tolbutamide has been researched along with Aging in 31 studies
Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dihydrotachysterol (DHT)-induced progeria, a syndrome with symptoms similar to those seen in normal aging, was evaluated as an old age model." | 7.66 | Examination of dihydrotachysterol-induced progeria as a model for aging changes in carbohydrate metabolism. ( Schriefer, JA; Spratto, GR, 1980) |
| "The role of insulin resistance in the impaired glucose-stimulated insulin release of Zucker fatty rats was investigated using the insulin-sensitizing thiazolidinedione drug pioglitazone." | 3.69 | Insulin secretory defect in Zucker fa/fa rats is improved by ameliorating insulin resistance. ( de Souza, CJ; Meglasson, MD; Robinson, DD; Ulrich, RG; Yu, JH, 1995) |
| " Dihydrotachysterol (DHT)-induced progeria, a syndrome with symptoms similar to those seen in normal aging, was evaluated as an old age model." | 3.66 | Examination of dihydrotachysterol-induced progeria as a model for aging changes in carbohydrate metabolism. ( Schriefer, JA; Spratto, GR, 1980) |
| "When diazepam was given for sedative purpose in neonates and infants, the in-vivo urinary excretion of desmethyl diazepam, temazepam and oxazepam was extremely low in 1-2 day newborns (less than 5 nmol metabolites excreted in 24 h per kg body weight) and developed in the first week after birth." | 1.30 | Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility. ( Cheron, G; Cresteil, T; Gueret, G; Sonnier, M; Treluyer, JM, 1997) |
| "Tolbutamide (1 g/70 kg) was administered as a single intravenous dose to 31 healthy, non-smoking, drug-free males between 23 and 87 years old and the total amounts of hydroxy and carboxytolbutamide excreted in 24 h were measured." | 1.28 | Excretion of tolbutamide metabolites in young and old subjects. ( Adir, J; Miller, AK; Vestal, RE, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (74.19) | 18.7374 |
| 1990's | 8 (25.81) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| KLOTZBUCHER, E | 1 |
| BASTENIE, PA | 1 |
| MARIGO, S | 2 |
| TRIPATHY, BB | 1 |
| KAR, BC | 1 |
| SANTAMBROGIO, S | 1 |
| CONTI, F | 1 |
| DELBONO, P | 1 |
| MELANI, F | 1 |
| POGGI, E | 1 |
| Swerdloff, RS | 1 |
| Pozefsky, T | 1 |
| Tobin, JD | 1 |
| Andres, R | 2 |
| Tattersall, RB | 1 |
| Katsumata, K | 1 |
| Katsumata, Y | 1 |
| Gregory, NG | 2 |
| Truscott, TG | 2 |
| Wood, JD | 2 |
| Schriefer, JA | 1 |
| Spratto, GR | 1 |
| Reaven, GM | 1 |
| Reaven, EP | 1 |
| de Souza, CJ | 1 |
| Yu, JH | 1 |
| Robinson, DD | 1 |
| Ulrich, RG | 1 |
| Meglasson, MD | 1 |
| Williams, AJ | 1 |
| Beales, PE | 1 |
| Krug, J | 1 |
| Procaccini, E | 1 |
| Signore, A | 1 |
| Xu, S | 1 |
| Gale, EA | 1 |
| Pozzilli, P | 1 |
| Jay, TR | 1 |
| Heald, KA | 1 |
| Downing, R | 1 |
| Treluyer, JM | 1 |
| Gueret, G | 1 |
| Cheron, G | 1 |
| Sonnier, M | 1 |
| Cresteil, T | 1 |
| Viviani, GL | 1 |
| Pacini, G | 1 |
| Miller, AK | 2 |
| Adir, J | 2 |
| Vestal, RE | 2 |
| Viani, A | 1 |
| Pacifici, GM | 1 |
| Tsuchiyama, S | 1 |
| Tanigawa, K | 1 |
| Kato, Y | 1 |
| Curry, DL | 1 |
| Safarik, RH | 1 |
| Reaven, E | 1 |
| Costin, G | 1 |
| Kogut, MD | 1 |
| Ikegami, H | 1 |
| Joffe, BI | 1 |
| Vinik, AI | 1 |
| Jackson, WP | 1 |
| Shuman, CR | 1 |
| Johansen, K | 1 |
| Kosaka, K | 1 |
| Haguro, R | 1 |
| Odagiri, R | 1 |
| Locatelli, GR | 1 |
| Piotti, LE | 1 |
2 reviews available for tolbutamide and Aging
| Article | Year |
|---|---|
[25 years of diabetic treatment by oral hypoglycemic agents: successes and failures].
Topics: Aged; Aging; Blood Glucose; Cardiovascular Diseases; Chlorpropamide; Diabetes Complications; Diabete | 1984 |
Effects of age on various aspects of glucose and insulin metabolism.
Topics: Adolescent; Adult; Aged; Aging; Animals; Blood Glucose; Child; Diabetes Mellitus; Female; Glucose; G | 1980 |
29 other studies available for tolbutamide and Aging
| Article | Year |
|---|---|
[Hypoglycemic action of the antidiabetic artosin (D 860) in subjects with normal metabolism in various ages].
Topics: Aging; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Tolbutamide | 1958 |
[PREDIABETES: METHODS OF EXAMINATION].
Topics: Adolescent; Aging; Child; Clinical Laboratory Techniques; Diabetes Mellitus; Geriatrics; Glucose Tol | 1964 |
[DIAGNOSTIC APPLICATION OF ORAL HYPOGLYCEMIZING DRUGS IN DIABETES MELLITUS].
