Page last updated: 2024-11-05

tolbutamide and Diabetic Angiopathies

tolbutamide has been researched along with Diabetic Angiopathies in 54 studies

Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.

Diabetic Angiopathies: VASCULAR DISEASES that are associated with DIABETES MELLITUS.

Research Excerpts

Excerpt	Relevance	Reference
"No reduction of NIDDM development was seen."	2.40	Pharmacological intervention: the antidiabetic approach. ( Melander, A, 1998)

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	52 (96.30)	18.7374
1990's	2 (3.70)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
SINGH, I	1
CHAND, I	1
CHATTERJEE, SC	1
BRARA, NS	1
JOSHI, MJ	1
GARDNER, P	1
GOODNER, CJ	1
DOWLING, JT	1
GELFAND, M	1
FORBES, JI	1
ONOE, K	1
KOBASHI, K	1
FUJINAKA, S	1
KEEN, H	3
BAUER, HG	1
Hagenfeldt, L	1
Wahlberg, F	2
Kawaguchi, K	1
Oribe, Y	1
Uzawa, H	1
O'Brien, RC	1
Luo, M	1
Melander, A	1
Ganda, OP	1
Soeldner, JS	1
Gleason, RE	1
Smith, TM	1
Kilo, C	2
Williamson, JR	2
Fajans, SS	1
Cloutier, MC	1
Crowther, RL	1
Persson, G	1
Prout, TE	3
Knowles, HC	2
Sagel, J	1
Colwell, JA	1
Crook, L	1
Laimins, M	1
Colt, EW	1
Siperstein, MD	1
Raskin, P	1
Burns, H	1
Ghilchik, MW	1
Morris, AS	1
Lenti, G	1
Uchiyama, Y	1
Goto, Y	1
Stehling, L	1
Turtle, JR	1
Klein, G	1
Mayrhofer, E	1
Klieber, M	1
Weitgasser, H	1
Trautwein, H	1
Julitz, R	1
Jarrett, RJ	1
Ward, JD	1
Fuller, JH	1
Marble, A	1
Feldman, R	1
Crawford, D	1
Elashoff, R	1
Glass, A	1
Popescu, P	1
Anghel, S	1
Idu, S	1
Mihai, N	1
Moldovan, T	1
Mihail, A	1
de Haas, WH	1
Sauer, H	1
Böninger, C	1
Meinert, CL	2
Knatterud, GL	2
Klimt, CR	2
Osborne, RK	1
Martin, DB	1
Salsburg, DS	1
Mehnert, H	1
Paasikivi, J	1
Bacon, GE	1
Parkhurst, RD	1
Lubetzki, J	2
Ziegelasch, HJ	1
Canivet, J	1
Deuil, R	1
Eschwege, E	1
Hazard, J	1
Tchobroutsky, G	1
Valleron, A	1
Bielawiec, M	1
Myśliwiec, M	1
Perzanowski, A	1
Frick, E	1
de L'Hortet, GC	1
Bercovici, JP	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Prospective, Parallel Goups Study, Aimed to Evaluating Possible Benefits of the Treatment of New Generation Hypoglycaemic Drugs Compared to Sulphonylureas for the Tratment of Type 2 Diabetes Mellitus[NCT04272359]				138 participants (Anticipated)	Observational [Patient Registry]	2019-05-06	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for tolbutamide and Diabetic Angiopathies

