tolazoline has been researched along with Hernias, Diaphragmatic, Congenital in 20 studies
Tolazoline: A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
tolazoline : A member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group.
Hernias, Diaphragmatic, Congenital: Protrusion of abdominal structures into the THORAX as a result of embryologic defects in the DIAPHRAGM often present in the neonatal period. It can be isolated, syndromic, non-syndromic or be a part of chromosome abnormality. Associated pulmonary hypoplasia and PULMONARY HYPERTENSION can further complicate stabilization and surgical intervention.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After antenatal induction of diaphragmatic hernias in fetal lambs, prostaglandins D2, E1, and I2 were compared to tolazoline, or isoprenaline, for the treatment of pulmonary hypertension." | 7.68 | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. ( Barker, AP; Ford, WD; Lee, CM; Sen, S, 1990) |
| "After antenatal induction of diaphragmatic hernias in fetal lambs, prostaglandins D2, E1, and I2 were compared to tolazoline, or isoprenaline, for the treatment of pulmonary hypertension." | 3.68 | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. ( Barker, AP; Ford, WD; Lee, CM; Sen, S, 1990) |
| "There were 47 seriously-ill neonates with medical causes of respiratory distress and 10 infants with severe respiratory distress secondary to a congenital diaphragmatic hernia treated with tolazoline according to a strict protocol designed to manage persistent fetal circulation (PFC)." | 3.66 | An analysis of tolazoline therapy in the critically-ill neonate. ( Bryson, CQ; Bull, MJ; Gresham, EL; Grosfeld, JL; Lemons, JA; Schreiner, RL; Stevens, DC; Weber, TR, 1980) |
| "Tolazoline did not lower AaDO2 and OI values, but MABP dropped significantly." | 2.67 | Persistent pulmonary hypertension in high-risk congenital diaphragmatic hernia patients: incidence and vasodilator therapy. ( Bos, AP; Hazebroek, FW; Koot, VC; Molenaar, JC; Tibboel, D, 1993) |
| "Infants with congenital diaphragmatic hernia (CDH) die, because their lungs are hypoplastic and their pulmonary vascular resistance remains elevated after birth." | 1.29 | High-frequency ventilation in newborn lambs after intra-uterine creation of diaphragmatic hernia. ( Chourrout, Y; Ghnassia, D; Harf, A; Isabey, D; Jaubert, F; Martelli, H; Piquet, J; Revillon, Y; Sidi, D, 1993) |
| "After repair of a Bochdalek diaphragmatic hernia, shunting of blood away from the lungs produced progressive hypoxaemia in a neonate." | 1.27 | Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations. ( Ford, WD; James, MJ; Walsh, JA, 1984) |
| "Twenty-two cases of diaphragmatic hernia, presenting from 1978 to 1982, were reviewed." | 1.27 | Congenital diaphragmatic hernia and the management of persistent foetal circulation. ( Fong, LV; Pemberton, PJ, 1985) |
| "The incidence of death from congenital diaphragmatic hernia appears to be unchanged in recent years despite advances in resuscitation, transport, and ventilatory support." | 1.26 | Congenital diaphragmatic hernia: pathophysiology and pharmacologic support. ( Aranda, JV; Beardmore, HE; Bloss, RS, 1981) |
| "In three babies' hypoxemia was present from birth." | 1.26 | [Pulmonary hypertension and fetal circulation after severe congenital diaphragmatic hernia (author's transl)]. ( Besson-Leaud, M; Cloup, M; Laufenburger, A; Lavaud, J; Mselati, JC; Pellerin, D; Revillon, Y, 1979) |
| "Seven infants with progressive hypoxemia were treated with a vasodilator, tolazoline." | 1.26 | Congenital diaphragmatic hernia. New concept in management. ( Ford, WD; Maisels, MJ; Naeye, RL; Shochat, SJ; Whitman, V, 1979) |
| "Tolazoline appears to be an important pharmacologic agent for use in the postoperative care of infants with diaphragmatic hernia and associated hypoxemia and acidosis." | 1.26 | Use of tolazoline in newborn infants with diaphragmatic hernia and severe cardiopulmonary disease. A preliminary report. ( Feldt, RH; Kleinberg, F; Moodie, DS; Telander, RL, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (85.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ward, CF | 1 |
| Ihara, K | 1 |
| Maeda, S | 1 |
| Otani, M | 1 |
| Sasako, Y | 1 |
| Kinoshita, M | 1 |
| Nakaba, H | 1 |
| Takao, T | 1 |
| Miyagawa, S | 1 |
| Kashii, H | 1 |
| Shiga, S | 1 |
| Ford, WD | 3 |
| James, MJ | 1 |
| Walsh, JA | 1 |
| Sumner, E | 1 |
| Frank, JD | 1 |
| Gruel, Y | 1 |
| Bourdelat, D | 1 |
| Thomas, M | 1 |
| Allouis, M | 1 |
| Babut, JM | 1 |
| Stevens, DC | 1 |
| Schreiner, RL | 1 |
| Bull, MJ | 1 |
| Bryson, CQ | 1 |
| Lemons, JA | 1 |
| Gresham, EL | 1 |
| Grosfeld, JL | 1 |
| Weber, TR | 1 |
| Wiener, ES | 1 |
| Bloss, RS | 2 |
| Aranda, JV | 2 |
| Beardmore, HE | 2 |
| Ein, SH | 1 |
| Barker, G | 1 |
| Olley, P | 1 |
| Shandling, B | 1 |
| Simpson, JS | 1 |
| Stephens, CA | 1 |
| Filler, RM | 1 |
