Page last updated: 2024-11-05

tolbutamide and Cardiovascular Stroke

tolbutamide has been researched along with Cardiovascular Stroke in 45 studies

Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.

Research Excerpts

Excerpt	Relevance	Reference
"Using nationwide administrative Danish registries, we followed all individuals without prior stroke or myocardial infarction who initiated metformin and an IS from 1997 through 2009."	3.81	Metformin in combination with various insulin secretagogues in type 2 diabetes and associated risk of cardiovascular morbidity and mortality--a retrospective nationwide study. ( Andersson, C; Fosbøl, EL; Gislason, G; Køber, L; Mogensen, UM; Scheller, NM; Schramm, TK; Torp-Pedersen, C; Vaag, A, 2015)

Research

Studies (45)

Timeframe	Studies, this research(%)	All Research%
pre-1990	41 (91.11)	18.7374
1990's	2 (4.44)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (4.44)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Douros, A	1
Yin, H	1
Yu, OHY	1
Filion, KB	1
Azoulay, L	1
Suissa, S	1
Mogensen, UM	1
Andersson, C	1
Fosbøl, EL	1
Schramm, TK	1
Vaag, A	1
Scheller, NM	1
Torp-Pedersen, C	1
Gislason, G	1
Køber, L	1
Itagaki, T	1
Gross, GJ	1
Yao, Z	1
Pieper, GM	1
Auchampach, JA	1
Persson, G	1
Scott, J	1
Poffenbarger, PL	1
Soler, NG	1
Bennett, MA	1
Pentecost, BL	1
Fitzgerald, MG	1
Malins, JM	1
Prout, TE	1
Ballagi-Pordány, G	1
Köszeghy, A	1
Koltai, MZ	1
Aranyi, Z	1
Pogátsa, G	1
Khachadurian, AK	1
Badeer, HS	1
Nikkilä, EA	1
Miettinen, TA	1
Vesenne, MR	1
Pelkonen, R	1
Fontana, G	1
Addarii, F	1
Peta, G	1
Taylor, SH	4
Saxton, C	3
Majid, PA	2
Dykes, JR	3
Ghosh, P	1
Stoker, JB	1
Csapó, G	1
Bauch, K	1
Dempe, A	1
Hartig, W	1
Ruttloff, J	1
Opie, LH	1
Trautwein, H	3
Julitz, R	3
Paasikivi, J	6
Feldman, R	1
Crawford, D	1
Elashoff, R	1
Glass, A	1
Hagenfeldt, L	1
Sjögren, A	1
Bozadzhieva, EK	1
Petrova, VP	1
Kewitz, H	1
Fidel, J	1
Nelken, L	1
Wahlberg, F	1
Kaffarnik, H	1
Lingelbach, H	1
Gassel, WD	1
Heimsoth, V	1
Erhardt, LR	1
Keen, H	2
Kashyap, ML	1
Magill, F	1
Rojas, L	1
Hoffman, MM	1
Möller, E	1
Klein, B	1
Sharma, B	1
Möller, H	1
Hanusch, AW	1
Kaiser, G	1
Braunsteiner, H	1
Sailer, S	1
Sandhofer, F	1
Di Pauli, R	1
Gabl, F	1
Jung, A	1
Nestel, PJ	1
Shaw, JR	1
Butler, AM	1
Srivastava, SC	1
Singh, A	1
Arora, BS	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Prospective, Parallel Goups Study, Aimed to Evaluating Possible Benefits of the Treatment of New Generation Hypoglycaemic Drugs Compared to Sulphonylureas for the Tratment of Type 2 Diabetes Mellitus[NCT04272359]				138 participants (Anticipated)	Observational [Patient Registry]	2019-05-06	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for tolbutamide and Cardiovascular Stroke

Article	Year
The general and local metabolic response to acute myocardial infarction. Acta biologica et medica Germanica, 1972, Volume: 28, Issue:6 Topics: Adenosine Triphosphate; Aerobiosis; Anaerobiosis; Arrhythmias, Cardiac; Blood Glucose; Catecholamine	1972

