tizanidine has been researched along with Muscle Contraction in 18 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to clarify the changes of inhibitory interneuronal activity in patients with chronic tension-type headache with disorder of pericranial muscle after treatment, and the pharmacological mechanisms of tizanidine--an alpha 2 adrenergic agonist." | 9.07 | Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache. ( Nakashima, K; Sakuma, K; Shimoda, M; Takahashi, K; Tumura, R; Wang, Y, 1994) |
| "The efficacy of tizanidine in chronic tension-type headache was compared with placebo in a randomized, double-blind and cross-over study in 37 women aged 20 to 59 years with a history of headache for 7 months to 30 years (median 5 years)." | 9.07 | Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study. ( Fogelholm, R; Murros, K, 1992) |
| "Seventy-eight patients with tension-type headache (TH) were treated with tizanidine hydrochloride (tizanidine)." | 9.07 | Treatment of tension-type headache with tizanidine hydrochloride: its efficacy and relationship to the plasma MHPG concentration. ( Awaki, E; Kowa, H; Shimomura, T; Takahashi, K, 1991) |
| "Tizanidine treatment reduced muscle tone significantly, as shown by improved Ashworth scores and increased knee swing amplitude recorded by the pendulum test, both of which correlated significantly with plasma concentration." | 6.68 | Relationship of the antispasticity effect of tizanidine to plasma concentration in patients with multiple sclerosis. ( Cohen, JA; Francis, GS; Hudson, S; Lindsey, JW; Lynch, SG; Mass, MK; Nance, PW; O'Connor, P; Schapiro, RT; Shellenberger, K; Sheremata, WA; Vollmer, T; Whitham, R, 1997) |
| "The aim of this study was to clarify the changes of inhibitory interneuronal activity in patients with chronic tension-type headache with disorder of pericranial muscle after treatment, and the pharmacological mechanisms of tizanidine--an alpha 2 adrenergic agonist." | 5.07 | Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache. ( Nakashima, K; Sakuma, K; Shimoda, M; Takahashi, K; Tumura, R; Wang, Y, 1994) |
| "The efficacy of tizanidine in chronic tension-type headache was compared with placebo in a randomized, double-blind and cross-over study in 37 women aged 20 to 59 years with a history of headache for 7 months to 30 years (median 5 years)." | 5.07 | Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study. ( Fogelholm, R; Murros, K, 1992) |
| "Seventy-eight patients with tension-type headache (TH) were treated with tizanidine hydrochloride (tizanidine)." | 5.07 | Treatment of tension-type headache with tizanidine hydrochloride: its efficacy and relationship to the plasma MHPG concentration. ( Awaki, E; Kowa, H; Shimomura, T; Takahashi, K, 1991) |
| "Tizanidine treatment reduced muscle tone significantly, as shown by improved Ashworth scores and increased knee swing amplitude recorded by the pendulum test, both of which correlated significantly with plasma concentration." | 2.68 | Relationship of the antispasticity effect of tizanidine to plasma concentration in patients with multiple sclerosis. ( Cohen, JA; Francis, GS; Hudson, S; Lindsey, JW; Lynch, SG; Mass, MK; Nance, PW; O'Connor, P; Schapiro, RT; Shellenberger, K; Sheremata, WA; Vollmer, T; Whitham, R, 1997) |
| " The study consisted of 4 parts: I, double-blind cross-over trial at maximal dosage 10 mg/day in 13 patients; II, open trial at maximal dosage 32 mg/day in 10 patients; III, long-term medication at dosage 32 mg/day for 6-15 months in 4 patients; IV, single dose (12 mg) administration in 3 patients." | 2.65 | Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis. ( Gransberg, L; Knutsson, E; Mårtensson, A, 1982) |
| "Tizanidine (TZD) is an alpha-2-adrenergic drug with potential spinal analgesic action and could be a substitute or additive for intrathecal (i." | 1.30 | Distribution, tolerability and tissue compatibility of intrathecal tizanidine in the sheep. ( Loew, M; Ochs, G; Tonn, J; Toyka, K, 1998) |
| "Tizanidine (TIZ) has long been known to be an alpha 2-adrenoceptor agonist and inhibitor of ASP and GLU release." | 1.28 | Effects of tizanidine on morphine physical dependence: attenuation and intensification. ( Ariciŏglu, F; Dizdar, Y; Esin, Y; Koyuncuŏglu, H; Uresin, Y, 1992) |
| "tizanidine was antagonized by co-administration of prazosin but not by yohimbine." | 1.28 | Myorelaxant effect after intrathecal injection of antispastic drugs in rats. ( Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Wüllner, U, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (38.89) | 18.7374 |
| 1990's | 7 (38.89) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uysal, H | 1 |
| Kızılay, F | 1 |
| Inel, SE | 1 |
| Özen, H | 1 |
| Pek, G | 1 |
| Rossi, M | 1 |
| Ianigro, G | 1 |
| Liberatoscioli, G | 1 |
| Di Castelnuovo, A | 1 |
| Grimani, V | 1 |
| Garofano, A | 1 |
| Camposarcone, N | 1 |
| Nardi, LF | 1 |
| Lourenço, G | 1 |
| Iglesias, C | 1 |
| Cavallari, P | 1 |
| Pierrot-Deseilligny, E | 1 |
| Marchand-Pauvert, V | 1 |
| Knutsson, E | 3 |
