tolbutamide has been researched along with Disease Models, Animal in 31 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to present a deductive compartment pharmacokinetic (PK) model to predict the concentration profiles of drugs in plasma and peritoneal fluid in peritoneal dialysis (PD) rats." | 1.40 | Effects of peritoneal dialysis on pharmacotherapy: a deductive pharmacokinetic-model approach to predict drug concentration profiles in plasma and peritoneal fluid. ( Aiba, T; Horiuchi, M; Kurosaki, Y; Moriyama, S; Takahata, Y, 2014) |
| " Similar pharmacokinetic changes were observed in HL rats after oral administration of tolbutamide." | 1.40 | Pharmacokinetics of tolbutamide and its metabolite 4-hydroxy tolbutamide in poloxamer 407-induced hyperlipidemic rats. ( Cho, YY; Choi, HD; Choi, MR; Kang, HE; Kim, YC; Kwon, MH, 2014) |
| " Among the various dosages of nicotinamide tested in 3-month-old Wistar rats (100-350 mg/kg body wt), the dosage of 230 mg/kg, given intraperitoneally 15 min before STZ administration (65 mg/kg i." | 1.30 | Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. ( Broca, C; Gross, R; Hillaire-Buys, D; Manteghetti, M; Masiello, P; Novelli, M; Ribes, G; Roye, M, 1998) |
| "In five patients with islet cell tumors and fasting hypoglycemia, basal proinsulin-like component ranged from 26 to 79% of the total immunoreactive insulin." | 1.25 | Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors. ( Gorden, P; Roth, J; Sherman, B, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (41.94) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 7 (22.58) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Li, J | 1 |
| O'Leary, EI | 1 |
| Tanner, GR | 1 |
| Horiuchi, M | 1 |
| Moriyama, S | 1 |
| Takahata, Y | 1 |
| Aiba, T | 1 |
| Kurosaki, Y | 1 |
| Choi, MR | 1 |
| Kwon, MH | 1 |
| Cho, YY | 1 |
| Choi, HD | 1 |
| Kim, YC | 1 |
| Kang, HE | 1 |
| Suzuki, S | 1 |
| Sato, Y | 1 |
| Umegaki, K | 1 |
| Chiba, T | 1 |
| Girard, CA | 1 |
| Wunderlich, FT | 1 |
| Shimomura, K | 1 |
| Collins, S | 1 |
| Kaizik, S | 1 |
| Proks, P | 1 |
| Abdulkader, F | 1 |
| Clark, A | 1 |
| Ball, V | 1 |
| Zubcevic, L | 1 |
| Bentley, L | 1 |
| Clark, R | 1 |
| Church, C | 1 |
| Hugill, A | 1 |
| Galvanovskis, J | 1 |
| Cox, R | 1 |
| Rorsman, P | 1 |
| Brüning, JC | 1 |
| Ashcroft, FM | 1 |
| Wu, HT | 1 |
| Chang, CK | 1 |
| Tsao, CW | 1 |
| Wen, YJ | 1 |
| Ling, SM | 1 |
| Cheng, KC | 1 |
| Chang, CJ | 1 |
| Cheng, JT | 1 |
| Matsui, K | 1 |
| Oda, T | 1 |
| Nishizawa, E | 1 |
| Sano, R | 1 |
| Yamamoto, H | 1 |
| Fukuda, S | 1 |
| Sasase, T | 1 |
| Miyajima, K | 1 |
| Ueda, N | 1 |
| Ishii, Y | 1 |
| Ohta, T | 1 |
| Matsushita, M | 1 |
| Kim, SJ | 1 |
| Zhang, H | 1 |
| Khaliulin, I | 1 |
| Choisy, SC | 1 |
| Bond, R | 1 |
| Lin, H | 1 |
| El Haou, S | 1 |
| Milnes, JT | 1 |
| Hancox, JC | 1 |
| Suleiman, MS | 1 |
| James, AF | 1 |
| Stone, B | 1 |
| Evans, L | 1 |
| Coleman, J | 1 |
