Page last updated: 2024-08-23

tobramycin and Disease Models, Animal

tobramycin has been researched along with Disease Models, Animal in 87 studies

Research

Studies (87)

TimeframeStudies, this research(%)All Research%
pre-199014 (16.09)18.7374
1990's18 (20.69)18.2507
2000's21 (24.14)29.6817
2010's26 (29.89)24.3611
2020's8 (9.20)2.80

Authors

AuthorsStudies
Borrell, N; Maciá, MD; Moya, B; Oliver, A; Pérez, JL; Plasencia, V1
Dudley, MN; Griffith, DC; Miller, CE; Nolan, TG; Sabet, M; Senekeo-Effenberger, K1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV1
Andrén, PE; Becker, K; Berruga-Fernández, T; Böttger, EC; Brönstrup, M; Cao, S; Crich, D; Erlandsson, M; Friberg, LE; Grinberga, S; Haldimann, K; Hansen, J; Hobbie, SN; Hotop, SK; Hughes, D; Huseby, DL; Kuka, J; Liepinsh, E; Lindmark, E; Nilsson, A; Platzack, B; Shariatgorji, R; Vingsbo Lundberg, C1
Kopecki, Z; Kral, A; Prestidge, CA; Thomas, N; Thorn, CR; Wignall, A1
Awad, R; Couet, W; Marchand, S; Tewes, F; Torres, BGS1
Christophersen, L; Henneberg, KÅ; Høiby, N; Kragh, KN; Laulund, AS; Lerche, CJ; Moser, C; Sams, T; Schwartz, FA; Svanekjær, T; Thomsen, K1
Bian, M; Fu, X; Gao, Y; Li, Z; Lv, B; Sun, F; Wang, Y1
Hu, R; Huang, X; Jin, X; Yuan, K; Zhang, L; Zhu, B1
Larsson, A; Lipcsey, M; Maudsdotter, L; Sjölin, J; Skorup, P1
Abdelsamie, AS; Bals, R; Berwanger, A; Blankenfeldt, W; Börger, C; Christmann, R; Empting, M; Hamed, MM; Hartmann, RW; Herr, C; Hirsch, AKH; Ho, DK; Horstmann, JC; Kany, AM; Koch, M; Lehr, CM; Loretz, B; Murgia, X; Röhrig, T; Rox, K; Schmelz, S; Schütz, C; Scrima, A; Siebenbürger, L; Wirth, M; Yahiaoui, S1
Caljon, G; Cappoen, D; Coenye, T; Cools, F; Cos, P; Delputte, P; Maes, L; Maira, BM; Martinet, W; Torfs, E; Vanhoutte, B1
Armstrong, ME; Bernhagen, J; Bucala, R; Caraher, E; Cooke, G; Donnelly, SC; Fabre, A; Jülicher, K; Kennedy, S; Leng, L; Maher, L; Mawhinney, L; McKone, EF; O'Dwyer, D; O'Reilly, C; Schaffer, K; Tynan, A1
Castegren, M; Larsson, A; Lipcsey, M; Maudsdotter, L; Sjölin, J; Skorup, P; Tano, E1
Bähre, H; Felgner, S; Häussler, S; Müsken, M; Pawar, V; Schwebs, T; Weiss, S1
Abba, Y; Karunanidhi, A; Lulu, GA; Mohamad Yusof, L; Mohd Fauzi, F; Othman, F1
Davis, S; Doiron, A; Gil, J; Goodwine, J; Higa, A; Sauer, K; Solis, M; Valdes, J1
Caceres, S; Caverly, L; Fratelli, C; Kim, SH; Malcolm, K; Moskowitz, S; Nichols, DP; Nick, JA; Poch, KR; Saavedra, M; Solomon, G; Taylor-Cousar, J1
Brown, D; Drusano, GL; Fikes, S; Liu, W; Louie, A1
Murray, CK; Penn-Barwell, JG; Wenke, JC1
Ambrose, CG; Clyburn, TA; Gogola, GR; Kaplan, HB; Mika, J; Mikos, AG; Wanger, A1
Babcock, CI; Cook, KE; Fabiilli, ML; Fowlkes, JB; Orizondo, RA; Pavlovsky, L; Younger, JG1
Castegren, M; Jonsson, AB; Larsson, A; Lipcsey, M; Maudsdotter, L; Sjölin, J; Skorup, P1
Bielecki, P; Gocht, B; Häussler, S; Kasnitz, N; Komor, U; Moter, A; Pawar, V; Pils, MC; Rohde, M; Weiss, S1
Bundgaard, H; Christophersen, LJ; Hougen, HP; Høiby, N; Jensen, PØ; Lerche, CJ; Moser, C; Thomsen, K; Trøstrup, H1
Douce, GR; Evans, TJ; McCaughey, LC; Ritchie, ND; Walker, D1
Monogue, ML; Nicolau, DP1
Brackman, G; Cappoen, D; Coenye, T; Cos, P; Crabbé, A; Rigole, P; Van den Driessche, F; Vanhoutte, B; Vercruysse, J; Verstraete, G; Vervaet, C1
Naranjo-Tackman, R; Stangogiannis-Druya, C; Stangogiannis-Druya, E; Vanzzini, V; Villar-Kurí, J1
Algotsson, L; Carlsson, M; Eriksson, M; Larsson, A; Lipcsey, M; Lukinius, A; Sjölin, J1
Bjarnsholt, T; Calum, H; Christensen, LD; Christophersen, L; Ciofu, O; Givskov, M; Hougen, HP; Høiby, N; Jensen, PØ; Molin, S; Moser, C; van Gennip, M1
Noble, DW1
Gordon, YJ; Kowalski, RP; Mah, FS; Romanowski, EG; Shanks, RM1
Bhattacharjee, PS; Capriotti, JA; Clement, C; Foster, TP; Hill, JM; Hobden, JA; Kumar, M; Liang, B; Mahmud, R; Thompson, HW1
