tizanidine has been researched along with Long QT Syndrome in 2 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We aimed to quantify co-administration of MQAB with interacting drugs and associated adverse drug reactions." | 1.43 | Drug safety of macrolide and quinolone antibiotics in a tertiary care hospital: administration of interacting co-medication and QT prolongation. ( Corti, N; Hoppe, L; Kovari, H; Maechler, S; Niedrig, D; Russmann, S, 2016) |
| "Tizanidine (Zanaflex) is a centrally acting imidazoline muscle relaxant that is structurally similar to clonidine (α(2)-adrenergic agonist) but not to other myorelaxants such as baclofen or benzodiazepines." | 1.38 | Tizanidine (Zanaflex): a muscle relaxant that may prolong the QT interval by blocking IKr. ( Drolet, B; Kaddar, N; Patoine, D; Pilote, S; Simard, C; Vigneault, P, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Niedrig, D | 1 |
| Maechler, S | 1 |
| Hoppe, L | 1 |
| Corti, N | 1 |
| Kovari, H | 1 |
| Russmann, S | 1 |
| Kaddar, N | 1 |
| Vigneault, P | 1 |
| Pilote, S | 1 |
| Patoine, D | 1 |
| Simard, C | 1 |
| Drolet, B | 1 |
2 other studies available for tizanidine and Long QT Syndrome
| Article | Year |
|---|---|
Drug safety of macrolide and quinolone antibiotics in a tertiary care hospital: administration of interacting co-medication and QT prolongation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Atorvastatin; Clonidine; Drug Int | 2016 |
Tizanidine (Zanaflex): a muscle relaxant that may prolong the QT interval by blocking IKr.
Topics: Animals; CHO Cells; Clonidine; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Guinea Pigs | 2012 |