| Kuebler, D | 1 |
| Orhan, DD | 1 |
| Aslan, M | 1 |
| Sendogdu, N | 1 |
| Ergun, F | 1 |
| Yesilada, E | 1 |
| Alberton, EH | 1 |
| Damazio, RG | 1 |
| Cazarolli, LH | 1 |
| Chiaradia, LD | 1 |
| Leal, PC | 1 |
| Nunes, RJ | 1 |
| Yunes, RA | 1 |
| Silva, FR | 1 |
| Weir, GC | 1 |
| Clore, ET | 1 |
| Zmachinski, CJ | 1 |
| Bonner-Weir, S | 1 |
| Masiello, P | 1 |
| Broca, C | 1 |
| Gross, R | 1 |
| Roye, M | 1 |
| Manteghetti, M | 1 |
| Hillaire-Buys, D | 1 |
| Novelli, M | 1 |
| Ribes, G | 1 |
| Luo, J | 1 |
| Quan, J | 1 |
| Tsai, J | 1 |
| Hobensack, CK | 1 |
| Sullivan, C | 1 |
| Hector, R | 1 |
| Reaven, GM | 1 |
| Liss, B | 1 |
| Bruns, R | 1 |
| Roeper, J | 1 |
| Watanabe, M | 1 |
| Watanabe, K | 1 |
| Matsui, H | 1 |
| Rumpf, KD | 1 |
| Zick, R | 1 |
| Thiele, J | 1 |
| Valdés, M | 1 |
| Pascual Leone, A | 1 |
| O'Connor, C | 1 |
| Weinkove, C | 1 |
| Weinkove, EA | 1 |
| Pimstone, BL | 1 |
| Wu, CF | 1 |
| Haider, B | 1 |
| Ahmed, SS | 1 |
| Oldewurtel, HA | 1 |
| Lyons, MM | 1 |
| Regan, TJ | 1 |
| Davidson, MB | 1 |
| Wang, SL | 1 |
| Lorch, E | 1 |
| Gey, KF | 1 |
| Sommer, P | 1 |
| Gorden, P | 1 |
| Sherman, B | 1 |
| Roth, J | 1 |
| Lebovitz, HE | 1 |
| White, S | 1 |
| Mikat, E | 1 |
| Hackel, DB | 1 |
| Andreev, D | 2 |
| Strashimirov, D | 2 |
| Ditsov, S | 1 |
| Dashev, G | 2 |
| Ditzov, S | 1 |
| Pemberton, LB | 1 |
| Manax, WG | 1 |
| Binder, PS | 1 |
| Heiskell, CA | 1 |
| Adams, JR | 1 |
| Cerra, FB | 1 |
| Eilert, JB | 1 |
| Bergan, JJ | 1 |
31 other studies available for tolbutamide and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
The ketogenic diet metabolite beta-hydroxybutyrate (β-HB) reduces incidence of seizure-like activity (SLA) in a K
Topics: 3-Hydroxybutyric Acid; Animals; Animals, Genetically Modified; Anticonvulsants; Disease Models, Anim | 2017 |
Effects of peritoneal dialysis on pharmacotherapy: a deductive pharmacokinetic-model approach to predict drug concentration profiles in plasma and peritoneal fluid.
Topics: Acute Kidney Injury; Animals; Ascitic Fluid; Cefazolin; Disease Models, Animal; Male; Models, Biolog | 2014 |
Pharmacokinetics of tolbutamide and its metabolite 4-hydroxy tolbutamide in poloxamer 407-induced hyperlipidemic rats.
Topics: Administration, Oral; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P450 Fami | 2014 |
Influence of High-fat and High-cholesterol Diet on Major CYP Activities in the Liver.
Topics: Animals; Cholesterol, Dietary; Cytochrome P-450 Enzyme System; Diet, High-Fat; Disease Models, Anima | 2016 |
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
Topics: Adenosine Triphosphate; Animals; Calcium; Diabetes Mellitus; Disease Models, Animal; Female; Humans; | 2009 |
Insulin resistance without obesity induced by cotton pellet granuloma in mice.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Blood Glucose; Chemokines; Cotton Fiber; Dise | 2009 |
Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage.