Balzli, CL; Caballero, AR; McCormick, CC; O'Callaghan, RJ; Tang, A1
Li, Y; Liu, MT; Sheng, MY; Zhang, Y1
Bhavsar, T; Cantor, J; Liu, M; Liu, X1
Alhede, M; Bjarnsholt, T; Christensen, LD; Givskov, M; Hougen, HP; Høiby, N; Jakobsen, TH; van Gennip, M1
Asseray, N; Bugnon, D; Caillon, J; Dubé, L; Jacqueline, C; Potel, G1
Douglas, G; Erickson, G; Grayson, JK; Large, TM1
Calhoun, JH; Lathrop, JT; Mader, JT; Ruble, R; Stevens, CM; Stevens, JH1
Contag, PR; Francis, KP; Kadurugamuwa, JL; Kimura, R; Purchio, T; Sin, LV; Yu, J1
Dickson, EW; Doern, GV; Heard, SO; Mazzoni, M; Trevino, L1
Fleiszig, SM; Lee, EJ; Mendoza, MN; Truong, TN1
Ambrose, CG; Clyburn, TA; Gogola, GR; Gulati, P; Joseph, J; Louden, K; Mikos, AG; Wright, J1
Bugnon, D; Caillon, J; Gras-Le Guen, C; Jacqueline, C; Kergueris, MF; Navas, D; Potel, G1
Ariza, J; Ayats, J; Borraz, C; Cabellos, C; Corbella, X; Doménech, A; Gudiol, F; Montero, A; Tubau, F1
Borrell, N; Gómez, C; Maciá, MD; Oliver, A; Pérez, JL; Segura, M1
Brooks, DE; Owens, BD; Svoboda, SJ; Wenke, JC1
Alvarez, FG; Amorena, B; García-Alvarez, F; García-Alvarez, I; Grasa, JM; Laclériga, A; Monzón, M; Navarro-Zorraquino, M1
Benghuzzi, H; Franklin, L; Marks, T; Patel, R; Russell, G; Tucci, M; Wingerter, S; Woodall, J1
Gordon, YJ; Kowalski, RP; Mah, FS; Romanowski, EG; Yates, KA1
Bouchard, CS; Bu, P; Carey, R; Riske, PS; Zaya, NE1
Balzli, C; Caballero, A; McCormick, C; O'Callaghan, R; Song, J; Tang, A1
Davis, SD; Hyndiuk, RA; Sarff, LD3
Pieper, JA; Schentag, JJ; Vidal, RA1
Fernández-del Castillo, C; Ferraro, MJ; Foitzik, T; Mithöfer, K; Rattner, DW; Warshaw, AL1
Callegan, MC; Engel, LS; Hill, JM; Hobden, JA; O'Callaghan, RJ; Reidy, JJ1
Carbon, C; Crémieux, AC; Devine, C; Muffat-Joly, M; Pocidalo, JJ; Saleh-Mghir, A; Vallois, JM1
Cohen, KL; Lauffenburger, MD1
Dickneite, G; Pâques, EP1
Chen, JS; Liang, HP; Lu, LR; Sheng, ZY; Shi, ZG; Yao, YM; Yu, Y; Zhou, BT1
Battles, A; Liu, QF; Liu, W; Louie, A; Miller, DA; Miller, MH; Sucke, AC1
Hirner, A; Späth, G1
Fagrhi, M; Rosenberg, B; Seligson, D; Voos, K1
Beaulac, C; Lagacé, J; Sachetelli, S1
Amorena, B; García-Alvarez, F; Gracia, E; Laclériga, A; Leiva, J; Monzón, M; Oteiza, C1
Bennet, WM; Gilbert, DN; Houghton, DC; Plamp, C; Porter, G; Starr, P1
Belfort, R; Kim, HB; Okumoto, M; Siverio, CE; Smolin, G1
Eckert, P; Eichen, R; Schassan, HH1
Hatala, M; Liska, M; Modr, Z; Morávek, J; Prát, V1
Gilman, JT; Kearns, GL; Möller, JC; Raszynski, A; Reed, MD; Sussmane, JB; Wolfsdorf, J1
Clinch, TE; Engel, LS; Hill, JM; Hobden, JA; Kaufmann, HE; O'Callaghan, RJ1
Assil, KK; Brown, SI; Douglas, H; Frucht-Perry, J; Schanzlin, DJ; Weinreb, RN; Ziegler, E1
Gonzalez, VH; Gritz, DC; Kwitko, S; McDonnell, PJ; Trousdale, MD1
Gritz, DC; Gwon, A; Hubbard, BB; Lee, TY; McDonnell, PJ; Tang-Liu, D1
Petri, WH1
Kowalski, RP; Stuart, JC; Turgeon, PT1
Gritz, DC; Kwitko, S; Lee, TY; McDonnell, PJ1
Azancot, A; Bouvet, A; Carbon, C; Cremieux, AC; Maziere, B; Ottaviani, M; Pocidalo, JJ; Raffoul, H; Vallois, JM1
Gilbert, ML; Osato, MS; Wilhelmus, KR2
Chambers, HF; Hackbarth, CJ; Sande, MA; Shibl, AM; Stella, F1
Kapusnik, JE; Sande, MA1
Antsiferova, NG; Moroz, AF; Radkevich, SA; Vetkova, LG1

Other Studies

87 other study(ies) available for tobramycin and Disease Models, Animal

ArticleYear
Influence of high mutation rates on the mechanisms and dynamics of in vitro and in vivo resistance development to single or combined antipseudomonal agents.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Ceftazidime; Ciprofloxacin; Disease Models, Animal; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Female; Humans; In Vitro Techniques; Lung; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Mutation; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin

