tolbutamide has been researched along with Cholestasis in 10 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The average elimination half-life of hexobarbital had decreased from 624 to 262 min and that of tolbutamide from 292 to 160 min following rifampicin treatment." | 5.26 | Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance. ( Breimer, DD; Richter, E; Zilly, W, 1977) |
| " The metabolism of meprobamate, pentobarbital and tolbutamide was assessed in subjects with intrahepatic recurrent cholestasis (3), cholestatic hepatitis (6), extrahepatic biliary obstruction (7) and normal controls (16)." | 3.65 | Alteration of drug metabolism during cholestasis in man. ( Carulli, N; Ferrari, A; Gallo, M; Manenti, F; Ponz de Leon, M; Salvioli, G, 1975) |
| " The result of the pharmacokinetic analysis showed no change in the elimination rate constant, but a significant increase in the volume of distribution in the OJ state." | 1.29 | Pharmacokinetics of tolbutamide following intravenous and oral administrations in rats with obstructive jaundice. ( Furuhama, K; Kimura, T; Kurosaki, Y; Nakagami, H; Nakayama, T; Onodera, T; Yamao, T, 1994) |
| " The average elimination half-life of hexobarbital had decreased from 624 to 262 min and that of tolbutamide from 292 to 160 min following rifampicin treatment." | 1.26 | Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance. ( Breimer, DD; Richter, E; Zilly, W, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (80.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Gregory, DH | 1 |
| Zaki, GF | 1 |
| Sarcosi, GA | 1 |
| Carey, JB | 1 |
| Yamao, T | 1 |
| Nakagami, H | 1 |
| Furuhama, K | 1 |
| Onodera, T | 1 |
| Kurosaki, Y | 1 |
| Nakayama, T | 1 |
| Kimura, T | 1 |
| Zilly, W | 2 |
| Breimer, DD | 1 |
| Richter, E | 2 |
| Gallenkamp, H | 1 |
| Wilhelm, T | 1 |
| Carulli, N | 1 |
| Manenti, F | 1 |
| Ponz de Leon, M | 1 |
| Ferrari, A | 1 |
| Salvioli, G | 1 |
| Gallo, M | 1 |
| Soler, NG | 1 |
| Exon, PD | 1 |
| Paton, A | 1 |
| Sanbe, K | 1 |
| Kamegaya, K | 1 |
| Oda, M | 1 |
| Okazaki, I | 1 |
| Hirayama, C | 1 |
| Marabelli, A | 1 |
2 reviews available for tolbutamide and Cholestasis
| Article | Year |
|---|---|
[Advances in the treatment of jaundice in the department of internal medicine].
Topics: Adrenal Cortex Hormones; Adult; Bilirubin; Cholestasis; Female; Humans; Hyperbilirubinemia; Jaundice | 1972 |
[Enzyme induction therapy of liver diseases].
Topics: Adrenal Cortex Hormones; Anabolic Agents; Cholestasis; Endoplasmic Reticulum; Enzyme Induction; Gluc | 1971 |
8 other studies available for tolbutamide and Cholestasis
| Article | Year |
|---|---|
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Chronic cholestasis following prolonged tolbutamide administration.
Topics: Adult; Cholestasis; Diabetes Mellitus; Fatal Outcome; Female; Humans; Hypoglycemic Agents; Jaundice; | 1967 |
Pharmacokinetics of tolbutamide following intravenous and oral administrations in rats with obstructive jaundice.
Topics: Administration, Oral; Animals; Blood Proteins; Cholestasis; Cytochrome P-450 Enzyme System; Injectio | 1994 |
Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance.
Topics: Adult; Aged; Cholestasis; Female; Hexobarbital; Humans; Kinetics; Liver Cirrhosis; Male; Metabolic C | 1977 |
[Metabolism in vitro and metabolic clearance in vivo of tolbutamide in rats with experimental cholestasis].
Topics: Animals; Cholestasis; Half-Life; In Vitro Techniques; Male; Metabolic Clearance Rate; Microsomes, Li | 1976 |
Alteration of drug metabolism during cholestasis in man.
Topics: Adolescent; Adult; Aged; Cholestasis; Female; Half-Life; Hepatitis; Humans; Liver; Male; Meprobamate | 1975 |
Carbohydrate tolerance and insulin responses in obstructive jaundice.
Topics: Aged; Blood Glucose; Cholestasis; Diagnosis, Differential; Female; Glucagon; Glucose Tolerance Test; | 1974 |
[The use of the tolbutamide test in the diagnosis of obstructive jaundices].
Topics: Adult; Aged; Blood Glucose; Cholelithiasis; Cholestasis; Diagnosis, Differential; Female; Humans; Ma | 1966 |