tizanidine has been researched along with Brain Injuries in 2 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tizanidine is an imidazoline central alpha(2)-adrenoceptor agonist widely used to manage spasticity secondary to conditions such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI)." | 8.84 | A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. ( Henney, HR; Kamen, L; Runyan, JD, 2008) |
| "Tizanidine is an imidazoline central alpha(2)-adrenoceptor agonist widely used to manage spasticity secondary to conditions such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI)." | 4.84 | A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. ( Henney, HR; Kamen, L; Runyan, JD, 2008) |
| " The average dosage at 4 weeks was 25." | 2.70 | Prospective assessment of tizanidine for spasticity due to acquired brain injury. ( Brunner, RM; Guin-Renfroe, S; Johnson, A; Meythaler, JM, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kamen, L | 1 |
| Henney, HR | 1 |
| Runyan, JD | 1 |
| Meythaler, JM | 1 |
| Guin-Renfroe, S | 1 |
| Johnson, A | 1 |
| Brunner, RM | 1 |
1 review available for tizanidine and Brain Injuries
| Article | Year |
|---|---|
A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.
Topics: Brain Injuries; Clonidine; Disease Progression; Drug Interactions; Female; Humans; Middle Aged; Mult | 2008 |
1 trial available for tizanidine and Brain Injuries
| Article | Year |
|---|---|
Prospective assessment of tizanidine for spasticity due to acquired brain injury.
Topics: Administration, Oral; Adult; Aged; Brain Injuries; Clonidine; Cross-Over Studies; Dose-Response Rela | 2001 |