tizanidine has been researched along with Paraplegia in 3 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The study consisted of 4 parts: I, double-blind cross-over trial at maximal dosage 10 mg/day in 13 patients; II, open trial at maximal dosage 32 mg/day in 10 patients; III, long-term medication at dosage 32 mg/day for 6-15 months in 4 patients; IV, single dose (12 mg) administration in 3 patients." | 2.65 | Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis. ( Gransberg, L; Knutsson, E; Mårtensson, A, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fuchigami, T | 1 |
| Kakinohana, O | 1 |
| Hefferan, MP | 1 |
| Lukacova, N | 1 |
| Marsala, S | 1 |
| Platoshyn, O | 1 |
| Sugahara, K | 1 |
| Yaksh, TL | 1 |
| Marsala, M | 1 |
| Knutsson, E | 1 |
| Mårtensson, A | 1 |
| Gransberg, L | 1 |
1 trial available for tizanidine and Paraplegia
| Article | Year |
|---|---|
Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis.
Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug; Double-Blind Met | 1982 |
2 other studies available for tizanidine and Paraplegia
| Article | Year |
|---|---|
Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.
Topics: Animals; Chronic Disease; Clonidine; Disease Models, Animal; Male; Muscle Relaxants, Central; Neural | 2011 |
[Current data on bipolar disorders, epilepsy and spasm. 4th Neuro-Forum, Dresden].
Topics: Baclofen; Benzodiazepines; Bipolar Disorder; Clonidine; Epilepsy; Humans; Muscle Relaxants, Central; | 1999 |