tizanidine has been researched along with Hemiplegia in 6 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Hemiplegia: Severe or complete loss of motor function on one side of the body. This condition is usually caused by BRAIN DISEASES that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, BRAIN STEM lesions; cervical SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; and other conditions may manifest as hemiplegia. The term hemiparesis (see PARESIS) refers to mild to moderate weakness involving one side of the body.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind study was carried out in 105 patients with chronic spasticity associated with hemiplegia in order to compare the efficacy and tolerability of tizanidine with that of diazepam." | 9.06 | A multi-centre, double-blind trial of tizanidine, a new antispastic agent, in spasticity associated with hemiplegia. ( Bes, A; Eyssette, M; Pierrot-Deseilligny, E; Rohmer, F; Warter, JM, 1988) |
| "To investigate the effect of tizanidine (an alpha(2) noradrenergic agonist) on transmission in the interneuronal pathway coactivated by group I and group II afferents in post-stroke patients with spastic hemiplegia." | 5.11 | Modulation of the transmission in group II heteronymous pathways by tizanidine in spastic hemiplegic patients. ( Marque, P; Maupas, E; Roques, CF; Simonetta-Moreau, M, 2004) |
| "A double-blind study was carried out in 105 patients with chronic spasticity associated with hemiplegia in order to compare the efficacy and tolerability of tizanidine with that of diazepam." | 5.06 | A multi-centre, double-blind trial of tizanidine, a new antispastic agent, in spasticity associated with hemiplegia. ( Bes, A; Eyssette, M; Pierrot-Deseilligny, E; Rohmer, F; Warter, JM, 1988) |
| "Thirty patients with old post-stroke spastic hemiparesis took part in the investigation." | 1.29 | Mechanisms of tizanidine action on spasticity. ( Georgiev, D; Milanov, I, 1994) |
| "On the spastic side a reflex with prolonged latencies and durations, as well as with decreased amplitudes and thresholds of both reflex responses was found." | 1.28 | Flexor reflex for assessment of common interneurone activity in spasticity. ( Milanov, IG, 1992) |
| "Twelve spastic patients received single oral doses of a new anti-spastic drug DS103-282 (Sandoz) 6 mg, baclofen 20 mg, and placebo on three separate days." | 1.26 | Double-blind comparison of single doses of DS103-282, baclofen and placebo for suppression of spasticity. ( Hassan, N; McLellan, DL, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uysal, H | 1 |
| Larsson, LE | 1 |
| Efendi, H | 1 |
| Burke, D | 1 |
| Ertekin, C | 1 |
| Maupas, E | 1 |
| Marque, P | 1 |
| Roques, CF | 1 |
| Simonetta-Moreau, M | 1 |
| Hassan, N | 1 |
| McLellan, DL | 1 |
| Milanov, I | 1 |
| Georgiev, D | 1 |
| Milanov, IG | 1 |
| Bes, A | 1 |
| Eyssette, M | 1 |
| Pierrot-Deseilligny, E | 1 |
| Rohmer, F | 1 |
| Warter, JM | 1 |
2 trials available for tizanidine and Hemiplegia
| Article | Year |
|---|---|
Modulation of the transmission in group II heteronymous pathways by tizanidine in spastic hemiplegic patients.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Female; Hemiplegia; Humans; | 2004 |
A multi-centre, double-blind trial of tizanidine, a new antispastic agent, in spasticity associated with hemiplegia.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Clonidine; Diazepam; Double-Blind Method; Female; | 1988 |
4 other studies available for tizanidine and Hemiplegia
| Article | Year |
|---|---|
Medium-latency reflex response of soleus elicited by peroneal nerve stimulation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Clonidine; Cold Temperature; Electric Stimulation; Elec | 2009 |
Double-blind comparison of single doses of DS103-282, baclofen and placebo for suppression of spasticity.
Topics: Adolescent; Adult; Aged; Baclofen; Clonidine; Double-Blind Method; Electromyography; Female; Hemiple | 1980 |
Mechanisms of tizanidine action on spasticity.
Topics: Adult; Aged; Cerebrovascular Disorders; Clonidine; Electromyography; Female; H-Reflex; Hemiplegia; H | 1994 |
Flexor reflex for assessment of common interneurone activity in spasticity.
Topics: Adult; Aged; Anti-Anxiety Agents; Baclofen; Benzodiazepines; Benzodiazepinones; Cerebrovascular Diso | 1992 |