Compounds > tipifarnib
Page last updated: 2024-09-04

tipifarnib and Disease Models, Animal

tipifarnib has been researched along with Disease Models, Animal in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's2 (25.00)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV1
Jones, RD; Li, H; Liao, J; Sun, L; Tong, X; Xu, D; Yang, GY1
Akahoshi, T; Guo, J; Mizuta, Y; Murata, M; Shirozu, K; Yamaura, K1
Abdul-Salam, VB; Ahmetaj-Shala, B; Aldabbous, L; Dubois, OD; Duluc, L; Iannone, L; Mahomed, AS; Mitchell, J; Oliver, E; Storck, EM; Tate, EW; Wilkins, MR; Wojciak-Stothard, B; Zhao, L1
Avallone, H; Cao, K; Capell, BC; Chen, X; Collins, FS; Conneely, KN; Erdos, MR; Faddah, DA; Ganesh, SK; Kolodgie, FD; Nabel, EG; Olive, M; Qu, X; San, H; Tavarez, UL; Virmani, R1
Cheson, BD; Gravell, AE; Wright, JJ; Zerivitz, K1
Alyaqoub, FS; Gunning, WT; Kramer, PM; Lubet, RA; Pereira, MA; Steele, VE; Tao, L2

Other Studies

8 other study(ies) available for tipifarnib and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

2020
Inhibition of mutant Kras and p53-driven pancreatic carcinogenesis by atorvastatin: Mainly via targeting of the farnesylated DNAJA1 in chaperoning mutant p53.
    Molecular carcinogenesis, 2019, Volume: 58, Issue:11

    Topics: Animals; Atorvastatin; Carcinogenesis; Cell Line, Tumor; Disease Models, Animal; Farnesyltranstransferase; Gene Expression Regulation, Neoplastic; HSP40 Heat-Shock Proteins; Humans; Mice; Molecular Chaperones; Mutant Proteins; Pancreas; Pancreatic Neoplasms; Prenylation; Proto-Oncogene Proteins p21(ras); Quinolones; Tumor Suppressor Protein p53

2019
The farnesyltransferase inhibitor tipifarnib protects against autoimmune hepatitis induced by Concanavalin A.
    International immunopharmacology, 2020, Volume: 83

    Topics: Animals; Antineoplastic Agents; CD4-Positive T-Lymphocytes; Cells, Cultured; Concanavalin A; Disease Models, Animal; Hepatitis, Autoimmune; Humans; Interferon-gamma; Liver; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Quinolones

2020
Tipifarnib prevents development of hypoxia-induced pulmonary hypertension.
    Cardiovascular research, 2017, 03-01, Volume: 113, Issue:3

    Topics: Animals; Antihypertensive Agents; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Hypertension, Pulmonary; Hypoxia; Male; Mice, Inbred C57BL; Phenotype; Protein Prenylation; Proteomics; Pulmonary Artery; Quinolones; rhoB GTP-Binding Protein; Time Factors; Transfection; Vasoconstriction; Vasodilation

2017
A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Oct-14, Volume: 105, Issue:41

    Topics: Animals; Cardiovascular Diseases; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesyltranstransferase; Mice; Progeria; Quinolones

2008
Clinical trials referral resource. Current clinical trials of R115777 (Zarnestra).
    Oncology (Williston Park, N.Y.), 2002, Volume: 16, Issue:7

    Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Disease Models, Animal; Humans; Mice; Neoplasms; Quinolones; Transplantation, Heterologous

2002
Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT).
    Carcinogenesis, 2006, Volume: 27, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Budesonide; Disease Models, Animal; DNA Methylation; Drug Therapy, Combination; Female; Lung Neoplasms; Mice; Mice, Inbred A; Quinolones

2006
Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra MT).
    Carcinogenesis, 2007, Volume: 28, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Budesonide; Chemoprevention; Disease Models, Animal; DNA Methylation; Drug Therapy, Combination; Female; Lung Neoplasms; Mice; Mice, Inbred A; Quinolones; Urethane

2007