todralazine has been researched along with Liver Failure in 2 studies
Todralazine: An antihypertensive agent with both central and peripheral action; it has some central nervous system depressant effects.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to investigate the precise mechanism of liver failure by hydralazine derivatives, with special reference to liver regeneration failure." | 7.74 | A novel mechanism for drug-induced liver failure: inhibition of histone acetylation by hydralazine derivatives. ( Hamada, M; Murata, K; Nakano, T; Sugimoto, K, 2007) |
| "The aim of this study was to investigate the precise mechanism of liver failure by hydralazine derivatives, with special reference to liver regeneration failure." | 3.74 | A novel mechanism for drug-induced liver failure: inhibition of histone acetylation by hydralazine derivatives. ( Hamada, M; Murata, K; Nakano, T; Sugimoto, K, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murata, K | 1 |
| Hamada, M | 1 |
| Sugimoto, K | 1 |
| Nakano, T | 1 |
| Elsharkawy, AM | 1 |
2 other studies available for todralazine and Liver Failure
| Article | Year |
|---|---|
A novel mechanism for drug-induced liver failure: inhibition of histone acetylation by hydralazine derivatives.
Topics: Acetylation; Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Disease Models, Animal; fas | 2007 |
Todralazine hepatotoxicity: a sting in the histone tail.
Topics: Acetylation; Animals; Antihypertensive Agents; Histones; Humans; Liver; Liver Failure; Mice; Todrala | 2007 |