todralazine has been researched along with Hypertension in 10 studies
Todralazine: An antihypertensive agent with both central and peripheral action; it has some central nervous system depressant effects.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydrochlorothiazide and binazine treatment decreased systolic and diastolic blood pressure, the total electromechanical systolic time index (QS2I) and the left ventricular ejection time index (LVETI), and increased the PEP/LVET index at rest and after exercise." | 5.27 | Post-exertion changes in left ventricular systolic time intervals in patients with primary hypertension treated with hydrochlorothiazide, binazine, and propranolol. ( Cholewa, M; Górski, L; Markiewicz, K, 1985) |
| " LD50 values were 72 mg." | 1.29 | Acute systemic toxicity and antihypertensive activity of a novel todralazine analog in rats. ( Aranjo, P; Biniecki, K; Ciszewski, L; Czyzewska-Szafran, H; Fijałek, Z; Goźlińska, B; Jastrzebski, Z; Jedrych, A; Mazurek, AP; Wutkiewicz, M, 1993) |
| "Hydrochlorothiazide and binazine treatment decreased systolic and diastolic blood pressure, the total electromechanical systolic time index (QS2I) and the left ventricular ejection time index (LVETI), and increased the PEP/LVET index at rest and after exercise." | 1.27 | Post-exertion changes in left ventricular systolic time intervals in patients with primary hypertension treated with hydrochlorothiazide, binazine, and propranolol. ( Cholewa, M; Górski, L; Markiewicz, K, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (80.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kolber-Postepska, B | 2 |
| Kleinrok, Z | 1 |
| Markiewicz, M | 4 |
| Cybulska, I | 1 |
| Kedrowa, S | 1 |
| Kudlicki, J | 1 |
| Jastrzebski, Z | 1 |
| Czyzewska-Szafran, H | 1 |
| Goźlińska, B | 1 |
| Wutkiewicz, M | 1 |
| Jedrych, A | 1 |
| Fijałek, Z | 1 |
| Biniecki, K | 1 |
| Aranjo, P | 1 |
| Ciszewski, L | 1 |
| Mazurek, AP | 1 |
| Dohi, Y | 1 |
| Kojima, M | 1 |
| Sato, K | 1 |
| Parravicini, F | 1 |
| Scarpitta, G | 1 |
| Dorigotti, L | 1 |
| Pifferi, G | 1 |
| Reiterer, W | 1 |
| Czitober, H | 1 |
| Markiewicz, K | 1 |
| Górski, L | 1 |
| Cholewa, M | 1 |
10 other studies available for todralazine and Hypertension
| Article | Year |
|---|---|
[Effect of various hypotensive drugs on the plasma level of kininogen and prekallikrein in hypertension].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Furosemide; Humans; Hypertension; Kallikrein | 1980 |
[Phthalazine derivatives in the treatment of arterial hypertension].
Topics: Arterioles; Blood Pressure; Humans; Hydralazine; Hydrazines; Hypertension; Todralazine; Vasodilator | 1981 |
[Hypotensive action of binazine in the light of our studies].
Topics: Adult; Aged; Female; Humans; Hydrazines; Hypertension; Hypertension, Renal; Male; Middle Aged; Todra | 1980 |
Acute systemic toxicity and antihypertensive activity of a novel todralazine analog in rats.
Topics: Animals; Blood Pressure; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Todralazine | 1993 |
Benidipine improves endothelial function in renal resistance arteries of hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropy | 1996 |
[3-Hydrazinepyridazine derivatives. III. Synthesis and anti-hypertensive activity of new 3-(2-acylhydrazine)-pyridazine-6-alkylamino substitutes].
Topics: Animals; Antihypertensive Agents; Hydralazine; Hydrazines; Hypertension; Pyridazines; Rats; Todralaz | 1979 |
[The influence of guanazodine and todralazine on blood pressure regulation during dynamic and static exercise in essential hypertension (author's transl)].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Female; Guanidines; Heart Rate; Humans; Hydrazines; | 1977 |
[Value of simultaneous administration of propranolol, binazine and furosemide in the treatment of hypertension].
Topics: Adult; Drug Therapy, Combination; Female; Furosemide; Humans; Hydrazines; Hypertension; Male; Middle | 1977 |
[Value of simultaneous administration of Propranolol and Binazin in the treatment of arterial hypertension].
Topics: Adult; Drug Therapy, Combination; Female; Humans; Hydrazines; Hypertension; Male; Middle Aged; Propr | 1975 |
Post-exertion changes in left ventricular systolic time intervals in patients with primary hypertension treated with hydrochlorothiazide, binazine, and propranolol.
Topics: Adult; Aged; Female; Heart Ventricles; Humans; Hydrazines; Hydrochlorothiazide; Hypertension; Male; | 1985 |