Topics: Animals; Arginine; Benzoates; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibi | 2009 |
Activation of glibenclamide-sensitive ATP-sensitive K+ channels during β-adrenergically induced metabolic stress produces a substrate for atrial tachyarrhythmia.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; G | 2012 |
Genetic and pharmacological manipulations that alter metabolism suppress seizure-like activity in Drosophila.
Topics: Animals; Animals, Genetically Modified; Carbon Dioxide; Disease Models, Animal; Disease Susceptibili | 2013 |
Evaluation of the hypoglycemic effect and antioxidant activity of three Viscum album subspecies (European mistletoe) in streptozotocin-diabetic rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease | 2005 |
Influence of chalcone analogues on serum glucose levels in hyperglycemic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Chalcone; Disease Models, Animal; Dose-Response Relati | 2008 |
Islet secretion in a new experimental model for non-insulin-dependent diabetes.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucagon; Glucos | 1981 |
Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glucos | 1998 |
Nongenetic mouse models of non-insulin-dependent diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Di | 1998 |
Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons.
Topics: Animals; ATP-Binding Cassette Transporters; Brain; Disease Models, Animal; Dopamine; Gene Expression | 1999 |
Hypoglycemic and hypotriglyceridemic effects of tolbutamide in triphenyltin chloride-induced diabetic rabbits.
Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Diabetes Mellitus; Disease Models, Animal; Do | 2002 |
[Methods of evaluating the function of transplanted islets of Langerhans (author's transl)].
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Disease Models, Animal; Drinking Behavior; G | 1977 |
[Relation of uric acid and arteriosclerosis on an experimental model of chickens fed with eggs. Influence of insulin and oral antidiabetics (glibenclamide and tolbutamide)].
Topics: Animals; Arteriosclerosis; Chickens; Cholesterol, Dietary; Disease Models, Animal; Eggs; Glyburide; | 1975 |
Glucose tolerance and insulin release in malnourished rats.
Topics: Aminophylline; Animals; Blood Glucose; Disease Models, Animal; Glucose; Glucose Tolerance Test; Insu | 1976 |
The effects of tolbutamide on the myocardium in experimental diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Heart; Hemody | 1977 |
Metabolic studies in the pyelonephritic rat.
Topics: Adipose Tissue; Animals; Body Weight; Creatinine; Diet; Disease Models, Animal; Epinephrine; Fatty A | 1975 |
[A 5-year interval report on study of burn metabolism and nutrition].
Topics: Adult; Animals; Burns; Disease Models, Animal; Drugs, Chinese Herbal; Energy Intake; Enteral Nutriti | 1992 |
[Glibornuride, a new high-effective antidiabetic agent. Pharmacological and biochemical comparative studies in various animal species and animal experimental models].
Topics: Administration, Oral; Animals; Blood Glucose; Camphanes; Chemical Phenomena; Chemistry; Cholesterol; | 1972 |
Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors.
Topics: Acromegaly; Adenoma, Islet Cell; Adolescent; Adult; Animals; Child; Chromatography, Gel; Cricetinae; | 1971 |
Control of insulin secretion in the Egyptian sand rat ((Psammomys obesus).
Topics: Animals; Blood Glucose; Bucladesine; Disease Models, Animal; Epididymis; Female; Glucagon; Glucose; | 1974 |
[An acute diabetic syndrome induced in rats by anti-insulin serum as an experimental model for the study of several antidiabetic agents].
Topics: Animals; Diabetes Mellitus; Disease Models, Animal; Guinea Pigs; Hypophysectomy; Insulin Antibodies; | 1974 |
Experimental insulin deficiency due to insulin antibodies as a model for study of some antidiabetic effects.
Topics: Animals; Antibodies; Blood Glucose; Diabetes Mellitus; Disease Models, Animal; Glycosuria; Hypophyse | 1974 |
Control of alloxan diabetes in dogs by islet cell transplantation.
Topics: Animals; Atrophy; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Gluc | 1971 |
Pancreatic function after normothermic ischemia. I. In vivo ischemia.
Topics: Amylases; Animals; Blood Glucose; Body Temperature; Disease Models, Animal; Dogs; Drug Tolerance; Fe | 1970 |