toceranib-phosphate and Leukemia--Myeloid

Treatment of chronic monocytic leukemia (CMoL) in dogs has traditionally consisted of hydroxyurea. The use of tyrosine kinase inhibitors has been proposed as a treatment option for dogs with CMoL but has never been reported. We report a case of CMoL in a young dog that achieved clinical remission with treatment with the tyrosine kinase inhibitor toceranib and prednisone.

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Dog Diseases; Dogs; Female; Fusion Proteins, bcr-abl; In Situ Hybridization, Fluorescence; Indoles; Leukemia, Myeloid; Prednisone; Pyrroles; Translocation, Genetic; Treatment Outcome