tolazamide and Diabetes Mellitus studies

Tolazamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
tolazamide : An N-sulfonylurea that is 1-tosylurea in which a hydrogen attached to the nitrogen at position 3 is replaced by an azepan-1-yl group. A hypoglycemic agent, it is used for the treatment of type 2 diabetes mellitus.

Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Research Excerpts

Excerpt	Relevance	Reference
"Insulin requirements, C-peptide levels, and serum lipids have been assessed in 12 obese, insulin-requiring (greater than 60 U/day) patients with type II diabetes mellitus, in a randomized crossover fashion with two treatment regimens: NPH alone and combined NPH and tolazamide, over a period of 3 months each, with maintenance of weight and glycemic control (HgA1, 2hpp and mean 24h glucose profile) at comparable levels."	9.06	Combined therapy of insulin and tolazamide decreases insulin requirement and serum triglycerides in obese patients with noninsulin-dependent diabetes mellitus. ( Kitabchi, AE; Lawson-Grant, V; Radparvar, A; Soria, AG, 1987)
"Insulin requirements, C-peptide levels, and serum lipids have been assessed in 12 obese, insulin-requiring (greater than 60 U/day) patients with type II diabetes mellitus, in a randomized crossover fashion with two treatment regimens: NPH alone and combined NPH and tolazamide, over a period of 3 months each, with maintenance of weight and glycemic control (HgA1, 2hpp and mean 24h glucose profile) at comparable levels."	5.06	Combined therapy of insulin and tolazamide decreases insulin requirement and serum triglycerides in obese patients with noninsulin-dependent diabetes mellitus. ( Kitabchi, AE; Lawson-Grant, V; Radparvar, A; Soria, AG, 1987)
"A unique hepatic adenoma developed in a 26-year-old woman who had used oral contraceptives for 10 years and Tolinase (tolazamide sulfonylurea) for adult-onset diabetes mellitus for five years."	3.67	"Alcoholic hepatitis" in a hepatic adenoma. ( Finegold, MJ; Heffelfinger, S; Irani, DR, 1987)
"Glyburide and other sulfonylureas consistently enhance receptor binding in cells from patients with non-insulin-dependent diabetes mellitus, whereas no effects and mixed effects have been demonstrated in cells from patients with insulin-dependent diabetes mellitus and in normal cells, respectively."	3.67	Dual actions of sulfonylureas and glyburide. Receptor and post-receptor effects. ( Gavin, JR, 1985)
"We compared 24 obese Pima Indians with NIDDM to 24 Pima Indians with normal glucose tolerance to determine whether resting metabolic rate changes may be an additional factor influencing the weight shifts."	1.27	Increased resting metabolic rates in obese subjects with non-insulin-dependent diabetes mellitus and the effect of sulfonylurea therapy. ( Bogardus, C; Howard, BV; Lillioja, S; Mott, D; Taskinen, MR; Zawadzki, J, 1986)

