tizanidine has been researched along with Seizures in 5 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of alpha-adrenoceptors agents on seizures induced by intraperitoneal administration of lidocaine (75 mg/kg) were studied in mice." | 3.70 | Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors. ( Altenburg, SP; Farah, MB, 1999) |
| "Treatment with tizanidine was effective in 60% of the patients; there were high correlations between spasticity before and after tizanidine administration and the severity of symptoms and also between the degree of improvement in spasticity and in that of the symptoms." | 1.28 | Development of a simple spasticity quantification method: effects of tizanidine on spasticity in patients with sequelae of cerebrovascular disease. ( Asanuma, M; Hirata, H; Ogawa, N; Ota, Z; Yamamoto, M; Yamawaki, Y, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Altenburg, SP | 1 |
| Farah, MB | 1 |
| Denizbaşi, A | 1 |
| Berkman, K | 1 |
| Ozyazgan, S | 1 |
| Eşkazan, E | 1 |
| Enginar, N | 1 |
| Yamantürk, P | 1 |
| Nurten, A | 1 |
| Koyuncuoğlu, H | 1 |
| Ogawa, N | 1 |
| Asanuma, M | 1 |
| Hirata, H | 1 |
| Ota, Z | 1 |
| Yamawaki, Y | 1 |
| Yamamoto, M | 1 |
| Ueno, K | 1 |
| Miyai, K | 1 |
| Mitsuzane, K | 1 |
5 other studies available for tizanidine and Seizures
| Article | Year |
|---|---|
Tizanidine protects mice against convulsions induced by lidocaine: involvement of alpha 2-adrenoceptors.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonidine; Drug Interactions; Lidocaine; Male; Mice; Phe | 1999 |
The effect of tizanidine on maximal electroshock seizures (MES) in mice.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Clonidine; Electroshoc | 1999 |
Scopolamine-induced convulsions in food given fasted mice: effects of clonidine and tizanidine.
Topics: Animals; Anticonvulsants; Clonidine; Fasting; Male; Mice; Scopolamine; Seizures | 1999 |
Development of a simple spasticity quantification method: effects of tizanidine on spasticity in patients with sequelae of cerebrovascular disease.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Clonidine; Female; Humans; Male; Middle Aged; Musc | 1992 |
Phenytoin-tizanidine interaction.
Topics: Anticonvulsants; Biotransformation; Clonidine; Drug Interactions; Drug Monitoring; Female; Humans; M | 1991 |