| Lassaletta, L | 1 |
| Ros, Z | 1 |
| Queizán, A | 1 |
| Benavent, M | 1 |
| Cabrera, R | 1 |
| Jaureguizar, E | 1 |
| Martínez, A | 1 |
| Bos, AP | 1 |
| Tibboel, D | 1 |
| Koot, VC | 1 |
| Hazebroek, FW | 1 |
| Molenaar, JC | 1 |
| Revillon, Y | 2 |
| Sidi, D | 1 |
| Chourrout, Y | 1 |
| Martelli, H | 1 |
| Ghnassia, D | 1 |
| Piquet, J | 1 |
| Isabey, D | 1 |
| Harf, A | 1 |
| Jaubert, F | 1 |
| Mselati, JC | 1 |
| Besson-Leaud, M | 1 |
| Laufenburger, A | 1 |
| Lavaud, J | 1 |
| Cloup, M | 1 |
| Pellerin, D | 1 |
| Shochat, SJ | 1 |
| Naeye, RL | 1 |
| Whitman, V | 1 |
| Maisels, MJ | 1 |
| Moodie, DS | 1 |
| Telander, RL | 1 |
| Kleinberg, F | 1 |
| Feldt, RH | 1 |
| Collins, DL | 1 |
| Pomerance, JJ | 1 |
| Travis, KW | 1 |
| Turner, SW | 1 |
| Pappelbaum, SJ | 1 |
| Sen, S | 1 |
| Barker, AP | 1 |
| Lee, CM | 1 |
| Brereton, RJ | 1 |
| Kumar, D | 1 |
| Spitz, L | 1 |
| Fong, LV | 1 |
| Pemberton, PJ | 1 |
1 trial available for tolazoline and Hernias, Diaphragmatic, Congenital
| Article | Year |
|---|---|
Persistent pulmonary hypertension in high-risk congenital diaphragmatic hernia patients: incidence and vasodilator therapy.
Topics: Blood Pressure; Combined Modality Therapy; Epoprostenol; Hernia, Diaphragmatic; Hernias, Diaphragmat | 1993 |
19 other studies available for tolazoline and Hernias, Diaphragmatic, Congenital
| Article | Year |
|---|---|
Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations.
Topics: Hernias, Diaphragmatic, Congenital; Humans; Infant, Newborn; Pulmonary Circulation; Thromboxanes; To | 1984 |
[A survival case of persistent fetal circulation following surgery of diaphragmatic hernia by ligature of the ductus arteriosus].
Topics: Ductus Arteriosus; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Infant, Newbor | 1984 |
Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations.
Topics: 6-Ketoprostaglandin F1 alpha; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Inf | 1984 |
Tolazoline in the treatment of congenital diaphragmatic hernias.
Topics: Carbon Dioxide; Female; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Infant, N | 1981 |
[Value of neuroleptoanalgesia in preventing recurrence of fetal shunts during treatment of diaphragmatic hernias].
Topics: Chlorpromazine; Cyanosis; Female; Hernias, Diaphragmatic, Congenital; Humans; Infant, Newborn; Lung; | 1983 |
An analysis of tolazoline therapy in the critically-ill neonate.
Topics: Erythema; Gastrointestinal Hemorrhage; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Hu | 1980 |
Congenital posterolateral diaphragmatic hernia: new dimensions in management.
Topics: Chlorpromazine; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Infant, Newborn; | 1982 |
Congenital diaphragmatic hernia: pathophysiology and pharmacologic support.
Topics: Animals; Cattle; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Infant, Newborn; | 1981 |
Vasodilator response and prediction of survival in congenital diaphragmatic hernia.
Topics: Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Infant, Newborn; Oxygen; Persiste | 1981 |
The pharmacologic treatment of newborn diaphragmatic hernia--a 2-year evaluation.
Topics: Acetylcholine; Chlorpromazine; Dopamine; Ductus Arteriosus, Patent; Hernia, Diaphragmatic; Hernias, | 1980 |
[Tolazoline in postoperative period of diaphragmatic hernia (author's transl)].
Topics: Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Infant, Newborn; Infant, Newborn, | 1980 |
High-frequency ventilation in newborn lambs after intra-uterine creation of diaphragmatic hernia.
Topics: Animals; Animals, Newborn; Female; Hemodynamics; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Cong | 1993 |
[Pulmonary hypertension and fetal circulation after severe congenital diaphragmatic hernia (author's transl)].
Topics: Ductus Arteriosus, Patent; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Hypert | 1979 |
Congenital diaphragmatic hernia. New concept in management.
Topics: Female; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Hypoxia; Infant, Newborn; | 1979 |
Use of tolazoline in newborn infants with diaphragmatic hernia and severe cardiopulmonary disease. A preliminary report.
Topics: Acidosis, Respiratory; Blood Pressure; Carbon Dioxide; Drug Evaluation; Hernias, Diaphragmatic, Cong | 1978 |
A new approach to congenital posterolateral diaphragmatic hernia.
Topics: Acetylcholine; Blood Gas Analysis; Chlorpromazine; Ductus Arteriosus, Patent; Hernia, Diaphragmatic; | 1977 |
Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Hernia, Diaphragmatic; Hernias | 1990 |
Diaphragmatic hernia in neonate.
Topics: Carbon Dioxide; Dopamine; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Infant, | 1985 |
Congenital diaphragmatic hernia and the management of persistent foetal circulation.
Topics: Female; Hernia, Diaphragmatic; Hernias, Diaphragmatic, Congenital; Humans; Hyperventilation; Infant, | 1985 |