Timeframe	Studies, this research(%)	All Research%
pre-1990	54 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
MCDONALD, WP	1
YAMAMURA, Y	1
KLINGER, R	1
DALLECOSTE, P	1
GRINNELL, EH	1
SKILLMAN, TG	2
BARSE, R	1
MOLLER, CL	1
BRESSLER, R	3
KATZ, R	1
BECKETT, AG	1
DONOVAN, RJ	1
Moorhouse, JA	1
Baird, IM	1
Evans, JH	1
Hirst, J	1
Longson, D	1
Feldman, JM	1
Coxe, JS	1
O'Dorisio, TM	1
Cataland, S	1
Crockett, SE	1
DeLawter, DE	2
Boden, G	1
Master, RW	1
Gordon, SS	1
Shuman, CR	1
Owen, OE	1
Bagdade, JD	1
Walters, E	1
Schultz, TA	1
Lewis, SB	1
Davis, JL	1
Rost, CR	1
Bliziotes, MM	1
Shen, SW	1
Kudzma, DJ	1
Friedberg, SJ	1
Schmeltz, R	1
Wendorff, HJ	1
Field, JB	1
Watson, WA	1
Petrie, JC	1
Galloway, DB	1
Bullock, I	1
Gilbert, JC	1
Tsalikian, E	1
Dunphy, TW	1
Bohannon, NV	1
Lorenzi, M	1
Gerich, JE	1
Forsham, PH	1
Kane, JP	1
Karam, JH	1
Heffelfinger, S	1
Irani, DR	1
Finegold, MJ	1
Kitabchi, AE	1
Soria, AG	1
Radparvar, A	1
Lawson-Grant, V	1
True, BL	1
Perry, PJ	1
Burns, EA	1
Gavin, JR	1
Bogardus, C	1
Taskinen, MR	1
Zawadzki, J	1
Lillioja, S	1
Mott, D	1
Howard, BV	1
Nakao, NL	1
Gelb, AM	1
Stenger, RJ	1
Siegel, JH	1
Schless, GL	1
Lee, CT	1
Stowers, JM	1
Scoville, AB	1
Stehling, L	1
Molnar, GD	1
Taylor, WF	1
Langworthy, AL	1
Moss, JM	1
Tewari, SN	1
Fletcher, R	1
Mashimo, K	1
Nakagawa, S	1
Hanai, N	1
Jackson, WP	1
Bricker, LA	1
Mintz, DH	1
Sherwood, G	1
Balodimos, MC	1
Marble, A	1
Garcia, M	1
Miller, M	1
Moses, AM	1
Pereira, VG	1
Wajchenberg, BL	1
Shnaider, J	1
Beidleman, B	1
Prevatt, AL	1
Palmer, RC	1
Genes, SG	1
Grinchenko, TS	1
Lobanovskaia, LI	1
Laursen, B	1
Gormsen, J	1
Vogel, G	1
Krummel, E	1
Düntsch, G	2
Turtle, JR	1
Sheldon, J	1
Kanzler, G	1
Trenkner, G	1
Rausch-Stroomann, JB	1
Milani, R	1

Article	Year
Clinical pharmacology of oral antidiabetic agents (first of two parts). The New England journal of medicine, 1977, Mar-03, Volume: 296, Issue:9 Topics: Acetohexamide; Administration, Oral; Chemical Phenomena; Chemistry; Chlorpropamide; Diabetes Mellitu	1977
Oral treatment in diabetes. Clinics in endocrinology and metabolism, 1972, Volume: 1, Issue:3 Topics: Acetohexamide; Acidosis; Administration, Oral; Animals; Biguanides; Cardiovascular Diseases; Chlorpr	1972
Hypoglycemic drugs. Clinical anesthesia, 1974, Volume: 10, Issue:1 Topics: Acetohexamide; Anesthetics; Blood Glucose; Carbohydrate Metabolism; Chlorpropamide; Diabetes Mellitu	1974
[Evaluation of therapy of diabetes mellitus with oral antidiabetics]. Nihon rinsho. Japanese journal of clinical medicine, 1969, Volume: 27, Issue:8 Topics: Adult; Biguanides; Chemical Phenomena; Chemistry; Diabetes Mellitus; Diet, Diabetic; Female; Humans;	1969
Oral sulphonylureas in the management of diabetes. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1971, Jan-30, Volume: 45, Issue:5 Topics: Acetohexamide; Chlorpropamide; Cyclohexanes; Diabetes Mellitus; Endocrine Glands; Glucose Tolerance	1971
Insulin-independent diabetes mellitus. The Medical clinics of North America, 1971, Volume: 55, Issue:2 Topics: Acetohexamide; Adult; Age Factors; Aged; Basement Membrane; Capillaries; Carbohydrate Metabolism, In	1971

Article	Year
Effect of sulfonylurea therapy and plasma glucose levels on hemoglobin A1c in type II diabetes mellitus. The American journal of medicine, 1981, Volume: 70, Issue:2 Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Double-Blind Method; Female; Hemoglobin A; Humans; Ma	1981
Potentiation of hypoglycemic effect of chlorpropamide and phenfromin by halofenate. Diabetes, 1977, Volume: 26, Issue:4 Topics: Blood Glucose; Chlorpropamide; Clinical Trials as Topic; Clofibrate; Diabetes Mellitus; Drug Synergi	1977
Combined therapy of insulin and tolazamide decreases insulin requirement and serum triglycerides in obese patients with noninsulin-dependent diabetes mellitus. The American journal of the medical sciences, 1987, Volume: 294, Issue:1 Topics: Adult; Aged; Blood Glucose; C-Peptide; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dr	1987
Value of tolazamide "'Tolanase') as an oral hypoglycaemic agent. The British journal of clinical practice, 1967, Sep-09, Volume: 21, Issue:9 Topics: Adult; Aged; Clinical Trials as Topic; Diabetes Mellitus; Diet, Diabetic; Female; Humans; Hypoglycem	1967
Comparision of chlorpropamide with tolazamide in the treatment of diabetes mellitus. Current therapeutic research, clinical and experimental, 1968, Volume: 10, Issue:8 Topics: Chlorpropamide; Diabetes Mellitus; Humans; Hypoglycemic Agents; Tolazamide; Urea	1968
[Study of oral hypoglycemic agents. VI. Comparative study on acute oral overload using tolbutamide and tolazamide in normal and diabetic subjects. Various aspects of the prolonged use of tolazamide in comparison with other sulfonylureas]. Arquivos brasileiros de endocrinologia e metabologia, 1965, Volume: 14, Issue:2 Topics: Adult; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Female; Humans; Hypoglycemic Agen	1965
The use of tolazamide in the treatment of diabetes mellitus. The Journal of the Florida Medical Association, 1966, Volume: 53, Issue:3 Topics: Adult; Aged; Clinical Trials as Topic; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male;	1966