Article	Year
[INSULIN ANTIBODIES]. Saishin igaku. Modern medicine, 1964, Volume: 19 Topics: Adrenocorticotropic Hormone; Animals; Autoimmune Diseases; Diabetes Mellitus; Diabetic Angiopathies;	1964
Pharmacological intervention: the antidiabetic approach. European journal of clinical investigation, 1998, Volume: 28 Suppl 2 Topics: Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diet, Diabeti	1998
Clinical and etiological heterogeneity of idiopathic diabetes mellitus. The banting memorial lecture. Schweizerische medizinische Wochenschrift, 1979, Dec-01, Volume: 109, Issue:46 Topics: Adenoma, Islet Cell; Adult; Antibodies, Viral; Autoantibodies; Cell Adhesion; Chlorpropamide; Chromo	1979
[Treatment of pancreatic endocrinopathy]. Horumon to rinsho. Clinical endocrinology, 1971, Volume: 19, Issue:3 Topics: Adenoma, Islet Cell; Adult; Aged; Antibiotics, Antineoplastic; Blood Glucose; Diabetes Mellitus; Dia	1971
Hypoglycemic drugs. Clinical anesthesia, 1974, Volume: 10, Issue:1 Topics: Acetohexamide; Anesthetics; Blood Glucose; Carbohydrate Metabolism; Chlorpropamide; Diabetes Mellitu	1974
Recent developments in the management of diabetes mellitus. The Medical journal of Australia, 1974, Jun-08, Volume: 1, Issue:23 Topics: Animals; Australia; Coronary Disease; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathie	1974
"Footnotes" on diabetes, with special reference to calcification of the metatarsal arteries. Folia medica Neerlandica, 1969, Volume: 12, Issue:5 Topics: Aged; Bone Resorption; Calcinosis; Diabetes Complications; Diabetic Angiopathies; Diabetic Neuropath	1969
Metabolic considerations in the treatment of juvenile diabetes mellitus. The Medical clinics of North America, 1969, Volume: 53, Issue:6 Topics: Acid-Base Equilibrium; Amino Acids; Blood Glucose; Child, Preschool; Diabetes Mellitus, Type 1; Diab	1969

Trials

14 trials available for tolbutamide and Diabetic Angiopathies

Article	Year
Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. VIII. Evaluation of insulin therapy: final report. Diabetes, 1982, Volume: 31 Suppl 5 Topics: Adult; Aged; Blood Glucose; Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Mellitus; Di	1982
Exercise tests in individuals with borderline glucose tolerance and varying smoking habits. Acta medica Scandinavica. Supplementum, 1977, Volume: 605 Topics: Aged; Arteriosclerosis; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic	1977
A progress report on the University Group Diabetes Program. International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2 Topics: Clinical Trials as Topic; Diabetes Mellitus; Diabetic Angiopathies; Drug Industry; Health Expenditur	1975
The University Group Diabetes Program. A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. V. Evaluation of pheniformin therapy. Diabetes, 1975, Volume: 24 Suppl 1 Topics: Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Clinical Tri	1975
The controversial American University Group Diabetes Study--a look at sulfonylurea and biguanide therapy. Hormone and metabolic research. Supplement series, 1985, Volume: 15 Topics: Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; H	1985
Sulfonylureas: effects in vivo and in vitro. Annals of internal medicine, 1971, Volume: 75, Issue:4 Topics: Adenylyl Cyclases; Blood Glucose; Blood Platelets; Clinical Trials as Topic; Culture Techniques; Cyc	1971
Phenformin and vascular complications of diabetes. The Medical letter on drugs and therapeutics, 1972, Jan-07, Volume: 14, Issue:1 Topics: Clinical Trials as Topic; Diabetic Angiopathies; Humans; Insulin; Phenformin; Placebos; Tolbutamide	1972
The UGDP--tolbutamide and mortality. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1974, Volume: Suppl 4 Topics: Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Diabetic Angiopathies; Humans; Hyperglyc	1974
Borderline diabetics and their response to tolbutamide. Advances in metabolic disorders, 1973, Volume: 2 Topics: Arrhythmias, Cardiac; Arteriosclerosis; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Diab	1973
A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results. Diabetes, 1970, Volume: 19 Topics: Adult; Age Factors; Aged; Blood Glucose; Body Weight; Cardiovascular Diseases; Cholesterol; Clinical	1970
Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. IV. A preliminary report on phenoformin results. JAMA, 1971, Aug-09, Volume: 217, Issue:6 Topics: Age Factors; Aged; Blood Glucose; Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Compli	1971
The UGDP study. JAMA, 1971, Dec-13, Volume: 218, Issue:11 Topics: Aged; Blood Glucose; Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Mellitus; Diabetic	1971
Preventive tolbutamide treatment and arterial disease in mild hyperglycaemia. Diabetologia, 1971, Volume: 7, Issue:5 Topics: Aged; Clinical Trials as Topic; Diabetes Mellitus; Diabetic Angiopathies; Female; Follow-Up Studies;	1971
A prospective view of the treatment of adult-onset diabetes with special reference to the University Group Diabetes Program and oral hypoglycemic agents. The Medical clinics of North America, 1971, Volume: 55, Issue:4 Topics: Angina Pectoris; Blood Glucose; Clinical Trials as Topic; Creatinine; Diabetes Complications; Diabet	1971