2007
Efficacy of aerosol MP-376, a levofloxacin inhalation solution, in models of mouse lung infection due to Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:9

    Topics: Administration, Inhalation; Aerosols; Animals; Anti-Bacterial Agents; Aztreonam; Disease Models, Animal; Female; Levofloxacin; Lung Diseases; Mice; Microbial Sensitivity Tests; Ofloxacin; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin

2009
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

2020
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
    EBioMedicine, 2021, Volume: 73

    Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Humans; Hydrogen-Ion Concentration; Mice; Microbial Sensitivity Tests; Nebramycin; Pyelonephritis; Rats; Treatment Outcome; Urinary Tract Infections

2021
Liquid Crystal Nanoparticles Enhance Tobramycin Efficacy in a Murine Model of
    ACS infectious diseases, 2022, 04-08, Volume: 8, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Biofilms; Disease Models, Animal; Liquid Crystals; Mice; Nanoparticles; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin; Wound Infection

2022
In vitro evaluation of Pseudomonas aeruginosa chronic lung infection models: Are agar and calcium-alginate beads interchangeable?
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2019, Volume: 143

    Topics: Agar; Alginates; Animals; Anti-Bacterial Agents; Ciprofloxacin; Disease Models, Animal; Lung; Pseudomonas aeruginosa; Pseudomonas Infections; Respiratory Tract Infections; Tobramycin

2019
In vivo demonstration of Pseudomonas aeruginosa biofilms as independent pharmacological microcompartments.
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2020, Volume: 19, Issue:6

    Topics: Alginates; Animals; Biofilms; Cystic Fibrosis; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Pseudomonas aeruginosa; Tobramycin

2020
5-Methylindole Potentiates Aminoglycoside Against Gram-Positive Bacteria Including
    Frontiers in cellular and infection microbiology, 2020, Volume: 10

    Topics: Adenosine Triphosphate; Aminoglycosides; Animals; Anti-Bacterial Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combination; Enterococcus faecalis; Indoles; Male; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Osmotic Pressure; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Streptococcus pyogenes; Tobramycin; Wound Healing

2020
Neutrophil extracellular traps may have a dual role in Pseudomonas aeruginosa keratitis.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2021, Volume: 40, Issue:1

    Topics: Animals; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Extracellular Traps; Keratitis; Male; Mice; Mice, Inbred C57BL; Neutrophils; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin

2021
Mode of bacterial killing affects the inflammatory response and associated organ dysfunctions in a porcine E. coli intensive care sepsis model.
    Critical care (London, England), 2020, 11-14, Volume: 24, Issue:1

    Topics: Animals; Cefuroxime; Disease Models, Animal; Endotoxins; Escherichia coli; Escherichia coli Infections; Inflammation; Interleukin-10; Interleukin-6; Multiple Organ Failure; Organ Dysfunction Scores; Penicillin-Binding Proteins; Prospective Studies; Sepsis; Swine; Tobramycin; Tumor Necrosis Factor-alpha

2020
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021, Volume: 8, Issue:12

    Topics: Animals; Biofilms; Disease Models, Animal; Mice; Pseudomonas aeruginosa; Pseudomonas Infections; Quinolones; Quorum Sensing; Tobramycin

2021
Optimization and characterization of a murine lung infection model for the evaluation of novel therapeutics against Burkholderia cenocepacia.
    Journal of microbiological methods, 2017, Volume: 139

    Topics: Animals; Anti-Bacterial Agents; Burkholderia cenocepacia; Burkholderia Infections; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Liver; Lung; Mice; Mice, Inbred BALB C; Pneumonia; Respiratory Tract Infections; Spleen; Tobramycin

2017
Macrophage migration inhibitory factor enhances
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017, Volume: 31, Issue:11

    Topics: Animals; Biofilms; Cystic Fibrosis; Disease Models, Animal; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Mice; Pseudomonas aeruginosa; Recombinant Proteins; Tobramycin

2017
Dynamics of Endotoxin, Inflammatory Variables, and Organ Dysfunction After Treatment With Antibiotics in an Escherichia coli Porcine Intensive Care Sepsis Model.
    Critical care medicine, 2018, Volume: 46, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Cefuroxime; Disease Models, Animal; Drug Therapy, Combination; Endotoxins; Escherichia coli Infections; Female; Inflammation; Interleukin-6; Leukocyte Count; Male; Multiple Organ Failure; Sepsis; Swine; Tobramycin; Tumor Necrosis Factor-alpha

2018
Breaking the Vicious Cycle of Antibiotic Killing and Regrowth of Biofilm-Residing
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Biofilms; Colistin; Colonic Neoplasms; Colony Count, Microbial; Disease Models, Animal; Drug Administration Schedule; Drug Dosage Calculations; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin; Treatment Outcome

2018
In vivo efficacy of tobramycin-loaded synthetic calcium phosphate beads in a rabbit model of staphylococcal osteomyelitis.
    Annals of clinical microbiology and antimicrobials, 2018, Dec-28, Volume: 17, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Calcium Phosphates; Disease Models, Animal; Drug Delivery Systems; Humans; Male; Osteomyelitis; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Tobramycin

2018
Pyruvate-depleting conditions induce biofilm dispersion and enhance the efficacy of antibiotics in killing biofilms in vitro and in vivo.
    Scientific reports, 2019, 03-06, Volume: 9, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Biofilms; Burns; Culture Media; Disease Models, Animal; Fermentation; Humans; Pseudomonas aeruginosa; Pseudomonas Infections; Pyruvic Acid; Staphylococcus aureus; Swine; Tobramycin

2019
Effects of azithromycin in Pseudomonas aeruginosa burn wound infection.
    The Journal of surgical research, 2013, Volume: 183, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Azithromycin; Burns; Ciprofloxacin; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Male; Mice; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin; Treatment Outcome; Wound Infection