Article	Year
"THE TOLBUTAMIDE TOLERANCE TEST, THE EFFECTS OF CHLOROTHIAZIDE ON GLUCOSE METABOLISM, AND THE PRESENT STATUS OF ORAL HYPOGLYCEMIC AGENTS IN THE TREATMENT OF DIABETES". Memphis and Mid-South medical journal, 1963, Volume: 38 Topics: Chlorothiazide; Diabetes Mellitus; Glucose; Humans; Hypoglycemic Agents; Tolazamide; Tolbutamide	1963
[ASSOCIATION OF PULMONARY TUBERCULOSIS AND DIABETES MELLITUS]. Naika. Internal medicine, 1964, Volume: 13 Topics: Diabetes Mellitus; Humans; Hypoglycemic Agents; Insulin; Insulin, Long-Acting; Isoniazid; Kanamycin;	1964
[ON TOLAZAMIDE: APROPOS OF A NEW HYPOGLYCEMIC SULFANYLUREA AND OF ACQUIRED SULFANYLUREAU RESISTANCE]. Minerva medica, 1964, Jul-14, Volume: 55 Topics: Carbutamide; Chlorpropamide; Diabetes Mellitus; Drug Tolerance; Humans; Hypoglycemic Agents; Insulin	1964
CLINICAL EFFECTS OF A NEW, POTENT, NON-TOXIC SULFONYLUREA (TOLAZAMIDE). Current therapeutic research, clinical and experimental, 1964, Volume: 6 Topics: Biomedical Research; Blood Glucose; Chemical Phenomena; Chemistry; Chlorpropamide; Diabetes Mellitus	1964
EVALUATION OF TOLAZAMIDE IN THE TREATMENT OF DIABETES MELLITUS. Current therapeutic research, clinical and experimental, 1965, Volume: 7 Topics: Cholesterol; Diabetes Mellitus; Drug Therapy; Geriatrics; Hypoglycemic Agents; Obesity; Pharmacology	1965
TOLAZAMIDE (TOLANASE) -- A NEW SULPHONYLUREA. The British journal of clinical practice, 1965, Volume: 19 Topics: Body Weight; Diabetes Mellitus; Drug Therapy; Geriatrics; Hypoglycemic Agents; Phenformin; Sulfonylu	1965
A comparison of the effects of tolazamide and tolbutamide upon blood glucose and serum insulin and lipid levels in diabetic subjects. Canadian Medical Association journal, 1967, Mar-04, Volume: 96, Issue:9 Topics: Adult; Aged; Blood Glucose; Cholesterol; Diabetes Mellitus; Female; Glycerides; Humans; Hypoglycemic	1967
Tolazamide in the treatment of diabetes mellitus. The Practitioner, 1967, Volume: 198, Issue:184 Topics: Adult; Aged; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Tolazamide	1967
The pharmacology of sulfonylureas. The American journal of medicine, 1981, Volume: 70, Issue:2 Topics: Acetohexamide; Blood Glucose; Chlorpropamide; Diabetes Mellitus; Glyburide; Humans; Insulin; Sulfony	1981
Gastric inhibitory polypeptide hypersecretion in diabetes mellitus: effect of sulfonylurea treatment. The Journal of clinical endocrinology and metabolism, 1981, Volume: 52, Issue:5 Topics: Adult; Blood Glucose; Diabetes Mellitus; Female; Food; Gastric Inhibitory Polypeptide; Gastrointesti	1981
One minute with diabetes. Maryland state medical journal, 1981, Volume: 30, Issue:8 Topics: Diabetes Mellitus; Humans; Male; Middle Aged; Tolazamide	1981
Monitoring metabolic control in diabetic outpatients with glycosylated hemoglobin. Annals of internal medicine, 1980, Volume: 92, Issue:3 Topics: Administration, Oral; Aged; Ambulatory Care; Blood Glucose; Chlorpropamide; Diabetes Mellitus; Fasti	1980
Impaired granulocyte adherence in mildly diabetic patients: effects of tolazamide treatment. Diabetes, 1980, Volume: 29, Issue:4 Topics: Cell Adhesion; Diabetes Mellitus; Female; Granulocytes; Humans; Male; Tolazamide	1980
Effect of control of blood glucose on plasma insulin responses to various stimuli in secondary failures to oral hypoglycemic agents and in newly diagnosed, maturity onset, ketosis-resistant diabetics. The Journal of clinical endocrinology and metabolism, 1978, Volume: 46, Issue:4 Topics: Adult; Aged; Blood Glucose; Chlorpropamide; Diabetes Mellitus; Female; Glucose Tolerance Test; Human	1978
