tixocortol-pivalate and Dermatitis--Contact

Topics: Administration, Topical; Adrenal Cortex Hormones; Adult; Dermatitis, Contact; Drug Eruptions; Female; Humans; Hydrocortisone; Intradermal Tests; Male; Middle Aged

In order to map the frequency of contact hypersensitivity (CH) to epoxy resin, methyldibromoglutaronitrile (MDBGN), tixocortol pivalate (TP) and budesonide patch tests were carried out.. The tests were performed in 1448 patients. Most patients belong to the allergic and irritative contact dermatitis groups. The tests were administered with the allergens epoxy resin 1%, MDBGN 0.3%, TP 1% and budesonide 0.1%, applied on the back. Reactions were evaluated at 40 min, on day 2 (D2), day 3 (D3) and day 4 (D4). In the patients of the Dept. of Dermatology, Venerology and Dermatooncology of Semmelweis University (patients number =1073) reactions were evaluated on day 7 as well.. Epoxy resin elicited immediate reactions in 1 patient at 40 min. Further evaluations showed no difference on D3, D4 and D7 with a frequency of CH of 1.03%. Patch testing for MDBGN did not provoke immediate reactions, evaluations showed an increasing hypersensitivity rate (D2: 0.93%; D7:1.77%). Patch tests with TP yielded no immediate reactions, the frequency of CH increased from 0.47% (D2) to 2.01% (D7). No immediate reactions were observed by budesonide; an increase was seen in frequency of CH (D2:0.93% to D7:3.84%). CH to the studied allergens was observed mostly in allergic contact dermatitis group, to budesonide in irritative contact dermatitis and in atopic dermatitis groups as well.. The data of the present study are the first results about this four allergens in Hungary and to our knowledge from our region as well.

Topics: Allergens; Budesonide; Dermatitis, Allergic Contact; Dermatitis, Contact; Dermatitis, Irritant; Epoxy Resins; Humans; Hungary; Hydrocortisone; Hypersensitivity, Immediate; Nitriles; Patch Tests; Preservatives, Pharmaceutical; Urticaria

Topics: Anti-Allergic Agents; Child; Child, Preschool; Dermatitis, Contact; Family Health; Female; Humans; Hydrocortisone; Nickel; Patch Tests

We have found a high incidence (4.8%) of allergy to hydrocortisone in patients with suspected allergic contact dermatitis. In view of this finding we would suggest that, in any condition that does not improve or that deteriorates after administration of hydrocortisone, allergy to this compound should be considered.

Topics: Administration, Topical; Anti-Inflammatory Agents; Dermatitis, Contact; Evaluation Studies as Topic; Humans; Hydrocortisone; Patch Tests

3 corticosteroids have so far been tried as markers for corticosteroid contact sensitivity: hydrocortisone, tixocortol pivalate and hydrocortisone-17-butyrate. The present study compared these steroids for screening in addition to a standard patch test series. Of 727 patients, 28 (3.9%) reacted to tixocortol pivalate and 10 (1.4%) to hydrocortisone-17-butyrate; hydrocortisone gave an allergic reaction in 2 of 521 (0.4%) patients. Serial dilutions suggested that tixocortol pivalate, not marketed in Finland, caused allergic reactions which could possibly be cross-reactions to hydrocortisone. In contrast to previously published data, frequent cross-reactions occurred with hydrocortisone-17-butyrate and tixocortol pivalate. All allergic reactions to other corticosteroids found by testing with tixocortol pivalate concurred with reactions to hydrocortisone-17-butyrate. The study suggests that the most effective choice for routine testing for corticosteroid contact sensitivity would be both tixocortol pivalate and hydrocortisone-17-butyrate.

Topics: Administration, Topical; Anti-Inflammatory Agents; Dermatitis, Contact; Drug Eruptions; Finland; Humans; Hydrocortisone; Patch Tests; Retrospective Studies

Topics: Administration, Topical; Anti-Inflammatory Agents; Dermatitis, Contact; Humans; Hydrocortisone; Injections, Intradermal; Patch Tests; Prospective Studies

Topics: Administration, Intranasal; Administration, Topical; Aerosols; Anti-Inflammatory Agents; Dermatitis, Contact; Drug Eruptions; Female; Humans; Hydrocortisone; Middle Aged; Rhinitis, Allergic, Perennial

Topics: Administration, Topical; Anti-Inflammatory Agents; Dermatitis, Contact; Europe; Humans; Hydrocortisone; Patch Tests

Allergic contact dermatitis to pharmaceutical topical products containing corticosteroids are not uncommon. The study of these cases must combine patch test with standard series, vehicles, special components of each commercial cream and tixocortol pivalate. The importance of these substance is specially emphasized in that paper.

Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Betamethasone; Chemical Phenomena; Chemistry; Clobetasol; Cresols; Dermatitis, Contact; False Negative Reactions; Female; Humans; Hydrocortisone; Middle Aged; Skin Tests

Topics: Administration, Topical; Anti-Inflammatory Agents; Cross Reactions; Dermatitis, Contact; Humans; Hydrocortisone; Patch Tests

Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Dermatitis, Contact; Female; Humans; Hydrocortisone; Nickel; Patch Tests; Rhinitis

Topics: Animals; Anti-Inflammatory Agents; Dermatitis, Contact; Guinea Pigs; Hydrocortisone; Skin Tests

Several of the difficulties involved in the detection of corticosteroid allergy are illustrated by the problems encountered in a patient sensitive to a preparation containing hydrocortisone and miconazole nitrate. The importance of appropriate concentrations and vehicles for patch testing, the possible rôle of impurities, and cross-sensitivity of corticosteroid molecules are discussed.

Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dermatitis, Contact; Female; Humans; Hydrocortisone; Miconazole; Patch Tests

6 cases of hypersensitivity to Tixocortol pivalate and 3 to Amcinonide are reported. The 9 female patients all presented with features of contact dermatitis.

Topics: Administration, Topical; Adult; Aged; Chemical Phenomena; Chemistry; Dermatitis, Contact; Facial Dermatoses; Female; Humans; Hydrocortisone; Middle Aged; Triamcinolone