2013
Impact of meropenem in combination with tobramycin in a murine model of Pseudomonas aeruginosa pneumonia.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Female; Humans; Lung; Meropenem; Mice; Microbial Sensitivity Tests; Models, Theoretical; Pneumonia, Bacterial; Pseudomonas aeruginosa; Thienamycins; Tobramycin; Treatment Outcome

2013
Local antibiotic delivery by a bioabsorbable gel is superior to PMMA bead depot in reducing infection in an open fracture model.
    Journal of orthopaedic trauma, 2014, Volume: 28, Issue:6

    Topics: Absorbable Implants; Administration, Topical; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Carriers; Femoral Fractures; Fractures, Open; Gels; Gentamicins; Polymethyl Methacrylate; Rats; Staphylococcal Infections; Staphylococcus aureus; Surgical Wound Infection; Tobramycin; Vancomycin

2014
Evaluation of antibiotic-impregnated microspheres for the prevention of implant-associated orthopaedic infections.
    The Journal of bone and joint surgery. American volume, 2014, Jan-15, Volume: 96, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Delivery Systems; Male; Microspheres; Prostheses and Implants; Prosthesis Implantation; Prosthesis-Related Infections; Rabbits; Random Allocation; Reference Values; Sensitivity and Specificity; Staphylococcal Infections; Tobramycin; Treatment Outcome

2014
Characterization of a reverse-phase perfluorocarbon emulsion for the pulmonary delivery of tobramycin.
    Journal of aerosol medicine and pulmonary drug delivery, 2014, Volume: 27, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Biofilms; Disease Models, Animal; Drug Delivery Systems; Fluorocarbons; Lung; Male; Pseudomonas aeruginosa; Pseudomonas Infections; Rats; Rats, Sprague-Dawley; Surface Tension; Time Factors; Tobramycin; Viscosity

2014
Beneficial antimicrobial effect of the addition of an aminoglycoside to a β-lactam antibiotic in an E. coli porcine intensive care severe sepsis model.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Bacteremia; Bacterial Load; Cefuroxime; Critical Care; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Escherichia coli; Escherichia coli Infections; Female; Humans; Immunity, Innate; Liver; Male; Sepsis; Spleen; Swine; Tobramycin

2014
In Vivo Efficacy of Antimicrobials against Biofilm-Producing Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8

    Topics: Animals; Anti-Infective Agents; Biofilms; Cell Line, Tumor; Colistin; Cystic Fibrosis; Disease Models, Animal; Female; Lung Diseases; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin

2015
Low efficacy of tobramycin in experimental Staphylococcus aureus endocarditis.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2015, Volume: 34, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Aortic Valve; Bacterial Load; Cytokines; Disease Models, Animal; Endocarditis, Bacterial; Myocardium; Rats, Wistar; Spleen; Staphylococcal Infections; Staphylococcus aureus; Tobramycin; Treatment Outcome

2015
Efficacy of species-specific protein antibiotics in a murine model of acute Pseudomonas aeruginosa lung infection.
    Scientific reports, 2016, 07-22, Volume: 6

    Topics: Animals; Anti-Bacterial Agents; Bacteriocins; Disease Models, Animal; Female; Lung; Lung Diseases; Mice; Mice, Inbred C57BL; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocins; Species Specificity; Tobramycin

2016
In Vitro-In Vivo Discordance with Humanized Piperacillin-Tazobactam Exposures against Piperacillin-Tazobactam-Resistant/Pan-β-Lactam-Susceptible Escherichia coli.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Cephalosporins; Colistin; Culture Media; Disease Models, Animal; Drug Administration Schedule; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Female; Humans; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Neutropenia; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tobramycin; Treatment Outcome

2016
Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: A549 Cells; Animals; Biofilms; Burkholderia cenocepacia; Burkholderia Infections; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Econazole; Female; Humans; Mice; Mice, Inbred BALB C; Miconazole; Pneumonia, Bacterial; Tobramycin

2017
[Bacterial corneal ulcer treated with intrastromal antibiotic. Experimental model in vivo].
    Archivos de la Sociedad Espanola de Oftalmologia, 2009, Volume: 84, Issue:3

    Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Cornea; Corneal Stroma; Corneal Ulcer; Data Interpretation, Statistical; Disease Models, Animal; Female; Gentamicins; Ofloxacin; Prospective Studies; Pseudomonas Infections; Rabbits; Tobramycin; Treatment Outcome

2009
Effect of a single dose of tobramycin on systemic inflammatory response-induced acute kidney injury in a 6-hour porcine model.
    Critical care medicine, 2009, Volume: 37, Issue:10

    Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Anti-Bacterial Agents; Biopsy; Creatinine; Cystatin C; Disease Models, Animal; Electrolytes; Endotoxins; Escherichia coli; Kidney; Kidney Function Tests; Microscopy, Electron, Transmission; Swine; Systemic Inflammatory Response Syndrome; Tobramycin; Water-Electrolyte Balance

2009
Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa.
    The Journal of antimicrobial chemotherapy, 2009, Volume: 64, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Chemokine CXCL2; Colony Count, Microbial; Cystic Fibrosis; Disease Models, Animal; Female; Granulocyte Colony-Stimulating Factor; Humans; Lung; Mice; Mice, Inbred BALB C; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Severity of Illness Index; Time Factors; Tobramycin

2009
Aminoglycosides--engineering important patient-centered outcomes with antibiotics.
    Critical care medicine, 2009, Volume: 37, Issue:10

    Topics: Acute Kidney Injury; Aminoglycosides; Animals; Anti-Bacterial Agents; Creatinine; Cystatin C; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Intensive Care Units; Kidney Function Tests; Swine; Systemic Inflammatory Response Syndrome; Tobramycin; Treatment Outcome; Water-Electrolyte Balance

