tolbutamide has been researched along with Cystic Fibrosis in 13 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") tolbutamide administration on glucose and hormone levels in cystic fibrosis (CF) patients with impaired first-phase insulin secretion and oral glucose tolerance (oral glucose tolerance test [OGTT]) and compared them with CF patients with only an impaired first-phase insulin secretion and healthy control subjects." | 7.69 | Tolbutamide causes a modest increase in insulin secretion in cystic fibrosis patients with impaired glucose tolerance. ( Hinds, A; Parsons, HG; Sheehan, AG, 1995) |
| "We hypothesized that elevated hepatic glucose output (HGO) may occur in children with cystic fibrosis (CF) as an early sign of declining insulin secretion and that tolbutamide therapy would correct the defect." | 3.69 | Elevated hepatic glucose production in children with cystic fibrosis. ( Horswill, CA; Kien, CL; McCoy, KS; O'Dorisio, T; Zipf, WB, 1995) |
| ") tolbutamide administration on glucose and hormone levels in cystic fibrosis (CF) patients with impaired first-phase insulin secretion and oral glucose tolerance (oral glucose tolerance test [OGTT]) and compared them with CF patients with only an impaired first-phase insulin secretion and healthy control subjects." | 3.69 | Tolbutamide causes a modest increase in insulin secretion in cystic fibrosis patients with impaired glucose tolerance. ( Hinds, A; Parsons, HG; Sheehan, AG, 1995) |
| "We evaluated carbohydrate tolerance in nine thin cystic fibrosis (CF) patients and in six controls, measuring responsiveness to the following insulinotropic secretagogues: oral glucose, IV glucose, and IV tolbutamide." | 3.67 | Carbohydrate tolerance in cystic fibrosis is closely linked to pancreatic exocrine function. ( Geffner, ME; Gillard, BK; Itami, RM; Kaplan, SA; Levin, SR; Lippe, BM; Taylor, IL, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (61.54) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, WJ | 1 |
| Goeckeler-Fried, JL | 1 |
| Havasi, V | 1 |
| Chiang, A | 1 |
| Rowe, SM | 1 |
| Plyler, ZE | 1 |
| Hong, JS | 1 |
| Mazur, M | 1 |
| Piazza, GA | 1 |
| Keeton, AB | 1 |
| White, EL | 1 |
| Rasmussen, L | 1 |
| Weissman, AM | 1 |
| Denny, RA | 1 |
| Brodsky, JL | 1 |
| Sorscher, EJ | 1 |
| ROSAN, RC | 2 |
| NIELAND, ML | 2 |
| SHWACHMAN, H | 3 |
| KAYNE, HL | 1 |
| Geffner, ME | 1 |
| Lippe, BM | 1 |
| Kaplan, SA | 1 |
| Itami, RM | 1 |
| Gillard, BK | 1 |
| Levin, SR | 1 |
| Taylor, IL | 1 |
| Kien, CL | 2 |
| Horswill, CA | 2 |
| Zipf, WB | 2 |
| McCoy, KS | 2 |
| O'Dorisio, T | 2 |
| Hinds, A | 1 |
| Sheehan, AG | 1 |
| Parsons, HG | 1 |
| Hongre, AS | 1 |
| Baró, I | 1 |
| Berthon, B | 1 |
| Escande, D | 1 |
| Wilmshurst, EG | 1 |
| Soeldner, JS | 1 |
| Holsclaw, DS | 1 |
| Kaufmann, RL | 1 |
| Aoki, TT | 1 |
| Gleason, RE | 1 |
| Pinyerd, BL | 1 |
| Peden, VH | 1 |
| Powell, KR | 1 |
| Rejent, AJ | 1 |
| Milner, AD | 1 |
| Handwerger, S | 1 |
| Roth, J | 1 |
| Gorden, P | 1 |
| Di Sant' Agnese, P | 1 |
| Carpenter, DF | 1 |
| Peter, G | 1 |
| Deckert, T | 1 |
| Kolendorf, K | 1 |
| Persson, I | 1 |
| Worning, H | 1 |
13 other studies available for tolbutamide and Cystic Fibrosis
| Article | Year |
|---|---|
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2016 |
Intravenous tolbutamide test in cystic fibrosis of the pancreas: a pilot study.
Topics: Cystic Fibrosis; Humans; Pilot Projects; Tolbutamide | 1963 |
SOME METABOLIC RESPONSES TO INTRAVENOUS TOLBUTAMIDE IN PATIENTS WITH CYSTIC FIBROSIS OF THE PANCREAS.
Topics: Adolescent; Biomedical Research; Blood; Blood Chemical Analysis; Blood Glucose; Carbohydrate Metabol | 1964 |
Carbohydrate tolerance in cystic fibrosis is closely linked to pancreatic exocrine function.
Topics: Adult; Amylases; Blood Glucose; Carbohydrates; Cystic Fibrosis; Drug Tolerance; Glucagon; Glucose To | 1984 |
Elevated hepatic glucose production in children with cystic fibrosis.
Topics: C-Peptide; Child; Cystic Fibrosis; Fasting; Female; Glucose; Humans; Infusions, Intravenous; Insulin | 1995 |
Tolbutamide causes a modest increase in insulin secretion in cystic fibrosis patients with impaired glucose tolerance.
Topics: Administration, Oral; Adolescent; Adult; C-Peptide; Cystic Fibrosis; Female; Glucagon; Glucose; Gluc | 1995 |
Effects of sulphonylureas on cAMP-stimulated Cl- transport via the cystic fibrosis gene product in human epithelial cells.
Topics: Adenosine Triphosphate; Blood Proteins; Cell Line; Chloride Channels; Colforsin; Cyclic AMP; Cystic | 1994 |
Endogenous and exogenous insulin responses in patients with cystic fibrosis.
Topics: Administration, Oral; Adolescent; Adult; Blood Glucose; Carbohydrate Metabolism; Cystic Fibrosis; Fa | 1975 |
Effects of tolbutamide on growth and body composition of nondiabetic children with cystic fibrosis.
Topics: Adolescent; Blood Glucose; Body Composition; Child; Cystic Fibrosis; Female; Growth; Humans; Insulin | 1991 |
Glucose intolerance in a three-year-old child with cystic fibrosis.
Topics: Anti-Bacterial Agents; Blood Glucose; Child, Preschool; Cystic Fibrosis; Diabetes Mellitus, Type 1; | 1974 |
Blood glucose and serum insulin levels in children with cystic fibrosis.
Topics: Adolescent; Blood Glucose; Child; Child, Preschool; Cystic Fibrosis; Diabetes Mellitus; Glucagon; Gl | 1969 |
Glucose intolerance in cystic fibrosis.
Topics: Adolescent; Adult; Blood Glucose; Child; Cystic Fibrosis; Diabetes Mellitus; Diabetes Mellitus, Type | 1969 |
Insulin secretion after tolbutamide and after secretin in patients with pancreatic diseases.
Topics: Adolescent; Adult; Aged; Amylases; Blood Glucose; Calcinosis; Cystic Fibrosis; Duodenum; Feces; Fema | 1972 |