tolbutamide has been researched along with Epilepsy in 11 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of tolbutamide administration on the plasma concentrations of diphenylhydantoin (DPH) was investigated in seventeen long-stay patients with epilepsy." | 3.65 | Interaction of diphenylhydantoin (DPH) and tolbutamide in man. ( Mols-Thürkow, I; Wesseling, H, 1975) |
| "Insular hyperplasia was the only abnormal factor determined to be present." | 1.25 | Hypoglycemia and insular hyperplasia: review of 148 cases. ( Basoli, A; Carboni, M; Patrassi, N; Stefanini, P, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (81.82) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GREEN, JB | 1 |
| MOSOVICH, A | 1 |
| ETCHEPAREBORDA, J | 1 |
| Masia, R | 1 |
| Koster, JC | 1 |
| Tumini, S | 1 |
| Chiarelli, F | 1 |
| Colombo, C | 1 |
| Nichols, CG | 1 |
| Barbetti, F | 1 |
| Goldberg, DM | 1 |
| Kamali, F | 1 |
| Ball, DE | 1 |
| McLaughlin, WS | 1 |
| Seymour, RA | 1 |
| Müller-Oerlinghausen, B | 1 |
| Wesseling, H | 1 |
| Mols-Thürkow, I | 1 |
| Stefanini, P | 1 |
| Carboni, M | 1 |
| Patrassi, N | 1 |
| Basoli, A | 1 |
| Hoenig, J | 1 |
| Gittleson, NL | 1 |
| Lewis, T | 1 |
| Hosák, L | 1 |
| Komenda, S | 1 |
| Pieralisi, G | 1 |
| Berti Ceroni, G | 1 |
1 review available for tolbutamide and Epilepsy
| Article | Year |
|---|---|
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; E | 1980 |
10 other studies available for tolbutamide and Epilepsy
| Article | Year |
|---|---|
The activation of electroencephalographic abnormalities by tolbutamide-induced hypoglycemia.
Topics: Brain Diseases; Electroencephalography; Epilepsy; Humans; Hypoglycemia; Tolbutamide | 1963 |
[THE ROLE OF ORAL ANTIDIABETICS AS ACTIVATORS IN EPILEPSY].
Topics: Electroencephalography; Epilepsy; Hypoglycemic Agents; Tolbutamide; Toxicology | 1963 |
An ATP-binding mutation (G334D) in KCNJ11 is associated with a sulfonylurea-insensitive form of developmental delay, epilepsy, and neonatal diabetes.
Topics: Adenosine Triphosphate; Adolescent; Alleles; ATP-Binding Cassette Transporters; Binding Sites; Devel | 2007 |
Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth.
Topics: Adult; Aged; Animals; Anticonvulsants; Area Under Curve; Biotransformation; Cats; Chlorophyll; Chrom | 1999 |
[Effects of combination of anti-epileptic drugs].
Topics: Adrenergic beta-Antagonists; Anticonvulsants; Benzodiazepines; Carbamazepine; Digitoxin; Drug Intera | 1975 |
Interaction of diphenylhydantoin (DPH) and tolbutamide in man.
Topics: Adult; Animals; Blood Proteins; Drug Interactions; Epilepsy; Female; Humans; In Vitro Techniques; Ma | 1975 |
Hypoglycemia and insular hyperplasia: review of 148 cases.
Topics: Adenoma, Islet Cell; Adult; Age Factors; Blood Glucose; Child; Diagnosis, Differential; Epilepsy; Fa | 1974 |
Tolbutamide for weight gaining in psychiatric patients.
Topics: Antisocial Personality Disorder; Epilepsy; Feeding and Eating Disorders; Female; Humans; Insulin; Ma | 1965 |
[The anticonvulsive effect of tolbutamide (Orabet) in the management of schizophrenia associated with hypoglycemic comas].
Topics: Anticonvulsants; Barbiturates; Diabetic Coma; Epilepsy; Humans; Schizophrenia; Tolbutamide; Unconsci | 1969 |
[Modifications induced by hypoglycemia from tolbutamide on the electroencephalogram of epileptic subjects].
Topics: Adolescent; Adult; Electroencephalography; Epilepsy; Female; Humans; Middle Aged; Tolbutamide | 1966 |