tizanidine has been researched along with Disorders of Excessive Somnolence in 2 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Disorders of Excessive Somnolence: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tizanidine HCl is an alpha2 adrenergic agonist indicated for treating spasticity due to MS or spinal cord injury." | 6.75 | Nightly sublingual tizanidine HCl in multiple sclerosis: clinical efficacy and safety. ( Auriel, E; Karni, A; Vakhapova, V, 2010) |
| "Tizanidine HCl is an alpha2 adrenergic agonist indicated for treating spasticity due to MS or spinal cord injury." | 2.75 | Nightly sublingual tizanidine HCl in multiple sclerosis: clinical efficacy and safety. ( Auriel, E; Karni, A; Vakhapova, V, 2010) |
| " Blood samples were collected to determine plasma tizanidine pharmacokinetic profiles, and computerized cognitive function tests were performed that yielded a validated composite score, Power of Attention, an index of sedation." | 2.72 | Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers. ( Henney, HR; Kovelesky, RA; Shah, J; Wesnes, KA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vakhapova, V | 1 |
| Auriel, E | 1 |
| Karni, A | 1 |
| Shah, J | 1 |
| Wesnes, KA | 1 |
| Kovelesky, RA | 1 |
| Henney, HR | 1 |
2 trials available for tizanidine and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
Nightly sublingual tizanidine HCl in multiple sclerosis: clinical efficacy and safety.
Topics: Administration, Sublingual; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; | 2010 |
Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers.
Topics: Adolescent; Adult; Capsules; Clonidine; Cognition; Cross-Over Studies; Disorders of Excessive Somnol | 2006 |