tizanidine has been researched along with Chronic Disease in 16 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of the modified-release formulation of tizanidine (Sirdalud) was compared with placebo in a randomized, double-blind, parallel-group study of 138 women and 47 men, aged 18 to 79 years, with a history of chronic tension-type headache (IHS categories 2." | 9.09 | Modified-release formulation of tizanidine in chronic tension-type headache. ( Färkkilä, M; Havanka, H; Hedman, C; Kataja, M; Keränen, T; Murros, K; Peltola, J; Säkö, E, 2000) |
| "The efficacy of tizanidine in chronic tension-type headache was compared with placebo in a randomized, double-blind and cross-over study in 37 women aged 20 to 59 years with a history of headache for 7 months to 30 years (median 5 years)." | 9.07 | Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study. ( Fogelholm, R; Murros, K, 1992) |
| "A double-blind trial with two parallel groups was carried out to compare the antispastic effect and tolerability of a new muscle relaxant, tizanidine (DS 103-282), with those of baclofen in the treatment of spasticity due to multiple sclerosis." | 9.05 | A double-blind comparative trial of new muscle relaxant, tizanidine (DS 103-282), and baclofen in the treatment of chronic spasticity in multiple sclerosis. ( Muff, S; Smolenski, C; Smolenski-Kautz, S, 1981) |
| "The efficacy of the modified-release formulation of tizanidine (Sirdalud) was compared with placebo in a randomized, double-blind, parallel-group study of 138 women and 47 men, aged 18 to 79 years, with a history of chronic tension-type headache (IHS categories 2." | 5.09 | Modified-release formulation of tizanidine in chronic tension-type headache. ( Färkkilä, M; Havanka, H; Hedman, C; Kataja, M; Keränen, T; Murros, K; Peltola, J; Säkö, E, 2000) |
| "The efficacy of tizanidine in chronic tension-type headache was compared with placebo in a randomized, double-blind and cross-over study in 37 women aged 20 to 59 years with a history of headache for 7 months to 30 years (median 5 years)." | 5.07 | Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study. ( Fogelholm, R; Murros, K, 1992) |
| "A double-blind trial with two parallel groups was carried out to compare the antispastic effect and tolerability of a new muscle relaxant, tizanidine (DS 103-282), with those of baclofen in the treatment of spasticity due to multiple sclerosis." | 5.05 | A double-blind comparative trial of new muscle relaxant, tizanidine (DS 103-282), and baclofen in the treatment of chronic spasticity in multiple sclerosis. ( Muff, S; Smolenski, C; Smolenski-Kautz, S, 1981) |
| " The first group was used as control group (Control) (n = 20), in the second group subarachnoid hemorrhage was performed (SAH) (n = 20), in the third group Tizanidine was administered in addition to SAH (SAH + Tizanidine administration) (n = 20)." | 3.70 | The effect of tizanidine on chronic vasospasm in rats. ( Berkman, MK; Berkman, MZ; Erbengi, T; Iplikçioğlu, AC; San, T; Sav, A, 2000) |
| "The antinociceptive actions of morphine and tizanidine (an alpha 2-adrenergic agonist) administered intrathecally in a rat model of mononeuropathic pain were investigated." | 3.69 | A comparison of intrathecally administered narcotic and nonnarcotic analgesics for experimental chronic neuropathic pain. ( Dills, CV; Kim, DL; Leiphart, JW; Levy, RM; Zikel, OM, 1995) |
| "Tizanidine is an alpha2-adrenergic agonist that inhibits the release of norepinephrine at both the spinal cord and brain, with antinociceptive effects that are independent of the endogenous opioid system." | 2.70 | Chronic daily headache prophylaxis with tizanidine: a double-blind, placebo-controlled, multicenter outcome study. ( Cantrell, DT; Lake, AE; Saper, JR; White, JR; Winner, PK, 2002) |
| "Chronic migraine is an important public health problem." | 1.36 | Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials. ( D'Amico, D, 2010) |
| "Tizanidine (TZD) is an alpha-2-adrenergic drug with potential spinal analgesic action and could be a substitute or additive for intrathecal (i." | 1.30 | Distribution, tolerability and tissue compatibility of intrathecal tizanidine in the sheep. ( Loew, M; Ochs, G; Tonn, J; Toyka, K, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duffell, LD | 1 |
| Brown, GL | 1 |
| Mirbagheri, MM | 1 |
| D'Amico, D | 1 |
| Fuchigami, T | 1 |
| Kakinohana, O | 1 |
| Hefferan, MP | 1 |
| Lukacova, N | 1 |
| Marsala, S | 1 |
| Platoshyn, O | 1 |
| Sugahara, K | 1 |
| Yaksh, TL | 1 |
| Marsala, M | 1 |
| Saper, JR | 1 |
| Lake, AE | 1 |
| Cantrell, DT | 1 |
| Winner, PK | 1 |
