Page last updated: 2024-11-05

tolbutamide and Benign Neoplasms

tolbutamide has been researched along with Benign Neoplasms in 16 studies

Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.

Research Excerpts

ExcerptRelevanceReference
"10 subjects with cancer who were currently receiving treatment and 10 additional subjects without cancer who were matched to the subjects with cancer based on gender and race were enrolled into the study."2.73Cytochrome P450 2C9 mediated metabolism in people with and without cancer. ( Cavallari, LH; Deyo, K; Molokie, RE; Momary, K; Neceskas, J; Patel, SR; Shord, SS; Viana, MA, 2008)
"Patients with cancer had increased serum concentrations of the acute-phase protein alpha 1-acid glycoprotein (AAG) and lowered serum concentration of albumin."1.26Altered plasma drug binding in cancer: role of alpha 1-acid glycoprotein and albumin. ( Jackson, PR; Tucker, GT; Woods, HF, 1982)
"The choice of an effective method to treat priapism is challenging because precise causes in the majority of patients have not been well defined."1.26Priapism: evolution of management in 48 patients in a 22-year series. ( Nelson, JH; Winter, CC, 1977)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199012 (75.00)18.7374
1990's0 (0.00)18.2507
2000's2 (12.50)29.6817
2010's2 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Diamandis, P1
Wildenhain, J1
Clarke, ID1
Sacher, AG1
Graham, J1
Bellows, DS1
Ling, EK1
Ward, RJ1
Jamieson, LG1
Tyers, M1
Dirks, PB1
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y1
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Bo, S1
Castiglione, A1
Ghigo, E1
Gentile, L1
Durazzo, M1
Cavallo-Perin, P1
Ciccone, G1
Shord, SS1
Cavallari, LH1
Viana, MA1
Momary, K1
Neceskas, J1
Molokie, RE1
Deyo, K1
Patel, SR1
CUNNINGHAM, GC1
SHIMIZU, J2
KOBAYASHI, J2
OTA, T2
YOSHIDA, H2
FUJII, H2
SAKAKIBARA, N2
ARIMASA, S2
BLACK, KO1
BIRNSTINGL, MA1
HECKER, E1
FROMM, GA1
NAJENSON, H1
FARAONI, H1
GINSBERG, DM1
Jackson, PR1
Tucker, GT1
Woods, HF1
Nelson, JH1
Winter, CC1
Searle, GL1
Keen, H1
Jarrett, RJ1
Ward, JD1
Fuller, JH1
Wüstenberg, PW1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective, Parallel Goups Study, Aimed to Evaluating Possible Benefits of the Treatment of New Generation Hypoglycaemic Drugs Compared to Sulphonylureas for the Tratment of Type 2 Diabetes Mellitus[NCT04272359]138 participants (Anticipated)Observational [Patient Registry]2019-05-06Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for tolbutamide and Benign Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
HYPOGLYCEMIA ASSOCIATED WITH EXTRAPANCREATIC NEOPLASMS, WITH A NOTE ON OTHER UNUSUAL FORMS OF HYPOGLYCEMIA.
    Advances in internal medicine, 1964, Volume: 12

    Topics: Adrenogenital Syndrome; Carcinoma, Hepatocellular; Drug Therapy; Glycogen Storage Disease Type I; Hu

1964
The use of isotope turnover techniques in the study of carbohydrate metabolism in man.
    Clinics in endocrinology and metabolism, 1976, Volume: 5, Issue:3

    Topics: Acromegaly; Alanine; Blood Glucose; Carbohydrate Metabolism; Carbon Dioxide; Carbon Isotopes; Ethano

1976
[The hypoglycemia syndrome].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1970, Jun-01, Volume: 25, Issue:11

    Topics: Alloxan; Angiography; Antibiotics, Antineoplastic; Blood Glucose; Diagnosis, Differential; Diazoxide

1970

Trials

2 trials available for tolbutamide and Benign Neoplasms

ArticleYear
Cytochrome P450 2C9 mediated metabolism in people with and without cancer.
    International journal of clinical pharmacology and therapeutics, 2008, Volume: 46, Issue:7

    Topics: Administration, Oral; Adult; Age Factors; Aged; Aryl Hydrocarbon Hydroxylases; Case-Control Studies;

2008
Borderline diabetics and their response to tolbutamide.
    Advances in metabolic disorders, 1973, Volume: 2

    Topics: Arrhythmias, Cardiac; Arteriosclerosis; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Diab

1973

Other Studies

10 other studies available for tolbutamide and Benign Neoplasms

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic

2007
Mortality outcomes of different sulphonylurea drugs: the results of a 14-year cohort study of type 2 diabetic patients.
    European journal of endocrinology, 2013, Volume: 169, Issue:1

    Topics: Adult; Aged; Cardiovascular Diseases; Cause of Death; Cohort Studies; Confounding Factors, Epidemiol

2013
TOLBUTAMIDE TOLERANCE IN HYPOGLYCEMIC CHILDREN.
    American journal of diseases of children (1960), 1964, Volume: 107

    Topics: Adenoma, Islet Cell; Blood Glucose; Child; Hypoglycemic Agents; Neoplasms; Pancreatic Neoplasms; Pha

1964
[ON ISLET CELL TUMOR].
    Clinical science, 1964, Volume: 27

    Topics: Adenoma, Islet Cell; Atropine; Blood Chemical Analysis; Blood Glucose; Epinephrine; Neoplasms; Pancr

1964
[ON ISLET CELL TUMOR].
    Rinsho geka. Journal of clinical surgery, 1964, Volume: 19

    Topics: Adenoma, Islet Cell; Atropine; Blood Chemical Analysis; Blood Glucose; Epinephrine; Neoplasms; Pancr

1964
INSULINOMA WITH SYMPTOMS FOR THIRTY YEARS.
    Proceedings of the Royal Society of Medicine, 1964, Volume: 57

    Topics: Adenoma, Islet Cell; Blood Glucose; Fasting; Geriatrics; Glucose Tolerance Test; Humans; Hypoglycemi

1964
[DIAGNOSTIC VALUE OF TOLBUTAMIDE AND 1-LYSINE IN INSULAR ADENOMA OF THE PANCREAS].
    Revista argentina de endocrinologia y metabolismo, 1964, Volume: 10

    Topics: Adenoma, Islet Cell; Humans; Hyperinsulinism; Hypoglycemia; Lysine; Neoplasms; Pancreatic Neoplasms;

1964
Altered plasma drug binding in cancer: role of alpha 1-acid glycoprotein and albumin.
    Clinical pharmacology and therapeutics, 1982, Volume: 32, Issue:3

    Topics: Female; Humans; Lidocaine; Male; Middle Aged; Neoplasms; Orosomucoid; Pharmaceutical Preparations; P

1982
Priapism: evolution of management in 48 patients in a 22-year series.
    The Journal of urology, 1977, Volume: 117, Issue:4

    Topics: Adolescent; Adult; Aged; Anemia, Sickle Cell; Anticoagulants; Antipsychotic Agents; Child; Child, Pr

1977
A study of the effects of hypoglycemia agents on vascular complications in patients with adult-onset diabetes. VI. Supplementary report on nonfatal events in patients treated with tolbutamide.
    Diabetes, 1976, Volume: 25, Issue:12

    Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic

1976