2009
Topical levofloxacin 1.5% overcomes in vitro resistance in rabbit keratitis models.
    Acta ophthalmologica, 2010, Volume: 88, Issue:4

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Cefazolin; Ciprofloxacin; Colony Count, Microbial; Corneal Stroma; Corneal Ulcer; Disease Models, Animal; Drug Resistance, Bacterial; Eye Infections, Bacterial; Levofloxacin; Ofloxacin; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Tobramycin; Vancomycin

2010
Clinical and antiviral efficacy of an ophthalmic formulation of dexamethasone povidone-iodine in a rabbit model of adenoviral keratoconjunctivitis.
    Investigative ophthalmology & visual science, 2011, Volume: 52, Issue:1

    Topics: Adenoviridae; Adenoviridae Infections; Animals; Anti-Infective Agents, Local; Cidofovir; Conjunctiva; Conjunctivitis, Viral; Cytosine; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Ophthalmic Solutions; Organophosphonates; Pharmaceutical Preparations; Povidone-Iodine; Rabbits; Tobramycin; Treatment Outcome; Viral Plaque Assay

2011
The effectiveness of an improved combination therapy for experimental Staphylococcus aureus keratitis.
    Advances in therapy, 2010, Volume: 27, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Colony Count, Microbial; Cornea; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Eye Infections, Bacterial; Keratitis; Polysaccharides, Bacterial; Prednisolone; Pseudomonas Infections; Rabbits; Tobramycin

2010
[Combined application of ciprofloxacin and tobramycin on mutant selective windows of ciprofloxacin against Pseudomonas aeruginosa].
    Zhonghua yi xue za zhi, 2011, May-31, Volume: 91, Issue:20

    Topics: Animals; Ciprofloxacin; Disease Models, Animal; Drug Resistance, Bacterial; Drug Therapy, Combination; Microbial Sensitivity Tests; Mutation; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Tobramycin

2011
Aerosolized recombinant human lysozyme enhances the bactericidal effect of tobramycin in a hamster model of Pseudomonas aeruginosa-induced pneumonia.
    Experimental lung research, 2011, Volume: 37, Issue:9

    Topics: Administration, Inhalation; Animals; Anti-Bacterial Agents; Bronchoalveolar Lavage Fluid; Cricetinae; Disease Models, Animal; Drug Synergism; Female; Humans; Lung; Mesocricetus; Muramidase; Neutrophils; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Recombinant Proteins; Tobramycin

2011
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Foreign Bodies; Histocytochemistry; Mice; Mice, Inbred BALB C; Peritonitis; Pseudomonas aeruginosa; Pseudomonas Infections; Quorum Sensing; Tobramycin

2012
The optimal aminoglycoside and its dosage for the treatment of severe Enterococcus faecalis infection. An experimental study in the rabbit endocarditis model.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2012, Volume: 31, Issue:10

    Topics: Amikacin; Animals; Anti-Bacterial Agents; Bacterial Load; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Endocarditis, Bacterial; Enterococcus faecalis; Female; Gentamicins; Gram-Positive Bacterial Infections; Netilmicin; Rabbits; Time Factors; Tobramycin

2012
Effect of negative pressure wound therapy on the elution of antibiotics from polymethylmethacrylate beads in a porcine simulated open femur fracture model.
    Journal of orthopaedic trauma, 2012, Volume: 26, Issue:9

    Topics: Animals; Anti-Bacterial Agents; Body Fluids; Disease Models, Animal; Dosage Forms; Fasciotomy; Female; Femoral Fractures; Fractures, Open; Male; Microspheres; Negative-Pressure Wound Therapy; Polymethyl Methacrylate; Swine; Tobramycin; Treatment Outcome; Vancomycin

2012
Treatment of experimental osteomyelitis with a fibrin sealant antibiotic implant.
    Clinical orthopaedics and related research, 2002, Issue:403

    Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Implants; Female; Fibrin Tissue Adhesive; Microbial Sensitivity Tests; Osteomyelitis; Polymethyl Methacrylate; Rabbits; Tissue Adhesives; Tobramycin; Vasodilator Agents

2002
Rapid direct method for monitoring antibiotics in a mouse model of bacterial biofilm infection.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:10

    Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Biofilms; Catheterization; Ciprofloxacin; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Monitoring; Luminescent Measurements; Mice; Rifampin; Staphylococcus aureus; Tobramycin

2003
Prevention of descending pneumonia in rts with perflubron-delivered tobramycin.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2003, Volume: 10, Issue:10

    Topics: Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Disease Models, Animal; Intubation; Klebsiella Infections; Klebsiella pneumoniae; Pneumonia, Bacterial; Prospective Studies; Rats; Rats, Wistar; Tobramycin; Ventilators, Mechanical

2003
A comparison of invasive and cytotoxic Pseudomonas aeruginosa strain-induced corneal disease responses to therapeutics.
    Current eye research, 2003, Volume: 27, Issue:5

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Cornea; Corneal Ulcer; Disease Models, Animal; Drug Therapy, Combination; Eye Infections, Bacterial; Female; Glucocorticoids; Mice; Mice, Inbred C57BL; Ofloxacin; Prednisolone; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin

2003
Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model.
    Clinical orthopaedics and related research, 2004, Issue:421

    Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Cefazolin; Disease Models, Animal; Drug Carriers; Infusions, Parenteral; Lactic Acid; Male; Microspheres; Osteomyelitis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Polymethyl Methacrylate; Rabbits; Radiography; Radius; Staphylococcal Infections; Tobramycin

2004
Comparison of in vivo intrinsic activity of cefepime and imipenem in a Pseudomonas aeruginosa rabbit endocarditis model: effect of combination with tobramycin simulating human serum pharmacokinetics.
    The Journal of antimicrobial chemotherapy, 2004, Volume: 54, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Cefepime; Cephalosporins; Disease Models, Animal; Drug Therapy, Combination; Endocarditis, Bacterial; Female; Humans; Imipenem; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Tobramycin