In vivo cytogenetic activity of sulphonylurea drugs in man. Mutation research, 1976, Volume: 38, Issue:1 Topics: Adult; Chlorpropamide; Chromosome Aberrations; Chromosome Deletion; Diabetes Mellitus; Female; Glybu	1976
The effect of chronic oral antidiabetic therapy on insulin and glucagon responses to a meal. Diabetes, 1977, Volume: 26, Issue:4 Topics: Acetohexamide; Administration, Oral; Adult; Aged; Chlorpropamide; Diabetes Mellitus; Female; Glucago	1977
"Alcoholic hepatitis" in a hepatic adenoma. Human pathology, 1987, Volume: 18, Issue:7 Topics: Adenoma; Adult; Contraceptives, Oral; Diabetes Complications; Diabetes Mellitus; Fatty Liver; Female	1987
Profound hypoglycemia with the addition of a tricyclic antidepressant to maintenance sulfonylurea therapy. The American journal of psychiatry, 1987, Volume: 144, Issue:9 Topics: Aged; Chlorpropamide; Depressive Disorder; Diabetes Complications; Diabetes Mellitus; Doxepin; Drug	1987
Dual actions of sulfonylureas and glyburide. Receptor and post-receptor effects. The American journal of medicine, 1985, Sep-20, Volume: 79, Issue:3B Topics: Adipose Tissue; Animals; Cells, Cultured; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mel	1985
Increased resting metabolic rates in obese subjects with non-insulin-dependent diabetes mellitus and the effect of sulfonylurea therapy. Diabetes, 1986, Volume: 35, Issue:1 Topics: Adolescent; Adult; Blood Glucose; Calorimetry; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy	1986
A case of chronic liver disease due to tolazamide. Gastroenterology, 1985, Volume: 89, Issue:1 Topics: Aged; Chemical and Drug Induced Liver Injury; Chlorpropamide; Diabetes Mellitus; Female; Humans; Jau	1985
Oral hypoglycemic therapy and associated hypothyroidism. Annals of the New York Academy of Sciences, 1968, Mar-26, Volume: 148, Issue:3 Topics: Acetohexamide; Aged; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Hypothyroidism; Iatroge	1968
Editorial: Oral therapy in diabetes mellitus. Southern medical journal, 1974, Volume: 67, Issue:6 Topics: Acetohexamide; Biguanides; Chlorpropamide; Diabetes Mellitus; Diabetic Ketoacidosis; Diet Therapy; H	1974
Diabetes mellitus: the thin maturity-onset diabetic. British medical journal, 1972, Sep-16, Volume: 3, Issue:5828 Topics: Acetohexamide; Body Weight; Chlorpropamide; Diabetes Mellitus; Glyburide; Humans; Hypoglycemia; Hypo	1972
Plasma immunoreactive insulin patterns in insulin-treated diabetics. Studies during continuous blood glucose monitoring. Mayo Clinic proceedings, 1972, Volume: 47, Issue:10 Topics: Acetohexamide; Adult; Aged; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus; Female; H	1972
Long-term results with oral hypoglycemic drugs. Journal of the American Geriatrics Society, 1973, Volume: 21, Issue:2 Topics: Acetohexamide; Adult; Aged; Blood Glucose; Chlorpropamide; Diabetes Mellitus; Diet, Diabetic; Humans	1973
Tolazamide in the treatment of diabetes mellitus: clinical experience and review of the literature. Current therapeutic research, clinical and experimental, 1971, Volume: 13, Issue:1 Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male; Middle Age	1971
