tolazoline has been researched along with Disease Models, Animal in 11 studies
Tolazoline: A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
tolazoline : A member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After antenatal induction of diaphragmatic hernias in fetal lambs, prostaglandins D2, E1, and I2 were compared to tolazoline, or isoprenaline, for the treatment of pulmonary hypertension." | 7.68 | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. ( Barker, AP; Ford, WD; Lee, CM; Sen, S, 1990) |
| "The effect of tolazoline (Tz) on mesenteric blood flow was evaluated in a piglet model of group B streptococcal (GBS) sepsis." | 7.67 | Nonhomogeneous redistribution of mesenteric blood flow after tolazoline during group B streptococcal sepsis in piglets. ( Meadow, WL; Meus, PJ, 1985) |
| " A recent clinical report, however, suggested that intraarterial injection of reserpine was affective in limiting tissue necrosis." | 3.68 | The role of intraarterial vasodilators in the treatment of inadvertent intraarterial injection injuries. ( Crawford, CR; Terranova, WA, 1990) |
| "After antenatal induction of diaphragmatic hernias in fetal lambs, prostaglandins D2, E1, and I2 were compared to tolazoline, or isoprenaline, for the treatment of pulmonary hypertension." | 3.68 | Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline. ( Barker, AP; Ford, WD; Lee, CM; Sen, S, 1990) |
| "The effect of tolazoline (Tz) on mesenteric blood flow was evaluated in a piglet model of group B streptococcal (GBS) sepsis." | 3.67 | Nonhomogeneous redistribution of mesenteric blood flow after tolazoline during group B streptococcal sepsis in piglets. ( Meadow, WL; Meus, PJ, 1985) |
| "Tolazoline is a potent vasodilator of arteries and veins and has a powerful effect on the pulmonary vasculature, reducing hypoxic pulmonary vasoconstriction and lowering pulmonary artery pressure." | 1.30 | Pharmacokinetics of endobronchial tolazoline administration in dogs. ( Barzilay, Z; Ben-Abraham, R; Eyal, O; Ezra, D; Manisterski, Y; Mayan, H; Paret, G; Vardi, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Galley, G | 1 |
| Stalder, H | 1 |
| Goergler, A | 1 |
| Hoener, MC | 1 |
| Norcross, RD | 1 |
| Meadow, WL | 2 |
| Meus, PJ | 2 |
| Jovanović-Mićić, D | 1 |
| Samardzić, R | 1 |
| Beleslin, DB | 1 |
| Paret, G | 1 |
| Eyal, O | 1 |
| Mayan, H | 1 |
| Ben-Abraham, R | 1 |
| Vardi, A | 1 |
| Manisterski, Y | 1 |
| Barzilay, Z | 1 |
| Ezra, D | 1 |
| Snider, RL | 1 |
| Porter, JM | 1 |
| Crawford, CR | 1 |
| Terranova, WA | 1 |
| Ford, WD | 1 |
| Sen, S | 1 |
| Barker, AP | 1 |
| Lee, CM | 1 |
| Tiefenbrunn, LJ | 1 |
| Riemenschneider, TA | 1 |
| Turss, R | 1 |
| Boden, K | 1 |
| Fehring, G | 1 |
| Weissenhofer, W | 1 |
| Schenk, WG | 1 |
1 review available for tolazoline and Disease Models, Animal
| Article | Year |
|---|---|
Persistent pulmonary hypertension of the newborn.
Topics: Animals; Cardiomyopathies; Catheterization; Diagnosis, Differential; Disease Models, Animal; Dobutam | 1986 |
10 other studies available for tolazoline and Disease Models, Animal
| Article | Year |
|---|---|
Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012.
Topics: Administration, Oral; Aniline Compounds; Animals; Behavior, Animal; Disease Models, Animal; Drug Eva | 2012 |
Hemodynamic consequences of tolazoline in neonatal group B streptococcal bacteremia: an animal model.
Topics: Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Disease Models, Animal; Dose-Response Rel | 1984 |
The role of alpha-adrenergic mechanisms within the area postrema in dopamine-induced emesis.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Atropine; Cats; Cerebral Ventricles; Di | 1995 |
Pharmacokinetics of endobronchial tolazoline administration in dogs.
Topics: Absorption; Animals; Area Under Curve; Disease Models, Animal; Dogs; Female; Heart Rate; Hemodynamic | 1999 |
Treatment of experimental frostbite with intra-arterial sympathetic blocking drugs.
Topics: Animals; Dextrans; Disease Models, Animal; Female; Frostbite; Hot Temperature; Injections, Intra-Art | 1975 |
The role of intraarterial vasodilators in the treatment of inadvertent intraarterial injection injuries.
Topics: Animals; Arteries; Disease Models, Animal; Ear, External; Injections, Intra-Arterial; Necrosis; Rabb | 1990 |
Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Hernia, Diaphragmatic; Hernias | 1990 |
Nonhomogeneous redistribution of mesenteric blood flow after tolazoline during group B streptococcal sepsis in piglets.
Topics: Animals; Animals, Newborn; Cardiac Output; Disease Models, Animal; Sepsis; Splanchnic Circulation; S | 1985 |
[Corneal nutrition in alkali burns and the effect of tolazoline (author's transl)].
Topics: Animals; Aqueous Humor; Burns, Chemical; Ciliary Body; Conjunctiva; Cornea; Corneal Ulcer; Disease M | 1974 |
Hemodynamic response to vasodilation and exercise in "critical" arterial stenosis. An experimental study in a canine model.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Disease Models, Animal; Dogs; Hemodynamics; He | 1974 |