Other Studies

32 other studies available for tolbutamide and Diabetic Angiopathies

Article	Year
Tolbutamide in the treatment of ischaemic cardio-vascular disease. The Journal of the Association of Physicians of India, 1962, Volume: 10 Topics: Diabetic Angiopathies; Heart; Humans; Intermittent Claudication; Thromboangiitis Obliterans; Tolbuta	1962
SEVERE HYPOGLYCEMIA IN ELDERLY PATIENTS RECEIVING THERAPEUTIC DOSES OF TOLBUTAMIDE. JAMA, 1963, Dec-14, Volume: 186 Topics: Aged; Cerebrovascular Disorders; Diabetic Angiopathies; Diagnosis, Differential; Geriatrics; Humans;	1963
DIABETES MELLITUS IN THE RHODESIAN AFRICAN. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1963, Nov-30, Volume: 37 Topics: Adolescent; Child; Chlorpropamide; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Coma; Diabetic	1963
THE FAMILY DOCTOR AND THE DIABETIC. The Practitioner, 1965, Volume: 194 Topics: Acidosis; Adolescent; Child; Chlorpropamide; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetic	1965
SEVERE AND PROLONGED HYPOGLYCEMIC SHOCK DURING SULFONYLUREA TREATMENT. Metabolism: clinical and experimental, 1965, Volume: 14 Topics: Acetohexamide; Chlorpropamide; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Coma; Geriatrics;	1965
Comparison of intravenous glucose tolerance and intravenous tolbutamide response in ischemic cardiovascular disease. Diabetes, 1967, Volume: 16, Issue:1 Topics: Adult; Aged; Cardiovascular Diseases; Diabetic Angiopathies; Female; Glucose Tolerance Test; Humans;	1967
Tolbutamide effect on cultured human endothelial cells with special reference to platelet aggregation. The Tohoku journal of experimental medicine, 1983, Volume: 141 Suppl Topics: Adenosine Diphosphate; Cells, Cultured; Diabetic Angiopathies; Endothelium; Epoprostenol; Humans; Pl	1983
The effects of gliclazide and other sulfonylureas on low-density lipoprotein oxidation in vitro. Metabolism: clinical and experimental, 1997, Volume: 46, Issue:12 Suppl 1 Topics: Administration, Oral; Adult; Antioxidants; Ascorbic Acid; Coronary Artery Disease; Diabetes Mellitus	1997
Monozygotic triplets with discordance for diabetes mellitus and diabetic microangiopathy. Diabetes, 1977, Volume: 26, Issue:5 Topics: Adolescent; Adult; Antigens; Basement Membrane; Blood Glucose; Capillaries; Cortisone; Diabetes Mell	1977
An historical view of the medical-social aspects of the UGDP. Transactions of the American Clinical and Climatological Association, 1977, Volume: 88 Topics: Cardiovascular Diseases; Diabetes Mellitus; Diabetic Angiopathies; Hospitals, University; Humans; Mi	1977
A study of the effects of hypoglycemia agents on vascular complications in patients with adult-onset diabetes. VI. Supplementary report on nonfatal events in patients treated with tolbutamide. Diabetes, 1976, Volume: 25, Issue:12 Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic	1976
Increased platelet aggregation in early diabetus mellitus. Annals of internal medicine, 1975, Volume: 82, Issue:6 Topics: Adenosine Diphosphate; Administration, Oral; Aspirin; Collagen; Diabetes Mellitus; Diabetic Angiopat	1975
Antidiabetic drugs and atherogenesis. Lancet (London, England), 1970, Nov-28, Volume: 2, Issue:7683 Topics: Adult; Animals; Arteriosclerosis; Carbon Isotopes; Diabetes Mellitus; Diabetic Angiopathies; Humans;	1970
Electron microscopic quantification of diabetic microangiopathy. Diabetes, 1973, Volume: 22, Issue:7 Topics: Adolescent; Adult; Aged; Basement Membrane; Capillaries; Diabetes Mellitus; Diabetic Angiopathies; E	1973
Abnormal insulin response in patients with small-vessel disease. Lancet (London, England), 1971, Dec-04, Volume: 2, Issue:7736 Topics: Diabetic Angiopathies; Diagnosis, Differential; Female; Foot; Glucose Tolerance Test; Humans; Insuli	1971
[The diabetic disease (M.D.). Clinical picture and complications]. Minerva medica, 1974, Aug-18, Volume: 65, Issue:58 Topics: Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Diabeti	1974