2004
Antibiotic combinations for serious infections caused by carbapenem-resistant Acinetobacter baumannii in a mouse pneumonia model.
    The Journal of antimicrobial chemotherapy, 2004, Volume: 54, Issue:6

    Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Anti-Bacterial Agents; beta-Lactams; Carbapenems; Colistin; Disease Models, Animal; Drug Resistance, Bacterial; Drug Therapy, Combination; Female; Humans; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pneumonia, Bacterial; Rifampin; Tobramycin

2004
Efficacy and potential for resistance selection of antipseudomonal treatments in a mouse model of lung infection by hypermutable Pseudomonas aeruginosa.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Disease Models, Animal; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Female; Lung; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Mutation; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin

2006
Effectiveness of commercially-available antibiotic-impregnated implants.
    The Journal of bone and joint surgery. British volume, 2006, Volume: 88, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Bone Diseases, Infectious; Calcium Sulfate; Colony Count, Microbial; Disease Models, Animal; Drug Implants; Fractures, Bone; Goats; Male; Microspheres; Polymethyl Methacrylate; Staphylococcus aureus; Tobramycin; Treatment Outcome

2006
Interleukin-1, interleukin-6, and interleukin-10 responses after antibiotic treatment in experimental chronic Staphylococcus aureus osteomyelitis.
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2006, Volume: 11, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Biofilms; Cefuroxime; Chronic Disease; Ciprofloxacin; Disease Models, Animal; Interleukin-1; Interleukin-10; Interleukin-6; Interleukins; Male; Osteomyelitis; Rats; Rats, Wistar; Staphylococcal Infections; Tibia; Tobramycin; Vancomycin

2006
Histological and radiographic comparison of allograft substitutes using a continuous delivery model in segmental defects.
    Biomedical sciences instrumentation, 2007, Volume: 43

    Topics: Animals; Anti-Bacterial Agents; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Bone Substitutes; Delayed-Action Preparations; Disease Models, Animal; Drug Combinations; Femoral Fractures; Femur; Fracture Healing; Radiography; Rats; Rats, Sprague-Dawley; Tobramycin; Transforming Growth Factor beta; Transplantation, Homologous; Treatment Outcome

2007
Zymar (Gatifloxacin 0.3%) shows excellent Gram-negative activity against Serratia marcescens and Pseudomonas aeruginosa in a New Zealand White rabbit keratitis model.
    Cornea, 2007, Volume: 26, Issue:5

    Topics: Animals; Anti-Infective Agents; Ciprofloxacin; Colony Count, Microbial; Corneal Ulcer; Disease Models, Animal; Eye Infections, Bacterial; Female; Fluoroquinolones; Gatifloxacin; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Serratia Infections; Serratia marcescens; Tobramycin

2007
A comparison of topical chlorhexidine, ciprofloxacin, and fortified tobramycin/cefazolin in rabbit models of Staphylococcus and Pseudomonas keratitis.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2007, Volume: 23, Issue:3

    Topics: Administration, Topical; Animals; Anti-Infective Agents, Local; Cefazolin; Chlorhexidine; Ciprofloxacin; Colony Count, Microbial; Cornea; Disease Models, Animal; Drug Combinations; Eye Infections, Bacterial; Keratitis; Microbial Sensitivity Tests; Ophthalmic Solutions; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Tobramycin

2007
Effectiveness of a new tobramycin (0.3%) and dexamethasone (0.05%) formulation in the treatment of experimental Pseudomonas keratitis.
    Current medical research and opinion, 2008, Volume: 24, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Dexamethasone; Disease Models, Animal; Drug Compounding; Eye Infections, Bacterial; Keratitis; Polysaccharides, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Random Allocation; Tobramycin; Treatment Outcome

2008
Relative efficacy of the topical use of amikacin, gentamicin and tobramycin in experimental Pseudomonas keratitis.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1980, Volume: 15, Issue:1

    Topics: Amikacin; Animals; Anti-Bacterial Agents; Disease Models, Animal; Gentamicins; Guinea Pigs; Keratitis; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin

1980
Animal model distinguishing in vitro from in vivo carbenicillin-aminoglycoside interactions.
    Antimicrobial agents and chemotherapy, 1980, Volume: 18, Issue:4

    Topics: Aminoglycosides; Animals; Biological Assay; Carbenicillin; Disease Models, Animal; Dogs; Drug Interactions; Drug Stability; Kidney Diseases; Penicillinase; Radioimmunoassay; Tobramycin

1980
Pathogenesis and prevention of early pancreatic infection in experimental acute necrotizing pancreatitis.
    Annals of surgery, 1995, Volume: 222, Issue:2

    Topics: Acute Disease; Administration, Oral; Amphotericin B; Animals; Bacteria; Bacterial Infections; Bacterial Physiological Phenomena; Cecal Diseases; Cefotaxime; Colistin; Disease Models, Animal; Drug Therapy, Combination; Imipenem; Injections, Intravenous; Kidney Diseases; Male; Necrosis; Pancreas; Pancreatic Diseases; Pancreatitis; Rats; Rats, Sprague-Dawley; Survival Rate; Tobramycin

1995
Effectiveness of specific antibiotic/steroid combinations for therapy of experimental Pseudomonas aeruginosa keratitis.
    Current eye research, 1995, Volume: 14, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Colony Count, Microbial; Cornea; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Eye Infections, Bacterial; Glucocorticoids; Keratitis; Ophthalmic Solutions; Prednisolone; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Tobramycin

1995
Influence of the pre-treatment duration of infection on the efficacies of various antibiotic regimens in experimental streptococcal endocarditis.
    The Journal of antimicrobial chemotherapy, 1993, Volume: 32, Issue:6

    Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Endocarditis, Bacterial; Female; Injections, Intramuscular; Penicillin G Procaine; Rabbits; Species Specificity; Streptococcal Infections; Streptococcus; Teicoplanin; Time Factors; Tobramycin

1993
Topical ciprofloxacin versus topical fortified antibiotics in rabbit models of Staphylococcus and Pseudomonas keratitis.
    Cornea, 1993, Volume: 12, Issue:6

    Topics: Administration, Topical; Animals; Cefazolin; Ciprofloxacin; Colony Count, Microbial; Cornea; Disease Models, Animal; Drug Therapy, Combination; Eye Infections, Bacterial; Keratitis; Ophthalmic Solutions; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Tobramycin

1993
Reduction of mortality with antithrombin III in septicemic rats: a study of Klebsiella pneumoniae induced sepsis.
    Thrombosis and haemostasis, 1993, Feb-01, Volume: 69, Issue:2

    Topics: Animals; Antithrombin III; Bacteremia; Disease Models, Animal; Disseminated Intravascular Coagulation; Drug Therapy, Combination; Female; Klebsiella Infections; Klebsiella pneumoniae; Lipopolysaccharides; Rats; Tobramycin

1993
Influence of selective decontamination of the digestive tract on cell-mediated immune function and bacteria/endotoxin translocation in thermally injured rats.
    The Journal of trauma, 1997, Volume: 42, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Bacterial Translocation; Burns; Cell Division; Cells, Cultured; Colistin; Digestive System; Disease Models, Animal; Endotoxins; Flucytosine; Immunity, Cellular; Immunosuppression Therapy; Interleukin-2; Intestines; Lymphocyte Subsets; Rats; Rats, Sprague-Dawley; Spleen; Tobramycin

1997
Predictive value of several signs of infection as surrogate markers for mortality in a neutropenic guinea pig model of Pseudomonas aeruginosa sepsis.
    Laboratory animal science, 1997, Volume: 47, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Biomarkers; Ceftazidime; Cephalosporins; Diarrhea; Disease Models, Animal; Female; Guinea Pigs; Imipenem; Meropenem; Movement Disorders; Neutropenia; Predictive Value of Tests; Pseudomonas Infections; Regression Analysis; Respiration; Thienamycins; Time Factors; Tobramycin; Weight Loss

1997
Microbial translocation and impairment of mucosal immunity induced by an elemental diet in rats is prevented by selective decontamination of the digestive tract.
    The European journal of surgery = Acta chirurgica, 1998, Volume: 164, Issue:3

    Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Bacterial Translocation; Colistin; Culture Techniques; Digestive System; Disease Models, Animal; Female; Food, Formulated; Fungi; Gram-Negative Bacteria; Intestinal Mucosa; Parenteral Nutrition, Total; Probability; Rats; Rats, Inbred Strains; Tobramycin

1998
Use of a tobramycin-impregnated polymethylmethacrylate pin sleeve for the prevention of pin-tract infection in goats.
    Journal of orthopaedic trauma, 1999, Volume: 13, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Bone Cements; Bone Nails; Disease Models, Animal; Drug Implants; Equipment Contamination; External Fixators; Fracture Fixation; Goats; Materials Testing; Polymethyl Methacrylate; Reference Values; Surgical Wound Infection; Tobramycin

1999
Aerosolization of low phase transition temperature liposomal tobramycin as a dry powder in an animal model of chronic pulmonary infection caused by Pseudomonas aeruginosa.
    Journal of drug targeting, 1999, Volume: 7, Issue:1

    Topics: Aerosols; Animals; Anti-Bacterial Agents; Chronic Disease; Disease Models, Animal; Drug Carriers; Liposomes; Lung Diseases; Powders; Pseudomonas Infections; Rats; Rats, Sprague-Dawley; Temperature; Tobramycin

1999
A simple infection model using pre-colonized implants to reproduce rat chronic Staphylococcus aureus osteomyelitis and study antibiotic treatment.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2001, Volume: 19, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Cefuroxime; Cephalosporins; Chronic Disease; Ciprofloxacin; Disease Models, Animal; Male; Osteomyelitis; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus aureus; Tibia; Tobramycin; Vancomycin

2001
Antibiotic therapy of experimental Pseudomonas keratitis in guinea pigs.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1977, Volume: 95, Issue:9

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Aqueous Humor; Carbenicillin; Cornea; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Gentamicins; Guinea Pigs; Humans; Injections, Intramuscular; Keratitis; Kinetics; Male; Polymyxins; Pseudomonas aeruginosa; Pseudomonas Infections; Tobramycin

1977
Comparison of therapeutic routes in experimental Pseudomonas keratitis.
    American journal of ophthalmology, 1979, Volume: 87, Issue:5

    Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Disease Models, Animal; Guinea Pigs; Humans; Injections; Injections, Intramuscular; Keratitis; Kinetics; Pseudomonas Infections; Rabbits; Tobramycin

1979
Comparative nephrotoxicity of gentamicin and tobramycin in rats.
    Antimicrobial agents and chemotherapy, 1978, Volume: 13, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Gentamicins; Kidney; Kidney Tubular Necrosis, Acute; Rats; Tobramycin

1978
Proteus species isolated from human eyes.
    American journal of ophthalmology, 1976, Volume: 81, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Eye Diseases; Gentamicins; Humans; Keratitis; Male; Microbial Sensitivity Tests; Proteus; Proteus Infections; Proteus mirabilis; Proteus vulgaris; Rabbits; Tobramycin

1976
[Level of antibiotics in the serum and tissue in experimental peritonitis].
    Die Medizinische Welt, 1977, Apr-29, Volume: 28, Issue:17

    Topics: Ampicillin; Animals; Anti-Bacterial Agents; Disease Models, Animal; Lung; Peritonitis; Rats; Respiratory Distress Syndrome; Tobramycin

