tizanidine has been researched along with Tension-Type Headache in 9 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Tension-Type Headache: A common primary headache disorder, characterized by a dull, non-pulsatile, diffuse, band-like (or vice-like) PAIN of mild to moderate intensity in the HEAD; SCALP; or NECK. The subtypes are classified by frequency and severity of symptoms. There is no clear cause even though it has been associated with MUSCLE CONTRACTION and stress. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of the modified-release formulation of tizanidine (Sirdalud) was compared with placebo in a randomized, double-blind, parallel-group study of 138 women and 47 men, aged 18 to 79 years, with a history of chronic tension-type headache (IHS categories 2." | 9.09 | Modified-release formulation of tizanidine in chronic tension-type headache. ( Färkkilä, M; Havanka, H; Hedman, C; Kataja, M; Keränen, T; Murros, K; Peltola, J; Säkö, E, 2000) |
| "The aim of this study was to clarify the changes of inhibitory interneuronal activity in patients with chronic tension-type headache with disorder of pericranial muscle after treatment, and the pharmacological mechanisms of tizanidine--an alpha 2 adrenergic agonist." | 9.07 | Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache. ( Nakashima, K; Sakuma, K; Shimoda, M; Takahashi, K; Tumura, R; Wang, Y, 1994) |
| "The efficacy of the modified-release formulation of tizanidine (Sirdalud) was compared with placebo in a randomized, double-blind, parallel-group study of 138 women and 47 men, aged 18 to 79 years, with a history of chronic tension-type headache (IHS categories 2." | 5.09 | Modified-release formulation of tizanidine in chronic tension-type headache. ( Färkkilä, M; Havanka, H; Hedman, C; Kataja, M; Keränen, T; Murros, K; Peltola, J; Säkö, E, 2000) |
| "The aim of this study was to clarify the changes of inhibitory interneuronal activity in patients with chronic tension-type headache with disorder of pericranial muscle after treatment, and the pharmacological mechanisms of tizanidine--an alpha 2 adrenergic agonist." | 5.07 | Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache. ( Nakashima, K; Sakuma, K; Shimoda, M; Takahashi, K; Tumura, R; Wang, Y, 1994) |
| "Baclofen, tizanidine and botulinum toxin A, agents used to treat disorders of muscle tone, have been studied as potential preventative treatments for migraine, tension-type headache and other related disorders." | 4.82 | Preventative treatment for migraine and tension-type headaches : do drugs having effects on muscle spasm and tone have a role? ( Freitag, FG, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thapa, AS | 1 |
| Duma, SN | 1 |
| Medvedeva, LA | 2 |
| Avakian, GN | 1 |
| Zagorul'ko, OI | 2 |
| Gnezdilov, AV | 2 |
| Esin, RG | 1 |
| Esin, OR | 1 |
| Naprienko, MV | 1 |
| Freitag, FG | 1 |
| Syrovegin, AV | 1 |
| Samoilova, NV | 1 |
| Nakashima, K | 1 |
| Tumura, R | 1 |
| Wang, Y | 1 |
| Shimoda, M | 1 |
| Sakuma, K | 1 |
| Takahashi, K | 1 |
| Filatova, EG | 1 |
| Solov'eva, AD | 1 |
| Danilov, AB | 1 |
| Murros, K | 1 |
| Kataja, M | 1 |
| Hedman, C | 1 |
| Havanka, H | 1 |
| Säkö, E | 1 |
| Färkkilä, M | 1 |
| Peltola, J | 1 |
| Keränen, T | 1 |
1 review available for tizanidine and Tension-Type Headache
| Article | Year |
|---|---|
Preventative treatment for migraine and tension-type headaches : do drugs having effects on muscle spasm and tone have a role?
Topics: Baclofen; Botulinum Toxins, Type A; Clonidine; GABA Agonists; Humans; Migraine Disorders; Muscle Rel | 2003 |
5 trials available for tizanidine and Tension-Type Headache
| Article | Year |
|---|---|
Amitriptyline versus tizanidine in the management of tension-type headache in Nepal.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Aged; Amitriptyline; Analgesics; Clonidine; Female; | 2013 |
[A role of treatment of autonomic syndrome in patients with tension-type headache].
Topics: Administration, Oral; Adult; Analgesics, Non-Narcotic; Autonomic Nervous System; Autonomic Nervous S | 2015 |
Efficacy of neuroprotectors in patients with tension headaches.
Topics: Acupressure; Adolescent; Adult; Aged; Analgesics; Clonidine; Combined Modality Therapy; Drug Therapy | 2007 |
Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache.
Topics: Clonidine; Electric Stimulation; Humans; Muscle Contraction; Muscle Relaxants, Central; Temporal Mus | 1994 |
Modified-release formulation of tizanidine in chronic tension-type headache.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Chronic Disease; Clonidine; Delayed-Action Preparations; Dou | 2000 |
3 other studies available for tizanidine and Tension-Type Headache
| Article | Year |
|---|---|
[Therapeutic blockades and reflexotherapy in the complex treatment of tension headache].
Topics: Adult; Anesthetics, Local; Bupivacaine; Clonidine; Combined Modality Therapy; Female; Fluoxetine; Hu | 2010 |
[Clinical features of headache of tension type and principles of treatment].
Topics: Adult; Aged; Analgesics; Clonidine; Cyclohexanols; Female; Humans; Male; Masticatory Muscles; Middle | 2010 |
[The treatment of tension headache with sirdalud].
Topics: Adult; Chronic Disease; Clonidine; Drug Evaluation; Female; Humans; Male; Muscle Relaxants, Central; | 1997 |