| White, JR | 1 |
| Moufarrege, G | 1 |
| Frank, E | 1 |
| Carstens, DD | 1 |
| Bettucci, D | 1 |
| Testa, L | 1 |
| Calzoni, S | 1 |
| Mantegazza, P | 1 |
| Viana, M | 1 |
| Monaco, F | 1 |
| Smolenski, C | 1 |
| Muff, S | 1 |
| Smolenski-Kautz, S | 1 |
| Iakhno, NN | 1 |
| Damulin, IV | 1 |
| Chernenko, OA | 1 |
| Ianakaeva, TA | 1 |
| Kondrat'eva, ON | 1 |
| Kur'ianova, PT | 1 |
| Leiphart, JW | 1 |
| Dills, CV | 1 |
| Zikel, OM | 1 |
| Kim, DL | 1 |
| Levy, RM | 1 |
| Vorobeĭchik, IaM | 1 |
| Kukushkin, ML | 1 |
| Reshetniak, VK | 1 |
| Ovechkin, AM | 1 |
| Gnezdilov, AV | 1 |
| Filatova, EG | 1 |
| Solov'eva, AD | 1 |
| Danilov, AB | 1 |
| Ochs, G | 1 |
| Loew, M | 1 |
| Tonn, J | 1 |
| Toyka, K | 1 |
| Murros, K | 2 |
| Kataja, M | 1 |
| Hedman, C | 1 |
| Havanka, H | 1 |
| Säkö, E | 1 |
| Färkkilä, M | 1 |
| Peltola, J | 1 |
| Keränen, T | 1 |
| Berkman, MZ | 1 |
| Iplikçioğlu, AC | 1 |
| Berkman, MK | 1 |
| Erbengi, T | 1 |
| San, T | 1 |
| Sav, A | 1 |
| Smith, TR | 1 |
| Fogelholm, R | 1 |
8 trials available for tizanidine and Chronic Disease
| Article | Year |
|---|---|
Interventions to Reduce Spasticity and Improve Function in People With Chronic Incomplete Spinal Cord Injury: Distinctions Revealed by Different Analytical Methods.
Topics: Analysis of Variance; Cervical Vertebrae; Chronic Disease; Clonidine; Data Interpretation, Statistic | 2015 |
Chronic daily headache prophylaxis with tizanidine: a double-blind, placebo-controlled, multicenter outcome study.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Chronic Disease; Clonidine; Double-Blind Method; Femal | 2002 |
Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension-type headache: evaluation of efficacy and impact on quality of life.
Topics: Adult; Amitriptyline; Analgesics; Chronic Disease; Clonidine; Drug Therapy, Combination; Female; Hea | 2006 |
A double-blind comparative trial of new muscle relaxant, tizanidine (DS 103-282), and baclofen in the treatment of chronic spasticity in multiple sclerosis.
Topics: Adult; Aged; Baclofen; Chronic Disease; Clinical Trials as Topic; Clonidine; Double-Blind Method; Fe | 1981 |
[The efficacy of sirdalud in the drug therapy of pain in the spine].
Topics: Acute Disease; Adult; Aged; Analgesics; Back Pain; Chronic Disease; Clonidine; Female; Humans; Male; | 1994 |
[The treatment of the phantom pain syndrome with tizanidine].
Topics: Adult; Aged; Analgesics; Chronic Disease; Clonidine; Double-Blind Method; Female; Humans; Male; Midd | 1997 |
Modified-release formulation of tizanidine in chronic tension-type headache.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Chronic Disease; Clonidine; Delayed-Action Preparations; Dou | 2000 |
Tizanidine in chronic tension-type headache: a placebo controlled double-blind cross-over study.
Topics: Adult; Analgesics; Chronic Disease; Clonidine; Depression; Dose-Response Relationship, Drug; Double- | 1992 |
8 other studies available for tizanidine and Chronic Disease
| Article | Year |
|---|---|
Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials.
Topics: Amines; Analgesics; Chronic Disease; Clonidine; Cyclohexanecarboxylic Acids; Diagnosis, Differential | 2010 |
Potent suppression of stretch reflex activity after systemic or spinal delivery of tizanidine in rats with spinal ischemia-induced chronic spastic paraplegia.
Topics: Animals; Chronic Disease; Clonidine; Disease Models, Animal; Male; Muscle Relaxants, Central; Neural | 2011 |
Eosinophilic exudative pleural effusion after initiation of tizanidine treatment: a case report.
Topics: Adult; Analgesics; Chronic Disease; Clonidine; Eosinophilia; Humans; Low Back Pain; Male; Pleural Ef | 2003 |
A comparison of intrathecally administered narcotic and nonnarcotic analgesics for experimental chronic neuropathic pain.
Topics: Analgesics; Animals; Chronic Disease; Clonidine; Dose-Response Relationship, Drug; Humans; Injection | 1995 |
[The treatment of tension headache with sirdalud].
Topics: Adult; Chronic Disease; Clonidine; Drug Evaluation; Female; Humans; Male; Muscle Relaxants, Central; | 1997 |
Distribution, tolerability and tissue compatibility of intrathecal tizanidine in the sheep.
Topics: Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Animals; Behavior, A | 1998 |
The effect of tizanidine on chronic vasospasm in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Chronic Disease; Clonidine; Disease Models, Animal; F | 2000 |
Low-dose tizanidine with nonsteroidal anti-inflammatory drugs for detoxification from analgesic rebound headache.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Clonidine; Dose-R | 2002 |