Compounds > tolbutamide
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tolbutamide and Chemical and Drug Induced Liver Injury

tolbutamide has been researched along with Chemical and Drug Induced Liver Injury in 28 studies

Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.

Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.

Research Excerpts

ExcerptRelevanceReference
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."1.37FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199016 (57.14)18.7374
1990's0 (0.00)18.2507
2000's1 (3.57)29.6817
2010's11 (39.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Morgan, RE2
Trauner, M1
van Staden, CJ2
Lee, PH1
Ramachandran, B1
Eschenberg, M1
Afshari, CA2
Qualls, CW1
Lightfoot-Dunn, R1
Hamadeh, HK2
Ekins, S1
Williams, AJ1
Xu, JJ1
Chen, M2
Vijay, V1
Shi, Q2
Liu, Z3
Fang, H2
Tong, W3
Dawson, S1
Stahl, S2
Paul, N1
Barber, J1
Kenna, JG2
Ding, D1
Kelly, R1
Warner, DJ1
Chen, H1
Cantin, LD1
Walker, CL1
Noeske, T1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Lin, K1
Zhang, Q1
Yang, S1
Lin, Y1
Wen, C1
Zheng, Y1
MCMAHON, TF1
VARGA, F1
MOLNAR, Z1
CIAMMAICHELLA, A1
CANTERA, N1
BRAEUNLICH, H1
STRATMANN, FW1
Yokogawa, K1
Watanabe, M1
Takeshita, H1
Nomura, M1
Mano, Y1
Miyamoto, K1
Prescott, LF1
Forrest, JA1
Adjepon-Yamoah, KK1
Finlayson, ND1
Iber, FL1
Thiessen, JJ1
Sellers, EM1
Denbeigh, P1
Dolman, L1
Wada, O1
Yano, Y1
Urata, G1
Nakao, K1
De Matteis, F1
Schein, P1
Kahn, R1
Gorden, P1
Wells, S1
Devita, VT1
Boyer, JF1
Fornaris, M1
Donnet, V1
Göttinger, E1
Manenti, F1
Carulli, N1
Agnolucci, MT1
Coppo, M1
Wilson, RB1
Wilson, WD1
Ananth, JV1
Ban, TA1
Lehmann, HE1

Reviews

3 reviews available for tolbutamide and Chemical and Drug Induced Liver Injury

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
Drug metabolism in liver disease.
    Journal of clinical pathology. Supplement (Royal College of Pathologists), 1975, Volume: 9

    Topics: Acetaminophen; Acute Disease; Antipyrine; Chemical and Drug Induced Liver Injury; Chronic Disease; H

1975
Toxic hepatic porphyrias.
    Seminars in hematology, 1968, Volume: 5, Issue:4

    Topics: Alcoholism; Antifungal Agents; Chemical and Drug Induced Liver Injury; Chlorpropamide; Hexachlorocyc

1968

Other Studies

25 other studies available for tolbutamide and Chemical and Drug Induced Liver Injury

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des

2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
Effects of suberoylanilide hydroxamic acid on rat cytochrome P450 enzyme activities.
    International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:5

    Topics: Administration, Oral; Animals; Bupropion; Chemical and Drug Induced Liver Injury; Chromatography, Li

2015
CHOLESTATIC JAUNDICE, LIVER DECOMPENSATION, AND SHOCK RESULTING FROM TOLBUTAMIDE: REPORT OF A CASE.
    The Medical annals of the District of Columbia, 1963, Volume: 32

    Topics: Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Hepatitis; Hepatitis A; Jaundice; Jaundic

1963
[THE PROTECTIVE EFFECT OF ANTIDIABETIC SULFOCARBAMIDES IN THE LIVER].
    Arzneimittel-Forschung, 1963, Volume: 13

    Topics: Carbon Tetrachloride Poisoning; Carbutamide; Chemical and Drug Induced Liver Injury; Chlorpropamide;

