on day following admission, with samples obtained every 10-15 minutes, for each sequence of calibration errors
| Intervention | mmol/l (Mean) | |
|---|---|---|
| Peak glucose concentration | Nadir glucose concentration | |
| Gain Decreased and Target Increased | 11.3 | 6.6 |
| Gain Increased and Target Decreased | 13.3 | 4.5 |
| Nadir Mean | 11.8 | 4.8 |
1 review available for tolbutamide and Glucose Intolerance
| Article | Year |
|---|---|
Review of previous impaired glucose tolerance intervention studies.
Topics: Diabetes Mellitus, Type 2; Dietary Carbohydrates; Exercise; Follow-Up Studies; Glucose Intolerance; | 1996 |
4 trials available for tolbutamide and Glucose Intolerance
| Article | Year |
|---|---|
Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM.
Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; California; Cholesterol, HDL; Cholesterol, LD | 1996 |
Glucose tolerance and mortality, including a substudy of tolbutamide treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Blood Glucose; Cause of Death; Confidence I | 1997 |
Acarbose controls postprandial hyperproinsulinemia in non-insulin dependent diabetes mellitus.
Topics: Acarbose; Aged; Blood Glucose; C-Peptide; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; | 1997 |
Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes.
Topics: Adult; Chromans; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucose; Glucose Intolera | 2000 |
8 other studies available for tolbutamide and Glucose Intolerance
| Article | Year |
|---|---|
INTRAVENOUS TOLBUTAMIDE IN THE DIAGNOSIS OF LATENT DIABETES MELLITUS.
Topics: Carbohydrate Metabolism; Cortisone; Diabetes Mellitus; Diagnosis; Glucose Intolerance; Glucose Toler | 1963 |
ABNORMAL ORAL GLUCOSE TOLERANCE RESPONSE IN ERYTHROCYTE GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY.
Topics: Black People; Carbohydrate Metabolism; Cortisone; Erythrocytes; Glucose Intolerance; Glucose Toleran | 1964 |
Study of the anti-hyperglycemic effect of anti-diabetic plants in rabbits with impaired glucose tolerance.
Topics: Animals; Area Under Curve; Asteraceae; Blood Glucose; Glucose Intolerance; Glucose Tolerance Test; G | 2003 |
A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.
Topics: Animals; Blood Glucose; Calcium Signaling; Crosses, Genetic; Diabetes Mellitus, Type 2; Fasting; Fem | 2005 |
Improvement of insulin resistance by panax ginseng in fructose-rich chow-fed rats.
Topics: Animals; Blood Glucose; Drugs, Chinese Herbal; Fructose; Glucose Intolerance; Glucose Tolerance Test | 2005 |
The BIGTT test: a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance.
Topics: Aged; Blood Glucose; Glucose Intolerance; Glucose Tolerance Test; Homeostasis; Humans; Hypoglycemic | 2007 |
Accumulated end products participate in glucose intolerance and insulin resistance in uremia.
Topics: Animals; Glucose; Glucose Intolerance; Hippurates; Humans; In Vitro Techniques; Insulin Resistance; | 1993 |
Reduced glucose effectiveness as a feature of glucose intolerance: evidence in elderly type-2 diabetic subjects.
Topics: Adult; Age Factors; Aged; Aging; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Fasting; Fem | 1999 |