Chlorpropamide-induced water retention in patients with diabetes mellitus. Annals of internal medicine, 1971, Volume: 75, Issue:4 Topics: Aged; Chlorpropamide; Diabetes Mellitus; Female; Humans; Hyponatremia; Kidney Tubules; Male; Tolazam	1971
[Use of tolinase (tolazamide) in diabetes mellitus]. Vrachebnoe delo, 1969, Volume: 4 Topics: Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Male; Tolazamide; Urea	1969
Pharmacological enhancement and short-term stimulation of blood fibrinolytic activity. Scandinavian journal of haematology, 1969, Volume: 6, Issue:6 Topics: Adolescent; Adult; Aged; Aminocaproates; Anticholesteremic Agents; Arteriosclerosis; Arthritis, Rheu	1969
[Oral treatment of diabetes mellitus with the new sulfonylurea tolazamide]. Arzneimittel-Forschung, 1969, Volume: 19, Issue:7 Topics: Adult; Aged; Biguanides; Blood Glucose; Depression, Chemical; Diabetes Mellitus; Female; Humans; Hyp	1969
[Results of oral therapy of diabetes mellitus with the new sulfonylurea tolazamide under ambulatory conditions]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:4 Topics: Ambulatory Care; Blood Glucose; Cholesterol; Depression, Chemical; Diabetes Mellitus; Female; Humans	1970
[Results of oral therapy of diabetes mellitus with the new sulfonylurea tolazamide under ambulatory conditions]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:4 Topics: Ambulatory Care; Blood Glucose; Cholesterol; Depression, Chemical; Diabetes Mellitus; Female; Humans	1970
Status of problem of usage of tolbutamide. Preliminary statements. Diabetes, 1970, Volume: 19, Issue:6 Topics: Acetohexamide; Chlorpropamide; Diabetes Mellitus; Diet Therapy; Humans; Tolazamide; Tolbutamide; Uni	1970
Glucose and insulin secretory response patterns following diet and tolazamide therapy in diabetes. British medical journal, 1970, Sep-12, Volume: 3, Issue:5723 Topics: Adult; Blood Glucose; Carbohydrate Metabolism, Inborn Errors; Diabetes Mellitus; Diet, Diabetic; Glu	1970
Glucose and insulin after diet and tolazamide treatment. British medical journal, 1970, Oct-24, Volume: 4, Issue:5729 Topics: Blood Glucose; Diabetes Mellitus; Diet, Diabetic; Humans; Hypoglycemic Agents; Insulin; Tolazamide;	1970
Tolanase - a sulphonylurea antidiabetic agent. Drug and therapeutics bulletin, 1968, Mar-29, Volume: 6, Issue:7 Topics: Acetohexamide; Diabetes Mellitus; Humans; Hypoglycemic Agents; Tolazamide; Tolbutamide; Urea	1968
[Experiences with sulfonylurea tolazamide in an out-patient clinic for diabetics]. Arzneimittel-Forschung, 1968, Volume: 18, Issue:10 Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Cholesterol; Diabetes Mellitus; Fema	1968
[Acute hypoglycemizing activity of intravenous tolazamide and tolbutamide: comparative study in normal, diabetic and hepatopathic man. Preliminary note]. Minerva medica, 1965, Sep-15, Volume: 56, Issue:74 Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Injections, Intr	1965
A new oral hypoglycemic agent. Tolazamide (Tolinase). JAMA, 1966, Oct-17, Volume: 198, Issue:3 Topics: Blood Glucose; Diabetes Mellitus; Drug Synergism; Humans; Hypoglycemia; Hypoglycemic Agents; Tolazam	1966
Tolinase--a new oral antidiabetic drug. The Medical letter on drugs and therapeutics, 1966, Sep-23, Volume: 8, Issue:19 Topics: Diabetes Mellitus; Diabetes Mellitus, Type 1; Humans; Hypoglycemic Agents; Phenformin; Tolazamide	1966

tolazamide and Diabetes Mellitus

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