tofacitinib and Brain-Ischemia

tofacitinib has been researched along with Brain-Ischemia* in 1 studies

Other Studies

1 other study(ies) available for tofacitinib and Brain-Ischemia

ArticleYear
Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model.
    Biochemical and biophysical research communications, 2010, Nov-19, Volume: 402, Issue:3

    Recently, T cell cytokines such as IL-17 and IFN-γ have been shown to play important roles in the progression of brain injury induced by ischemia. We have shown that IL-23 from infiltrated macrophages activates γδT cells, thereby inducing IL-17 from these cells. However, deletion of the IL-23 gene in mice showed a more dramatic protective effect against brain ischemia reperfusion (I/R) model than γδT cell depletion did, suggesting that IL-23 plays some other pivotal role in brain injury in addition to its role in IL-17 induction. To develop therapeutic methods based on these findings, we examined the effect of the JAK kinase inhibitor CP-690550 and an anti-IL12/23 monoclonal antibody on an I/R model. CP-690550 efficiently inhibited IL-17 production from memory T cells in vitro and partly suppressed infarct volume increase after I/R. Anti-p40 antibody, which blocks both IL-12 and IL-23, efficiently suppressed I/R injury and improved recovery of neurological deficits. The number of IL-17-producing cells was decreased by anti-p40 antibody treatment. Thus the JAK inhibitor and anti-p40 antibody, both of which have already been under trial for the treatment of several human inflammatory diseases, appear to be promising therapeutic agents for the amelioration of stroke.

    Topics: Animals; Antibodies, Monoclonal; Brain Ischemia; Disease Models, Animal; Humans; Immunologic Memory; Interleukin-12; Interleukin-17; Interleukin-23; Janus Kinase 3; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrimidines; Pyrroles; T-Lymphocytes

2010