Page last updated: 2024-11-05

tolbutamide and Glioma

tolbutamide has been researched along with Glioma in 3 studies

Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"Our previous work has shown that tolbutamide increases gap junctional permeability in poorly coupled C6 glioma cells and that this effect is similar and additive to that found with dbcAMP, a well-known activator of gap junctional communication."7.73Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. ( Herrero-González, S; Medina, JM; Paíno, T; Sánchez-Alvarez, R; Tabernero, A, 2006)
"Our previous work has shown that tolbutamide increases gap junctional permeability in poorly coupled C6 glioma cells and that this effect is similar and additive to that found with dbcAMP, a well-known activator of gap junctional communication."3.73Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. ( Herrero-González, S; Medina, JM; Paíno, T; Sánchez-Alvarez, R; Tabernero, A, 2006)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sánchez-Alvarez, R3
Tabernero, A3
Medina, JM3
Paíno, T1
Herrero-González, S1
Sánchez-Abarca, LI1
Orfao, A1
Giaume, C1

Other Studies

3 other studies available for tolbutamide and Glioma

ArticleYear
The increase in gap junctional communication decreases the rate of glucose uptake in C6 glioma cells by releasing hexokinase from mitochondria.
    Brain research, 2005, Mar-28, Volume: 1039, Issue:1-2

    Topics: Animals; Bucladesine; Cell Communication; Cell Proliferation; Gap Junctions; Glioma; Glucose; Glucos

2005
Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation.
    Glia, 2006, Aug-01, Volume: 54, Issue:2

    Topics: Animals; Cell Proliferation; Connexin 43; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Ki

2006
Proliferation of C6 glioma cells is blunted by the increase in gap junction communication caused by tolbutamide.
    FEBS letters, 2001, Dec-07, Volume: 509, Issue:2

    Topics: Animals; Cell Communication; Cell Division; Cell Membrane Permeability; Connexin 43; Cyclic AMP; Gap

2001