Compounds > tolbutamide
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tolbutamide and Abnormalities, Drug-Induced

tolbutamide has been researched along with Abnormalities, Drug-Induced in 23 studies

Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
"Tolbutamide-treated serum was then supplemented with glucose to control for potential effects of hypoglycemia."1.28Teratogenic effects of tolbutamide on early-somite mouse embryos in vitro. ( Smoak, IW, 1992)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199020 (86.96)18.7374
1990's2 (8.70)18.2507
2000's0 (0.00)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Singh, G1
Kumar, A1
Sinha, N1
SMITHBERG, M2
RUNNER, MN1
COHLAN, SQ2
MALINS, JM1
COOKE, AM1
PYKE, DA1
FITZGERALD, MG1
NELMANS, FA1
MCCOLL, JD2
GLOBUS, M2
ROBINSON, S2
Milad, M1
Wassif, N1
Sabet, S1
Stanisstreet, M1
Belisle, RJ1
Long, SY1
Smoak, IW1
Saili, A1
Sarna, MS1
Gastol-Lewińska, L1
Tuchmann-Duplessis, H1
Tanimura, T1
Takino, T1
Nishimura, H1
Notelovitz, M1
Göttinger, E1
Schiff, D1
Aranda, JV1
Stern, L1
Heisig, N1
Theiler, K1
Dixit, PK1
Horký, Z1

Reviews

2 reviews available for tolbutamide and Abnormalities, Drug-Induced

ArticleYear
TERATOGENIC AGENTS AND CONGENITAL MALFORMATIONS.
    The Journal of pediatrics, 1963, Volume: 63

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminopterin; Congenital Abnormalities; Female;

1963
FETAL AND NEONATAL HAZARDS FROM DRUGS ADMINISTERED DURING PREGNANCY.
    New York state journal of medicine, 1964, Feb-15, Volume: 64

    Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Anticoagulants; Antimetabolites; Antineoplastic

1964

Trials

1 trial available for tolbutamide and Abnormalities, Drug-Induced

ArticleYear
Sulphonylurea therapy in the treatment of the pregnant diabetic.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1971, Feb-27, Volume: 45, Issue:9

    Topics: Abnormalities, Drug-Induced; Adult; Apgar Score; Blood Glucose; Chlorpropamide; Diet Therapy; Female

1971

Other Studies

20 other studies available for tolbutamide and Abnormalities, Drug-Induced

ArticleYear
Studying significance of apoptosis in mediating tolbutamide-induced teratogenesis in vitro.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Apoptosis; DNA; DNA Fragmentation; Embryo, Mammalian; Nervous

2012
TERATOGENIC EFFECTS OF HYPOGLYCEMIC TREATMENTS IN INBRED STRAINS OF MICE.
    The American journal of anatomy, 1963, Volume: 113

    Topics: Abnormalities, Drug-Induced; Animals; Hypoglycemic Agents; Insulin; Mice; Mice, Inbred Strains; Niac

1963
SULPHONYLUREA DRUGS IN PREGNANCY.
    British medical journal, 1964, Jul-18, Volume: 2, Issue:5402

    Topics: Abnormalities, Drug-Induced; Chlorpropamide; Diabetes Mellitus; Female; Fetal Death; Humans; Pregnan

1964
[DRUGS WHICH SHOULD NOT BE GIVEN TO A PREGNANT WOMAN].
    Nederlands tijdschrift voor geneeskunde, 1964, Nov-21, Volume: 108

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Antineoplastic Agents; Dihydrostreptomycin Sul

1964
EFFECT OF SOME THERAPEUTIC AGENTS ON THE DEVELOPING RAT FETUS.
    Toxicology and applied pharmacology, 1965, Volume: 7

    Topics: Abnormalities, Drug-Induced; Animals; Antipyrine; Aspirin; Chloral Hydrate; Dimenhydrinate; Female;

1965
Effect of some therapeutic agents on the rabbit fetus.
    Toxicology and applied pharmacology, 1967, Volume: 10, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Aspirin; Dimenhydrinate; Female; Fetus; Glut

1967
The pathogenesis of the teratogenic effect of the antidiabetic drug "tolbutamide": an experimental study.
    The Journal of the Egyptian Public Health Association, 1977, Volume: 52, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Mice; Mice, Inbred Strains; Muscles; Pregnancy;

1977
The effect of tolbutamide on early embryos of Xenopus laevis.
    Experientia, 1977, Oct-15, Volume: 33, Issue:10

    Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Terato

1977
Tolbutamide treatment of pregnant mice: repeated administration reduces fetal lethality.
    Teratology, 1976, Volume: 13, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Enzyme Induction; Female; Fetal Death; Fetal Resorption; Fetus

1976
Teratogenic effects of tolbutamide on early-somite mouse embryos in vitro.
    Diabetes research and clinical practice, 1992, Volume: 17, Issue:3

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Dose-Response Relationship, Drug; Embryo

1992
Tolbutamide: teratogenic effects.
    Indian pediatrics, 1991, Volume: 28, Issue:8

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Arm; Female; Humans; Infant, Newborn; Leg; Mal

1991
Evaluation of the toxicity and teratogenecity of drugs.
    Polish journal of pharmacology and pharmacy, 1973, Volume: 25, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Barbiturates; Chick Embryo; Gestational Age; Insulin; Methotre

1973
[The teratogenic risk].
    Archives d'anatomie, d'histologie et d'embryologie normales et experimentales, 1968, Volume: 51, Issue:5

    Topics: Abnormalities, Drug-Induced; Animals; Azathioprine; Busulfan; Carbutamide; Congenital Abnormalities;

1968
Modification of the teratogenic effect of thio-TEPA on the mouse offspring by successive maternal treatment with tolbutamide.
    Okajimas folia anatomica Japonica, 1966, Volume: 42, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Female; Mice; Pregnancy; Thiotepa; Tolbutamide

1966
[Toxicology of chemical sweetening agents].
    Wiener medizinische Wochenschrift (1946), 1971, Jun-19, Volume: 121, Issue:25

    Topics: Abnormalities, Drug-Induced; Animals; Blood Coagulation Disorders; Chemical and Drug Induced Liver I

1971
Neonatal thrombocytopenia and congenital malformations associated with administration of tolbutamide to the mother.
    The Journal of pediatrics, 1970, Volume: 77, Issue:3

    Topics: Abnormalities, Drug-Induced; Ear; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male;

1970
[Oral antidiabetics in pregnancy].
    Medizinische Klinik, 1971, Mar-19, Volume: 66, Issue:12

    Topics: Abnormalities, Drug-Induced; Biguanides; Carbutamide; Chlorpropamide; Female; Fetus; Humans; Hypogly

1971
[Metamere disturbances and their consequences in mammal experiments].
    Zeitschrift fur Anatomie und Entwicklungsgeschichte, 1967, Volume: 126, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Mice; Ribs; Spine; Tail; Tolbutamide

1967
Incorporation and utilization of radioglucose in the fish embryo Oryzias latipes during teratogenesis.
    Teratology, 1968, Volume: 1, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Cell Membrane Permeability; Cyprinidae; Gluco

1968
[Peroral antidiabetics during pregnancy].
    Zentralblatt fur Gynakologie, 1965, Jul-10, Volume: 87, Issue:28

    Topics: Abnormalities, Drug-Induced; Carbutamide; Female; Fetal Death; Heart Defects, Congenital; Humans; Hy

1965