[Quantitative immunological determination of plasma proteins in diabetic microangiopathy]. Wiener klinische Wochenschrift, 1973, Mar-23, Volume: 85, Issue:12 Topics: Adult; Aged; Blood Proteins; Complement System Proteins; Diabetic Angiopathies; Humans; Immunodiffus	1973
[Incidence of diabetes in patients with arteriosclerotic occlusive disease of the legs]. Wiener klinische Wochenschrift, 1972, Dec-29, Volume: 84, Issue:52 Topics: Administration, Oral; Aged; Arteriosclerosis Obliterans; Body Weight; Cortisone; Diabetic Angiopathi	1972
[Relationships between diabetes mellitus and certain dermatoses]. Zeitschrift fur Haut- und Geschlechtskrankheiten, 1972, Aug-15, Volume: 47, Issue:16 Topics: Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Female; Follow-Up S	1972
[Diabetic metabolism and arteriosclerosis]. Medizinische Klinik, 1973, Apr-13, Volume: 68, Issue:15 Topics: Adult; Aged; Arteries; Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopa	1973
Vascular disease in diabetes and the effect of oral antidiabetic agents. Advances in metabolic disorders, 1973, Volume: 2 Topics: Arteriosclerosis; Cardiovascular Diseases; Cerebrovascular Disorders; Coronary Disease; Diabetes Mel	1973
Progress report on the prophylactic use of oral hypoglycemic drugs in asymptomatic diabetes: neurovascular studies. Advances in metabolic disorders, 1973, Volume: 2 Topics: Adult; Angina Pectoris; Arteries; Blood Glucose; Cardiovascular Diseases; Cerebrovascular Disorders;	1973
[On the intravenous tolbutamide test (ivTT) in patients with coronary disease. (Glucide-lipid metabolic relationships)]. Medicina interna, 1974, Volume: 26, Issue:4 Topics: Adult; Aged; Carbohydrate Metabolism; Coronary Disease; Diabetic Angiopathies; Female; Humans; Hyper	1974
[What is reliable in the therapy of diabetes mellitus?]. Der Internist, 1970, Volume: 11, Issue:12 Topics: Carbutamide; Chlorpropamide; Chronic Disease; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nep	1970
[Differential therapy using oral antidiabetics]. Der Internist, 1971, Volume: 12, Issue:11 Topics: Administration, Oral; Biguanides; Blood Glucose; Chemical Phenomena; Chemistry; Diabetes Mellitus; D	1971
[Considerations on diabetic angiopathies. Relations to hypoglycemic treatments]. La Nouvelle presse medicale, 1972, Mar-11, Volume: 1, Issue:11 Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Dia	1972
[Extreme hypoglycemia during combined tolbutamide, n-1-butylbiguanide hydrochloride and chloramphenicol therapy]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1972, Jan-15, Volume: 27, Issue:2 Topics: Age Factors; Aged; Biguanides; Chloramphenicol; Diabetes Mellitus; Diabetic Angiopathies; Diabetic N	1972
Factors influencing the progress of atherosclerosis in the diabetic. Acta diabetologica latina, 1971, Volume: 8 Suppl 1 Topics: Adolescent; Adult; Aged; Arteriosclerosis; Child; Diabetes Mellitus; Diabetic Angiopathies; Female;	1971
[Do oral antidiabetics play a part in the cardiovascular mortality of diabetics? Apropos of the University Group Diabetes Program report and the controversies it has raised]. La Presse medicale, 1971, Dec-11, Volume: 79, Issue:53 Topics: Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus; Diabetic Angiopathies; Diet Therapy; Gluc	1971
Platelet adhesiveness in diabetics. Polish medical journal, 1970, Volume: 9, Issue:5 Topics: Adolescent; Adult; Age Factors; Aged; Blood Platelets; Coronary Vessels; Diabetes Mellitus; Diabetic	1970
[Cerebral sclerosis and latent diabetic metabolic disorders]. Munchener medizinische Wochenschrift (1950), 1967, Dec-22, Volume: 109, Issue:51 Topics: Adult; Aged; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Fatty Acids, Nonester	1967
[Diabetes mellitus. Present concepts and therapeutic implications]. La Presse medicale, 1968, Dec-21, Volume: 76, Issue:50 Topics: Adolescent; Adult; Birth Weight; Child; Cortisone; Diabetes Mellitus; Diabetic Angiopathies; Fatty A	1968