Topics: Aging; Biomedical Research; Blood Glucose; Clinical Laboratory Techniques; Diabetes Mellitus; Geriat | 1964 |
OBSERVATIONS ON CLINICAL PATTERNS OF DIABETES MELLITUS IN INDIA.
Topics: Acidosis; Aging; Body Height; Body Weight; Carbutamide; Chlorpropamide; Diabetes Mellitus; Diabetic | 1965 |
[GLUCOSE METABOLISM IN OLD AGE: THE TOLBUTAMIDE TEST].
Topics: Adolescent; Aging; Blood Glucose; Carbohydrate Metabolism; Child; Geriatrics; Humans; Tolbutamide | 1965 |
[The tolbutamide test (Rastinon test) in subjects of senile age].
Topics: Aged; Aged, 80 and over; Aging; Diabetes Mellitus; Humans; Tolbutamide | 1962 |
Influence of age on the intravenous tolbutamide response test.
Topics: Adult; Aged; Aging; Blood Glucose; Fasting; Humans; Injections, Intravenous; Male; Middle Aged; Tolb | 1967 |
[Oxidative phosphorylation of liver mitochondria in the aged rats].
Topics: Aging; Animals; Male; Mitochondria, Liver; Oxidative Phosphorylation; Rats; Rats, Inbred Strains; To | 1983 |
Insulin secreting ability in relation to fatness in cattle.
Topics: Adipose Tissue; Aging; Animals; Body Composition; Cattle; Insulin; Insulin Secretion; Male; Species | 1980 |
Examination of dihydrotachysterol-induced progeria as a model for aging changes in carbohydrate metabolism.
Topics: Aging; Animals; Body Weight; Carbohydrate Metabolism; Dihydrotachysterol; Eating; Glucose; Insulin; | 1980 |
Insulin secretion in relation to fatness in cattle.
Topics: Adipose Tissue; Aging; Animals; Cattle; Insulin; Male; Species Specificity; Tolbutamide | 1982 |
Insulin secretory defect in Zucker fa/fa rats is improved by ameliorating insulin resistance.
Topics: Aging; Amino Acids; Animals; Blood Glucose; Fatty Acids, Nonesterified; Female; Glucose; Hypoglycemi | 1995 |
Tolbutamide reduces the incidence of diabetes mellitus, but not insulitis, in the non-obese-diabetic mouse.
Topics: Aging; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Diazoxide; Female; Insulin; Islets of Lang | 1993 |
Effect of donor age on porcine insulin secretion.
Topics: Aging; Animals; Carbachol; Cells, Cultured; Glucose; Insulin; Insulin Secretion; Islets of Langerhan | 1997 |
Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility.
Topics: Adult; Aging; Child, Preschool; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Female; | 1997 |
Reduced glucose effectiveness as a feature of glucose intolerance: evidence in elderly type-2 diabetic subjects.
Topics: Adult; Age Factors; Aged; Aging; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Fasting; Fem | 1999 |
Tolbutamide binding to plasma proteins of young and old human subjects.
Topics: Adult; Aged; Aging; Blood Proteins; Humans; In Vitro Techniques; Male; Middle Aged; Protein Binding; | 1978 |
Quantitative contribution of endogenous compounds and hypoalbuminemia in reducing the binding of furosemide in the plasma of newborn infants.
Topics: Aging; Apazone; Dialysis; Dimethyl Sulfoxide; Furosemide; Humans; Infant, Newborn; Protein Binding; | 1992 |
Effect of aging on the sensitivity of pancreatic beta-cells to insulin secretagogues in rats.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Blood Glucose; Female; Glucose; Insulin; Insulin Secret | 1991 |
Excretion of tolbutamide metabolites in young and old subjects.
Topics: Adult; Aged; Aged, 80 and over; Aging; Humans; Male; Middle Aged; Tolbutamide | 1990 |
Effect of age on the insulin secretory response of perfused rat pancreas to arginine and tolbutamide.
Topics: Aging; Animals; Arginine; Body Weight; In Vitro Techniques; Insulin; Insulin Secretion; Islets of La | 1987 |
Carbohydrate intolerance in gonadal dysgenesis: evidence for insulin resistance and hyperglucagonemia.
Topics: Adolescent; Adult; Aging; Arginine; Blood Glucose; Body Weight; Child; Glucagon; Glucose Tolerance T | 1985 |
[The effect of aging on pharmacokinetics and pharmacodynamics of tolbutamide].
Topics: Administration, Oral; Adult; Aged; Aging; Diabetes Mellitus, Type 2; Humans; Kinetics; Male; Middle | 1985 |
Insulin reserve in elderly subjects.
Topics: Adult; Aged; Aging; Blood Glucose; Glucagon; Glucose; Humans; Insulin; Insulin Secretion; Tolbutamid | 1969 |
Diabetes detection.
Topics: Aged; Aging; Animals; Diabetes Mellitus; Fasting; Glucose Tolerance Test; Haplorhini; Humans; Method | 1969 |
Normal initial insulin response in elderly people with glucose tolerance test diabetes.
Topics: Aged; Aging; Diabetes Mellitus; Glucose Tolerance Test; Humans; Insulin; Tolbutamide | 1972 |
Aging and diabetes.
Topics: Administration, Oral; Adult; Aged; Aging; Arteriosclerosis; Blood Pressure; Body Weight; Cortisone; | 1971 |
[Aging and pancreatic secretion].
Topics: Adult; Age Factors; Aged; Aging; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Femal | 1969 |
[On the plasmatic concentration of non-esterified fatty acids during the intravenous tolbutamide test in the aged].
Topics: Adult; Aged; Aging; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Humans; Middle Age | 1966 |