1963
[CONTRIBUTION TO THE STUDY OF THE TOXIC EFFECTS DUE TO HYPOGLYCEMIC SULFONYLUREAS].
    Minerva medica, 1964, Mar-03, Volume: 55

    Topics: Carbutamide; Chemical and Drug Induced Liver Injury; Chlorpropamide; Diabetes Mellitus; Drug Eruptio

1964
[THE ALTERATION OF THE HYPERGLYCEMIC EFFECT OF MORPHINE BY OPIATE ANTAGONISTS AND OTHER DRUGS].
    Acta biologica et medica Germanica, 1964, Volume: 12

    Topics: Chemical and Drug Induced Liver Injury; Dimercaprol; Ergotamine; Hepatitis A; Hyperglycemia; Insulin

1964
[LATEST IN THE FIELD OF DISEASES DUE TO DIGESTION DISORDERS].
    Der Landarzt, 1965, Apr-30, Volume: 41

    Topics: Carbutamide; Chemical and Drug Induced Liver Injury; Drug Therapy; Hepatitis; Tolbutamide; Toxicolog

1965
Serum aminotransferase activity as a predictor of clearance of drugs metabolized by CYP isoforms in rats with acute hepatic failure induced by carbon tetrachloride.
    International journal of pharmaceutics, 2004, Jan-28, Volume: 269, Issue:2

    Topics: Animals; Area Under Curve; Caffeine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver

2004
Drug metabolism in heavy consumers of ethyl alcohol.
    Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:5 Pt 2

    Topics: Adult; Alcohol Drinking; Alcoholism; Aminopyrine; Chemical and Drug Induced Liver Injury; Humans; Li

1977
Plasma protein binding of diazepam and tolbutamide in chronic alcoholics.
    Journal of clinical pharmacology, 1976, Volume: 16, Issue:7

    Topics: Alcoholism; Blood Proteins; Chemical and Drug Induced Liver Injury; Chronic Disease; Diazepam; Femal

1976
Behavior of hepatic microsomal cytochromes after treatment of mice with drugs known to disturb porphyrin metabolism in liver.
    Biochemical pharmacology, 1968, Volume: 17, Issue:4

    Topics: Amino Acids; Animals; Barbiturates; Chemical and Drug Induced Liver Injury; Cytochromes; Depression,

1968
Streptozotocin for malignant insulinomas and carcinoid tumor. Report of eight cases and review of the literature.
    Archives of internal medicine, 1973, Volume: 132, Issue:4

    Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Carcinoid Tumor; Chemical and Drug Induced Liver Injury;

1973
[Action of tolbutamide on experimental cirrhosis development in the dog].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1972, Nov-09, Volume: 166, Issue:2

    Topics: Animals; Biopsy; Chemical and Drug Induced Liver Injury; Dogs; Liver; Liver Cirrhosis, Experimental;

1972
[Toxicology of chemical sweetening agents].
    Wiener medizinische Wochenschrift (1946), 1971, Jun-19, Volume: 121, Issue:25

    Topics: Abnormalities, Drug-Induced; Animals; Blood Coagulation Disorders; Chemical and Drug Induced Liver I

1971
[The liver and alcohol. Results of our research].
    Revue medico-chirurgicale des maladies du foie, 1971, Volume: 46, Issue:6

    Topics: Adult; Alcohol Oxidoreductases; Alcoholic Intoxication; Alcoholism; Animals; Chemical and Drug Induc

1971
Hepatotoxicity of tolbutamide in dogs.
    Journal of the American Veterinary Medical Association, 1970, Jun-01, Volume: 156, Issue:11

    Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Blood Glucose; Body Weight; Chemical and

1970
Tolbutamide jundice associated with multiple drug therapy.
    Canadian Medical Association journal, 1970, Nov-21, Volume: 103, Issue:11

    Topics: Adjustment Disorders; Aged; Chemical and Drug Induced Liver Injury; Dextroamphetamine; Diabetes Mell

1970