tizanidine has been researched along with Trigeminal Neuralgia in 5 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Trigeminal Neuralgia: A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind study the efficacy and tolerability of tizanidine was compared with those of carbamazepine in the management of trigeminal neuralgia." | 9.06 | Tizanidine in the management of trigeminal neuralgia. ( Lataste, X; Lyberg, T; Vilming, ST, 1986) |
| "The limited efficacy of TZD in the treatment of trigeminal neuralgia may be related to the fact that it has no effect on neuronal responses to low-threshold mechanoceptive stimuli, suggesting that low-threshold mechanoceptive neurons play an important role in the pathogenesis of trigeminal neuralgia." | 6.67 | A clinical and experimental investigation of the effects of tizanidine in trigeminal neuralgia. ( Aumentado, D; Fromm, GH; Terrence, CF, 1993) |
| "In a double-blind study the efficacy and tolerability of tizanidine was compared with those of carbamazepine in the management of trigeminal neuralgia." | 5.06 | Tizanidine in the management of trigeminal neuralgia. ( Lataste, X; Lyberg, T; Vilming, ST, 1986) |
| "There is low-quality evidence that the effect of tizanidine is not significantly different than that of carbamazepine in treating trigeminal neuralgia." | 4.89 | Non-antiepileptic drugs for trigeminal neuralgia. ( Chen, N; He, L; Yang, M; Zakrzewska, JM; Zhang, J; Zhou, M, 2013) |
| "The limited efficacy of TZD in the treatment of trigeminal neuralgia may be related to the fact that it has no effect on neuronal responses to low-threshold mechanoceptive stimuli, suggesting that low-threshold mechanoceptive neurons play an important role in the pathogenesis of trigeminal neuralgia." | 2.67 | A clinical and experimental investigation of the effects of tizanidine in trigeminal neuralgia. ( Aumentado, D; Fromm, GH; Terrence, CF, 1993) |
| "Tizanidine was investigated in two trials." | 2.43 | Non-antiepileptic drugs for trigeminal neuralgia. ( He, L; Wu, B; Zhou, M, 2006) |
| "Among the more common symptoms is spasticity." | 2.41 | Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis. ( Schapiro, RT, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 1 |
| Yang, M | 1 |
| Zhou, M | 2 |
| He, L | 2 |
| Chen, N | 1 |
| Zakrzewska, JM | 1 |
| Wu, B | 1 |
| Fromm, GH | 1 |
| Aumentado, D | 1 |
| Terrence, CF | 1 |
| Schapiro, RT | 1 |
| Vilming, ST | 1 |
| Lyberg, T | 1 |
| Lataste, X | 1 |
3 reviews available for tizanidine and Trigeminal Neuralgia
| Article | Year |
|---|---|
Non-antiepileptic drugs for trigeminal neuralgia.
Topics: Amitriptyline; Analgesics; Anticonvulsants; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans | 2013 |
Non-antiepileptic drugs for trigeminal neuralgia.
Topics: Amitriptyline; Baclofen; Carbamazepine; Clomipramine; Clonidine; Humans; Pimozide; Propoxycaine; Ran | 2006 |
Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis.
Topics: Acetates; Amines; Autoimmune Diseases; Baclofen; Benzodiazepines; Botulinum Toxins, Type A; Cannabin | 2001 |
2 trials available for tizanidine and Trigeminal Neuralgia
| Article | Year |
|---|---|
A clinical and experimental investigation of the effects of tizanidine in trigeminal neuralgia.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Animals; Cats; Clonidine; Double-Blind Method; Drug Resi | 1993 |
Tizanidine in the management of trigeminal neuralgia.
Topics: Aged; Analgesics; Carbamazepine; Clinical Trials as Topic; Clonidine; Double-Blind Method; Humans; M | 1986 |