tizanidine has been researched along with Neuralgia in 4 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tizanidine was more effective in female than male neuropathic rats." | 1.72 | Sex-dependent antiallodynic effect of α ( Caram-Salas, NL; Castelo-Flores, DG; Centurión, D; De la Luz-Cuellar, YE; Granados-Soto, V; Rodríguez-Palma, EJ; Salinas-Abarca, AB, 2022) |
| "Occipital neuralgia is the third most common headache syndrome after migraine and tension type headaches." | 1.48 | Transcutaneous Electrical Nerve Stimulation in Treatment of Occipital Neuralgia: A Case Report. ( Candido, KD; Ghaly, RF; Knezevic, NN; Plesca, A, 2018) |
| "tizanidine is a highly selective α2-AR agonist, but the effect mechanism of tizanidine in neuropathic pain remains largely unknown." | 1.48 | Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF-κB pathway. ( Li, L; Pei, W; Wang, W; Wei, L; Zhao, Y; Zou, Y, 2018) |
| "Tizanidine was effective in reducing sensitivity to heat, as measured by paw withdrawal latency, and did not cause sedation at smaller doses." | 1.31 | Systemic tizanidine hydrochloride (Zanaflex) relieves thermal hyperalgesia in rats with an experimental mononeuropathy. ( Azevedo, MI; Chalfoun, AG; Denson, DD; Hord, AH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodríguez-Palma, EJ | 1 |
| Castelo-Flores, DG | 1 |
| Caram-Salas, NL | 1 |
| Salinas-Abarca, AB | 1 |
| Centurión, D | 1 |
| De la Luz-Cuellar, YE | 1 |
| Granados-Soto, V | 1 |
| Ghaly, RF | 1 |
| Plesca, A | 1 |
| Candido, KD | 1 |
| Knezevic, NN | 1 |
| Pei, W | 1 |
| Zou, Y | 1 |
| Wang, W | 1 |
| Wei, L | 1 |
| Zhao, Y | 1 |
| Li, L | 1 |
| Hord, AH | 1 |
| Chalfoun, AG | 1 |
| Denson, DD | 1 |
| Azevedo, MI | 1 |
4 other studies available for tizanidine and Neuralgia
| Article | Year |
|---|---|
Sex-dependent antiallodynic effect of α
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Clonidine; Female; Hyperalgesia; Male; Neuralgia; Rat | 2022 |
Transcutaneous Electrical Nerve Stimulation in Treatment of Occipital Neuralgia: A Case Report.
Topics: Adult; Analgesics; Clonidine; Female; Headache Disorders; Humans; Neck Pain; Neuralgia; Occipital Lo | 2018 |
Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF-κB pathway.
Topics: Analgesics; Animals; Clonidine; Interleukin-1beta; Interleukin-6; Male; Neuralgia; NF-kappa B; Rats; | 2018 |
Systemic tizanidine hydrochloride (Zanaflex) relieves thermal hyperalgesia in rats with an experimental mononeuropathy.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Disease Models, Animal; Hot Temperature; Hyperalgesia | 2001 |