Trials

5 trials available for tolbutamide and Cardiovascular Stroke

Article	Year
Exercise tests in individuals with borderline glucose tolerance and varying smoking habits. Acta medica Scandinavica. Supplementum, 1977, Volume: 605 Topics: Aged; Arteriosclerosis; Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic	1977
A progress report on the University Group Diabetes Program. International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2 Topics: Clinical Trials as Topic; Diabetes Mellitus; Diabetic Angiopathies; Drug Industry; Health Expenditur	1975
[Tolbutamide treatment after myocardial infarct]. Nordisk medicin, 1970, Sep-17, Volume: 84, Issue:38 Topics: Clinical Trials as Topic; Humans; Myocardial Infarction; Placebos; Tolbutamide	1970
Preventive tolbutamide treatment and arterial disease in mild hyperglycaemia. Diabetologia, 1971, Volume: 7, Issue:5 Topics: Aged; Clinical Trials as Topic; Diabetes Mellitus; Diabetic Angiopathies; Female; Follow-Up Studies;	1971
Long-term tolbutamide treatment after myocardial infarction. A clinical and biochemical study of 178 patients without overt diabetes. Acta medica Scandinavica. Supplementum, 1970, Volume: 507 Topics: Adult; Aged; Blood Sedimentation; Body Height; Body Weight; Cholesterol; Clinical Trials as Topic; D	1970

