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tizanidine and Catatonic Rigidity

tizanidine has been researched along with Catatonic Rigidity in 5 studies

tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.

Research Excerpts

ExcerptRelevanceReference
" Although rigidity was reduced by efaroxan (an imidazoline I(1) receptor and alpha(2)-adrenoceptor antagonist) and idazoxan (an imidazoline I(1) and I(2) receptor and alpha(2)-adrenoceptor antagonist), SKF86466 and yohimbine, both of which are alpha(2)-adrenoceptor antagonists with no affinity for imidazoline receptors, also suppressed rigidity, suggesting that activation rather than blockade of imidazoline I(1) receptors contributes to reduction of reserpine-induced muscle rigidity."7.74Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. ( Hashimoto, M; Ono, H; Tanabe, M, 2008)
" Although rigidity was reduced by efaroxan (an imidazoline I(1) receptor and alpha(2)-adrenoceptor antagonist) and idazoxan (an imidazoline I(1) and I(2) receptor and alpha(2)-adrenoceptor antagonist), SKF86466 and yohimbine, both of which are alpha(2)-adrenoceptor antagonists with no affinity for imidazoline receptors, also suppressed rigidity, suggesting that activation rather than blockade of imidazoline I(1) receptors contributes to reduction of reserpine-induced muscle rigidity."3.74Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. ( Hashimoto, M; Ono, H; Tanabe, M, 2008)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tanabe, M2
Hashimoto, M1
Ono, H1
Gazulla Abío, J1
Benavente Aguilar, I1
Capablo Liesa, JL1
Meinck, HM2
Ricker, K1
Conrad, B2
Kaneko, T1
Tonohiro, T1
Iwata, N1

Other Studies

5 other studies available for tizanidine and Catatonic Rigidity

ArticleYear
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
    European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines

2008
[Progressive encephalomyelitis with rigidity responsive to gabapentin: a pharmacological update].
    Neurologia (Barcelona, Spain), 2004, Volume: 19, Issue:8

    Topics: Amines; Antiparkinson Agents; Clonidine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Dr

2004
The stiff-man syndrome: new pathophysiological aspects from abnormal exteroceptive reflexes and the response to clomipramine, clonidine, and tizanidine.
    Journal of neurology, neurosurgery, and psychiatry, 1984, Volume: 47, Issue:3

    Topics: Adult; Brain Stem; Clomipramine; Clonidine; Diazepam; Electromyography; Female; Humans; Muscle Rigid

1984
The pharmacological properties of CS-722, a newly synthesized centrally acting muscle relaxant.
    Neuropharmacology, 1992, Volume: 31, Issue:10

    Topics: Animals; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Electroencephalography; Evo

1992
Neuropharmacological investigations in the stiff-man syndrome.
    Journal of neurology, 1986, Volume: 233, Issue:6

    Topics: Adrenergic Fibers; Central Nervous System Diseases; Clonidine; Diazepam; Female; Humans; Methampheta

1986