tizanidine has been researched along with Hypotension in 9 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of severe bradycardia and hypotension associated with concomitant tizanidine and lisinopril therapy is reported." | 7.76 | Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy. ( Branam, DL; Publow, SW, 2010) |
| "To report a case in which significant hypotension occurred after initiation of tizanidine in a patient using the antihypertensive agent lisinopril." | 7.72 | Hypotension due to interaction between lisinopril and tizanidine. ( Chang, JB; Chen, JT; Kao, CD; Liao, KK; Shan, DE; Wu, ZA, 2004) |
| " The authors present a 10-year-old boy chronically treated with lisinopril, an angiotensin converting enzyme inhibitor, to control hypertension who developed hypotension following the addition of tizanidine, an alpha-2 agonist, for the treatment of spasticity." | 7.70 | Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension. ( Johnson, TR; Tobias, JD, 2000) |
| " However, concomitant use of tizanidine with ciprofloxacin, a strong inhibitor of the P450-CYP1A2 cytochrome metabolic pathway of tizanidine, can result in increased tizanidine plasma levels and associated adverse outcomes, particularly hypotension." | 4.12 | Risk of tizanidine-induced adverse events after concomitant exposure to ciprofloxacin: A cohort study in the U.S. ( Giannouchos, TV; Gómez-Lumbreras, A; Malone, DC, 2022) |
| " Some of the important safety signals included interactions between tizanidine in a suspect or interacting role and ciprofloxacin (ROR for hypotension 28." | 4.12 | A Disproportionality Analysis of Drug-Drug Interactions of Tizanidine and CYP1A2 Inhibitors from the FDA Adverse Event Reporting System (FAERS). ( Boyce, RD; Gómez-Lumbreras, A; Horn, J; Malone, DC; Tan, MS; Villa-Zapata, L, 2022) |
| "A case of severe bradycardia and hypotension associated with concomitant tizanidine and lisinopril therapy is reported." | 3.76 | Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy. ( Branam, DL; Publow, SW, 2010) |
| "Although intrathecal clonidine produces pronounced analgesia, antinociceptive doses of intrathecal clonidine produce several side effects, including hypotension, bradycardia, and sedation." | 3.72 | Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain. ( Kawamata, T; Namiki, A; Omote, K; Toriyabe, M; Wada, K; Yamamoto, H, 2003) |
| "To report a case in which significant hypotension occurred after initiation of tizanidine in a patient using the antihypertensive agent lisinopril." | 3.72 | Hypotension due to interaction between lisinopril and tizanidine. ( Chang, JB; Chen, JT; Kao, CD; Liao, KK; Shan, DE; Wu, ZA, 2004) |
| " The authors present a 10-year-old boy chronically treated with lisinopril, an angiotensin converting enzyme inhibitor, to control hypertension who developed hypotension following the addition of tizanidine, an alpha-2 agonist, for the treatment of spasticity." | 3.70 | Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension. ( Johnson, TR; Tobias, JD, 2000) |
| "Clonidine was associated with the most respiratory (799, 2." | 1.40 | Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System. ( Heard, K; Le Lait, MC; Wang, GS, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Giannouchos, TV | 1 |
| Gómez-Lumbreras, A | 2 |
| Malone, DC | 2 |
| Villa-Zapata, L | 1 |
| Horn, J | 1 |
| Tan, MS | 1 |
| Boyce, RD | 1 |
| Chaugai, S | 1 |
| Dickson, AL | 1 |
| Shuey, MM | 1 |
| Feng, Q | 1 |
| Barker, KA | 1 |
| Wei, WQ | 1 |
| Luther, JM | 1 |
| Stein, CM | 1 |
| Chung, CP | 1 |
| Wang, GS | 1 |
| Le Lait, MC | 1 |
| Heard, K | 1 |
| Publow, SW | 1 |
| Branam, DL | 1 |
| Kawamata, T | 1 |
| Omote, K | 1 |
| Yamamoto, H | 1 |
| Toriyabe, M | 1 |
| Wada, K | 1 |
| Namiki, A | 1 |
| Kao, CD | 1 |
| Chang, JB | 1 |
| Chen, JT | 1 |
| Wu, ZA | 1 |
| Shan, DE | 1 |
| Liao, KK | 1 |
| Momo, K | 1 |
| Homma, M | 1 |
| Abei, M | 1 |
| Hyodo, I | 1 |
| Kohda, Y | 1 |
| Johnson, TR | 1 |
| Tobias, JD | 1 |
9 other studies available for tizanidine and Hypotension
| Article | Year |
|---|---|
Risk of tizanidine-induced adverse events after concomitant exposure to ciprofloxacin: A cohort study in the U.S.
Topics: Ciprofloxacin; Clonidine; Cohort Studies; Drug Interactions; Female; Humans; Hypotension; Middle Age | 2022 |
A Disproportionality Analysis of Drug-Drug Interactions of Tizanidine and CYP1A2 Inhibitors from the FDA Adverse Event Reporting System (FAERS).
Topics: Adverse Drug Reaction Reporting Systems; Ciprofloxacin; Clonidine; Cytochrome P-450 CYP1A2; Cytochro | 2022 |
Co-Prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.
Topics: Adult; Clonidine; Cohort Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug | 2019 |
Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System.
Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Child; Child, Preschool; Clonidine; Female; Guanf | 2014 |
Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; B | 2010 |
Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Behavior, Animal; Blood Pressure; Bradycardia; Cloni | 2003 |
Hypotension due to interaction between lisinopril and tizanidine.
Topics: Angiotensin-Converting Enzyme Inhibitors; Clonidine; Drug Interactions; Female; Humans; Hypotension; | 2004 |
Tizanidine-induced hypotension in patients with liver cirrhosis.
Topics: Aged; Clonidine; Female; Humans; Hypotension; Liver Cirrhosis; Male; Middle Aged; Parasympatholytics | 2008 |
Hypotension following the initiation of tizanidine in a patient treated with an angiotensin converting enzyme inhibitor for chronic hypertension.
Topics: Adrenergic alpha-Agonists; Angiotensin-Converting Enzyme Inhibitors; Child; Clonidine; Drug Interact | 2000 |