Other Studies

39 other studies available for tolbutamide and Cardiovascular Stroke

Article	Year
Pharmacologic Differences of Sulfonylureas and the Risk of Adverse Cardiovascular and Hypoglycemic Events. Diabetes care, 2017, Volume: 40, Issue:11 Topics: Aged; Aged, 80 and over; Body Mass Index; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus	2017
Metformin in combination with various insulin secretagogues in type 2 diabetes and associated risk of cardiovascular morbidity and mortality--a retrospective nationwide study. Diabetes research and clinical practice, 2015, Volume: 107, Issue:1 Topics: Aged; Carbamates; Cardiovascular Diseases; Denmark; Diabetes Mellitus, Type 2; Drug Therapy, Combina	2015
[Relationship between antihyperglycemic drugs and myocardial infarction in the aged--a retrospective study]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1984, Volume: 21, Issue:6 Topics: Aged; Blood Glucose; Coronary Disease; Diabetes Mellitus; Female; Glucose Tolerance Test; Humans; Ma	1984
The ATP-regulated potassium channel in ischemia-reperfusion injury. Annals of the New York Academy of Sciences, 1994, Jun-17, Volume: 723 Topics: Adenosine Triphosphate; Animals; Dogs; Glyburide; Ion Channel Gating; Myocardial Contraction; Myocar	1994
Tolbutamide pharmacogenetics and the UGDP controversy. JAMA, 1979, Jul-06, Volume: 242, Issue:1 Topics: Alleles; Black People; Cardiovascular Diseases; Diabetes Mellitus; Female; Genes; Humans; Male; Meth	1979
Myocardial infarction in diabetics. The Quarterly journal of medicine, 1975, Volume: 44, Issue:173 Topics: Administration, Oral; Adult; Aged; Chlorpropamide; Coronary Care Units; Diabetes Complications; Diab	1975
A study of the effects of hypoglycemia agents on vascular complications in patients with adult-onset diabetes. VI. Supplementary report on nonfatal events in patients treated with tolbutamide. Diabetes, 1976, Volume: 25, Issue:12 Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic	1976
Divergent cardiac effects of the first and second generation hypoglycemic sulfonylurea compounds. Diabetes research and clinical practice, 1990, Volume: 8, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Carbutamide; Dose-Response Relationship, Drug; Electro	1990
Cardiovascular effects of hypoglycaemic sulphonylureas. Lancet (London, England), 1972, Apr-01, Volume: 1, Issue:7753 Topics: Animals; Diabetes Mellitus; Dogs; Myocardial Infarction; Tolbutamide	1972
Plasma-insulin in coronary heart-disease: response to oral and intravenous glucose and to tolbutamide. Lancet (London, England), 1965, Sep-11, Volume: 2, Issue:7411 Topics: Adolescent; Adult; Aged; Blood; Cholesterol; Coronary Disease; Fatty Acids; Female; Glucose Toleranc	1965
[On a case of hypoglycemic coma in the course of tolbutamide and dicoumarol therapy]. Giornale di clinica medica, 1968, Volume: 49, Issue:9 Topics: Aged; Coma; Diabetes Mellitus; Dicumarol; Drug Synergism; Female; Humans; Hypoglycemia; Myocardial I	1968
Insulin secretion following myocardial infarction with particular respect to the pathogenesis of cardiogenic shock. Lancet (London, England), 1969, Dec-27, Volume: 2, Issue:7635 Topics: Adult; Aged; Blood Circulation; Blood Glucose; Cardiovascular Diseases; Catecholamines; Female; Huma	1969
Insulin and the heart. Lancet (London, England), 1970, Feb-28, Volume: 1, Issue:7644 Topics: Humans; Hypoglycemia; Insulin; Insulin Secretion; Myocardial Infarction; Stimulation, Chemical; Tolb	1970
Insulin and the heart. Lancet (London, England), 1970, Feb-28, Volume: 1, Issue:7644 Topics: Insulin; Insulin Secretion; Myocardial Infarction; Stimulation, Chemical; Tolbutamide	1970
[Pre-, intra- and postoperative control of metabolism in diabetic patients using intravenous doses of tolbutamide]. Zentralblatt fur Chirurgie, 1974, Jan-18, Volume: 99, Issue:3 Topics: Aged; Appendectomy; Blood Glucose; Cholecystectomy; Diabetes Complications; Diabetes Mellitus; Femal	1974
[Diabetic metabolism and arteriosclerosis]. Medizinische Klinik, 1973, Apr-13, Volume: 68, Issue:15 Topics: Adult; Aged; Arteries; Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopa	1973
Long-term treatment of patients with abnormal intravenous glucose tolerance after myocardial infarction. Advances in metabolic disorders, 1973, Volume: 2 Topics: Cholesterol; Evaluation Studies as Topic; Fatty Acids, Nonesterified; Female; Glucose Tolerance Test	1973
Progress report on the prophylactic use of oral hypoglycemic drugs in asymptomatic diabetes: neurovascular studies. Advances in metabolic disorders, 1973, Volume: 2 Topics: Adult; Angina Pectoris; Arteries; Blood Glucose; Cardiovascular Diseases; Cerebrovascular Disorders;	1973
Plasma levels of free polyunsaturated fatty acids in patients with ischemic heart disease. Metabolism: clinical and experimental, 1973, Volume: 23, Issue:2 Topics: Adult; Age Factors; Aged; Blood Glucose; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Human	1973