1977
[The effect of the combination of cephalexin with tobramycin on experimental pyelonephritis (author's transl)].
    Casopis lekaru ceskych, 1976, May-28, Volume: 115, Issue:20-21

    Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Cephalexin; Disease Models, Animal; Drug Synergism; Female; Injections, Intramuscular; Pyelonephritis; Rats; Tobramycin

1976
Effect of extracorporeal membrane oxygenation on tobramycin pharmacokinetics in sheep.
    Critical care medicine, 1992, Volume: 20, Issue:10

    Topics: Animals; Critical Illness; Disease Models, Animal; Drug Monitoring; Evaluation Studies as Topic; Extracorporeal Membrane Oxygenation; Infusions, Intravenous; Least-Squares Analysis; Metabolic Clearance Rate; Prospective Studies; Sheep; Tissue Distribution; Tobramycin

1992
Collagen shields containing tobramycin for sustained therapy (24 hours) of experimental Pseudomonas keratitis.
    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc, 1992, Volume: 18, Issue:4

    Topics: Animals; Biological Dressings; Collagen; Colony Count, Microbial; Cornea; Corneal Ulcer; Delayed-Action Preparations; Disease Models, Animal; Eye Infections, Bacterial; Ophthalmic Solutions; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Tobramycin

1992
Fibrin-enmeshed tobramycin liposomes: single application topical therapy of Pseudomonas keratitis.
    Cornea, 1992, Volume: 11, Issue:5

    Topics: Administration, Topical; Animals; Colony Count, Microbial; Cornea; Corneal Ulcer; Disease Models, Animal; Drug Carriers; Eye Infections, Bacterial; Fibrin; Liposomes; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Random Allocation; Tobramycin

1992
Recurrence of microbial keratitis concomitant with antiinflammatory treatment in an animal model.
    Cornea, 1992, Volume: 11, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cornea; Disease Models, Animal; Eye Infections, Bacterial; Keratitis; Methylprednisolone; Pneumococcal Infections; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Random Allocation; Recurrence; Streptococcus pneumoniae; Tobramycin

1992
Topical ofloxacin in the treatment of Pseudomonas keratitis in a rabbit model.
    Cornea, 1992, Volume: 11, Issue:2

    Topics: Administration, Topical; Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Disease Models, Animal; Eye Infections, Bacterial; Keratitis; Ofloxacin; Pseudomonas Infections; Rabbits; Tobramycin

1992
Evaluation of antibiotic-supplemented bone allograft in a rabbit model.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1991, Volume: 49, Issue:4

    Topics: Animals; Bone Transplantation; Cephalothin; Disease Models, Animal; Mandibular Fractures; Osteomyelitis; Prevotella melaninogenica; Rabbits; Staphylococcus aureus; Tobramycin; Transplantation, Homologous

1991
Aprotinin treatment of pseudomonal corneal infection.
    Cornea, 1991, Volume: 10, Issue:1

    Topics: Administration, Topical; Animals; Aprotinin; Conjunctiva; Corneal Ulcer; Disease Models, Animal; Drug Administration Routes; Drug Therapy, Combination; Pseudomonas Infections; Rabbits; Tobramycin

1991
Topical anti-inflammatory agents in an animal model of microbial keratitis.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1990, Volume: 108, Issue:7

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Flurbiprofen; Keratitis; Pharmaceutical Vehicles; Pneumococcal Infections; Prednisolone; Pseudomonas Infections; Rabbits; Tobramycin

1990
Evaluation of antibiotic diffusion into cardiac vegetations by quantitative autoradiography.
    The Journal of infectious diseases, 1989, Volume: 159, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Autoradiography; Disease Models, Animal; Endocarditis, Bacterial; Female; Glycopeptides; Myocardium; Penicillins; Rabbits; Teicoplanin; Tobramycin

1989
Intracanalicular collagen implants enhance topical antibiotic bioavailability.
    Cornea, 1986, Volume: 5, Issue:3

    Topics: Administration, Topical; Animals; Biological Availability; Collagen; Colony Count, Microbial; Cornea; Disease Models, Animal; Eye Infections, Bacterial; Keratitis; Lacrimal Duct Obstruction; Prostheses and Implants; Pseudomonas Infections; Rabbits; Tears; Tobramycin

1986
Ciprofloxacin in experimental Pseudomonas aeruginosa meningitis in rabbits.
    The Journal of antimicrobial chemotherapy, 1986, Volume: 18 Suppl D

    Topics: Animals; Ceftazidime; Ciprofloxacin; Disease Models, Animal; Meningitis; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits; Tobramycin

1986
Comparative bioavailability and efficacy of fortified topical tobramycin.
    Investigative ophthalmology & visual science, 1987, Volume: 28, Issue:5

    Topics: Animals; Bacterial Infections; Biological Availability; Disease Models, Animal; Eye Diseases; Keratitis; Kinetics; Male; Ophthalmic Solutions; Pseudomonas Infections; Rabbits; Rats; Rats, Inbred Strains; Tears; Tobramycin

1987
Novel approaches for the use of aminoglycosides: the value of experimental models.
    The Journal of antimicrobial chemotherapy, 1986, Volume: 17 Suppl A

    Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Bacterial Infections; Disease Models, Animal; Endocarditis, Bacterial; Guinea Pigs; Humans; Pneumonia; Pseudomonas Infections; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Tobramycin

1986
[Effectiveness of a polyvalent corpuscular Pseudomonas aeruginosa vaccine, antibiotics and their combinations in experimental chronic Pseudomonas aeruginosa infection].
    Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1985, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Bacterial Vaccines; Chronic Disease; Combined Modality Therapy; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mice; Polymyxin B; Pseudomonas aeruginosa; Pseudomonas Infections; Time Factors; Tobramycin

1985