tizanidine has been researched along with Bradyarrhythmia in 9 studies
tizanidine: RN given refers to parent cpd; structure
tizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 37-year-old man suffered irreversible profound symptomatic bradycardia requiring a pacemaker 3 days after beginning tizanidine/loxoprofen combination therapy for neck pain." | 7.88 | Irreversible profound symptomatic bradycardia requiring pacemaker after tizanidine/loxoprofen combination therapy: a case report. ( Jin, Y; Li, X, 2018) |
| "We report a case of profound symptomatic bradycardia after a single dose of tizanidine." | 7.81 | Profound symptomatic bradycardia requiring transvenous pacing after a single dose of tizanidine. ( Cortes, J; Hall, B; Redden, D, 2015) |
| "A case of severe bradycardia and hypotension associated with concomitant tizanidine and lisinopril therapy is reported." | 7.76 | Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy. ( Branam, DL; Publow, SW, 2010) |
| " During the 33 days before admission, she received oral tizanidine hydrochloride at 3 mg/day for leg cramps." | 7.73 | Symptomatic bradycardia probably due to tizanidine hydrochloride in a chronic hemodialysis patient. ( Abe, T; Akizawa, T; Kamimura, M; Kitabata, Y; Kobata, H; Narukawa, N; Orita, H; Shiizaki, K, 2005) |
| "The case of a 59-year-old healthy woman is described, who developed an extreme sinus bradycardia (30/min) with chest pain and acute right heart failure associated with gastrointestinal symptoms and elevation of the liver enzymes while simultaneously taking tizanidine (Sirdalud), diclofenac (Voltaren), and rofecoxib (Vioxx)." | 7.73 | [Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)]. ( Bertoli, R; Caduff Janosa, P; Cerny, A; Kick, A; Moschovitis, G, 2005) |
| "A 37-year-old man suffered irreversible profound symptomatic bradycardia requiring a pacemaker 3 days after beginning tizanidine/loxoprofen combination therapy for neck pain." | 3.88 | Irreversible profound symptomatic bradycardia requiring pacemaker after tizanidine/loxoprofen combination therapy: a case report. ( Jin, Y; Li, X, 2018) |
| "We report a case of profound symptomatic bradycardia after a single dose of tizanidine." | 3.81 | Profound symptomatic bradycardia requiring transvenous pacing after a single dose of tizanidine. ( Cortes, J; Hall, B; Redden, D, 2015) |
| "A case of severe bradycardia and hypotension associated with concomitant tizanidine and lisinopril therapy is reported." | 3.76 | Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy. ( Branam, DL; Publow, SW, 2010) |
| " During the 33 days before admission, she received oral tizanidine hydrochloride at 3 mg/day for leg cramps." | 3.73 | Symptomatic bradycardia probably due to tizanidine hydrochloride in a chronic hemodialysis patient. ( Abe, T; Akizawa, T; Kamimura, M; Kitabata, Y; Kobata, H; Narukawa, N; Orita, H; Shiizaki, K, 2005) |
| "The case of a 59-year-old healthy woman is described, who developed an extreme sinus bradycardia (30/min) with chest pain and acute right heart failure associated with gastrointestinal symptoms and elevation of the liver enzymes while simultaneously taking tizanidine (Sirdalud), diclofenac (Voltaren), and rofecoxib (Vioxx)." | 3.73 | [Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)]. ( Bertoli, R; Caduff Janosa, P; Cerny, A; Kick, A; Moschovitis, G, 2005) |
| "Although intrathecal clonidine produces pronounced analgesia, antinociceptive doses of intrathecal clonidine produce several side effects, including hypotension, bradycardia, and sedation." | 3.72 | Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain. ( Kawamata, T; Namiki, A; Omote, K; Toriyabe, M; Wada, K; Yamamoto, H, 2003) |
| "Clonidine was associated with the most respiratory (799, 2." | 1.40 | Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System. ( Heard, K; Le Lait, MC; Wang, GS, 2014) |
| "The tizanidine effect was inhibited by yohimbine and the alpha(2)/imidazoline antagonist idazoxan, as well as the parasympathetic blocker glycopyrrolate." | 1.29 | Intrathecal clonidine and tizanidine in conscious dogs: comparison of analgesic and hemodynamic effects. ( Ivankovich, AD; Kroin, JS; Lubenow, TR; McCarthy, RJ; Penn, RD, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Adams, A | 1 |
| Copley, C | 1 |
| Li, X | 1 |
| Jin, Y | 1 |
| Wang, GS | 1 |
| Le Lait, MC | 1 |
| Heard, K | 1 |
| Cortes, J | 1 |
| Hall, B | 1 |
| Redden, D | 1 |
| Publow, SW | 1 |
| Branam, DL | 1 |
| Kawamata, T | 1 |
| Omote, K | 1 |
| Yamamoto, H | 1 |
| Toriyabe, M | 1 |
| Wada, K | 1 |
| Namiki, A | 1 |
| Kitabata, Y | 1 |
| Orita, H | 1 |
| Kamimura, M | 1 |
| Shiizaki, K | 1 |
| Narukawa, N | 1 |
| Abe, T | 1 |
| Kobata, H | 1 |
| Akizawa, T | 1 |
| Kick, A | 1 |
| Bertoli, R | 1 |
| Moschovitis, G | 1 |
| Caduff Janosa, P | 1 |
| Cerny, A | 1 |
| Kroin, JS | 1 |
| McCarthy, RJ | 1 |
| Penn, RD | 1 |
| Lubenow, TR | 1 |
| Ivankovich, AD | 1 |
9 other studies available for tizanidine and Bradyarrhythmia
| Article | Year |
|---|---|
High dose naloxone for acute tizanidine overdose in the emergency department: a case report.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bradycardia; Clonidine; Drug Overdose; Emergency Servic | 2021 |
Irreversible profound symptomatic bradycardia requiring pacemaker after tizanidine/loxoprofen combination therapy: a case report.
Topics: Adult; Analgesics; Atrioventricular Block; Bradycardia; Cardiac Pacing, Artificial; Clonidine; Drug | 2018 |
Unintentional pediatric exposures to central alpha-2 agonists reported to the National Poison Data System.
Topics: Adrenergic alpha-2 Receptor Agonists; Bradycardia; Child; Child, Preschool; Clonidine; Female; Guanf | 2014 |
Profound symptomatic bradycardia requiring transvenous pacing after a single dose of tizanidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged, 80 and over; Bradycardia; Cardiac Pacing, Artificial; Cl | 2015 |
Hypotension and bradycardia associated with concomitant tizanidine and lisinopril therapy.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; B | 2010 |
Antihyperalgesic and side effects of intrathecal clonidine and tizanidine in a rat model of neuropathic pain.
Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Behavior, Animal; Blood Pressure; Bradycardia; Cloni | 2003 |
Symptomatic bradycardia probably due to tizanidine hydrochloride in a chronic hemodialysis patient.
Topics: Aged; Bradycardia; Clonidine; Female; Humans; Kidney Failure, Chronic; Muscle Cramp; Muscle Relaxant | 2005 |
[Extreme sinus bradycardia (30/min) with acute right heart failure under tizanidine (Sirdalud). Possible pharmacological interaction with rofecoxib (Vioxx)].
Topics: Acute Disease; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bradycardia; Clonidine; Cyclooxy | 2005 |
Intrathecal clonidine and tizanidine in conscious dogs: comparison of analgesic and hemodynamic effects.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Blood Pressure; Bradyc | 1996 |