[Dynamics of some indices of fat metabolism in myocardial infarct]. Vutreshni bolesti, 1973, Volume: 12, Issue:4 Topics: Cholesterol; Fats; Heparin; Lipid Metabolism; Myocardial Infarction; Tolbutamide	1973
[Drugs as causes of diseases]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1973, Volume: 79 Topics: Adult; Aged; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Female; Humans;	1973
Fatal vascular complications in diabetic patients treated by diet, sulfonylureas and insulin. A retrospective study. Israel journal of medical sciences, 1974, Volume: 10, Issue:7 Topics: Adult; Age Factors; Aged; Cardiovascular Diseases; Cerebrovascular Disorders; Chlorpropamide; Diabet	1974
[Incidence of diabetic metabolic disorders in patients with previous myocardial infarction. Parallel studies with two test methods]. Deutsche medizinische Wochenschrift (1946), 1971, Oct-22, Volume: 96, Issue:43 Topics: Age Factors; Aged; Blood Glucose; Body Weight; Diabetes Complications; Diabetes Mellitus; Female; Ge	1971
[Secondary prevention of myocardial infarct]. Lakartidningen, 1971, Nov-10, Volume: 68, Issue:46 Topics: Anticoagulants; Diet; Estrone; Humans; Male; Middle Aged; Myocardial Infarction; Prognosis; Tolbutam	1971
Factors influencing the progress of atherosclerosis in the diabetic. Acta diabetologica latina, 1971, Volume: 8 Suppl 1 Topics: Adolescent; Adult; Aged; Arteriosclerosis; Child; Diabetes Mellitus; Diabetic Angiopathies; Female;	1971
Long-term tolbutamide treatment of survivors from myocardial infarction. Acta diabetologica latina, 1971, Volume: 8 Suppl 1 Topics: Female; Follow-Up Studies; Glucose Tolerance Test; Humans; Male; Middle Aged; Myocardial Infarction;	1971
Insulin and non-esterified fatty acid metabolism in asymptomatic diabetics and atherosclerotic subjects. Canadian Medical Association journal, 1970, May-30, Volume: 102, Issue:11 Topics: Arteriosclerosis; Blood Glucose; Coronary Disease; Diabetes Mellitus; Fatty Acids, Nonesterified; Gl	1970
Minimal diabetes and arterial disease: prevalence and the effect of treatment. Advances in metabolic disorders, 1970, Volume: 1 Topics: Adult; Angina Pectoris; Diabetes Complications; Diet Therapy; Female; Humans; Male; Muscular Disease	1970
[Heart infarct and subclinical diabetes]. Die Medizinische Welt, 1970, Jun-27, Volume: 26 Topics: Adult; Aged; Blood Glucose; Carbohydrate Metabolism; Diabetes Complications; Female; Humans; Hyperte	1970
Plasma insulin in heart disease. Proceedings of the Royal Society of Medicine, 1971, Volume: 64, Issue:5 Topics: Cardiac Surgical Procedures; Heart Diseases; Heart Failure; Humans; Insulin; Insulin Secretion; Isop	1971
[Myocardial infarct, diabetic metabolism and lipid value]. Medizinische Klinik, 1967, Mar-10, Volume: 62, Issue:10 Topics: Adult; Aged; Blood Glucose; Cholesterol; Diabetes Complications; Diabetes Mellitus; Diagnosis, Diffe	1967
[Latent diabetes as a hazard factor in myocardial infarct]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1968, Mar-15, Volume: 23, Issue:6 Topics: Adult; Aged; Berlin; Diabetes Complications; Diabetes Mellitus; Female; Glucose Tolerance Test; Huma	1968
[Studies of latent diabetes mellitus]. Zeitschrift fur arztliche Fortbildung, 1969, Volume: 63, Issue:1 Topics: Adult; Aged; Blood Glucose; Cortisone; Diabetes Mellitus; Diagnosis, Differential; Female; Glucose;	1969
Insulin secretion in cardiogenic shock. British medical journal, 1969, May-24, Volume: 2, Issue:5655 Topics: Acute Disease; Aged; Blood Glucose; Catecholamines; Humans; Insulin; Insulin Secretion; Male; Middle	1969
[Lipid values in normal persons and patients with myocardial infarct. Statistical evaluation by means of an electronic computer]. Wiener klinische Wochenschrift, 1965, Nov-05, Volume: 77, Issue:44 Topics: Adult; Aged; Carbohydrate Metabolism; Cholesterol; Fatty Acids; Female; Glycerides; Humans; Hypoglyc	1965
Carbohydrate-induced hypertriglyceridemia and glucose utilization in ischemic heart disease. Metabolism: clinical and experimental, 1966, Volume: 15, Issue:9 Topics: Adult; Blood Glucose; Body Weight; Dietary Carbohydrates; Fatty Acids, Nonesterified; Glucose; Glyce	1966
Diabetic angiopathy and L-xylulose. JAMA, 1966, Nov-07, Volume: 198, Issue:6 Topics: Amputation, Surgical; Cataract; Diabetes Mellitus; Electrocardiography; Humans; Leg Ulcer; Male; Mid	1966
[Early diagnosis of diabetes mellitus by means of the tolbutamide test, especially in adipose, hypertensive and cardiovascular patients]. Die Medizinische Welt, 1966, Apr-16, Volume: 16 Topics: Diabetes Mellitus; Humans; Hypertension; Myocardial Infarction; Obesity; Tolbutamide	1966
Chemical and latent chemical diabetes in myocardial infarction, cerebral thrombosis and hypertension. Indian heart journal, 1966, Volume: 18, Issue:4 Topics: Adult; Aged; Diabetes Complications; Diabetes Mellitus; Female; Glucose Tolerance Test; Humans; Hype	1966