| Takayanagi, I | 1 |
| Konno, F | 1 |
| Ishii, C | 1 |
| Takemasa, T | 1 |
| Yanagida, Y | 1 |
| Shimizu, M | 1 |
| Mori, H | 1 |
| Sugane, H | 1 |
| Mackel, R | 1 |
| Brink, EE | 1 |
| Nakajima, Y | 1 |
| Mårtensson, A | 1 |
| Gransberg, L | 1 |
| Nakashima, K | 1 |
| Tumura, R | 1 |
| Wang, Y | 1 |
| Shimoda, M | 1 |
| Sakuma, K | 1 |
| Takahashi, K | 2 |
| Nance, PW | 1 |
| Sheremata, WA | 1 |
| Lynch, SG | 1 |
| Vollmer, T | 1 |
| Hudson, S | 1 |
| Francis, GS | 1 |
| O'Connor, P | 1 |
| Cohen, JA | 1 |
| Schapiro, RT | 1 |
| Whitham, R | 1 |
| Mass, MK | 1 |
| Lindsey, JW | 1 |
| Shellenberger, K | 1 |
| Ochs, G | 1 |
| Loew, M | 1 |
| Tonn, J | 1 |
| Toyka, K | 1 |
| Kontani, H | 1 |
| Tsuji, T | 1 |
| Kimura, S | 1 |
| Koyuncuŏglu, H | 1 |
| Ariciŏglu, F | 1 |
| Uresin, Y | 1 |
| Dizdar, Y | 1 |
| Esin, Y | 1 |
| Fogelholm, R | 1 |
| Murros, K | 1 |
| Shimomura, T | 1 |
| Awaki, E | 1 |
| Kowa, H | 1 |
| Palmeri, A | 1 |
| Wiesendanger, M | 2 |
| Chen, DF | 1 |
| Bianchetti, M | 1 |
| Klockgether, T | 1 |
| Schwarz, M | 1 |
| Wüllner, U | 1 |
| Turski, L | 1 |
| Sontag, KH | 1 |
6 trials available for tizanidine and Muscle Contraction
| Article | Year |
|---|---|
Eperisone versus tizanidine for treatment of chronic low back pain.
Topics: Analysis of Variance; Chronic Pain; Clonidine; Drug Therapy, Combination; Female; Humans; Italy; Low | 2012 |
Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis.
Topics: Adult; Aged; Clinical Trials as Topic; Clonidine; Dose-Response Relationship, Drug; Double-Blind Met | 1982 |
Effects of tizanidine administration on exteroceptive suppression of the temporalis muscle in patients with chronic tension-type headache.
Topics: Clonidine; Electric Stimulation; Humans; Muscle Contraction; Muscle Relaxants, Central; Temporal Mus | 1994 |
Relationship of the antispasticity effect of tizanidine to plasma concentration in patients with multiple sclerosis.
Topics: Adrenergic alpha-Agonists; Canada; Cardiovascular System; Clonidine; Dose-Response Relationship, Dru | 1997 |
Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study.
Topics: Adult; Analgesics; Chronic Disease; Clonidine; Depression; Dose-Response Relationship, Drug; Double- | 1992 |
Treatment of tension-type headache with tizanidine hydrochloride: its efficacy and relationship to the plasma MHPG concentration.
Topics: Clonidine; Fatty Acids, Nonesterified; Female; Headache; Humans; Male; Methoxyhydroxyphenylglycol; M | 1991 |
12 other studies available for tizanidine and Muscle Contraction
| Article | Year |
|---|---|
Medium-latency reflex response elicited from the flexor carpi radialis by radial nerve stimulation.
Topics: Adult; Clonidine; Electric Stimulation; Female; H-Reflex; Humans; Male; Middle Aged; Muscle Contract | 2012 |
Mediation of late excitation from human hand muscles via parallel group II spinal and group I transcortical pathways.
Topics: Adult; Aged; Arm; Cerebral Cortex; Clonidine; Cold Temperature; Electric Stimulation; Electromyograp | 2006 |
Analysis of gait and isokinetic movements for evaluation of antispastic drugs or physical therapies.
Topics: Cerebral Palsy; Clonidine; Electromyography; Gait; Humans; Motor Neurons; Muscle Contraction; Muscle | 1983 |
Actions of tizanidine on alpha 1-and alpha 2-adrenoceptors in the peripheral tissues.
Topics: Animals; Aorta, Thoracic; Clonidine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle C | 1984 |
Action of tizanidine on responses of forearm flexors and extensors to torque disturbances.
Topics: Adult; Blood Pressure; Clonidine; Electromyography; Female; Forearm; Humans; Male; Muscle Contractio | 1984 |
Muscle restraint in speed controlled voluntary and passive movements.
Topics: Clonidine; Electromyography; Humans; Knee; Leg; Movement; Muscle Contraction; Muscles; Paresis; Refl | 1982 |
Distribution, tolerability and tissue compatibility of intrathecal tizanidine in the sheep.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Animals; Behavior, A | 1998 |
Effects of adrenergic alpha2-receptor agonists on urinary bladder contraction in conscious rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Clonidine; Male; Muscle Co | 2000 |
Effects of tizanidine on morphine physical dependence: attenuation and intensification.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Aspartic Acid; Behavior, Animal; Clonidine; Glutamat | 1992 |
Concomitant depression of locus coeruleus neurons and of flexor reflexes by an alpha 2-adrenergic agonist in rats: a possible mechanism for an alpha 2-mediated muscle relaxation.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Female; Locus Coeruleus; Male; Muscle Contraction; Mu | 1990 |
The adrenergic agonist tizanidine has differential effects on flexor reflexes of intact and spinalized rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Clonidine; Decerebrate State; Dose-Response | 1987 |
Myorelaxant effect after intrathecal injection of antispastic drugs in rats.
Topics: Animals; Baclofen; Clonidine; Dose-Response Relationship, Drug; Female; H-Reflex; Injections, Spinal | 1989 |