tolbutamide has been researched along with Glial Cell Tumors in 3 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous work has shown that tolbutamide increases gap junctional permeability in poorly coupled C6 glioma cells and that this effect is similar and additive to that found with dbcAMP, a well-known activator of gap junctional communication." | 7.73 | Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. ( Herrero-González, S; Medina, JM; Paíno, T; Sánchez-Alvarez, R; Tabernero, A, 2006) |
| "Our previous work has shown that tolbutamide increases gap junctional permeability in poorly coupled C6 glioma cells and that this effect is similar and additive to that found with dbcAMP, a well-known activator of gap junctional communication." | 3.73 | Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. ( Herrero-González, S; Medina, JM; Paíno, T; Sánchez-Alvarez, R; Tabernero, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sánchez-Alvarez, R | 3 |
| Tabernero, A | 3 |
| Medina, JM | 3 |
| Paíno, T | 1 |
| Herrero-González, S | 1 |
| Sánchez-Abarca, LI | 1 |
| Orfao, A | 1 |
| Giaume, C | 1 |
3 other studies available for tolbutamide and Glial Cell Tumors
| Article | Year |
|---|---|
The increase in gap junctional communication decreases the rate of glucose uptake in C6 glioma cells by releasing hexokinase from mitochondria.
Topics: Animals; Bucladesine; Cell Communication; Cell Proliferation; Gap Junctions; Glioma; Glucose; Glucos | 2005 |
Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation.
Topics: Animals; Cell Proliferation; Connexin 43; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Ki | 2006 |
Proliferation of C6 glioma cells is blunted by the increase in gap junction communication caused by tolbutamide.
Topics: Animals; Cell Communication; Cell Division; Cell Membrane Permeability; Connexin 43; Cyclic AMP; Gap | 2001 |